The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of (...) activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task. We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed. (shrink)

ics. Each of these can be pursued independently to a large extent, but perhaps most intriguing is to contem- plate how progress in each will affect the other. The past several months have seen heightened interest <blockquote> _<b>The Ethics of Neuroscience</b>_ </blockquote> in the intersection of ethics and neuroscience. In the The ethics of neuroscience can be roughly subdivided popular press, the topic grabbed headlines in a May.