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  1. When Bioscience Meets Philosophy: Major Issues in the Philosophy of Biology.Sun Kyeong Yu - 2011 - Philosophy and Reality 91:99-110.
    CONTENT 1. Misconceptions of Darwin's Theory of Evolution 2. Darwinism against Essentialism and the Concept of Species 3. Function and Biological Explanation 4. The Gene 목차 1. 다윈의 진화론에 대한 오해들 2. 본질주의에 대한 진화론의 반대와 종(Species)의 개념 3. 기능(function)과 생명과학적 설명 4. 유전자 맺음말.
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  2. The Buddhist idea of Transmigration from the Bioscientific Perspective.Sun Kyeong Yu - 2020 - In Buddhism and Culture (Buddhist magazine in Korea). Seoul, South Korea: pp. The March Issue, 2020.
    죽고 다시 태어나는 반복의 과정을 논하는 불교의 윤회설은 끊임없이 변화하는 생명현상의 본래 모습을 그대로 보여준다. 어느 생명체도 변하지 않고 영구한 것은 없다. 오래된 개체의 삶이 끝나고 새로운 삶이 시작되는 반복의 자연현상이 윤회이다. 본고는 윤회를 생명과학적으로 해석하며 삼라만상에서 일어나는 윤회란 개체들뿐만 아니라 세포와 분자선상에서도 일어나는 자연스런 생명현상임을 밝히겠다.
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  3. When Bioscience Meets Philosophy: Major Issues in the Philosophy of Biology.Sun Kyeong Yu - 2011 - Philosophy and Reality 91:99-110.
    CONTENT 1. Misconceptions of Darwin's Theory of Evolution 2. Darwinism against Essentialism and the Concept of Species 3. Function and Biological Explanation 4. The Gene 목차 1. 다윈의 진화론에 대한 오해들 2. 본질주의에 대한 진화론의 반대와 종(Species)의 개념 3. 기능(function)과 생명과학적 설명 4. 유전자 맺음말.
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  4. What is a Hologenomic Adaptation? Emergent Individuality and Inter-Identity in Multispecies Systems.Javier Suárez & Vanessa Triviño - 2020 - Frontiers in Psychology 187 (11).
    Contemporary biological research has suggested that some host–microbiome multispecies systems (referred to as “holobionts”) can in certain circumstances evolve as unique biological individual, thus being a unit of selection in evolution. If this is so, then it is arguably the case that some biological adaptations have evolved at the level of the multispecies system, what we call hologenomic adaptations. However, no research has yet been devoted to investigating their nature, or how these adaptations can be distinguished from adaptations at the (...)
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  5. Are Synthetic Genomes Parts of a Genetic Lineage?Gunnar Babcock - forthcoming - British Journal for the Philosophy of Science.
    Biologists are nearing the creation of the first fully synthetic eukaryotic genome. Does this mean that we still soon be able to create genomes that are parts of an existing genetic lineage? If so, it might be possible to bring back extinct species. But do genomes that are synthetically assembled, no matter how similar they are to native genomes, really belong to the genetic lineage on which they were modelled? This article will argue that they are situated within the same (...)
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  6. An Herbiary of Plant Individuality.Sophie Gerber - 2018 - Philosophy, Theory, and Practice in Biology 10 (5):1-5.
    Questioning the nature of individuality has a long and a rich history, both in philosophy and in biology. Because they differ in several features from the pervasive vertebrate-human model, plants have been considered as complicating the question. Here, the various plant species on which authors—whether biologists or philosophers—rely to build the picture of plant individuality are examined and tracked for their peculiarities, thus constituting an “herbiary” of plant individuality. The herbiary of plant individuality has as its members species exhibiting a (...)
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  7. ImmPort, Toward Repurposing of Open Access Immunological Assay Data for Translational and Clinical Research.Sanchita Bhattacharya, Patrick Dunn, Cristel Thomas, Barry Smith, Henry Schaefer, Jieming Chen, Zicheng Hu, Kelly Zalocusky, Ravi Shankar & Shai Shen-Orr - 2018 - Scientific Data 5:180015.
    Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components–Private Data, Shared Data, Data (...)
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  8. OmniSearch: A Semantic Search System Based on the Ontology for MIcroRNA Target for microRNA-Target Gene Interaction Data.Huang Jingshan, Gutierrez Fernando, J. Strachan Harrison, Dou Dejing, Huang Weili, A. Blake Judith, Barry Smith, Eilbeck Karen, A. Natale Darren & Lin Yu - 2016 - Journal of Biomedical Semantics 7 (1):1.
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...)
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  9. On the Application of Formal Principles to Life Science Data: A Case Study in the Gene Ontology.Jacob Köhler, Anand Kumar & Barry Smith - 2004 - In Proceedings of DILS 2004 (Data Integration in the Life Sciences), (Lecture Notes in Bioinformatics 2994). Berlin: Springer. pp. 79-94.
    Formal principles governing best practices in classification and definition have for too long been neglected in the construction of biomedical ontologies, in ways which have important negative consequences for data integration and ontology alignment. We argue that the use of such principles in ontology construction can serve as a valuable tool in error-detection and also in supporting reliable manual curation. We argue also that such principles are a prerequisite for the successful application of advanced data integration techniques such as ontology-based (...)
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  10. Recent Work in The Philosophy of Biology.Christopher J. Austin - 2017 - Analysis 77 (2):anx032.
    The biological sciences have always proven a fertile ground for philosophical analysis, one from which has grown a rich tradition stemming from Aristotle and flowering with Darwin. And although contemporary philosophy is increasingly becoming conceptually entwined with the study of the empirical sciences with the data of the latter now being regularly utilised in the establishment and defence of the frameworks of the former, a practice especially prominent in the philosophy of physics, the development of that tradition hasn’t received the (...)
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  11. A Metaphorical History of DNA Patents.Ivo Silvestro - 2016 - Rivista Italiana di Filosofia del Linguaggio 10 (2):49-63.
    The aim of this paper is to retrace the history of genetic patents, analyzing the metaphors used in the public debate, in patent offices, and in courtrooms. I have identified three frames with corresponding metaphor clusters: the first is the industrial frame, built around the idea that DNA is a chemical; the second is the informational frame, assembled around the concept of genetic information; last is the soul frame, based on the idea that DNA is or contains the essence of (...)
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  12. The End and Rebirth of Nature? From Politics of Nature to Synthetic Biology.Massimiliano Simons - 2016 - Philosophica -- Revista Do Departamento de Filosofia da Faculdade de Letras de Lisboa 47:109-124.
    In this article, two different claims about nature are discussed. On the one hand, environmental philosophy has forced us to reflect on our position within nature. We are not the masters of nature as was claimed before. On the other hand there are the recent developments within synthetic biology. It claims that, now at last, we can be the masters of nature we have never been before. The question is then raised how these two claims must be related to one (...)
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  13. Eugenics as Wrongful.Robert A. Wilson - 2014 - Eugenics Archives.
    In a landmark legal case in 1996, eugenics survivor Leilani Muir successfully sued the province of Alberta for wrongful confinement and sterilization. The legal finding implied that Ms. Muir should never have been institutionalized at the Provincial Training School of Alberta as a “moron” and sterilized under the Sexual Sterilization Act of Alberta. The trial itself revealed many unsettling features of the province’s practice of eugenics, raising questions about how a seemingly large number of people, like Ms. Muir, who were (...)
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  14. Toolbox Murders: Putting Genes in Their Epigenetic and Ecological Contexts: P. Griffiths and K. Stotz: Genetics and Philosophy: An Introduction. [REVIEW]Thomas Pradeu - 2016 - Biology and Philosophy 31 (1):125-142.
    Griffiths and Stotz’s Genetics and Philosophy: An Introduction offers a very good overview of scientific and philosophical issues raised by present-day genetics. Examining, in particular, the questions of how a “gene” should be defined and what a gene does from a causal point of view, the authors explore the different domains of the life sciences in which genetics has come to play a decisive role, from Mendelian genetics to molecular genetics, behavioural genetics, and evolution. In this review, I highlight what (...)
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  15. Ontologies of Cellular Networks. Arp - 2008 - Science Signalling 1 (50):1-3.
    As part of a series of workshops on different aspects of biomedical ontology sponsored by the National Center for Biomedical Ontology (NCBO), a workshop titled "Ontologies of Cellular Networks" took place in Newark, New Jersey, on 27 to 28 March 2008. This workshop included more than 30 participants from various backgrounds in biomedicine and bioinformatics. The goal of the workshop was to provide an introduction to the basic tools and methods of ontology, as well as to enhance coordination between groups (...)
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  16. The Individual in Biology and Psychology.Robert A. Wilson - 1999 - In V. Harcastle (ed.), Where Biology Meets Psychology. pp. 355--374.
    Individual organisms are obvious enough kinds of things to have been taken for granted as the entities that have many commonly attributed biological and psychological properties, both in common sense and in science. The sorts of morphological properties used by the folk to categorize individual animals and plants into common sense kinds (that's a dog; that's a rose), as well as the properties that feature as parts of phenotypes, are properties of individual organisms. And psychological properties, such as believing that (...)
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  17. Diagrams as Locality Aids for Explanation and Model Construction in Cell Biology.Nicholaos Jones & Olaf Wolkenhauer - 2012 - Biology and Philosophy 27 (5):705-721.
    Using as case studies two early diagrams that represent mechanisms of the cell division cycle, we aim to extend prior philosophical analyses of the roles of diagrams in scientific reasoning, and specifically their role in biological reasoning. The diagrams we discuss are, in practice, integral and indispensible elements of reasoning from experimental data about the cell division cycle to mathematical models of the cycle’s molecular mechanisms. In accordance with prior analyses, the diagrams provide functional explanations of the cell cycle and (...)
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  18. Genome Informatics: The Role of DNA in Cellular Computations.James A. Shapiro - 2006 - Biological Theory 1 (3):288-301.
    Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales. Information is stored in sequences, epigenetic modifications, and rapidly changing nucleoprotein complexes. Because DNA must operate through complexes formed with other molecules in the cell, genome functions are inherently interactive and involve two-way communication with various cellular compartments. Both coding sequences and repetitive sequences contribute to the hierarchical systemic organization of the genome. By virtue of nucleoprotein complexes, (...)
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  19. Framework for a Protein Ontology.Darren A. Natale, Cecilia N. Arighi, Winona Barker, Judith Blake, Ti-Cheng Chang, Zhangzhi Hu, Hongfang Liu, Barry Smith & Cathy H. Wu - 2007 - BMC Bioinformatics 8 (Suppl 9):S1.
    Biomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...)
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  20. Some Problems for Alternative Individualism.Robert A. Wilson - 2000 - Philosophy of Science 67 (4):671-679.
    This paper points to some problems for the position that D.M. Walsh calls "alternative individualism," and argues that in defending this view Walsh has omitted an important part of what separates individualists and externalists in psychology. Walsh's example of Hox gene complexes is discussed in detail to show why some sort of externalism about scientific taxonomy more generally is a more plausible view than any extant version of individualism.
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Genetics
  1. Urbis Et Orbis: Non-Euclidean Space of History.Alex V. Halapsis - 2015 - The European Philosophical and Historical Discourse 1 (2):37-42.
    Social space is superimposed on the civilization map of the world whereas the social time is correlated with the duration of civilization existence. Within own civilization the concept space is non-homogeneous, there are “singled out points” — “concept factories”. As social structures, cities may exist rather long, sometimes during several millennia, but as concept centres they are limited by the duration of civilization existence. If civilization is a “concept universe”, nobody and nothing may cross the boundaries, which include cities as (...)
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  2. El gen de la monogamia podría actuar también en humanos.Luis Santiago Lario Herrero - 2008 - Tendencias21 2008.
    Una investigación realizada en humanos ha desvelado la existencia de ciertas variantes genéticas en la conformación del gen AVPR1A que se traducirían en una mayor o menor disposición y aptitud hacia la vida en pareja. Eso significa que la actividad de ese gen influiría en la calidad de la vida conyugal y muy probablemente interferiría en la orientación de nuestro mundo afectivo.
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  3. The Monogamy Gene Could Also Act in Humans.Luis Santiago Lario Herrero - 2008 - Tendencias21 2008.
    Research has revealed that genetic variations in the human gene AVPR1A affect the disposition and aptitude of individuals to live in a relationship. Thus the activity of this gene could influence the quality of marital relationships and very likely our emotional inclinations.
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  4. The Altruism Paradox: A Consequence of Mistaken Genetic Modeling.Yussif Yakubu - 2013 - Biological Theory 8 (1):103-113.
    The theoretical heuristic of assuming distinct alleles (or genotypes) for alternative phenotypes is the foundation of the paradigm of evolutionary explanation we call the Modern Synthesis. In modeling the evolution of sociality, the heuristic has been to set altruism and selfishness as alternative phenotypes under distinct genotypes, which has been dubbed the “phenotypic gambit.” The prevalence of the altruistic genotype that is of lower evolutionary fitness relative to the alternative genotype for non-altruistic behavior in populations is the basis of the (...)
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  5. Prisoners of Abstraction? The Theory and Measure of Genetic Variation, and the Very Concept of 'Race'.Jonathan Michael Kaplan & Rasmus Grønfeldt Winther - 2013 - Biological Theory 7 (1):401-412.
    It is illegitimate to read any ontology about "race" off of biological theory or data. Indeed, the technical meaning of "genetic variation" is fluid, and there is no single theoretical agreed-upon criterion for defining and distinguishing populations (or groups or clusters) given a particular set of genetic variation data. Thus, by analyzing three formal senses of "genetic variation"—diversity, differentiation, and heterozygosity—we argue that the use of biological theory for making epistemic claims about "race" can only seem plausible when it relies (...)
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  6. Genetic Determinism and the Innate-Acquired Distinction.Maria Kronfeldner - 2009 - Medicine Studies 1 (2):167-181.
    This article illustrates in which sense genetic determinism is still part of the contemporary interactionist consensus in medicine. Three dimensions of this consensus are discussed: kinds of causes, a continuum of traits ranging from monogenetic diseases to car accidents, and different kinds of determination due to different norms of reaction. On this basis, this article explicates in which sense the interactionist consensus presupposes the innate?acquired distinction. After a descriptive Part 1, Part 2 reviews why the innate?acquired distinction is under attack (...)
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  7. Genetic Variance–Covariance Matrices: A Critique of the Evolutionary Quantitative Genetics Research Program.Massimo Pigliucci - 2006 - Biology and Philosophy 21 (1):1-23.
    This paper outlines a critique of the use of the genetic variance–covariance matrix (G), one of the central concepts in the modern study of natural selection and evolution. Specifically, I argue that for both conceptual and empirical reasons, studies of G cannot be used to elucidate so-called constraints on natural selection, nor can they be employed to detect or to measure past selection in natural populations – contrary to what assumed by most practicing biologists. I suggest that the search for (...)
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  8. On the Limits of Quantitative Genetics for the Study of Phenotypic Evolution.Massimo Pigliucci & Carl D. Schlichting - 1997 - Acta Biotheoretica 45 (2):143-160.
    During the last two decades the role of quantitative genetics in evolutionary theory has expanded considerably. Quantitative genetic-based models addressing long term phenotypic evolution, evolution in multiple environments (phenotypic plasticity) and evolution of ontogenies (developmental trajectories) have been proposed. Yet, the mathematical foundations of quantitative genetics were laid with a very different set of problems in mind (mostly the prediction of short term responses to artificial selection), and at a time in which any details of the genetic machinery were virtually (...)
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Classical Genetics
  1. Die Architektur der Synthese. Entstehung und Philosophie der modernen Evolutionstheorie.Marcel Weber - 1996 - Dissertation, University of Konstanz
    This Ph.D. thesis provides a pilosophical account of the structure of the evolutionary synthesis of the 1930s and 40s. The first, more historical part analyses how classical genetics came to be integrated into evolutionary thinking, highlighting in particular the importance of chromosomal mapping of Drosophila strains collected in the wild by Dobzansky, but also the work of Goldschmidt, Sumners, Timofeeff-Ressovsky and others. The second, more philosophical part attempts to answer the question wherein the unity of the synthesis consisted. I argue (...)
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  2. El genoma de los filósofos.Enrique Morata (ed.) - 2015 - Bubok.
    Trying to understand the genome with the classical philosophers. ISBN 978-84-686-6311-1, Bubok, 2015.This book cannot be download at Philpapers due to its 240 MB size . It can be read and download at the web Scribd.
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  3. Darwinland.Enrique Morata (ed.) - 2014 - America Star Books.
    A briefing of the book "Darwinland" , America Star, 2014.
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  4. Antes del universo.Enrique Morata - 2014 - Scribd.
    On the current fashion to look after a previous universe to explain the laws of our Universe.Esperando al nuevo Aristóteles, regreso a Henri Bergson y el "Parménides", el otro universo de Plotino. In Spanish.
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  5. THE HYBRIDIZATION WORK OF MENDEL, 102 YEARS AFTER STARTING THE CONTROVERSY.Rafael María Román-Bravo, Rogelio Garcidueñas-Piña, Ruy Ortiz-Rodríguez, Atilio Miguel Atencio-León, Luis Fabian Yáñez-Cuéllar & Jose Atilio Aranguren-Méndez - 2014 - Revista Cientifica, FCV-LUZ 24 (1):38-46.
    This research was carried out in order to verify by simulation Mendel’s laws and seek for the clarification, from the author’s point of view, the Mendel-Fisher controversy. It was demonstrated from: the experimental procedure and the first two steps of the Hardy-Weinberg law, that the null hypothesis in such experiments is absolutely and undeniably true. Consequently, repeating hybridizing experiments as those showed by Mendel, it makes sense to expect a highly coincidence between the observed and the expected cell frequencies. By (...)
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  6. Ejemplares, modelos y principios en la genética clásica.Pablo Lorenzano - 2005 - Scientiae Studia 3 (2):185-203.
    Taking as starting point Kuhn’s analysis of science textbooks and its application to Sinnott and Dunn’s (1925), it will be discussed the problem of the existence of laws in biology. In particular, it will be showed, in accordance with the proposals of Darden (1991) and Schaffner (1980, 1986, 1993), the relevance of the exemplars, diagrammatically or graphically represented, in the way in which is carried out the teaching and learning process of classical genetics, inasmuch as the information contained in them, (...)
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Classical and Molecular Genetics
  1. La differenza tra ereditarietà ed ereditabilità nello studio dei tratti psicologici.Davide Serpico - 2020 - Medicalive Magazine 6 (1):7-21.
    ITA: In questo articolo analizzerò la differenza tra il concetto di ereditarietà e quello di ereditabilità. In primo luogo, evidenzierò come i due concetti derivino storicamente da differenti tradizioni nello studio della variabili-tà fenotipica e del rapporto genotipo-fenotipo. Secondariamente, illustrerò gli aspetti teorici e metodologici alla base dei due concetti, che sono peraltro collegati a differenti aree delle scienze biologiche. Infine, spigherò brevemente come si sia recentemente tentato, con molte difficoltà, di connettere lo studio dei meccanismi dell’ereditarietà allo studio dell’ereditabilità. (...)
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  2. Re-Examining the Gene in Personalized Genomics.Jordan Bartol - 2013 - Science & Education 22 (10):2529-2546.
    Personalized genomics companies (PG; also called ‘direct-to-consumer genetics’) are businesses marketing genetic testing to consumers over the Internet. While much has been written about these new businesses, little attention has been given to their roles in science communication. This paper provides an analysis of the gene concept presented to customers and the relation between the information given and the science behind PG. Two quite different gene concepts are present in company rhetoric, but only one features in the science. To explain (...)
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  3. Effect of Trigona Honey to mRNA Expression of Interleukin-6 on Salmonella Typhi Induced of BALB/C Mice.Yuliana Syam, Rosdiana Natsir, Sutji Pratiwi Rahardjo, Andi Nilawati Usman, Ressy Dwiyanti & Mochammad Hatta - 2016 - American Journal of Microbiological Research 4 (3):77-80.
    Weak inflammatory response after Salmonella infection can cause persistent infection and facilitate the long survival of pathogens. Honey can induce key immunomodulators such as TNF-α, interleukin-6 (IL-6) and IL-1, that it can be used in the treatment of bacterial infectious diseases caused by Salmonella typhi. The purpose of this study is to determine the effect of honey on the mRNA expression of IL-6 in Salmonella enterica Typhi induced of BABL/c mice. The study used experimental pretest-posttest control design. Honey treatment was (...)
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  4. THE HYBRIDIZATION WORK OF MENDEL, 102 YEARS AFTER STARTING THE CONTROVERSY.Rafael María Román-Bravo, Rogelio Garcidueñas-Piña, Ruy Ortiz-Rodríguez, Atilio Miguel Atencio-León, Luis Fabian Yáñez-Cuéllar & Jose Atilio Aranguren-Méndez - 2014 - Revista Cientifica, FCV-LUZ 24 (1):38-46.
    This research was carried out in order to verify by simulation Mendel’s laws and seek for the clarification, from the author’s point of view, the Mendel-Fisher controversy. It was demonstrated from: the experimental procedure and the first two steps of the Hardy-Weinberg law, that the null hypothesis in such experiments is absolutely and undeniably true. Consequently, repeating hybridizing experiments as those showed by Mendel, it makes sense to expect a highly coincidence between the observed and the expected cell frequencies. By (...)
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  5. Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
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Genotypes and Phenotypes
  1. 评论"我们硬连线吗?克拉克·格兰斯坦·牛津 (2000) (Review of “Are We Hardwired? by Clark & Grunstein (2000)) (修订2019).Michael Richard Starks - 2020 - In 欢迎来到地球上的地狱: 婴儿,气候变化,比特币,卡特尔,中国,民主,多样性,养成基因,平等,黑客,人权,伊斯兰教,自由主义,繁荣,网络,混乱。饥饿,疾病,暴力,人工智能,战争. Las Vegas, NV USA: Reality Press. pp. 82-84.
    这是一个对行为上基因/环境相互作用的极好的回顾,尽管有点过时,但却是一个简单而值得阅读的。他们从双胞胎研究开始,这些研究显示了遗传学对行为的压倒性影响。他们注意到朱迪思·哈里斯越来越广为人知的研究,这 些研究扩展并总结了共享家庭环境对行为几乎没有影响的事实,领养的孩子长大后与选择的继兄弟姐妹一样不同。随机。一个基本点,他们(和几乎所有谁讨论行为遗传学)没有注意到的是,数百(取决于你的观点)人类行为普 遍性,包括我们个性的所有基本,是由我们的基因100%决定,与法线没有变化。每个人都把树看成一棵树,而不是一块石头,寻找和吃食物,生气和嫉妒等等。因此,他们主要讨论的是,环境(文化)能在多大程度上影响各 种特征的显示程度,而不是它们的外观。 最后,他们以通常的政治正确方式讨论优生学,没有注意到我们和所有生物体是自然优生学的产物,并且试图用医学、农业和整个文明来击败自然选择,灾难性的任何社会,坚持这样做。多达50%的所有受孕,或大约1亿/年 ,以早期自然流产结束,几乎所有的母亲都没有意识到。这种对缺陷基因的自然剔除推动了进化,使我们相对地保持遗传健康,并使社会成为可能。基因足以破坏文明,但人口过剩会先破坏文明。 那些希望从现代两个系统的观点来看为人类行为建立一个全面的最新框架的人,可以查阅我的书《路德维希的哲学、心理学、Min d和语言的逻辑结构》维特根斯坦和约翰·西尔的二等奖(2019年)。那些对我更多的作品感兴趣的人可能会看到《会说话的猴子——一个末日星球上的哲学、心理学、科学、宗教和政治——文章和评论2006-2017 年'3rd ed(2019)。.
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  2. An Invitation to Explore Unexamined Shifts and Variety in the Meanings of Genotype and Phenotype, and Their Distinction.Peter J. Taylor - 2018 - Philosophy, Theory, and Practice in Biology 10 (6).
    Noting minimal philosophical attention to the shift of the meanings of “genotype” and “phenotype,” and their distinction, as well as to the variety of meanings that have co-existed over the last hundred years, this note invites readers to join in exploring the implications of shifts that have been left unexamined.
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  3. Finding Our Way Through Phenotypes.Andrew R. Deans, Suzanna E. Lewis, Eva Huala, Salvatore S. Anzaldo, Michael Ashburner, James P. Balhoff, David C. Blackburn, Judith A. Blake, J. Gordon Burleigh, Bruno Chanet, Laurel D. Cooper, Mélanie Courtot, Sándor Csösz, Hong Cui, Barry Smith & Others - 2015 - PLoS Biol 13 (1):e1002033.
    Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...)
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  4. FRUSTRATION: PHYSICO-CHEMICAL PREREQUISITES FOR THE CONSTRUCTION OF A SYNTHETIC CELL.Antoine Danchin & Agnieszka Sekowska - 2008 - In Martin G. Hicks and Carsten Kettner (ed.), Proceedings of the International Beilstein Symposium on Systems Chemistry May 26th – 30th, 2008 Bozen, Italy. Beilstein Institute. pp. 1-19.
    To construct a synthetic cell we need to understand the rules that permit life. A central idea in modern biology is that in addition to the four entities making reality, matter, energy, space and time, a fifth one, information, plays a central role. As a consequence of this central importance of the management of information, the bacterial cell is organised as a Turing machine, where the machine, with its compartments defining an inside and an outside and its metabolism, reads and (...)
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  5. Military Genomic Testing: Proportionality, Expected Benefits, and the Connection Between Genotypes and Phenotypes.Charles H. Pence - 2015 - Journal of Law and the Biosciences 2 (1):85-91.
    Mehlman and Li offer a framework for approaching the bioethical issues raised by the military use of genomics that is compellingly grounded in both the contemporary civilian and military ethics of medical research, arguing that military commanders must be bound by the two principles of paternal- ism and proportionality. I agree fully. But I argue here that this is a much higher bar than we may fully realize. Just as the principle of proportionality relies upon a thorough assessment of harms (...)
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  6. The Dispositional Genome: Primus Inter Pares.Christopher J. Austin - 2015 - Biology and Philosophy 30 (2):227-246.
    According to the proponents of Developmental Systems Theory and the Causal Parity Thesis, the privileging of the genome as “first among equals” with respect to the development of phenotypic traits is more a reflection of our own heuristic prejudice than of ontology - the underlying causal structures responsible for that specified development no more single out the genome as primary than they do other broadly “environmental” factors. Parting with the methodology of the popular responses to the Thesis, this paper offers (...)
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  7. Unifying Diseases From a Genetic Point of View: The Example of the Genetic Theory of Infectious Diseases.Marie Darrason - 2013 - Theoretical Medicine and Bioethics 34 (4):327-344.
    In the contemporary biomedical literature, every disease is considered genetic. This extension of the concept of genetic disease is usually interpreted either in a trivial or genocentrist sense, but it is never taken seriously as the expression of a genetic theory of disease. However, a group of French researchers defend the idea of a genetic theory of infectious diseases. By identifying four common genetic mechanisms (Mendelian predisposition to multiple infections, Mendelian predisposition to one infection, and major gene and polygenic predispositions), (...)
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  8. Selection Without Replicators: The Origin of Genes, and the Replicator/Interactor Distinction in Etiobiology.John S. Wilkins, Ian Musgrave & Clem Stanyon - 2012 - Biology and Philosophy 27 (2):215-239.
    Genes are thought to have evolved from long-lived and multiply-interactive molecules in the early stages of the origins of life. However, at that stage there were no replicators, and the distinction between interactors and replicators did not yet apply. Nevertheless, the process of evolution that proceeded from initial autocatalytic hypercycles to full organisms was a Darwinian process of selection of favourable variants. We distinguish therefore between Neo-Darwinian evolution and the related Weismannian and Central Dogma divisions, on the one hand, and (...)
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  9. Genotype–Phenotype Mapping and the End of the ‘Genes as Blueprint’ Metaphor.Massimo Pigliucci - 2010 - Philosophical Transactions Royal Society B 365:557–566.
    In a now classic paper published in 1991, Alberch introduced the concept of genotype–phenotype (G!P) mapping to provide a framework for a more sophisticated discussion of the integration between genetics and developmental biology that was then available. The advent of evo-devo first and of the genomic era later would seem to have superseded talk of transitions in phenotypic space and the like, central to Alberch’s approach. On the contrary, this paper shows that recent empirical and theoretical advances have only sharpened (...)
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Molecular Genetics
  1. Metaanalysis of psychoanalysis.Andrej Poleev - 2016
    The perspective revolution of Sigmund Freud: An update.
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  2. Grounding Knowledge and Normative Valuation in Agent-Based Action and Scientific Commitment.Catherine Elizabeth Kendig - 2018 - In Hauke Riesch, Nathan Emmerich & Steven Wainwright (eds.), Philosophies and Sociologies of Bioethics: Crossing the Divides. Cham, Switzerland: pp. 41-64.
    Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced. However, little work has been done to investigate the processes by which these epistemological, metaphysical, and ethical forms of inquiry arise in the course of synthetic biology research. An attempt at this work relying on a particular area of synthetic biology will be the aim of this chapter. I focus on the reengineering of (...)
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