This article reevaluates the historical conditions of the concomitant rise of computational systems and DNA-coding in the 1950s and addresses the implementation of behavioral psychology and cybernetic technologies of control after the Second World War. From this historical perspective, this article interrogates the intersectional relation that automatic systems of control share with models of segregation and structures of knowledge oppression. It engages with the work of French philosopher Gilbert Simondon and poses Simondon’s cybernetic theory as an opportunity to question systems (...) of knowledge imposed on ontological domains. Finally, it reveals how cybernetics reproduces a model of cultural understanding based on exclusion/inclusion and addresses the difficulty of creating new critical paradigms from within the informational technologies of neo-colonial episteme. (shrink)