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  1. Scientific Explanation and the Causal Structure of the World.Wesley C. Salmon - 1984 - Princeton University Press.
    The philosophical theory of scientific explanation proposed here involves a radically new treatment of causality that accords with the pervasively statistical character of contemporary science. Wesley C. Salmon describes three fundamental conceptions of scientific explanation--the epistemic, modal, and ontic. He argues that the prevailing view is untenable and that the modal conception is scientifically out-dated. Significantly revising aspects of his earlier work, he defends a causal/mechanical theory that is a version of the ontic conception. Professor Salmon's theory furnishes a robust (...)
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  • Review of Scientific Explanation and the Causal Structure of the World. [REVIEW]James Woodward - 1988 - Noûs 22 (2):322-324.
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  • Big Data Biology: Between Eliminative Inferences and Exploratory Experiments.Emanuele Ratti - 2015 - Philosophy of Science 82 (2):198-218.
    Recently, biologists have argued that data - driven biology fosters a new scientific methodology; namely, one that is irreducible to traditional methodologies of molecular biology defined as the discovery strategies elucidated by mechanistic philosophy. Here I show how data - driven studies can be included into the traditional mechanistic approach in two respects. On the one hand, some studies provide eliminative inferential procedures to prioritize and develop mechanistic hypotheses. On the other, different studies play an exploratory role in providing useful (...)
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  • The Causal Nature of Modeling with Big Data.Wolfgang Pietsch - 2016 - Philosophy and Technology 29 (2):137-171.
    I argue for the causal character of modeling in data-intensive science, contrary to widespread claims that big data is only concerned with the search for correlations. After discussing the concept of data-intensive science and introducing two examples as illustration, several algorithms are examined. It is shown how they are able to identify causal relevance on the basis of eliminative induction and a related difference-making account of causation. I then situate data-intensive modeling within a broader framework of an epistemology of scientific (...)
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  • What makes Big Data, Big Data? Exploring the ontological characteristics of 26 datasets.Gavin McArdle & Rob Kitchin - 2016 - Big Data and Society 3 (1).
    Big Data has been variously defined in the literature. In the main, definitions suggest that Big Data possess a suite of key traits: volume, velocity and variety, but also exhaustivity, resolution, indexicality, relationality, extensionality and scalability. However, these definitions lack ontological clarity, with the term acting as an amorphous, catch-all label for a wide selection of data. In this paper, we consider the question ‘what makes Big Data, Big Data?’, applying Kitchin’s taxonomy of seven Big Data traits to 26 datasets (...)
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  • What difference does quantity make? On the epistemology of Big Data in biology.Sabina Leonelli - 2014 - Big Data and Society 1 (1):2053951714534395.
    Is Big Data science a whole new way of doing research? And what difference does data quantity make to knowledge production strategies and their outputs? I argue that the novelty of Big Data science does not lie in the sheer quantity of data involved, but rather in the prominence and status acquired by data as commodity and recognised output, both within and outside of the scientific community and the methods, infrastructures, technologies, skills and knowledge developed to handle data. These developments (...)
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  • Re-thinking organisms: The impact of databases on model organism biology.Sabina Leonelli & Rachel A. Ankeny - 2012 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 43 (1):29-36.
    Community databases have become crucial to the collection, ordering and retrieval of data gathered on model organisms, as well as to the ways in which these data are interpreted and used across a range of research contexts. This paper analyses the impact of community databases on research practices in model organism biology by focusing on the history and current use of four community databases: FlyBase, Mouse Genome Informatics, WormBase and The Arabidopsis Information Resource. We discuss the standards used by the (...)
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  • Classificatory Theory in Biology.Sabina Leonelli - 2013 - Biological Theory 7 (4):338-345.
    Scientific classification has long been recognized as involving a specific style of reasoning and doing research, and as occasionally affecting the development of scientific theories. However, the role played by classificatory activities in generating theories has not been closely investigated within the philosophy of science. I argue that classificatory systems can themselves become a form of theory, which I call classificatory theory, when they come to formalize and express the scientific significance of the elements being classified. This is particularly evident (...)
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  • Data Interpretation in the Digital Age.Sabina Leonelli - 2014 - Perspectives on Science 22 (3):397-417.
    Scientific knowledge production is currently affected by the dissemination of data on an unprecedented scale. Technologies for the automated production and sharing of vast amounts of data have changed the way in which data are handled and interpreted in several scientific domains, most notably molecular biology and biomedicine. In these fields, the activity of data gathering has become increasingly technology-driven, with machines such as next generation genome sequencers and mass spectrometers generating billions of data points within hours, and with little (...)
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  • Big Data, new epistemologies and paradigm shifts.Rob Kitchin - 2014 - Big Data and Society 1 (1).
    This article examines how the availability of Big Data, coupled with new data analytics, challenges established epistemologies across the sciences, social sciences and humanities, and assesses the extent to which they are engendering paradigm shifts across multiple disciplines. In particular, it critically explores new forms of empiricism that declare ‘the end of theory’, the creation of data-driven rather than knowledge-driven science, and the development of digital humanities and computational social sciences that propose radically different ways to make sense of culture, (...)
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  • Information Channels and Biomarkers of Disease.Phyllis Illari & Federica Russo - 2016 - Topoi 35 (1):175-190.
    Current research in molecular epidemiology uses biomarkers to model the different disease phases from environmental exposure, to early clinical changes, to development of disease. The hope is to get a better understanding of the causal impact of a number of pollutants and chemicals on several diseases, including cancer and allergies. In a recent paper Russo and Williamson address the question of what evidential elements enter the conceptualisation and modelling stages of this type of biomarkers research. Recent research in causality has (...)
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  • Independence, invariance and the causal Markov condition.Daniel M. Hausman & James Woodward - 1999 - British Journal for the Philosophy of Science 50 (4):521-583.
    This essay explains what the Causal Markov Condition says and defends the condition from the many criticisms that have been launched against it. Although we are skeptical about some of the applications of the Causal Markov Condition, we argue that it is implicit in the view that causes can be used to manipulate their effects and that it cannot be surrendered without surrendering this view of causation.
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  • Big data and their epistemological challenge.Luciano Floridi - 2012 - Philosophy and Technology 25 (4):435-437.
    Between 2006 and 2011, humanity accumulated 1,600 EB of data. As a result of this growth, there is now more data produced than available storage. This article explores the problem of “Big Data,” arguing for an epistemological approach as a possible solution to this ever-increasing challenge.
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  • Nature's capacities and their measurement.Nancy Cartwright - 1989 - New York: Oxford University Press.
    Ever since David Hume, empiricists have barred powers and capacities from nature. In this book Cartwright argues that capacities are essential in our scientific world, and, contrary to empiricist orthodoxy, that they can meet sufficiently strict demands for testability. Econometrics is one discipline where probabilities are used to measure causal capacities, and the technology of modern physics provides several examples of testing capacities (such as lasers). Cartwright concludes by applying the lessons of the book about capacities and probabilities to the (...)
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  • Causality: Models, Reasoning and Inference.Judea Pearl - 2000 - New York: Cambridge University Press.
    Causality offers the first comprehensive coverage of causal analysis in many sciences, including recent advances using graphical methods. Pearl presents a unified account of the probabilistic, manipulative, counterfactual and structural approaches to causation, and devises simple mathematical tools for analyzing the relationships between causal connections, statistical associations, actions and observations. The book will open the way for including causal analysis in the standard curriculum of statistics, artificial intelligence, business, epidemiology, social science and economics.
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  • Causality: Philosophical theory meets scientific practice.Phyllis McKay Illari & Federica Russo - 2014 - Oxford, UK: Oxford University Press. Edited by Federica Russo.
    Scientific and philosophical literature on causality has become highly specialised. It is hard to find suitable access points for students, young researchers, or professionals outside this domain. This book provides a guide to the complex literature, explains the scientific problems of causality and the philosophical tools needed to address them.
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  • Unsimple Truths: Science, Complexity, and Policy.Sandra D. Mitchell - 2009 - London: University of Chicago Press.
    The world is complex, but acknowledging its complexity requires an appreciation for the many roles context plays in shaping natural phenomena. In _Unsimple Truths, _Sandra Mitchell argues that the long-standing scientific and philosophical deference to reductive explanations founded on simple universal laws, linear causal models, and predict-and-act strategies fails to accommodate the kinds of knowledge that many contemporary sciences are providing about the world. She advocates, instead, for a new understanding that represents the rich, variegated, interdependent fabric of many levels (...)
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  • Causality: Models, Reasoning and Inference.Judea Pearl - 2000 - Tijdschrift Voor Filosofie 64 (1):201-202.
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  • Big data and information quality.Luciano Floridi - 2014 - In The philosophy of information quality. pp. 303–315.
    This paper is divided into two parts. In the first, I shall briefly analyse the phenomenon of “big data”, and argue that the real epistemological challenge posed by the zettabyte era is small patterns. The valuable undercurrents in the ocean of data that we are accumulating are invisible to the computationally-naked eye, so more and better technology will help. However, because the problem with big data is small patterns, ultimately, the game will be won by those who “know how to (...)
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  • Mechanistic explanation and the nature-nurture controversy.William Bechtel & Adele Abrahamsen - 2005 - Bulletin d'Histoire Et d'pistmologie Des Sciences de La Vie 12:75-100.
    Both in biology and psychology there has been a tendency on the part of many investigators to focus solely on the mature organism and ignore development. There are many reasons for this, but an important one is that the explanatory framework often invoked in the life sciences for understanding a given phenomenon, according to which explanation consists in identifying the mechanism that produces that phenomenon, both makes it possible to side-step the development issue and to provide inadequate resources for actually (...)
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  • Causal Modelling.Christopher Hitchcock - 2009 - In Helen Beebee, Christopher Hitchcock & Peter Menzies (eds.), The Oxford Handbook of Causation. Oxford University Press.
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  • Big Data: A Revolution That Will Transform How We Live, Work, and Think.[author unknown] - 2013
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  • Orienteering Tools: Biomedical Research with Ontologies.Federico Boem - 2016 - Humana Mente 9 (30).
    Biomedical ontologies are considered a serious innovation for biomedical research and clinical practice. They promise to integrate information coming from different biological databases thus creating a common ground for the representation of knowledge in all the life sciences. Such a tool has potentially many implications for both basic biomedical research and clinical practice. Here I discuss how this tool has been generated and thought. Due to the analysis of some empirical cases I try to elaborate how biomedical ontologies constitute a (...)
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