According to the substantialist, substances should be regarded as the fundamental ontological category. It is substances that are the bearer of properties, that are causally efficacious and that compose the things we see and touch around us. Cumpa has argued that this metaphysics fits poorly with classical physics and Buonomo has extended this argument into the quantum realm. After reviewing their claims, I shall argue that simple reflection on the form of the Standard Model also undermines substantialism. I will then (...) explore Dasgupta’s qualitative factualism in this context before suggesting that modern physics does not compel us to adopt such a stance. The alternative is to adopt a form of structuralism which, although it may be rendered compatible with factualism, can also stand as a ‘third way’ between these stances. (shrink)