Several philosophers of science have taken inspiration from biological research on niches to conceptualise scientific practice. We systematise and extend three niche-based theories of scientific practice: conceptual ecology, cognitive niche construction, and scientific niche construction. We argue that research niches are a promising conceptual tool for understanding complex and dynamic research environments, which helps to investigate relevant forms of agency and material and social interdependencies, while also highlighting their historical and dynamic nature. To illustrate this, we develop a six-point framework (...) for conceptualising research niches. Within this framework, research niches incorporate multiple and heterogenous material, social and conceptual factors (multi-dimensionality); research outputs arise, persist and differentiate through interactions between researchers and research niches (processes); researchers actively respond to and construct research niches (agency); research niches enable certain interactions and processes and not others (capability); and research niches are defined in relation to particular entities, such as individual researchers, disciplines, or concepts (relationality), and in relation to goals, such as understanding, solving problems, intervention, or the persistence of concepts or instruments (normativity). (shrink)