Results for 'A. Natale Darren'

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  1. The Protein Ontology: A Structured Representation of Protein Forms and Complexes.Darren Natale, Cecilia N. Arighi, Winona C. Barker, Judith A. Blake, Carol J. Bult, Michael Caudy, Harold J. Drabkin, Peter D’Eustachio, Alexei V. Evsikov, Hongzhan Huang, Jules Nchoutmboube, Natalia V. Roberts, Barry Smith, Jian Zhang & Cathy H. Wu - 2011 - Nucleic Acids Research 39 (1):D539-D545.
    The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...)
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  2. Framework for a Protein Ontology.Darren A. Natale, Cecilia N. Arighi, Winona Barker, Judith Blake, Ti-Cheng Chang, Zhangzhi Hu, Hongfang Liu, Barry Smith & Cathy H. Wu - 2007 - BMC Bioinformatics 8 (Suppl 9):S1.
    Biomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...)
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  3. A Semantic Approach for Knowledge Capture of microRNA-Target Gene Interactions.Jingshan Huang, Fernando Gutierrez, Dejing Dou, Judith A. Blake, Karen Eilbeck, Darren A. Natale, Barry Smith, Yu Lin, Xiaowei Wang & Zixing Liu - 2015 - In IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2015),. pp. 975-982.
    Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...)
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  4. A Domain Ontology for the Non-Coding RNA Field.Jingshan Huang, Karen Eilbeck, Judith A. Blake, Dejing Dou, Darren A. Natale, Alan Ruttenberg, Barry Smith, Michael T. Zimmermann, Guoqian Jiang & Yu Lin - 2015 - In IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2015). pp. 621-624.
    Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.
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  5.  66
    Protein-Centric Connection of Biomedical Knowledge: Protein Ontology Research and Annotation Tools.Cecilia N. Arighi, Darren A. Natale, Judith A. Blake, Carol J. Bult, Michael Caudy, Alexander D. Diehl, Harold J. Drabkin, Peter D'Eustachio, Alexei Evsikov, Hongzhan Huang, Barry Smith & Others - 2011 - In Proceedings of the 2nd International Conference on Biomedical Ontology. Buffalo, NY: NCOR. pp. 285-287.
    The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.
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  6.  43
    Protein Ontology: Enhancing and Scaling Up the Representation of Protein Entities.Darren A. Natale, Cecilia N. Arighi, Judith A. Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R. Christie, Julie Cowart, Peter D'Eustachio, Alexander D. Diehl, Harold J. Drabkin, William D. Duncan, Hongzhan Huang, Jia Ren, Karen Ross & Alan Ruttenberg - 2017 - Nucleic Acids Research 45 (D1):D339-D346.
    The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...)
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  7. The Development of Non-Coding RNA Ontology.Jingshan Huang, Karen Eilbeck, Barry Smith, Judith Blake, Deijing Dou, Weili Huang, Darren Natale, Alan Ruttenberg, Jun Huan, Michael Zimmermann, Guoqian Jiang, Yu Lin, Bin Wu, Harrison Strachan, Nisansa de Silva & Mohan Vamsi Kasukurthi - 2016 - International Journal of Data Mining and Bioinformatics 15 (3):214--232.
    Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...)
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  8.  50
    The Representation of Protein Complexes in the Protein Ontology.Carol Bult, Harold Drabkin, Alexei Evsikov, Darren Natale, Cecilia Arighi, Natalia Roberts, Alan Ruttenberg, Peter D’Eustachio, Barry Smith, Judith Blake & Cathy Wu - 2011 - BMC Bioinformatics 12 (371):1-11.
    Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets. Although existing protin-centric informatics resources provide the biomedical research community with well-curated compendia of protein sequence and structure, these resources lack formal ontological representations of the relationships among the proteins themselves. The Protein Ontology (PRO) Consortium is filling this informatics resource gap by developing ontological representations and relationships among proteins and their variants and modified forms. Because (...)
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  9. TGF-Beta Signaling Proteins and the Protein Ontology.Arighi Cecilia, Liu Hongfang, Natale Darren, Barker Winona, Drabkin Harold, Blake Judith, Barry Smith & Wu Cathy - 2009 - BMC Bioinformatics 10 (Suppl 5):S3.
    The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework (...)
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  10. Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework.Cecilia Arighi, Veronica Shamovsky, Anna Maria Masci, Alan Ruttenberg, Barry Smith, Darren Natale, Cathy Wu & Peter D’Eustachio - 2015 - PLoS ONE 10 (4):e0122978.
    The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set (...)
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  11. Protein Ontology: A Controlled Structured Network of Protein Entities.A. Natale Darren, N. Arighi Cecilia, A. Blake Judith, J. Bult Carol, R. Christie Karen, Cowart Julie, D’Eustachio Peter, D. Diehl Alexander, J. Drabkin Harold, Helfer Olivia, Barry Smith & Others - 2013 - Nucleic Acids Research 42 (1):D415-21..
    The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...)
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  12.  55
    The Non-Coding RNA Ontology : A Comprehensive Resource for the Unification of Non-Coding RNA Biology.Huang Jingshan, Eilbeck Karen, Barry Smith, A. Blake Judith, Dou Dejing, Huang Weili, A. Natale Darren, Ruttenberg Alan, Huan Jun & T. Zimmermann Michael - 2016 - Journal of Biomedical Semantics 7 (1).
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...)
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  13.  56
    OmniSearch: A Semantic Search System Based on the Ontology for MIcroRNA Target for microRNA-Target Gene Interaction Data.Huang Jingshan, Gutierrez Fernando, J. Strachan Harrison, Dou Dejing, Huang Weili, A. Blake Judith, Barry Smith, Eilbeck Karen, A. Natale Darren & Lin Yu - 2016 - Journal of Biomedical Semantics 7 (1):1.
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...)
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  14. Justified Concepts and the Limits of the Conceptual Approach to the A Priori.Darren Bradley - 2011 - Croatian Journal of Philosophy 11 (3):267-274.
    Carrie Jenkins (2005, 2008) has developed a theory of the a priori that she claims solves the problem of how justification regarding our concepts can give us justification regarding the world. She claims that concepts themselves can be justified, and that beliefs formed by examining such concepts can be justified a priori. I object that we can have a priori justified beliefs with unjustified concepts if those beliefs have no existential import. I then argue that only beliefs without existential import (...)
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  15. A Priori Causal Laws.Darren Bradley - 2017 - Inquiry: An Interdisciplinary Journal of Philosophy 60 (4):358-370.
    Sober and Elgin defend the claim that there are a priori causal laws in biology. Lange and Rosenberg take issue with this on Humean grounds, among others. I will argue that Sober and Elgin don’t go far enough – there are a priori causal laws in many sciences. Furthermore, I will argue that this thesis is compatible with a Humean metaphysics and an empiricist epistemology.
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  16. Naturalness as a Constraint on Priors.Darren Bradley - 2019 - Mind 129 (513):179-203.
    Many epistemological problems can be solved by the objective Bayesian view that there are rationality constraints on priors, that is, inductive probabilities. But attempts to work out these constraints have run into such serious problems that many have rejected objective Bayesianism altogether. I argue that the epistemologist should borrow the metaphysician’s concept of naturalness and assign higher priors to more natural hypotheses.
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  17. Confirmation in a Branching World: The Everett Interpretation and Sleeping Beauty.Darren Bradley - 2011 - British Journal for the Philosophy of Science 62 (2):323-342.
    Sometimes we learn what the world is like, and sometimes we learn where in the world we are. Are there any interesting differences between the two kinds of cases? The main aim of this article is to argue that learning where we are in the world brings into view the same kind of observation selection effects that operate when sampling from a population. I will first explain what observation selection effects are ( Section 1 ) and how they are relevant (...)
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  18. Sleeping Beauty: A Note on Dorr's Argument for 1/3.Darren Bradley - 2003 - Analysis 63 (3):266–268.
    Cian Dorr (2002) gives an argument for the 1/3 position in Sleeping Beauty. I argue this is based on a mistake about Sleeping Beauty's epistemic position.
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  19. A Relevant Alternatives Solution to the Bootstrapping and Self-Knowledge Problems.Darren Bradley - 2014 - Journal of Philosophy 111 (7):379-393.
    The main argument given for relevant alternatives theories of knowledge has been that they answer scepticism about the external world. I will argue that relevant alternatives also solve two other problems that have been much discussed in recent years, a) the bootstrapping problem and b) the apparent conflict between semantic externalism and armchair self-knowledge. Furthermore, I will argue that scepticism and Mooreanism can be embedded within the relevant alternatives framework.
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  20. Being in a Position to Know and Closure.Jan Heylen - 2016 - Thought: A Journal of Philosophy 5 (1):63-67.
    The focus of this article is the question whether the notion of being in a position to know is closed under modus ponens. The question is answered negatively.
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  21.  59
    Filozofowanie a prawda o człowieku / Philosophizing and the True Knowledge of Human Being, 2014.Marek A. Pepliński - 2014 - Filo-Sofija 26 (3):85-98.
    Philosophizing and the True Knowledge of Human Being -/- The article presents the principles and method of classical philosophy. This kind of philosophy, developed mainly in ancient and medieval times, is still viable and interesting today. What is more important, it can be used as grounds for academic philosophy. Doing so provides a philosopher with resources for autonomy in her philosophical inquiry as well as the usefulness and application of its results for various cultural, social, and political tasks. The last (...)
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  22. Law Is the Command of the Sovereign: H. L. A. Hart Reconsidered.Andrew Stumpff Morrison - 2016 - Ratio Juris 29 (3):364-384.
    This article presents a critical reevaluation of the thesis—closely associated with H. L. A. Hart, and central to the views of most recent legal philosophers—that the idea of state coercion is not logically essential to the definition of law. The author argues that even laws governing contracts must ultimately be understood as “commands of the sovereign, backed by force.” This follows in part from recognition that the “sovereign,” defined rigorously, at the highest level of abstraction, is that person or entity (...)
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  23. A Passage Theory of Time.Martin A. Lipman - 2018 - In Karen Bennett & Dean Zimmerman (eds.), Oxford Studies in Metaphysics: Volume 11. Oxford University Press. pp. 95-122.
    This paper proposes a view of time that takes passage to be the most basic temporal notion, instead of the usual A-theoretic and B-theoretic notions, and explores how we should think of a world that exhibits such a genuine temporal passage. It will be argued that an objective passage of time can only be made sense of from an atemporal point of view and only when it is able to constitute a genuine change of objects across time. This requires that (...)
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  24. A Priori Conjectural Knowledge in Physics: The Comprehensibility of the Universe.Nicholas Maxwell - 2005 - In Michael Veber & Michael Shaffer (eds.), What Place for the A Priori? Chicago: Open Court. pp. 211-240.
    In this paper I argue for a priori conjectural scientific knowledge about the world. Physics persistently only accepts unified theories, even though endlessly many empirically more successful disunified rivals are always available. This persistent preference for unified theories, against empirical considerations, means that physics makes a substantial, persistent metaphysical assumption, to the effect that the universe has a (more or less) unified dynamic structure. In order to clarify what this assumption amounts to, I solve the problem of what it means (...)
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  25. A Manifesto for a Processual Philosophy of Biology.John A. Dupre & Daniel J. Nicholson - 2018 - In Daniel J. Nicholson & John A. Dupre (eds.), Everything Flows: Towards a Processual Philosophy of Biology.
    This chapter argues that scientific and philosophical progress in our understanding of the living world requires that we abandon a metaphysics of things in favour of one centred on processes. We identify three main empirical motivations for adopting a process ontology in biology: metabolic turnover, life cycles, and ecological interdependence. We show how taking a processual stance in the philosophy of biology enables us to ground existing critiques of essentialism, reductionism, and mechanicism, all of which have traditionally been associated with (...)
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  26. Aristóteles frente a Platón en torno a la separación y eternidad de la Forma.Silvana Di Camillo - 2018 - Páginas de Filosofía (Universidad Nacional del Comahue) 18 (21):140-163.
    Aristóteles comparte con Platón la concepción de la forma como causa del ser y del conocimiento de las cosas. Sin embargo, un análisis de sus críticas a las Ideas muestra que encuentra en la separación de las Ideas y las cosas sensibles la aporía fundamental de la teoría platónica. Con el propósito de circunscribir el significado de “separación” aplicable a las Ideas, concentraremos nuestro estudio en dos objeciones: 1) el argumento que conduce al tercer hombre y 2) la inutilidad de (...)
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  27. Descartes: A Biography; Cogito, Ergo Sum: The Life of René Descartes. [REVIEW]Gary Hatfield - 2008 - Isis 99 (1):177-178.
    Review of Desmond M. Clarke. Descartes: A Biography. xi + 507 pp., apps., figs., bibl., index. Cambridge: Cambridge University Press, 2006. $40 (cloth).; Richard Watson, Cogito, Ergo Sum: The Life of René Descartes. viii + 375 pp., figs., bibl., index. Boston: David R. Godine, 2002. $35 (cloth).
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  28. Keep Things in Perspective: Reasons, Rationality, and the A Priori.Daniel Whiting - 2014 - Journal of Ethics and Social Philosophy 8 (1):1-22.
    Objective reasons are given by the facts. Subjective reasons are given by one’s perspective on the facts. Subjective reasons, not objective reasons, determine what it is rational to do. In this paper, I argue against a prominent account of subjective reasons. The problem with that account, I suggest, is that it makes what one has subjective reason to do, and hence what it is rational to do, turn on matters outside or independent of one’s perspective. After explaining and establishing this (...)
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  29.  89
    On the Benefits of Philosophy as a Way of Life in a General Introductory Course.Jake Wright - forthcoming - Metaphilosophy.
    Philosophy as a way of life (PWOL) places investigations of value, meaning, and the good life at the center of philosophical investigation, especially of one’s own life. I argue PWOL is compatible with general introductory philosophy courses, further arguing that PWOL-based general introductions have several philosophical and pedagogical benefits. These include the ease with which high impact practices, situated skill development, and students’ ability to ‘think like a disciplinarian’ may be incorporated into such courses, relative to more traditional introductory courses, (...)
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  30. Sofia A. Yanovskaya: The Marxist Pioneer of Mathematical Logic in the Soviet Union.Dimitris Kilakos - 2019 - Transversal: International Journal for the Historiography of Science 6:49-64.
    K. Marx’s 200th jubilee coincides with the celebration of the 85 years from the first publication of his “Mathematical Manuscripts” in 1933. Its editor, Sofia Alexandrovna Yanovskaya (1896–1966), was a renowned Soviet mathematician, whose significant studies on the foundations of mathematics and mathematical logic, as well as on the history and philosophy of mathematics are unduly neglected nowadays. Yanovskaya, as a militant Marxist, was actively engaged in the ideological confrontation with idealism and its influence on modern mathematics and their interpretation. (...)
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  31. The Idea of A Priori Thinking Revisited.Sanjit Chakraborty - 2017 - Philosophia: E-Journal for Philosophy and Culture 17.
    In this article I would like to discuss the concept of a priori mainly focusing on Kant’s Copernican revolution. How is metaphysics at all possible and how a priority takes place in Kantian metaphysics are the questions that I have addressed in the first part of my article. In this context, I have explained analytic, synthetic distinction from epistemological, metaphysical and semantical perspectives and I want to show how the concept of a priori and other associated notions are derived from (...)
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  32.  35
    Can Time Flow at Different Rates? The Differential Passage of A-Ness.Kristie Miller & James Norton - forthcoming - Philosophical Studies:1-26.
    According to the No Alternate Possibilities (NAP) argument, (1) if time passes then the rate at which it passes could be different but (2) time cannot pass at different rates, and hence (3) time cannot pass. Typically, defenders of the NAP argument have focussed on defending premise (1), and have taken the truth of (2) for granted: they accept the orthodox view of rate necessitarianism. In this paper we argue that the defender of the NAP argument needs to turn her (...)
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  33. Serious Theories and Skeptical Theories: Why You Are Probably Not a Brain in a Vat.Michael Huemer - 2016 - Philosophical Studies 173 (4):1031-1052.
    Skeptical hypotheses such as the brain-in-a-vat hypothesis provide extremely poor explanations for our sensory experiences. Because these scenarios accommodate virtually any possible set of evidence, the probability of any given set of evidence on the skeptical scenario is near zero; hence, on Bayesian grounds, the scenario is not well supported by the evidence. By contrast, serious theories make reasonably specific predictions about the evidence and are then well supported when these predictions are satisfied.
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  34. Does Kant Demand Explanations for All Synthetic A Priori Claims?Colin Marshall - 2014 - Journal of the History of Philosophy 52 (3):549-576.
    Kant's philosophy promises to explain various synthetic a priori claims. Yet, as several of his commentators have noted, it is hard to see how these explanations could work unless they themselves rested on unexplained synthetic a priori claims. Since Kant appears to demand explanations for all synthetic a priori claims, it would seem that his project fails on its own terms. I argue, however, that Kant holds that explanations are required only for synthetic a priori claims about (purportedly) experience-independent entities, (...)
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  35. Defending the Traditional Interpretations of Kant’s Formula of a Law of Nature.Samuel J. M. Kahn - 2019 - Theoria 66 (158):76-102.
    In this paper I defend the traditional interpretations of Kant’s Formula of a Law of Nature from recent attacks leveled by Faviola Rivera-Castro, James Furner, Ido Geiger, Pauline Kleingeld and Sven Nyholm. After a short introduction, the paper is divided into four main sections. In the first, I set out the basics of the three traditional interpretations, the Logical Contradiction Interpretation, the Practical Contradiction Interpretation and the Teleological Contradiction Interpretation. In the second, I examine the work of Geiger, Kleingeld and (...)
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  36. Metaphysics and Contemporary Science: Why the Question of the Synthetic a Priori Shouldn’T Not Be Abandoned Prematurely.Kay Herrmann - manuscript
    The problem of synthetic judgements touches on the question of whether philosophy can draw independent statements about reality in the first place. For Kant, the synthetic judgements a priori formulate the conditions of the possibility for objectively valid knowledge. Despite the principle fallibility of its statements, modern science aims for objective knowledge. This gives the topic of synthetic a priori unbroken currency. This paper aims to show that a modernized version of transcendental philosophy, if it is to be feasible at (...)
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  37. Personal Values as A Catalyst for Corporate Social Entrepreneurship.Christine A. Hemingway - 2005 - Journal of Business Ethics 60 (3):233-249.
    The literature acknowledges a distinction between immoral, amoral and moral management. This paper makes a case for the employee (at any level) as a moral agent, even though the paper begins by highlighting a body of evidence which suggests that individual moral agency is sacrificed at work and is compromised in deference to other pressures. This leads to a discussion about the notion of discretion and an examination of a separate, contrary body of literature which indicates that some individuals in (...)
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  38. Model Robustness as a Confirmatory Virtue: The Case of Climate Science.Elisabeth A. Lloyd - 2015 - Studies in History and Philosophy of Science Part A 49:58-68.
    I propose a distinct type of robustness, which I suggest can support a confirmatory role in scientific reasoning, contrary to the usual philosophical claims. In model robustness, repeated production of the empirically successful model prediction or retrodiction against a background of independentlysupported and varying model constructions, within a group of models containing a shared causal factor, may suggest how confident we can be in the causal factor and predictions/retrodictions, especially once supported by a variety of evidence framework. I present climate (...)
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  39. There’s Nothing Quasi About Quasi-Realism: Moral Realism as a Moral Doctrine.Matthew H. Kramer - 2017 - The Journal of Ethics 21 (2):185-212.
    This paper seeks to clarify and defend the proposition that moral realism is best elaborated as a moral doctrine. I begin by upholding Ronald Dworkin’s anti-Archimedean critique of the error theory against some strictures by Michael Smith, and I then briefly suggest how a proponent of moral realism as a moral doctrine would respond to Smith’s defense of the Archimedeanism of expressivism. Thereafter, this paper moves to its chief endeavor. By differentiating clearly between expressivism and quasi-realism, the paper highlights both (...)
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  40. A Generalized Selected Effects Theory of Function.Justin Garson - 2017 - Philosophy of Science 84 (3):523-543.
    I present and defend the generalized selected effects theory (GSE) of function. According to GSE, the function of a trait consists in the activity that contributed to its bearer’s differential reproduction, or differential retention, within a population. Unlike the traditional selected effects (SE) theory, it does not require that the functional trait helped its bearer reproduce; differential retention is enough. Although the core theory has been presented previously, I go significantly beyond those presentations by providing a new argument for GSE (...)
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  41. What Anti-Individualists Cannot Know a Priori.Susana Nuccetelli - 1999 - Analysis 59 (1):48-51.
    Note first that knowledge of one's own thought-contents would not count as a priori according to the usual criteria for knowledge of this kind. Surely, then, incompatibilists are using this term to refer to some other, stipulatively defined, epistemic property. But could this be, as suggested by McKinsey { 1 99 1: 9), the property of being knowable 'just by thinking' or 'from the armchair'? Certainly not if these were metaphors for knowledge attainable on the basis of reason alone, since (...)
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  42. Two Kinds of a Priori Infallibility.Glen Hoffmann - 2011 - Synthese 181 (2):241-253.
    On rationalist infallibilism, a wide range of both (i) analytic and (ii) synthetic a priori propositions can be infallibly justified (or absolutely warranted), i.e., justified to a degree that entails their truth and precludes their falsity. Though rationalist infallibilism is indisputably running its course, adherence to at least one of the two species of infallible a priori justification refuses to disappear from mainstream epistemology. Among others, Putnam (1978) still professes the a priori infallibility of some category (i) propositions, while Burge (...)
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  43. Gadamer on the Event of Art, the Other, and a Gesture Toward a Gadamerian Approach to Free Jazz".Cynthia R. Nielsen - 2016 - Journal of Applied Hermeneutics (1).
    Several prominent contemporary philosophers, including Jürgen Habermas, John Caputo, and Robert Bernasconi, have at times painted a somewhat negative picture of Gadamer as not only an uncritical traditionalist, but also as one whose philosophical project fails to appreciate difference. Against such claims, I argue that Gadamer’s reflections on art exhibit a genuine appreciation for alterity not unrelated to his hermeneutical approach to the other. Thus, by bringing Gadamer’s reflections on our experience of art into conversation with key aspects of his (...)
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  44. Naturalism, Fallibilism, and the a Priori.Lisa Warenski - 2009 - Philosophical Studies 142 (3):403-426.
    This paper argues that a priori justification is, in principle, compatible with naturalism—if the a priori is understood in a way that is free of the inessential properties that, historically, have been associated with the concept. I argue that empirical indefeasibility is essential to the primary notion of the a priori ; however, the indefeasibility requirement should be interpreted in such a way that we can be fallibilist about apriori-justified claims. This fallibilist notion of the a priori accords with the (...)
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  45. On A- and B-Theoretic Elements of Branching Spacetimes.Matt Farr - 2012 - Synthese 188 (1):85-116.
    This paper assesses branching spacetime theories in light of metaphysical considerations concerning time. I present the A, B, and C series in terms of the temporal structure they impose on sets of events, and raise problems for two elements of extant branching spacetime theories—McCall’s ‘branch attrition’, and the ‘no backward branching’ feature of Belnap’s ‘branching space-time’—in terms of their respective A- and B-theoretic nature. I argue that McCall’s presentation of branch attrition can only be coherently formulated on a model with (...)
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  46. A Priori (Atheism).Felipe Leon - 2019 - In Joseph W. Koterski & Graham Oppy (eds.), Theism and Atheism: Opposing Arguments in Philosophy. MacMillan Reference.
    The primary aim of this chapter is to evaluate whether considerations about a priori domains and abstract objects favor atheism over theism.
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  47. What Is a Perfect Syllogism in Aristotelian Syllogistic?Theodor Ebert - 2015 - Ancient Philosophy 35 (2):351-374.
    The question as to what makes a perfect Aristotelian syllogism a perfect one has long been discussed by Aristotelian scholars. G. Patzig was the first to point the way to a correct answer: it is the evidence of the logical necessity that is the special feature of perfect syllogisms. Patzig moreover claimed that the evidence of a perfect syllogism can be seen for Barbara in the transitivity of the a-relation. However, this explanation would give Barbara a different status over the (...)
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  48. A Priori and A Posteriori: A Bootstrapping Relationship.Tuomas E. Tahko - 2011 - Metaphysica 12 (2):151-164.
    The distinction between a priori and a posteriori knowledge has been the subject of an enormous amount of discussion, but the literature is biased against recognizing the intimate relationship between these forms of knowledge. For instance, it seems to be almost impossible to find a sample of pure a priori or a posteriori knowledge. In this paper, it will be suggested that distinguishing between a priori and a posteriori is more problematic than is often suggested, and that a priori and (...)
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  49. Actuality and the a Priori.Fabio Lampert - 2018 - Philosophical Studies 175 (3):809-830.
    We consider a natural-language sentence that cannot be formally represented in a first-order language for epistemic two-dimensional semantics. We also prove this claim in the “Appendix” section. It turns out, however, that the most natural ways to repair the expressive inadequacy of the first-order language render moot the original philosophical motivation of formalizing a priori knowability as necessity along the diagonal.
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  50. The Possibility of a Fair Play Account of Legitimacy.Justin Tosi - 2017 - Ratio 30 (1):88-99.
    The philosophical literature on state legitimacy has recently seen a significant conceptual revision. Several philosophers have argued that the state's right to rule is better characterized not as a claim right to obedience, but as a power right. There have been few attempts to show that traditional justifications for the claim right might also be used to justify a power right, and there have been no such attempts involving the principle of fair play, which is widely regarded as the most (...)
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