In this article, we examine phantom limb syndrome to gain insights into how the brain functions as the mind and how consciousness arises. We further explore our previously proposed consciousness model in which consciousness and body schema arise when information from throughout the body is processed by corticothalamic feedback loops and integrated by the thalamus. The parietal lobe spatially maps visual and non-visual information and the thalamus integrates and recreates this processed sensory information within a three-dimensional space termed the ‘‘3D (...) default space.’’ We propose that phantom limb syndrome and phantom limb pain arise when the afferent signaling from the amputated limb is lost but the neural circuits remain intact. In addition, integration of conflicting sensory information within the default 3D space and the loss of inhibitory afferent feedback to efferent motor activity from the amputated limb may underlie phantom limb pain. (shrink)

Our experiences with the external world are possible mainly through vision, hearing, taste, touch, and smell providing us a sense of reality. How the brain is able to seamlessly integrate stimuli from our external and internal world into our sense of reality has yet to be adequately explained in the literature. We have previously proposed a three-dimensional unified model of consciousness that partly explains the dynamic mechanism. Here we further expand our model and include illustrations to provide a better conception (...) of the ill-defined space within the self, providing insight into a unified mind-body concept. In this article, we propose that our senses “super-impose” on an existing dynamic space within us after a slight, imperceptible delay. The existing space includes the entire intrapersonal space and can also be called the “the body’s internal 3D default space”. We provide examples from meditation experiences to help explain how the sense of ‘self’ can be experienced through meditation practice associated with underlying physiological processes that take place through cardio-respiratory synchronization and coherence that is developed among areas of the brain. Meditation practice can help keep the body in a parasympathetic dominant state during meditation, allowing an experience of inner ‘self’. Understanding this physical and functional space could help unlock the mysteries of the function of memory and cognition, allowing clinicians to better recognize and treat disorders of the mind by recommending proven techniques to reduce stress as an adjunct to medication treatment. (shrink)

Current research on the various forms of autoscopic phenomena addresses the clinical and neurological correlates of out-of-body experiences, autoscopic hallucinations,and heautoscopy. Yet most of this research is based on functional magnetic resonance imaging results and focuses predominantly on abnormal cortical activity. Previously we proposed that visual consciousness resulted from the dynamic retinogeniculo-cortical oscillations, such that the photoreceptors dynamically integrated with visual and other vision-associated cortices, and was theorized to be mapped out by photoreceptor discs and rich retinal networks which synchronized (...) with the retinotopic mapping and the associated cortex. The feedback from neural input that is received from the thalamus and cortex via retinogeniculo-cortical oscillations and sent to the retina is multifold higher than feed-forward input to the cortex. This can effectively translate into out-of-body experiences projected onto the screen formed by the retina as it is perceived via feedback and feed-forward oscillations from the reticular thalamic nucleus, or “internal searchlight”. This article explores the role of the reticular thalamic nucleus and the retinogeniculo-cortical oscillations as pivotal internal components in vision and various autoscopic phenomena. (shrink)

Located within the ascending reticular activating system are nuclei which release neurotransmitters such as acetylcholine, serotonin, dopamine, and norepinephrine. These nuclei have widespread projections that extend into the limbic system and throughout cortex. Activation of these neurotransmitters during awake states leads to arousal, while inhibition leads to the loss of consciousness experienced during slow-wave sleep. Previously, we proposed a mechanism in which cardiorespiratory synchronization may underlie the widespread hyperpolarization that occurs throughout the brain during slow-wave sleep. We further propose that (...) a similar homeostatic mechanism may be involved in sleep-wake transitions and maintaining various arousal states including rapid eye movement sleep, waking, and anxiety. Widespread depolarization associated with more rapid, shallow breathing and desynchronized cardiorespiratory oscillatory activity may underlie waking, anxiety, and rapid eye movement sleep states. The exact voltage values of these widespread membrane potential changes remain unknown and possibly highly variable between different neural areas and cell types. Here, we place these consciousness states on a spectrum of approximated widespread membrane potential values with anxiety states being the most depolarized, followed by waking states, and rapid eye movement sleep. We propose that although these widespread membrane potential changes are minor, they may underlie transitions between and maintenance of varying levels of arousal. Further research on these mechanisms could provide insights into how the brain functions. This homeodynamic arousal mechanism involves the established feed-forward and feedback signaling between the ascending reticular activating system and the hypothalamus, as well as the modulation by cardiorespiratory oscillatory feedback from the body. Understanding the basic mechanisms responsible for the states of sleep, waking, and anxiety could lead to better treatment options in health and disease. (shrink)

I consider the most serious problem for the traditional account of divine creation in theistic actualism. According to van Inwagen's modal collapse argument, ultimate explanation entails that gratitude to God for one's existence is totally inappropriate. Ultimately, the actual world, and everything in it, is self-explanatory, and not a consequence of divine creation. I argue that van Inwagen's argument is unsound. It is consistent with an ultimate explanation for the world that the actual world is contingently necessary. If God actualizes (...) the world as a matter of contingent necessity, then gratitude to God for one's existence is perfectly appropriate. It is true that we exist as a matter of necessity, but that necessary existence is just a contingent fact. There are possible worlds in which we fail to exist altogether. (shrink)

I argue that we find the articulation of a problem concerning bodily agency in the early works of the Merleau-Ponty which he explicates as analogous to what he explicitly calls the problem of perception. The problem of perception is the problem of seeing how we can have the object given in person through it perspectival appearances. The problem concerning bodily agency is the problem of seeing how our bodily movements can be the direct manifestation of a person’s intentions in the (...) world. In both cases what, according to Merleau-Ponty, obscures a recognition of the phenomenon in question is a conception of our bodily capacities, i.e. our sensibility and our motility, which reduces these to the workings of mechanisms that are blind to meaning. I argue that both the problem concerning perception and the problem concerning bodily agency can be properly called transcendental. The problem of perception is transcendental because it concerns the very intelligibility of appearances and judgements with empirical content. The problem of bodily agency is transcendental in the sense that it concerns the very intelligibility of our bodily capacity to carry out intentions and by implication the intelligibility of our intentions as such. (shrink)

The paper aims to show that, if S5 is the logic of metaphysical necessity, then no state of affairs in any possible world constitutes any non-trivial evidence for or against the existence of the traditional God. There might well be states of affairs in some worlds describing extraordinary goods and extraordinary evils, but it is false that these states of affairs constitute any (non-trivial) evidence for or against the existence of God. The epistemological and metaphysical consequences for philosophical theology of (...) assuming that S4 or Kσρ is the logic of metaphysical necessity are equally untenable. S4 guarantees that God does not exist if there is the slightest evidence against the existence of God. And Kσρ guarantees that God might survive the loss or acquisition of any essential property at all. (shrink)

The dead donor rule justifies current practice in organ procurement for transplantation and states that organ donors must be dead prior to donation. The majority of organ donors are diagnosed as having suffered brain death and hence are declared dead by neurological criteria. However, a significant amount of unrest in both the philosophical and the medical literature has surfaced since this practice began forty years ago. I argue that, first, declaring death by neurological criteria is both unreliable and unjustified but (...) further, the ethical principles which themselves justify the dead donor rule are better served by abandoning that rule and instead allowing individuals who have suffered severe and irreversible brain damage to become organ donors, even though they are not yet dead and even though the removal of their organs would be the proximal cause of death. (shrink)

The minimal God exemplifies essential omnipotence, omniscience, and moral perfection, but none of the other properties of the traditional God. I examine the consequences of the minimal God in augmented S5, S4, and Kρσ. The metaphysical consequences for the minimal God in S5 include the impossibility that God—or any other object—might acquire, lose, or exchange an essential property. It is impossible that an essentially divine being might become essentially human, for instance. The epistemological consequences include the impossibility of agnosticism—it is (...) impossible that P(◻︎FG |E) = P(~◻︎FG| E). Indeed, every weaker forms of agnosticism are also impossible—it is impossible that P(◻︎FG |E) = n, n(0 < n < 1). The metaphysical and epistemological consequences for the minimal God in S4 are equally untenable. I show that we can avoid all of these unwelcome epistemological consequences for the minimal God in Kρσ. But Kρσ has some extraordinary metaphysical consequences for the minimal God. All of the problems for the minimal God generalize to the maximal God. (shrink)

Philosophical discussions of Molyneux's problem within contemporary philosophy of mind tend to characterize the problem as primarily concerned with the role innately known principles, amodal spatial concepts, and rational cognitive faculties play in our perceptual lives. Indeed, for broadly similar reasons, rationalists have generally advocated an affirmative answer, while empiricists have generally advocated a negative one, to the question Molyneux posed after presenting his famous thought experiment. This historical characterization of the dialectic, however, somewhat obscures the role Molyneux's problem has (...) played in spawning debates within the empiricist tradition. Fortunately, the differences between various empiricist accounts have been widely recognized and discussed among historians of philosophy working on the topic. The focus of the present essay is to develop an interpretation of John Locke's views on Molyneux's problem that best coheres with his other views on human understanding as well as with the predominant scientific opinion about the nature of perception during the period in which he lived. (shrink)

Perhaps the greatest impediment to a viable libertarianism is the provision of a satisfactory explanation of how actions that are undetermined by an agent's character can still be under the control of, or ‘up to’, the agent. The ‘luck problem’ has been most assiduously examined by Robert Kane who supplies a detailed account of how this problem can be resolved. Although Kane's theory is innovative, insightful, and more resourceful than most of his critics believe, it ultimately cannot account for the (...) type of control that moral responsibility and (ultimate) agency legitimately require. (shrink)

In ‘Evil is Still Evidence: Comments on Almeida’ Robert Bass presents three objections to the central argument (ENE) in my ‘Evil is Not Evidence’. The first objection is that ENE is invalid. According to the second objection, it is a consequence of ENE that there can be no evidence for or against a posteriori necessities. The third objection is that, contrary to ENE, the likelihood of certain necessary identities varies with the evidence we have for them. In this reply I (...) explain why ENE has exactly none of the implications described by Bass. I argue in the concluding section that there is a modal solution to the epistemological problems presented by ENE. (shrink)

I provide the account of divine creation found in multiverse theorists Donald Turner, Klaas Kraay, and Tim O’Connor. I show that the accounts Kraay and Turner offer are incoherent. God does not survey all possible worlds and necessarily actualize those universes in the (on balance) good worlds or the worthy worlds. If God necessarily actualizes the multiverse, we have no idea which universes are parts of that multiverse. I show next that Tim O’Connor’s multiverse account of creation is also incoherent. (...) I argue that a preferable multiverse would include a much greater variety of universes than are included in Turner, Kraay or O’Connor. In the last section I offer some concluding remarks. (shrink)

Recently, scholars have criticized what they call the “Kantian-Republican” thesis of freedom as non-domination. The main complaint is that domination is unavoidable. This concern can be separated into the problem of state domination, which suggests that the state's intervening powers necessarily dominate its citizens, and the problem of majority domination, which suggests that the People necessarily dominate individual citizen as a result of the potential to form dominating majorities.

A number of Christian theologians and philosophers have been critical of overly moralizing approaches to the doctrine of sin, but nearly all Christian thinkers maintain that moral fault is necessary or sufficient for sin to obtain. Call this the “Moral Consensus.” I begin by clarifying the relevance of impurities to the biblical cataloguing of sins. I then present four extensional problems for the Moral Consensus on sin, based on the biblical catalogue of sins: (1) moral over-demandingness, (2) agential unfairness, (3) (...) moral repugnance, and (4) moral atrocity. Next, I survey several partial solutions to these problems, suggested by the recent philosophical literature. Then I evaluate two largely unexplored solutions: (a) genuine sin dilemmas and (b) defeasible sinfulness. I argue that (a) creates more problems than it solves and that, while (b) is well-motivated and solves or eases each of the above problems, (b) leaves many biblical ordinances about sin morally misleading, creating (5) a pedagogical problem of evil. I conclude by arguing that (5) places hefty explanatory burdens on those who would appeal to (b) to resolve the four extensional problems discussed in this paper. So Christian thinkers may need to consider a more radical separation of sin and moral fault. (shrink)

According to Paul Draper and Ryan Nichols the practice of philosophy of religion—and especially its theistically committed practitioners—regularly violate norms of rationality, objectivity, and impartiality in the review, assessment, and weighing of evidence. (Draper and Nichols, 2013). We consider the charge of epistemic partisanship and show that the observational data does not illustrate a norm-violating form of inquiry. The major oversight in the charge of epistemic partiality is the epistemically central role of prior probabilities in determining the significance of incongruent (...) evidence. We argue that reasonably divergent views on the likelihood of theism on incongruent evidence can also account for differences in significance. We conclude that it is an epistemic requirement that committed theists regard incongruent evils as much less significant evidence against theism than do lukewarm theists, agnostics, or atheists. Differences in the significance of evidence quite properly reflect differences in commitments to theism. (shrink)

I defend a theory of mental representation that satisfies naturalistic constraints. Briefly, we begin by distinguishing (i) what makes something a representation from (ii) given that a thing is a representation, what determines what it represents. Representations are states of biological organisms, so we should expect a unified theoretical framework for explaining both what it is to be a representation as well as what it is to be a heart or a kidney. I follow Millikan in explaining (i) in terms (...) of teleofunction, explicated in terms of natural selection. -/- To explain (ii), we begin by recognizing that representational states do not have content, that is, they are neither true nor false except insofar as they both “point to” or “refer” to something, as well as “say” something regarding whatever it is they are about. To distinguish veridical from false representations, there must be a way for these separate aspects to come apart; hence, we explain (ii) by providing independent theories of what I call f-reference and f-predication (the ‘f’ simply connotes ‘fundamental’, to distinguish these things from their natural language counterparts). -/- Causal theories of representation typically founder on error, or on what Fodor has called the disjunction problem. Resemblance or isomorphism theories typically founder on what I’ve called the non-uniqueness problem, which is that isomorphisms and resemblance are practically unconstrained and so representational content cannot be uniquely determined. These traditional problems provide the motivation for my theory, the structural preservation theory, as follows. F-reference, like reference, is a specific, asymmetric relation, as is causation. F-predication, like predication, is a non-specific relation, as predicates typically apply to many things, just as many relational systems can be isomorphic to any given relational system. Putting these observations together, a promising strategy is to explain f-reference via causal history and f-predication via something like isomorphism between relational systems. -/- This dissertation should be conceptualized as having three parts. After motivating and characterizing the problem in chapter 1, the first part is the negative project, where I review and critique Dretske’s, Fodor’s, and Millikan’s theories in chapters 2-4. Second, I construct my theory about the nature of representation in chapter 5 and defend it from objections in chapter 6. In chapters 7-8, which constitute the third and final part, I address the question of how representation is implemented in biological systems. In chapter 7 I argue that single-cell intracortical recordings taken from awake Macaque monkeys performing a cognitive task provide empirical evidence for structural preservation theory, and in chapter 8 I use the empirical results to illustrate, clarify, and refine the theory. (shrink)

This article was primarily a reaction to Dennett's Sweet Dreams (2005). In it Dennett pretends to renounce zombies. But what he means is that consciousness is nothing beyond that which can be tested behaviorally and objectively, so since zombies pass these tests, they can't be said to be unconscious – yet that is part of their definition. So they are a contradiction. In other words, zombies are inconceivable because a being that is "behaviorally, objectively indistinguishable from a conscious person" just (...) doesn't deserve in Dennett's eyes to be called unconscious. I argue, to the contrary, that zombies must lack brains since it is perfectly clear that in our universe having a brain (normally) entails having consciousness. I argue also that brain states are about people and things in the world, meaning for example that for some brain state S, necessarily if one is in brain state S, one is thinking about external object A. The brain "comes with" a world. The brain, therefore, transcends the boundaries of the skull. Science (and Dennett) cannot reduce the brain to something that doesn't pull off this most astonishing of feats. (shrink)

Assuming divine command theory is true, there are no moral limits on the commands God can issue. Nevertheless there are no possible worlds in which divine command theory is true and God commands cruelty for its own sake or the sacrifice of ten-year-olds in a gruesome ritual, or anything of the kind. The main conclusion of the argument is that God cannot command the morally horrible not because of God's moral perfection or God's lack of power, of God's kindness, etc., (...) but because commanding the morally horrible entails a contradiction. I show that the argument is an instance of a valid and uncontroversial counterfactual sequent. Divine command theory entails that there are commands that even an omnipotent and morally unconstrained being cannot issue. (shrink)

Kant’s Naturrecht Feyerabend has recently gained more sustained attention for its role in clarifying Kant’s published positions in political philosophy. However, too little attention has been given to the lecture’s relation to Gottfried Achenwall, whose book was the textbook for the course. In this paper, I will examine how Kant rejected and transforms Achenwall’s natural law system in the Feyerabend Lectures. Specifically, I will argue that Kant problematizes Achenwall’s foundational notion of a divine juridical state which opens up a normative (...) gap between objective law and subjective rights. In the absence of a divine sovereign, formal natural law is unable to justify subjective natural rights in the state of nature. In the Feyerabend Lectures, Kant, in order to close this gap, replaces the divine will with the “will of society”, making the state necessary for the possibility of rights. (shrink)

Philosophy is often divided into two traditions: analytic and continental philosophy. Characterizing the analytic-continental divide, however, is no easy task. Some philosophers explain the divide in terms of the place of argument in these traditions. This raises the following questions: Is analytic philosophy rife with arguments while continental philosophy is devoid of arguments? Or can different types of arguments be found in analytic and continental philosophy? This paper presents the results of an empirical study of a large corpus of philosophical (...) texts mined from the JSTOR database (n = 53,260) designed to find patterns of argumentation by type. Overall, the results suggest that there are no significant differences between the types of arguments advanced in analytic and continental philosophy journal articles. The findings, therefore, provide no empirical support to the hypothesis that the divide between analytic and continental philosophy has to do with the place of argument in these traditions. (shrink)

What is Derrida Saying to Us - Abstract Jacques Derrida is difficult and controversial. This article concentrates on the first part of On Grammatology (1967) as the Rosetta Stone to understanding him. It examines concepts such as the metaphysics of presence, the trace, differance, and deconstruction, aiming to interest readers further in pursuing him in more depth.

Many philosophers of science believe that empirical psychology can contribute little to the philosophical investigation of explanations. They take this to be shown by the fact that certain explanations fail to elicit any relevant psychological events (e.g., familiarity, insight, intelligibility, etc.). We report results from a study suggesting that, at least among those with extensive science training, a capacity to render an event intelligible is considered a requirement for explanation. We also investigate for whom explanations must be capable of rendering (...) events intelligible and whether or not accuracy is also viewed as a requirement. (shrink)

Most theists do not put a (subjective) probability of 1 (certainty) on God's existence. Most atheists do not put a probability of 0 on God's existence. I argue that these familiar positions are incoherent. On the assumption of S5 and the probability calculus it can be shown that the only coherent (subjective) probabilities an agent can assign to God's existence/non-existence are 0 or 1. Believers must be completely committed believers and non-believers must be completely committed non-believers. Agnosticism is not a (...) coherent position. (shrink)

Mental and behavioral disorders represent a significant portion of the public health burden in all countries. The human cost of these disorders is immense, yet treatment options for sufferers are currently limited, with many patients failing to respond sufficiently to available interventions and drugs. High quality ontologies facilitate data aggregation and comparison across different disciplines, and may therefore speed up the translation of primary research into novel therapeutics. Realism-based ontologies describe entities in reality and the relationships between them in such (...) a way that – once formulated in a suitable formal language – the ontologies can be used for sophisticated automated reasoning applications. Reference ontologies can be applied across different contexts in which different, and often mutually incompatible, domain-specific vocabularies have traditionally been used. In this contribution we describe the Mental Functioning Ontology (MF) and Mental Disease Ontology (MD), two realism-based ontologies currently under development for the description of humanmental functioning and disease. We describe the structure and upper levels of the ontologies and preliminary application scenarios, and identify some open questions. (shrink)

Freedom, liberty and rights are terms that long have suffered from vagueness that allows a host of differing interpretations, most of them ideological and overly simplistic. Good, serious modeling descriptions of those terms would not overlook the necessary complexity involved in these social interactions. MacCallum’s idea of (political and social) triadic freedom is here extended to include resources, ability, externalities, benefits to the exerciser, and reasons for non-interference. Interference is described as a subset of freedoms with significant externalities. A right (...) is then described as a compound of a freedom protected by interferences. This provides a basis for the analysis of the game-theoretic economics of rights and when they will be produced. (shrink)

There are few if any good summaries of this neglected work on the internet, or even in publication generally. The one given here is more extensive than most, and points out the wisdom and erudition of Kant's thinking about freedom of the will. It also paves the way for another article already on this website on Kant’s view of the world in general.

This essay examines three approaches to the concept of death: an existential approach by Heidegger, a pragmatic evaluation by Nagel, and an experiential account by Philip Gould, who was not a professional philosopher but who wrote a detailed description of the time before his death from cancer. It compares and contrasts the different approaches, and uses Gould's account as a real a life check on the two philosophical analyses.

This article consists of notes on Kant’s preparatory work on morality. I am indebted to Paton’s comments in his translation, and these are acknowledged in the text. As with the companion article on the “Critique of Practical Reason”, I am making preparations here for a later summary of Kant’s view of the world in general. .

There seems to me to be a problem with the interpretation of Jean-Paul Sartre’s use of the words “being” and “nothingness” in his philosophy. Is his idea of being the same as that of Heidegger? While I’m quite sure of the metaphysical aspects of the argument, I’m not sure whether within those aspects Sartre equates nothingness with freedom, or whether the freedom (of action) arises from the nothingness. This short essay attempts to find a solution to the problem.

This essay is about the way Kant sees the world rather than about his moral philosophy and his theories of justice. It concentrates on perception of the physical world, and how far this can take us in understanding the world of the mind and how we think and make decisions about our lives. It proposes that Kant can be seen as the founder not just of theories of the problem of knowledge, but also of such modern ideas as existentialism.

In an ideal, ordered world, answering metaethical questions (such as “what is goodness?” and “how can we tell the good from the bad”) would lead to statements about morality (principles set out for making decisions, having intentions and taking actions). However, the world is not ideal or ordered, and in life principles for moral action are based on various beliefs, religions and cultures and most of all by the background of the actor him/herself. -/- This corresponds to the view of (...) the great German philosopher Frederik Nietzsche, who Simon Blackburn (Blackburn, 2005) refers to as the “arch debunker”. Blackburn rates Nietzsche as “currently the most influential of the great philosophers” and there is certainly an arguable case for that assessment. Nietzsche is regarded as the bad boy of philosophy, the writer who speaks the unspeakable. But his ideas have been taken up by philosophers who came after him like no other. His views (along with Kierkegaard’s) lead to existentialism. Heidegger based much of his writing on Nietzsche, and the questions Nietzsche raises (but does not necessarily answer) about epistemology, ethics, religion, psychology, and the way we live our lives are profound and still puzzle modern philosophers and social scientists. -/- This article reviews Nietzsche's profound thoughts on these issues. -/- . (shrink)

Of all the great philosophers, Hegel is one of the most difficult to understand, and, at least by some philosophers, one of the most despised. Russell and Schopenhauer thought that his philosophy was devoid of any useful meaning, and Popper blamed him for the rise of totalitarianism. This teaching paper aims to summarise the main points of his work and give a balanced view.

Language is what separates us from other animals, and is why we are able to solve complex logical problems, and, as far as we can tell, experience consciousness. Wittgenstein is the philosopher of language par excellence. He asks: what is the role of language in philosophy, and in the wider sphere of thinking in everyday life? This teaching paper gives a summary of his ideas.

This is an imagined dialogue about this book, which is one of the most influential but difficult works written in the twentieth century.

Wiliam Lane Craig has famously argued that without God we simply cannot have objective morality and therefore we are left with nihilism. I agree with Craig that objective morality has no logical explanation without God, but disagree that this necessarily entails that atheism is nihilistic.

"On First Looking into Chapman's Homer" by John Keats, may seem archaic now, especially its language. But it expresses the poet's delight and excitement when he discovers a new literary revelation, hitherto hidden from him. He makes an intellectual discovery. I've had this sense of discovery when reading philosophy. Some new approach, some new idea, has made me see a concept I thought I understood in a different and more rigorous way; made me re- examine what I thought I'd understood (...) perfectly well before. It's not so much that the authors I was reading offered the last word on the subject, more that they offered the first word. Here are four examples. (shrink)

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

Lockheed Martin Corp. has funded research to generate a framework and methodology for developing semantic reasoning applications to support the discipline oflntelligence Analysis. This chapter outlines that framework, discusses how it may be used to advance the information sharing and integrated analytic needs of the Intelligence Community, and suggests a system I software architecture for such applications.