Festschrift in Honor of Barry Smith on the occasion of his 65th Birthday. Published as issue 4:4 of the journal Cosmos + Taxis: Studies in Emergent Order and Organization. Includes contributions by Wolfgang Grassl, Nicola Guarino, John T. Kearns, Rudolf Lüthe, Luc Schneider, Peter Simons, Wojciech Żełaniec, and Jan Woleński.

Reuse of elements from existing ontologies in the construction of new ontologies is a foundational principle in ontological design. It offers the benefits, among others, of consistency and interoperability between such knowledge structures as well as sharing resources. Reuse is widely found within important collections of established ontologies, such as BioPortal and the OBO Foundry. However, reuse comes with its own potential problems involving ontological commitment, granularity, and ambiguity. Guidelines are proposed to aid ontology developers and curators in their prospective (...) reuse of content. These guidelines have been gleaned over years of practice in the ontology field. The guidelines are couched in experiential reports on designing and curating particular ontologies (e.g., EXACT and EXACT2) and using generally accepted approaches (e.g., MIREOT) in doing so. Various software tools to assist in ontology reuse are surveyed and discussed. (shrink)

The automatic integration of rapidly expanding information resources in the life sciences is one of the most challenging goals facing biomedical research today. Controlled vocabularies, terminologies, and coding systems play an important role in realizing this goal, by making it possible to draw together information from heterogeneous sources – for example pertaining to genes and proteins, drugs and diseases – secure in the knowledge that the same terms will also represent the same entities on all occasions of use. In the (...) naming of genes, proteins, and other molecular structures, considerable efforts are under way to reduce the effects of the different naming conventions which have been spawned by different groups of researchers. Electronic patient records, too, increasingly involve the use of standardized terminologies, and tremendous efforts are currently being devoted to the creation of terminology resources that can meet the needs of a future era of personalized medicine, in which genomic and clinical data can be aligned in such a way that the corresponding information systems become interoperable. (shrink)

To address the problems of both structured coordination of linked and modularised ontologies and to query a large dynamic ontology system, we propose a basic granularity framework and a set of functions to query such a granulated system. The granularity framework enforces a constrained and structured modularization. This facilitates automation of both dividing a large body of represented information as well as relinking the pieces. The functions enable basic cross-granular querying in a transparent and scalable way, as they rely on (...) the unambiguous management layer provided by the granularity framework, and are reusable for ontologies represented and stored in different formats. (shrink)

Multiple different understandings and uses exist of what granularity is and how to implement it, where the former influences success of the latter with regards to storing granular data and using granularity for reasoning over the data or information. We propose a taxonomy of types of granularity and discuss for each leaf type how the entities or instances relate within its granular level. Such unambiguous distinctions can guide a conceptual modeler to better distinguish between the types of granularity and the (...) software developer to improve on implementations of granularity. (shrink)