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  1. Cancer genome sequencing: The challenges ahead.Henry H. Q. Heng - 2007 - Bioessays 29 (8):783-794.
    A major challenge for The Cancer Genome Atlas (TCGA) Project is solving the high level of genetic and epigenetic heterogeneity of cancer. For the majority of solid tumors, evolution patterns are stochastic and the end products are unpredictable, in contrast to the relatively predictable stepwise patterns classically described in many hematological cancers. Further, it is genome aberrations, rather than gene mutations, that are the dominant factor in generating abnormal levels of system heterogeneity in cancers. These features of cancer could significantly (...)
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  • For the biotechnology industry, the penny drops (at last): genes are not autonomous agents but function within networks!Adam S. Wilkins - 2007 - Bioessays 29 (12):1179-1181.
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