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  1. Fighting Aging as an Effective Altruism Cause: A Model of the Impact of the Clinical Trials of Simple Interventions.Alexey Turchin - manuscript
    The effective altruism movement aims to save lives in the most cost-effective ways. In the future, technology will allow radical life extension, and anyone who survives until that time will gain potentially indefinite life extension. Fighting aging now increases the number of people who will survive until radical life extension becomes possible. We suggest a simple model, where radical life extension is achieved in 2100, the human population is 10 billion, and life expectancy is increased by simple geroprotectors like metformin (...)
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  2. Multilevel Strategy for Immortality: Plan A – Fighting Aging, Plan B – Cryonics, Plan C – Digital Immortality, Plan D – Big World Immortality.Alexey Turchin - manuscript
    Abstract: The field of life extension is full of ideas but they are unstructured. Here we suggest a comprehensive strategy for reaching personal immortality based on the idea of multilevel defense, where the next life-preserving plan is implemented if the previous one fails, but all plans need to be prepared simultaneously in advance. The first plan, plan A, is the surviving until advanced AI creation via fighting aging and other causes of death and extending one’s life. Plan B is cryonics, (...)
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  3. No Theory for Old Man. Evolution led to an Equal Contribution of Various Aging Mechanisms.Alexey Turchin - manuscript
    Does a single mechanism of aging exit? Most scientists have their own pet theories about what is aging, but the lack of generally accepted theory is mind-blowing. Here we suggest an explanation: evolution works against unitary mechanism of aging because it equalizes ‘warranty period’ of different resilience systems. Therefore, we need life-extension methods that go beyond fighting specific aging mechanisms: such as using a combination of geroprotectors or repair-fixing bionanorobots controlled by AI.
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  4. Prudential Longtermism.Johan E. Gustafsson & Petra Kosonen - forthcoming - In Jacob Barrett, Hilary Greaves & David Thorstad (eds.), Essays on Longtermism. Oxford University Press.
    According to Longtermism, our acts’ expected influence on the expected value of the world is mainly determined by their effects in the far future. There is, given total utilitarianism, a straightforward argument for Longtermism due to the enormous number of people that might exist in the future, but this argument does not work on person-affecting views. In this paper, we will argue that these views might also lead to Longtermism if Prudential Longtermism is true. Prudential Longtermism holds for a person (...)
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  5. The Role of Hospice and Palliative Medicine in the Ars Moriendi.Durham Levi - forthcoming - Journal of Medicine and Philosophy.
    There is disagreement among physicians and medical ethicists on the precise goals of Hospice and Palliative Medicine (HPM). Some think that HPM's goals should differ from those of other branches of medicine and aim primarily at lessening pain, discomfort, and confusion; while others think that HPM's practices should, like all other branches of medicine, aim at promoting health. I take the latter position: using the ars moriendi to set a standard for what it means to die well, I argue that (...)
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  6. Healthspan extension, completeness of life and justice.Michal Masny - 2023 - Bioethics 37 (3):239-245.
    Recent progress in geroscience holds the promise of significantly slowing down or even reversing ageing and age-related diseases, and thus increasing our healthspans. In this paper, I offer a novel argument in favour of developing such technology and making it unconditionally available to everyone. In particular, I argue that justice requires that each person be provided with sufficient opportunities to have a ‘complete life’, that many people currently lack such opportunities, and that we would substantially improve the status quo by (...)
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  7. Of Blood Transfusions and Feeding Tubes: Anorexia-Nervosa and Consent.Samuel Director - 2021 - Public Affairs Quarterly 35 (4):247–276.
    Individuals suffering from anorexia-nervosa experience dysmorphic perceptions of their body and desire to act on these perceptions by refusing food. In some cases, anorexics want to refuse food to the point of death. In this paper, I answer this question: if an anorexic, A, wants to refuse food when the food would either be life-saving or prevent serious bodily harm, can A’s refusal be valid? I argue that there is compelling reason to think that anorexics can validly refuse food, even (...)
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  8. Hope and human longevity, an actual challenging topic.Gabriel Hasmațuchi & Maria Sinaci - 2021 - Revue Roumaine de Philosophie 2 (65):337-346.
    This paper represents an attempt to correlate the concept of hope with the notion of human longevity and reflects the actual debates around the problem of life extension. Our analysis combines ideas from philosophy, sociology, bioethics, and religion to illustrate the problem of longevity in the context of biomedical and technological progress, and - at the same time - to show the (possible) consequences of prolonging life over the human body limits. Extending human life through emerging technologies is much closer (...)
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  9. The Dignity of Human Life: Sketching Out an 'Equal Worth' Approach.Helen Watt - 2020 - Ethics and Medicine 36 (1):7-17.
    The term “value of life” can refer to life’s intrinsic dignity: something nonincremental and time-unaffected in contrast to the fluctuating, incremental “value” of our lives, as they are longer or shorter and more or less flourishing. Human beings are equal in their basic moral importance: the moral indignities we condemn in the treatment of e.g. those with dementia reflect the ongoing human dignity that is being violated. Indignities licensed by the person in advance remain indignities, as when people might volunteer (...)
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  10. Ethical perspectives on advances in biogerontology.Jean Woo, David Archard, Derrick Au, Sara Bergstresser, Alexandre Erler, Timothy Kwok, John Newman, Raymond Tong & Tom Walker - 2019 - Aging Medicine 2 (2):99-103.
    Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four. Accompanying this change is the rapid development of anti‐aging science. There are three schools of thought in the field of aging science. One perspective is the life course approach, which considers that aging is a good and natural process to be embraced as a necessary and positive aspect of life, (...)
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  11. Value in Very Long Lives.Preston Greene - 2017 - Journal of Moral Philosophy 14 (4):416-434.
    As things currently stand, our deaths are unavoidable and our lifespans short. It might be thought that these qualities leave room for improvement. According to a prominent line of argument in philosophy, however, this thought is mistaken. Against the idea that a longer life would be better, it is claimed that negative psychological states, such as boredom, would be unavoidable if our lives were significantly longer. Against the idea that a deathless life would be better, it is claimed that such (...)
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  12. The Medical Ethics of Miracle Max.Shea Brendan - 2015 - In Richard Greene & Rachel Robison-Greene (eds.), The Princess Bride and Philosophy: Inconceivable! Open Court. pp. 193-203.
    Miracle Max, it seems, is the only remaining miracle worker in all of Florin. Among other things, this means that he (unlike anyone else) can resurrect the recently dead, at least in certain circumstances. Max’s peculiar talents come with significant perks (for example, he can basically set his own prices!), but they also raise a number of ethical dilemmas that range from the merely amusing to the truly perplexing: -/- How much about Max’s “methods” does he need to reveal to (...)
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  13. Anticipating the ultimate innovation, volitional evolution: can it not be promoted or attempted responsibly?Lantz Fleming Miller - 2015 - Journal of Responsible Innovation 2 (3):280-300.
    The aspiration for volitional evolution, or human evolution directed by humans themselves,has increased in philosophical, scientific, technical, and commercial literature. The prospect of shaping the very being who is the consumer of all other innovations offers great commercial potential, one to which all other innovations would in effect be subservient. Actually an amalgam of projected technical/commercial developments, this prospective innovation has practical and ethical ramifications. However, because it is often discussed in a scientific way (specifically that of evolutionary theory), it (...)
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  14. 'Is Cryonics an Ethical Means of Life Extension?'.Rebekah Cron - 2014 - Dissertation, University of Exeter
    This dissertation discusses several ethical and moral issues which arise from the cryonics movement. Within each section, the question is posed: how does that problem impact on how we should think about cryonics? Is cryonics morally permissible and/or morally obligatory? Issues include a consideration of economic resource allocation, bodily ownership and identity.
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  15. Human Enhancement: a new issue in Philosophical Agenda.Marco Azevedo - 2013 - Princípios. Revista de Filosofía 20 (33):265-303.
    Since before we can remember, humanity aims to overcome its biological limitations; such a goal has certainly played a key role in the advent of technique. However, despite the benefits that technique may bring, the people who make use of it will inevitably be under risk of harm. Even though human technical wisdom consists in attaining the best result without compromising anybody’s safety, misuses are always a possibility in the horizon. Nowadays, technology can be used for more than just improving (...)
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  16. In Silico Approaches and the Role of Ontologies in Aging Research.Georg Fuellen, Melanie Börries, Hauke Busch, Aubrey de Grey, Udo Hahn, Thomas Hiller, Andreas Hoeflich, Ludger Jansen, Georges E. Janssens, Christoph Kaleta, Anne C. Meinema, Sascha Schäuble, Paul N. Schofield, Barry Smith & Others - 2013 - Rejuvenation Research 16 (6):540-546.
    The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney (...)
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  17. THE MAXIM OF SUICIDE: ONE ANGLE ON BIOMEDICAL ETHICS.Yusuke Kaneko - 2012 - ASIAN JOURNAL OF SOCIAL SCIENCES and HUMANITIES 1 (3).
    Addressing the question in the form of Kant’s maxim, this paper moves on to a more controversial topic in biomedical ethics, physician-assisted suicide. However, my conclusion is tentative, and what is worse, negative: I partially approve suicide. It does not imply a moral hazard. The situation is opposite: in the present times, terminal patients seriously wish it. I, as an author, put an emphasis on this very respect. Now suicide is, for certain circles, nothing but justice. The arguments of thinkers (...)
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