This volume focuses on various questions concerning the interpretation of probability and probabilistic reasoning in biology and physics. It is inspired by the idea that philosophers of biology and philosophers of physics who work on the foundations of their disciplines encounter similar questions and problems concerning the role and application of probability, and that interaction between the two communities will be both interesting and fruitful. In this introduction we present the background to the main questions that the volume focuses on (...) and summarize the highlights of the individual contributions. (shrink)