This article addresses the serotonin hypothesis of depression, as it was formulated in clinical and laboratory experiments during the 1950s. In the first instance I argue that the `challenge' posed by patients' subjectivities in clinical investigations into the potentially anti-depressant drug iproniazid was not solely due to the tensions generated by the subject/object dichotomy, but to an excess that exceeds the properties of the objects of the experiment, as well as its requirements and conditions. I then suggest that the serotonin (...) hypothesis too is possessed of an excess, and that this can be understood in terms of a real (actual and virtual) existence in duration. By exploiting the notions of the event and of duration, I offer an under-standing of the hypothesis that pertains not to reduction, reproducibility and sameness, but to differentiation, innovation and creation. (shrink)

In 1964, the British psychologist Hans Jürgen Eysenck published Crime and Personality, the book that set forth his theory of the criminal as a psychopathic poor conditioner. Crime and Personality went through three editions, and even those who vehemently rejected the theory acknowledged it as the most highly articulated and influential biological explanation of crime of its time. Yet today Eysenck’s name is fading from criminological memory - and none too soon, in the opinion of critics who continue to anathematize (...) him as a self-serving showman, charlatan, and dangerous right-wing conservative. This article addresses four questions. Who was Eysenck? What did he say about the causes of crime? Why was he (and why does he continue to be) such a controversial figure? And did he contribute any ideas of lasting significance to criminology? The answers open a window onto the late 20th-century revival of biocriminology, a return to biological explanations that continues into the present and seems to be accelerating. They also reveal characteristics of criminology itself as a knowledge enterprise that has changed over time. (shrink)

Representations of the active brain have served to establish a particular domain of competence for brain mappers and to distinguish brain mapping’s particular contributions to mind/brain research. At the heart of the claims about the emerging contributions of functional brain mapping is a paradox: functional imagers seem to reject representations while also using them at multiple points in their work. This article therefore considers a love-hate relationship between scientists and their object: the case of the iconoclastic imager. This paradoxical stance (...) is the result of the formation of an interdisciplinary approach that brings together a number of scientific traditions and their particular standards of what constitutes scientific evidence. By examining the various ways in which images are deployed and rejected, the origins of these conflicting tendencies can be traced to the technological, methodological, and institutional elements in the work of functional imagers. This approach provides insight into the current demarcation of imaging and reflects on features of visual knowledge. (shrink)

This article argues that a new diagram is emerging in the criminal justice system as it encounters developments in the neurosciences. This does not take the form that concerns many ‘neuroethicists’ — it does not entail a challenge to doctrines of free will and the notion of the autonomous legal subject — but is developing around the themes of susceptibility, risk, pre-emption and precaution. I term this diagram ‘screen and intervene’ and in this article I attempt to trace out this (...) new configuration and consider some of the consequences. (shrink)