In my dissertation, I present Hermann Cohen's foundation for the history and philosophy of science. My investigation begins with Cohen's formulation of a neo-Kantian epistemology. I analyze Cohen's early work, especially his contributions to 19th century debates about the theory of knowledge. I conclude by examining Cohen's mature theory of science in two works, The Principle of the Infinitesimal Method and its History of 1883, and Cohen's extensive 1914 Introduction to Friedrich Lange's History of Materialism. In the former, Cohen gives (...) an historical and philosophical analysis of the foundations of the infinitesimal method in mathematics. In the latter, Cohen presents a detailed account of Heinrich Hertz's Principles of Mechanics of 1894. Hertz considers a series of possible foundations for mechanics, in the interest of finding a secure conceptual basis for mechanical theories. Cohen argues that Hertz's analysis can be completed, and his goal achieved, by means of a philosophical examination of the role of mathematical principles and fundamental concepts in scientific theories. (shrink)