Philosophy Compass, Volume 17, Issue 1, January 2022.

Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain‐specific are (...) the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

A considerable number of areas of bioscience, including gene and drug discovery, metabolic engineering for the biotechnological improvement of organisms, and the processes of natural and directed evolution, are best viewed in terms of a ‘landscape’ representing a large search space of possible solutions or experiments populated by a considerably smaller number of actual solutions that then emerge. This is what makes these problems ‘hard’, but as such these are to be seen as combinatorial optimisation problems that are best attacked (...) by heuristic methods known from that field. Such landscapes, which may also represent or include multiple objectives, are effectively modelled in silico, with modern active learning algorithms such as those based on Darwinian evolution providing guidance, using existing knowledge, as to what is the ‘best’ experiment to do next. An awareness, and the application, of these methods can thereby enhance the scientific discovery process considerably. This analysis fits comfortably with an emerging epistemology that sees scientific reasoning, the search for solutions, and scientific discovery as Bayesian processes. (shrink)

In this paper we investigate the role of information machines in the scientific enterprise intended as a social activity. Our discussion is based on a powerful kind of information machines called scientific social agencies, which are multiagent systems of distributed artificial intelligence. Scientific social agency, on the one hand, can provide great benefits to the present common scientific practice but, on the other hand, its development represents a strong and still open technical challenge. This paper shows a coherent framework in (...) which scientific social agency is settled. Moreover, the double role of a scientific social agency in assisting scientists in their activity and in representing the products of their research is illustrated by means of some examples. (shrink)

Philosophy Compass, Volume 17, Issue 1, January 2022.

Speaking: from Intention to Articulation Willem J. M. Levelt, 1989 (1993 paperback) Cambridge, MA: MIT Press ISBN: 0–262–12137–9(hb), 0–262–62089–8(pb)Rules for Reasoning Richard E. Nisbett (Ed.), 1993 Hillsdale, NJ, Lawrence Erlbaum Associates ISBN: 0–8058–1256–3(hb), 0–8085–1257–1 (pb)Readings in Philosophy and Cognitive Science Alvin I. Goldman, 1993 Cambridge, MA, MIT Press ISBN: 0–262–07153–3(hb), 0–262–57100–5(pb)Language Comprehension in Ape and Child, Monographs of the Society for Research in Child Development, Serial No. 233, Vol. 58, Nos 3–4 Sue Savage‐Rumbaugh, Jeannine Murphy, Rose A. Sevcik, Karen E. (...) Brakke, Shelly L. Williams & Duane M. Rumbaugh, with commentary by Elizabeth Bates, and a reply by the authors, 1993 Chicago: University of Chicago Press ISBN: 0–226–73542–7Language, Music and Mind Diana Raffman, 1993 Cambridge, MIT Press/Bradford Books ISBN: 0–262–18150–9Psychology of Proof Lance J. Rips, 1994 Cambridge, MA, MIT Press ISBN: 0–262–18153–3Human and Machine Thinking P. Johnson‐Laird, 1993 Hillsdale, NJ, Erlbaum ISBN: 0–8058–0921‐XIntelligent Behavior in Animals and Robots David McFarland & Thomas Bosser, 1993 Cambridge, MA and London, UK: MIT Press/ Bradford Books ISBN: 0–262–13293–1The Eye and the Mind: Reflections on Perception and the Problem of Knowledge Charles Landesman, 1993 Dordrecht: Kluwer Academic Publishers ISBN: 0–7923–2586–9The Moral Self GilG. Noam & Thomas E. Wren (Eds), in cooperation with Gertud Nunner‐Winkler & Wolfgang Edelstein, 1993 Cambridge, MA: MIT Press ISBN: 0–262–14052–1The Logic of Discovery: A Theory of the Rationality of Scientific Research Scott A. Kleiner, 1993 Dordrecht: Kluwer Academic Publishers ISBN: 0–7923–2371–8Folk Psychology and the Philosophy of Mind S.M. Christenson & D.R. Turner (Eds), 1993 Hillsdale, NJ: Lawrence Erlbaum ISBN: 0–805–80931–7. (shrink)

It is considered in some quarters that hypothesis‐driven methods are the only valuable, reliable or significant means of scientific advance. Data‐driven or ‘inductive’ advances in scientific knowledge are then seen as marginal, irrelevant, insecure or wrong‐headed, while the development of technology—which is not of itself ‘hypothesis‐led’ (beyond the recognition that such tools might be of value)—must be seen as equally irrelevant to the hypothetico‐deductive scientific agenda. We argue here that data‐ and technology‐driven programmes are not alternatives to hypothesis‐led studies in (...) scientific knowledge discovery but are complementary and iterative partners with them. Many fields are data‐rich but hypothesis‐poor. Here, computational methods of data analysis, which may be automated, provide the means of generating novel hypotheses, especially in the post‐genomic era. BioEssays 26:99–105, 2004. © 2003 Wiley Periodicals, Inc. (shrink)

In artificial intelligence (AI), a number of criticisms were raised against the use of probability for dealing with uncertainty. All these criticisms, except what in this article we call the non-adequacy claim, have been eventually confuted. The non-adequacy claim is an exception because, unlike the other criticisms, it is exquisitely philosophical and, possibly for this reason, it was not discussed in the technical literature. A lack of clarity and understanding of this claim had a major impact on AI. Indeed, mostly (...) leaning on this claim, some scientists developed an alternative research direction and, as a result, the AI community split in two schools: a probabilistic and an alternative one. In this article, we argue that the non-adequacy claim has a strongly metaphysical character and, as such, should not be accepted as a conclusive argument against the adequacy of probability. (shrink)

In the course of researching the question ‘What does it mean for knowledge to grow?’, the author has developed a large and unique compendium of components, some of which are knowledge systems that serve as research and creativity support systems. The self-modifying, self-effecting creative process and the results of developing and working with these systems, using novel methods and drawing on eclectic sources, is discussed.