Following an analysis of the state of investigations and clinical outcomes in the Alzheimer's research field, I argue that the widely-accepted 'amyloid cascade' mechanistic explanation of Alzheimer's disease appears to be fundamentally incomplete. In this context, I propose that a framework termed 'principled mechanism' (PM) can help with remedying this problem. First, using a series of five 'tests', PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria, and hints at various ways of making (...) the mechanistic explanation more 'complete'. These steps will be demonstrated using the amyloid explanation, and its missing or problematic mechanistic elements will be highlighted. Second, PM makes an appeal for the discovery and application of 'biological principles' (BPs), which approximate ceteris paribus laws and are operative at the level of a biological cell. As such, although thermodynamic, evolutionary, ecological and other laws or principles from chemistry and the broader life sciences could inform them, BPs should be considered ontologically unique. BPs could augment different facets of the mechanistic explanation but also allow further independent nomological explanation of the phenomenon. Whilst this overall strategy can be complementary to certain 'New Mechanist' approaches, an important distinction of the PM framework is its equal attention to the explanatory utility of biological principles. Lastly, I detail two hypothetical BPs, and show how they could each inform and improve the potentially incomplete mechanistic aspects of the amyloid explanation and also how they could provide independent explanations of the cellular features associated with Alzheimer's disease. (shrink)

Few have given an extended treatment of the non-statistical sense of normality: a sense captured in sentences like “dogs have four legs,” or “hammers normally have metal heads,” or “it is normal for badgers to take dust baths.” The most direct extant treatment is Bernhard Nickel’s Between Logic and the World, where he claims that the normal or characteristic for a kind is what we can explain by appeal to the right sorts of explanations. Just which explanatory strategies can ground (...) normalities, though, is difficult to determine without inviting circularity into the account. After raising this and other worries for Nickel’s account, I develop my own account according to which normal features are those which are explained by the kind of thing involved. (shrink)

According to the Best System Account of lawhood, laws of nature are theorems of the deductive systems that best balance simplicity and strength. In this paper, I advocate a different account of lawhood which is related, in spirit, to the BSA: according to my account, laws are theorems of deductive systems that best balance simplicity, strength, and also calculational tractability. I discuss two problems that the BSA faces, and I show that my account solves them. I also use my account (...) to illuminate the nomological character of special science laws. (shrink)

This paper contributes to the clarification of the concept of “typicality” discussed in contemporary philosophy of physics by conceiving the nomological status of a typical behaviour such as that expressed in the Second Law of Thermodynamics as a “minutis rectis law”. A brief sketch of the discovery of “typicality” shows that there were ideas of typical behaviour not only in physics but also in sociology. On this basis and in analogy to the Second Law of Thermodynamics, it is shown that (...) the nomological status of sociological laws such as Gresham’s Law can also be conceived as “minutis rectis laws”. (shrink)

The better best system account, short BBSA, is a variation on Lewis’s theory of laws. The difference to the latter is that the BBSA suggests that best system analyses can be executed for any fixed set of properties. This affords the possibility to launch system analyses separately for the set of biological properties yielding the set of biological laws, chemical properties yielding chemical laws, and so on for the other special sciences. As such, the BBSA remains silent about possible interrelations (...) between these freestanding sets of laws. In this paper, I explicate an emergence relation between them which preserves the autonomy or novelty of each special science’s laws but also shows their dependence: the autonomy of each level’s generalisations is given because nomicity is conferred to them system intrinsic, their dependence is established via their supervenience on lower level laws. As will be shown, the autonomy of special science laws is further strengthened by their ceteris paribus character. (shrink)