In this inaugural lecture I offer, against the background of a discussion of knowledge representation and its tools, an overview of my research in the philosophy of science. I defend a relational model-theoretic realism as being the appropriate meta-stance most congruent with the model-theoretic view of science as a form of human engagement with the world. Making use of logics with preferential semantics within a model-theoretic paradigm, I give an account of science as process and product. I demonstrate the power (...) of the full-blown employment of this paradigm in the philosophy of science by discussing the main applications of model-theoretic realism to traditional problems in the philosophy of science. I discuss my views of the nature of logic and of its role in the philosophy of science today. I also specifically offer a brief discussion on the future of cognitive philosophy in South Africa. My conclusion is a general look at the nature of philosophical inquiry and its significance for philosophers today. South African Journal of Philosophy Vol. 25 (4) 2006: pp. 275-289. (shrink)