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  1. Computational Construction of the Reality: Abstraction and Exploration-Driven Strategies in Constructing Protein–Protein Interfaces.Sim-Hui Tee - 2019 - Axiomathes 29 (3):311-328.
    Computational modeling is one of the primary approaches to constructing protein–protein interfaces in the laboratory. The algorithm-driven computational protein design has been successfully applied to the construction of functional proteins with improved binding affinity and increased thermostability. It is intriguing how a computational protein modeling approach can construct and shape the reality of new functional proteins from scratch. I articulate an account of abstraction and exploration-driven strategies in this computational endeavor. I aim to show that how a computational modelling approach, (...)
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  • Evidence and Knowledge from Computer Simulation.Wendy S. Parker - 2020 - Erkenntnis 87 (4):1521-1538.
    Can computer simulation results be evidence for hypotheses about real-world systems and phenomena? If so, what sort of evidence? Can we gain genuinely new knowledge of the world via simulation? I argue that evidence from computer simulation is aptly characterized as higher-order evidence: it is evidence that other evidence regarding a hypothesis about the world has been collected. Insofar as particular epistemic agents do not have this other evidence, it is possible that they will gain genuinely new knowledge of the (...)
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  • Simulated Data in Empirical Science.Aki Lehtinen & Jani Raerinne - forthcoming - Foundations of Science:1-22.
    This paper provides the first systematic epistemological account of simulated data in empirical science. We focus on the epistemic issues modelers face when they generate simulated data to solve problems with empirical datasets, research tools, or experiments. We argue that for simulated data to count as epistemically reliable, a simulation model does not have to mimic its target. Instead, some models take empirical data as a target, and simulated data may successfully mimic such a target even if the model does (...)
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  • Computer Simulation, Experiment, and Novelty.Julie Jebeile - 2017 - International Studies in the Philosophy of Science 31 (4):379-395.
    It is often said that computer simulations generate new knowledge about the empirical world in the same way experiments do. My aim is to make sense of such a claim. I first show that the similarities between computer simulations and experiments do not allow them to generate new knowledge but invite the simulationist to interact with simulations in an experimental manner. I contend that, nevertheless, computer simulations and experiments yield new knowledge under the same epistemic circumstances, independently of any features (...)
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  • Science, assertion, and the common ground.Corey Dethier - 2022 - Synthese 200 (1):1-19.
    I argue that the appropriateness of an assertion is sensitive to context—or, really, the “common ground”—in a way that hasn’t previously been emphasized by philosophers. This kind of context-sensitivity explains why some scientific conclusions seem to be appropriately asserted even though they are not known, believed, or justified on the available evidence. I then consider other recent attempts to account for this phenomenon and argue that if they are to be successful, they need to recognize the kind of context-sensitivity that (...)
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  • Social Epistemology and Validation in Agent-Based Social Simulation.David Anzola - 2021 - Philosophy and Technology 34 (4):1333-1361.
    The literature in agent-based social simulation suggests that a model is validated when it is shown to ‘successfully’, ‘adequately’ or ‘satisfactorily’ represent the target phenomenon. The notion of ‘successful’, ‘adequate’ or ‘satisfactory’ representation, however, is both underspecified and difficult to generalise, in part, because practitioners use a multiplicity of criteria to judge representation, some of which are not entirely dependent on the testing of a computational model during validation processes. This article argues that practitioners should address social epistemology to achieve (...)
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  • When is an Ensemble like a Sample?Corey Dethier - 2022 - Synthese 200 (52):1-22.
    Climate scientists often apply statistical tools to a set of different estimates generated by an “ensemble” of models. In this paper, I argue that the resulting inferences are justified in the same way as any other statistical inference: what must be demonstrated is that the statistical model that licenses the inferences accurately represents the probabilistic relationship between data and target. This view of statistical practice is appropriately termed “model-based,” and I examine the use of statistics in climate fingerprinting to show (...)
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  • Measurement in Science.Eran Tal - 2015 - Stanford Encyclopedia of Philosophy.
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  • Thought Experiments and the Scientific Imagination.Alice Murphy - 2020 - Dissertation, University of Leeds
    Thought experiments (TEs) are important tools in science, used to both undermine and support theories, and communicate and explain complex phenomena. Their interest within philosophy of science has been dominated by a narrow question: How do TEs increase knowledge? My aim is to push beyond this to consider their broader value in scientific practice. I do this through an investigation into the scientific imagination. Part one explores questions regarding TEs as “experiments in the imagination” via a debate concerning the epistemic (...)
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