Mitchell & Gronenborn propose that we account for the presence of multiple models of protein structure, each produced in different contexts, through the framework of integrative pluralism. I argue that two interpretations of this framework are available, neither of which captures the relationship between a model and the protein structure it represents or between multiple models of protein structure. Further, it inclines us toward concluding prematurely that models of protein structure are right in their contexts and makes extrapolation of findings (...) from one context to another seem unwarranted. Instead, protein structure determination ought to be understood as modestly monistic. There is one model for every protein in each physicochemical context, and models of the same protein produced in different contexts are compatible with one another. ‘Integrating’ multiple models amounts to extrapolating from one context to another; this is possible because the effect of context on protein folding is relatively weak and predictable. Modest monism better describes the practice of protein structure determination than integrative pluralism and enables greater attention to how context affects protein folding. (shrink)

The goal of this dissertation is to reconstruct, critically evaluate, and apply the pluralism of Paul Feyerabend. I conclude by suggesting future points of contact between Feyerabend’s pluralism and topics of interest in contemporary philosophy of science. I begin, in Chapter 1, by reconstructing Feyerabend’s critical philosophy. I show how his published works from 1948 until 1970 show a remarkably consistent argumentative strategy which becomes more refined and general as Feyerabend’s thought matures. Specifically, I argue that Feyerabend develops a persuasive (...) case against rationalism, or the thesis that there exist normative and exclusive rules of scientific rationality. In Chapter 2, I reconstruct Feyerabend’s pluralism and detail its relationship to his humanitarianism and epistemological anarchism. I understand Feyerabend’s pluralism as the combination of the principles of proliferation and tenacity. I show the evolution and justification of these principles from Feyerabend’s early papers until the late 1970s. In Chapter 3, I defend Feyerabend’s pluralism from its most prominent criticisms. I then clarify that Feyerabend’s pluralism amounts to a conception of the logic of theory pursuit and modify his view using insights from C.S. Peirce, Pierre Duhem, and Michael Polanyi. From Peirce, I show how economic, sociological, and value-laden features of theory pursuit may be used to constrain proliferation and tenacity. From Duhem and Polanyi, I try to show the proper role of tacit knowledge within a Feyerabendian framework. Finally, I show what implications Feyerabend’s pluralism has for models of distributing funds within scientific communities. I contend that it provides a more promising model that the ‘well-ordered science’ proposal advanced by numerous philosophers and social scientists. Specifically, I aim to understand what taking Feyerabend’s pluralism seriously entails for principles of balancing funding allocation decisions and the role of peer-review in evaluating the potential success of research proposals. I conclude by suggesting future lines of research for further analyzing and applying Feyerabend’s pluralism. (shrink)

This thesis advances and defends a novel two-category ontology of objects and dimensions, latterly conceived as respects of comparability. The proposed 'dimensionist' ontology is set out and brought to bear on discussions of determinables and determinates, the problem of universals, fact ontologies, and nomic governance. Dimensionism is argued to fare well in comparison to a range of rival ontological accounts of property possession. A metametaphysical framework is set out to undergird the discussion, which draws on both realist and pragmatist resources.

In this thesis I will examine the philosophy of the physicist Max Born. As well as his scientific work, Born wrote on a number of philosophical topics: causation, realism, determinism, and probability. They appear as an interest throughout his career, but he particularly concentrates on them from the 1940s onwards. Born is a significant figure in the development of quantum mechanics whose philosophical work has been left largely unexamined. It is the aim of this thesis to elucidate and to critically (...) examine that work. I will give a defence of presentist historiography in the history and philosophy of science and a brief biography of Born. With regards to causation, the thesis will argue that he holds that there exist principles regarding causal relations that have guided the development of physics and have, in the modern formulation of the subject, been confirmed as having an empirical status. I will argue that he is a selective realist, initially with regards to invariant properties and, later on, a structural realist. With regards to determinism, I will argue that Born has produced an argument, compatible with modern philosophical definitions of determinism, that we were never entitled to conclude from the success of classical mechanics that the world was deterministic. Finally, I will argue that Born holds an objective interpretation of probabilities in quantum mechanics which, due to his strong belief in the physical reality of quantum-mechanical probabilities and his apparent disbelief in the superposition of the wave-function, is most likely a long-run propensity theory. (shrink)

The Fifth Joint Workshop on Integrated History and Philosophy of Science asked participants, “What is HPS for?” This clearly instrumental question generated a welcome spectrum of practical responses. Examples of “HPS-in-action” included the concept of complementary science, suggestions for new pedagogical strategies and investigations into the socio-political dimensions of science. On the other hand, a more theoretical underpinning did emerge in a discussion of the pros and cons of pluralism. This emphasis on pluralism not only underlies complementary science, but may (...) also provide a pragmatic working basis for developing a more active role for HPS in both science and society. (shrink)

When discrepancies are discovered between the outcomes of different measurement procedures, two sorts of explanation are open to scientists. Either some of the outcomes are inaccurate or the procedures are not measuring the same quantity. I argue that, due to the possibility of systematic error, the choice between and is underdetermined in principle by any possible evidence. Consequently, foundationalist criteria of quantity individuation are either empty or circular. I propose a coherentist, model-based account of measurement that avoids the underdetermination problem, (...) and use this account to explain how scientists individuate quantities in practice. (shrink)

There has been a great deal of skepticism towards the value of the realism/anti-realism debate. More specifically, many have argued that plausible formulations of realism and anti-realism do not differ substantially in any way. In this paper, I argue against this trend by demonstrating how a hypothetical resolution of the debate, through deeper engagement with the historical record, has important implications for our criterion of theory pursuit and science policy. I do this by revisiting Arthur Fine’s ‘small handful’ argument for (...) realism and show how the debate centers on whether continuity should be an indicator for the future fruitfulness of a theory. I then demonstrate how these debates work in practice by considering the case of the Human Brain Project. I close by considering some potential practical considerations of formulating meta-inductions. By doing this, I contribute three insights to the current debate: 1) demonstrate how the realism/anti-realism debate is a substantive debate, 2) connect debates about realism/anti-realism to debates about theory choice and pursuit, and 3) show the practical significance of meta-inductions. (shrink)

Prompted by Hasok Chang’s conception of the history and philosophy of science (HPS) as the continuation of science by other means, I examine the possibility of obtaining scientific knowledge through philosophical criticism and reflection, in the light of four historical cases, concerning (i) the role of absolute space in Newtonian dynamics, (ii) the purported contraction of rods and retardation of clocks in Special Relativity, (iii) the reality of the electromagnetic ether, and (iv) the so-called problem of time’s arrow. In all (...) four cases it is clear that a better understanding of such matters can be achieved —and has been achieved— through conceptual analysis. On the other hand, however, it would seem that this kind of advance has more to do with philosophical questions in science than with narrowly scientific questions. Hence, if HPS in effect continues the work of science by other means, it could well be doing it for other ends than those that working scientists ordinarily have in mind. (shrink)

The paper studies the nature of understanding in condensed matter physics (CMP), mediated by the successful employment of its models. I first consider two obvious candidates for the criteria of model-based understanding, Van Fraassen's sense of empirical adequacy and Hacking's instrumental utility , and conclude that both are unsatisfactory. Inspired by Hasok Chang's recent proposal to reformulate realism as the pursuit of ontological plausibility in our system of knowledge, we may require the model under consideration to be understood (or intelligible) (...) before claiming model-based understanding. Here the understanding of a model typically consists of the following: figuring out at least one plausible (preferably realistic) physical mechanism for the model, determining the theoretical consequences of the model by mathematically probing it and developing our physical intuitions about the model. I consider the q-state Potts model to illustrate. After having understood a model, we may employ the model to understand its target phenomena in the world. This is done by matching one of the interpretative models of the model with the central features of the phenomena. The matching should be motivated (ideally both theoretically and empirically) in the sense that we have good reason to believe that the central features of the phenomena can be thought of as having more or less the same structure as postulated by the interpretative model. In conclusion, I propose a two-stage account of model-based understanding in CMP: (1) understanding of a model and (2) matching a target phenomenon with a well-motivated interpretative model of the model. Empirical success and instrumental utility both play their roles in the evaluation of how successful the model is, but are not the essential part of model-based understanding. (shrink)