The presented study introduces a new theoretical model of collapse for social, cultural, or political systems. Based on the current form of quantum anthropology conceptualized by Heidi Ann Russell, further development of this field is provided. The new theoretical model is called the spiral model of collapses, and is suggested to provide an analytical framework for collapses in social, cultural, and political systems. The main conclusions of this study are: 1) The individual crises in the period before a collapse of (...) social, cultural, and political systems form the trajectory of a conical helix similar to a vortex. 2) The occurrences of crises in the period before a collapse have the shape of the trajectory on the surface of the circular cone with a convex wall narrowing up to its peak. The shape of this cone is based on the Fibonacci sequence coiled into the three-dimensional space. 3) The constant circular movement along the trajectory of crises can occur in exceptional situations in the development of social, cultural, and political systems; however, such a state is always temporary. In such cases, the trajectory of the crisis does not follow the Fibonacci sequence, but the shape of a regular helix. Remaining on the trajectory of a regular helix in the long-term is highly improbable for social, cultural, and political systems. 4) The creation of new potentialities after the final collapse of a system is explained by the conception of topological inversion, when the heretofore embodied part of the energy-information field returns to the global, wave-particle energy-information potential. 5) The global, wave-particle energy-information potential is a source of energy-information for future embodiments in the sense of the future collapses of wave functions. (shrink)

ABSTRACT The apparent consistency of Sobel sequences famously motivated David Lewis to defend a variably strict conditional semantics for counterfactuals. If Sophie had gone to the parade, she would have seen Pedro. If Sophie had gone to the parade and had been stuck behind someone tall, she would not have seen Pedro. But if the order of the counterfactuals in a Sobel sequence is reversed—in the example, if is asserted prior to —the second counterfactual asserted no longer rings true. (...) This is the Heim sequence problem. That the order of assertion makes this difference is surprising on the variably strict account. Some argue that this is reason to reject the Lewis-Stalnaker semantics outright. Others argue that the problem motivates a contextualist rendering of counterfactuals. Still others maintain that the explanation for the phenomenon is merely pragmatic. I argue that none of these is right, and I defend a novel way to understand the phenomenon. My proposal avoids the problems faced by the alternative analyses and enjoys independent support. There is, however, a difficulty for my view: it entails that many ordinarily accepted counterfactuals are not true. I argue that this cost is acceptable. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

The model of self-referential truth presented in this paper, named Revision-theoretic supervaluation, aims to incorporate the philosophical insights of Gupta and Belnap’s Revision Theory of Truth into the formal framework of Kripkean fixed-point semantics. In Kripke-style theories the final set of grounded true sentences can be reached from below along a strictly increasing sequence of sets of grounded true sentences: in this sense, each stage of the construction can be viewed as an improvement on the previous ones. I want (...) to do something similar replacing the Kripkean sets of grounded true sentences with revision-theoretic sets of stable true sentences. This can be done by defining a monotone operator through a variant of van Fraassen’s supervaluation scheme which is simply based on ω-length iterations of the Tarskian operator. Clearly, all virtues of Kripke-style theories are preserved, and we can also prove that the resulting set of “grounded” true sentences shares some nice features with the sets of stable true sentences which are provided by the usual ways of formalising revision. What is expected is that a clearer philosophical content could be associated to this way of doing revision; hopefully, a content directly linked with the insights underlying finite revision processes. (shrink)

We investigate the properties of Yablo sentences and for- mulas in theories of truth. Questions concerning provability of Yablo sentences in various truth systems, their provable equivalence, and their equivalence to the statements of their own untruth are discussed and answered.

A biologically unavoidable sequence is an infinite gender sequence which occurs in every gendered, infinite genealogical network satisfying certain tame conditions. We show that every eventually periodic sequence is biologically unavoidable (this generalizes König's Lemma), and we exhibit some biologically avoidable sequences. Finally we give an application of unavoidable sequences to cellular automata.

Horror film sequels have not received as much serious critical attention as they deserve – this is especially true of the Saw franchise, which has suffered a general dismissal under the derogatory banner ‘Torture Porn’. In this article I use detailed textual analysis of the Saw series to expound how film sequels employ and complicate expected temporal and spatial relations – in particular, I investigate how the Saw sequels tie space and time into their narrative, methodological and moral sensibilities. Far (...) from being a gimmick or a means of ensuring loyalty to the franchise (one has to be familiar with the events of previous episodes to ascertain what is happening), it is my contention that the Saw cycle directly requests that we examine the nature of space and time, in terms of both cinematic technique and our lived, off-screen temporal/spatial orientations. -/- . (shrink)

This paper investigates and develops generalizations of two-dimensional modal logics to any finite dimension. These logics are natural extensions of multidimensional systems known from the literature on logics for a priori knowledge. We prove a completeness theorem for propositional n-dimensional modal logics and show them to be decidable by means of a systematic tableau construction.

The distinction between doing and allowing appears to have moral significance, but the very nature of the distinction is as yet unclear. Philippa Foot's ‘pre-existing threats’ account of the doing/allowing distinction is highly influential. According to the best version of Foot's account an agent brings about an outcome if and only if his behaviour is part of the sequence leading to that outcome. When understood in this way, Foot's account escapes objections by Warren Quinn and Jonathan Bennett. However, more (...) analysis is required to show what makes a relevant condition part of a sequence. Foot's account is promising, but incomplete. (shrink)

According to the attentional resources account, mind wandering (or “task-unrelated thought”) is thought to compete with a focal task for attentional resources. Here, we tested two key predictions of this account: First, that mind wandering should not interfere with performance on a task that does not require attentional resources; second, that as task requirements become automatized, performance should improve and depth of mind wandering should increase. Here, we used a serial reaction time task with implicit- and explicit-learning groups to test (...) these predictions. Providing novel evidence for the attentional resource account’s first prediction, results indicated that depth of mind wandering was negatively associated with learning in the explicit, but not the implicit, group, indicating that mind wandering is associated with impaired explicit, but not implicit, learning. Corroborating the attention resource account’s second prediction, we also found that, overall, performance improved while at the same time depth of mind wandering increased. From an implicit learning perspective, these results are consistent with the claim that explicit learning is impaired under attentional load, but implicit learning is not. (shrink)

The rationale of this study was to examine the interactive effect of gender, test anxiety, and test items sequencing on the academic performance in mathematics among SS3 students in Calabar Education Zone, Cross River State. Two formulated null hypotheses directed the study. The study adopted the quasi-experimental design. Simple random sampling technique was used in drawing a sample of 474 students from a population of 8,549 SS3 students. A Mathematics Achievement Test (MAT) and a Test Anxiety Scale (TAS) were used (...) primarily as the instruments for data collection. The reliability coefficient obtained for both instruments were .88 and .82 respectively. The data collected were analyzed using descriptive statistics such as mean and standard deviation, while the null hypotheses were tested respectively, using Pearson product-moment Correlation, and Analysis of Covariance where applicable. Findings indicated that test anxiety contributes negatively to academic performance in Mathematics; there is a significant interaction effect between item sequencing and gender on academic performance; between item sequencing and test anxiety on academic performance; and between gender and test anxiety on academic performance in Mathematics respectively; The findings also showed that Based on these findings conclusion and recommendations were made. (shrink)

A set D subset of V(G) is a dominating set of a graph G if for all x ϵ V(G)\D, for some y ϵ D such that xy ϵ E(G). A dominating set D subset of V(G) is called a connected dominating set of a graph G if the subgraph <D> induced by D is connected. A connected domination number of G, denoted by γ_c(G), is the minimum cardinality of a connected dominating set D. The triple repetition sequence denoted (...) by {S_n:n ϵ Z+} is a sequence of positive integers which is repeated thrice, i.e., {S_n}={1,1,1,2,2,2,3,3,3, ...}. In this paper, we construct a combinatorial explicit formula for the triple repetition sequence of connected domination numbers of a triangular grid graph. (shrink)

Starting with the results of Li et al. in 1992 there is valuable interest in finding long range correlations in DNA sequences since it raises questions about the role of introns and intron-containing genes. In the present paper we studied two sequences that are the human T-cell receptor alpha/delta locus, Gen-Bank name HUMTCRADCV, a noncoding chromosomal fragment of M = 97630 bases (composed of less than 10% of coding regions), and the Escherichia Coli K12, Gen-Bank name ECO110K, a genomic fragment (...) with M = 111401 bases consisting of mostly coding regions and containing more that 80% of coding regions. We attributed the value (+1) to the purines and the value (-1) to the pirimidines and to such reconstructed random walk we applied the method of the Recurrence Quantification Analysis(RQA) that was introduced by Zbilut and Webber in 1994. By using dimension D=1 and Embedded Dimensions D=3 and D=5, we obtain some indicative results. Also by a simple eye examination of the reconstructed maps, the differences between coding and non coding regions are evident and impressive and consist in the presence in noncoding regions of long patches of the same colour that are absent in the coding sequence. At first sight this suggests a simple explanation to the concept of „long-range‟ correlation. On the quantitative plane, we used the %Rec., the %Det., the Ratio, the Entropy, the %Lam., and the Lmax that, as explained in detail in the text, represent the basic variables of RQA. The significant result that we have here is that both Lmax and Laminarity exhibit very large values in HUMTCRADCV and actually different in values respect to ECO110K where such variables assume more modest values. Therefore we suggest that there is the observed difference between HUMTCRADCV and ECO110K. The claimed higher long-range correlations of introns respect to exons from many authors may be explained here in reasonof such found higher values of Lmax and of Laminarity in HUMTCRADCV respect to ECO110K. (shrink)

This is a brief report of the first conference organized in Fribourg by the Réseau Romand de Narratologie. The title of the conference was Redefinitons of the Sequence in Postclassical Narratology.

This study explores the connections between time, travel, and creative acts such as painting and poetry, highlighting the similarities that unite these themes. It also focuses on the relationships between the East and the West in regards to these subjects, and posits that travel can be understood as an active form of meditation. The study argues that the meaning of wanderings can be found by learning to make them conscious, and that there has been a deep reflection on time, consciousness, (...) and mobility since ancient times. (shrink)

In this paper we describe a few interrelated issues for validating theories that posit levels of consciousness. First, validating levels of consciousness requires consensus about the ordering of conscious states, which cannot be easily achieved. This problem is particularly severe if we believe conscious states can be irreducibly smeared over time. Second, the relationship between conscious states is probably sometimes intransitive, which means levels of consciousness will not be amenable to a single continuous measure. Finally, even if a multidimensional approach (...) to levels of consciousness is adopted, we argue that there are further problems for its validation. (shrink)

This chapter presents a task-based lesson sequence based on Judith Butler's Gender Trouble. Gender Trouble is a great piece of philosophical literature. However, as philosophical literature is a genre rarely found in EFL teaching, this chapter first demonstrates in detail the merits of this genre for the teaching ofEnglish for Academic Purposes. After a brief analysis of the source text, which deconstructs the entire sex-gender link and presents both sex and gender as free-floating, this chapter presents task-based methodology and (...) how it is utilized in a lesson aimed at building gender awareness and acceptance. In the target task students are asked to take the role of an ethics teacher at an Irish high school, in which the discussion arose whether the school should introduce unisex toilets and changing rooms in order to not discriminate against transsexual students. Tue study of Butler's philosophy will provide students with both the knowledge and language to accomplish this task. Open follow-up discussions often lead to powerful ethical insights in the context of gender, homo- and transsexuality. (shrink)

Our focus in the article is to introduce a simple methodology of generating teaching-learning sequences using the semantic network techinque, followed by the emergent properties of such a network and their implications for the teaching-learning process (didactics) with marginal notes on epistemological implications. A collaborative portal for teachers, which publishes a network of prerequisites for teaching/learning any concept or an activity is introduced. The article ends with an appeal to the global community to contribute prerequisites of any subject to complete (...) the global roadmap for an altas being built on similar lines as Wikipedia. The portal is launched and waiting for community participation at http://www.gnowledge.org. (shrink)

The article is about a new online resource, a collaborative portal for teachers, which publishes a network of prerequisites for teaching/learning any concept or an activity. A simple and effective method of collaboratively constructing teaching-learning sequences is presented. The special emergent properties of the dependency network and their didactic and epistemic implications are pointed. The article ends with an appeal to the global teaching community to contribute prerequisites of any subject to complete the global roadmap for an altas being built (...) on similar lines as Wikipedia. The portal is launched and waiting for community participation at http://www.gnowledge.org. (shrink)

Two main cognitive theories predict that people find refuting evidence that falsifies their theorising difficult, if not impossible to consider, even though such reasoning may be pivotal to grounding their everyday thoughts in reality (i.e., Poletiek, 1996; Klayman & Ha, 1987). In the classic 2-4-6 number sequence task devised by psychologists to test such reasoning skills in a simulated environment – people fail the test more often than not. In the 2-4-6 task participants try to discover what rule the (...) number triple 2-4-6 conforms to. The rule is ‘ascending numbers’, but it is tricky to discover this rule. Participants tend to generate hypotheses with the properties of the 2-4-6 triple, for example, ‘even numbers ascending in twos’. They must search for evidence to test whether their hypothesis is the rule. But experimental evidence has shown that they tend to generate confirming triples that they expect to be consistent with their hypothesis rather than inconsistent falsifying triples. Counter to the two main hypothesis testing theories this paper demonstrates that falsification is possible in five 2-4-6 task experiments when participants consider an Imaginary Participant’s hypothesis. Experiment 1 and 2 show that competition with an opponent hypothesis tester facilitates falsification. Experiments 3 to 5 show that the consideration of an alternative hypothesis helps this falsification of hypotheses lead to rule discovery. The implications of the results for theories of hypothesis testing and reasoning are discussed. (shrink)

Sobel sequences have had a huge impact on the discussion of counterfactuals. They can be composed of conditionals and mere descriptions. What is especially puzzling about them is that they are often felicitously uttered when their reversal is not. Up to now, there is no unified explanation. I examine two strategies. We might begin with conditionals and proceed to descriptions. Or we might begin with descriptions and proceed to conditionals. I argue for the latter variant and outline a universal theory (...) of Sobel sequences in terms of presuppositional anaphora. One relevant result is that the phenomenon neither counts against nor in favour of the simplified standard account of counterfactuals à la Stalnaker-Lewis. (shrink)

Closure for justification is the claim that thinkers are justified in believing the logical consequences of their justified beliefs, at least when those consequences are competently deduced. Many have found this principle to be very plausible. Even more attractive is the special case of Closure known as Single-Premise Closure. In this paper, I present a challenge to Single-Premise Closure. The challenge is based on the phenomenon of rational self-doubt – it can be rational to be less than fully confident in (...) one's beliefs and patterns of reasoning. In rough outline, the argument is as follows: Consider a thinker who deduces a conclusion from a justified initial premise via an incredibly long sequence of small competent deductions. Surely, such a thinker should suspect that he has made a mistake somewhere. And surely, given this, he should not believe the conclusion of the deduction even though he has a justified belief in the initial premise. (shrink)

This monograph investigates the temporal interpretation of narrative discourse in two parts. The theme of the first part is narrative progression. It begins with a case study of the adverb ‘now’ and its interaction with the meaning of tense. The case study motivates an ontological distinction between events, states and times and proposes that ‘now’ seeks a prominent state that holds throughout the time described by the tense. Building on prior research, prominence is shown to be influenced by principles of (...) discourse coherence and two coherence principles, NARRATION and RESULT, are given a formally explicit characterization. The key innovation is a new method for testing the definitional adequacy of NARRATION and RESULT, namely by an abductive argument. This contribution opens a new way of thinking about how eventive and stative descriptions contribute to the perceived narrative progression in a discourse. -/- The theme of the second part of the monograph is the semantics and pragmatics of tense. A key innovation is that the present and past tenses are treated as scalar alternatives, a view that is motivated by adopting a particular hypothesis concerning stative predication. The proposed analysis accounts for tense in both matrix clauses and in complements of propositional attitudes, where the notorious double access reading arises. This reading is explored as part of a corpus study that provides a glimpse of how tense semantics interacts with Gricean principles and at-issueness. Several cross-linguistic predictions of the analysis are considered, including their consequences for the Sequence of Tense phenomenon and the Upper Limit Constraint. Finally, a hypothesis is provided about how tense meanings compose with temporal adverbs and verb phrases. Two influential analysis of viewpoint aspect are then compared in light of the hypothesis. (shrink)

In a recent paper, Cheng and Werning (2016) argue that the class of episodic memories constitutes a natural kind. Endorsing the homeostatic property cluster view of natural kinds, they suggest that episodic memories can be characterized by a cluster of properties unified by an underlying neural mechanism for coding sequences of events. Here, I argue that Cheng & Werning’s proposal faces some significant, and potentially insurmountable, difficulties. Two are described as most prominent. First, the proposal fails to satisfy an important (...) normative constraint on natural kind theorizing, not providing the requisite theoretical resources for arbitration between rival taxonomies of memory. Second, the proposal is in a direct tension with a foundational principle of the HPC view: the rejection of essentialism. This has far-reaching consequences, threatening to undermine the coherence of the proposal. (shrink)

In her recent book Causation and Free Will, Carolina Sartorio develops a distinctive version of an actual-sequence account of free will, according to which, when agents choose and act freely, their freedom is exclusively grounded in, and supervenes on, the actual causal history of such choices or actions. Against this proposal, I argue for an alternative- possibilities account, according to which agents’ freedom is partly grounded in their ability to choose or act otherwise. Actual-sequence accounts of freedom are (...) motivated by a reflection on so-called Frankfurt cases. Instead, other cases, such as two pairs of examples originally designed by van Inwagen, threaten actual-sequence accounts, including Sartorio’s. On the basis of her view of causation, Sartorio contends, however, that the two members of each pair have different causal histories, so that her view is not undermined by those cases after all. I discuss these test cases further and defend my alternative-possibilities account of freedom. (shrink)

The author has established a mathematical theory about the system of freedom in which components of freedom are ruled by the largest freedom principle, explaining how one invariant reality can be equated with the dynamical universe. Freedom as a whole is the reality, and components of freedom show variable phenomena and become a dynamic system. In freedom, component equality leads to sequence equality; therefore, various sequences coexist in the system. Because there are incompatible sequences for any sequence, the (...) interior of freedom cannot be a static sequence. In order for the system to be a whole, there must be some connecting sequences between any two sequences. Then, at every part of freedom, it is always possible to find a group of three independent sequences that, for most components, is located inside. For the sequence group, there is a sequence through which most components flow in and out. The most abundant three - sequence group and most abundant connecting sequence correspond to the space - time structure. Other incompatible sequences correspond to particles, and interactions between these sequences correspond to interactions between particles. The interactions have some symmetries similar to those in physics, such as SU (3) AND SU (2)×U (1), thus proving the feasibility of the hypothesis: the universe is equivalent with the system of freedom. (shrink)

This work demonstrates the implementation and use of an encoder-decoder model to perform a many-to-many mapping of video data to text captions. The many-to-many mapping occurs via an input temporal sequence of video frames to an output sequence of words to form a caption sentence. Data preprocessing, model construction, and model training are discussed. Caption correctness is evaluated using 2-gram BLEU scores across the different splits of the dataset. Specific examples of output captions were shown to demonstrate model (...) generality over the video temporal dimension. Predicted captions were shown to generalize over video action, even in instances where the video scene changed dramatically. Model architecture changes are discussed to improve sentence grammar and correctness. (shrink)

We characterize a type of functional explanation that addresses why a homologous trait originating deep in the evolutionary history of a group remains widespread and largely unchanged across the group’s lineages. We argue that biologists regularly provide this type of explanation when they attribute conserved functions to phenotypic and genetic traits. The concept of conserved function applies broadly to many biological domains, and we illustrate its importance using examples of molecular sequence alignments at the intersection of evolution and cell (...) biology. We use these examples to show how the study of conserved functions can integrate knowledge of a trait’s causal effects on fitness and its history of natural selection without invoking adaptation. We also show how conserved function provides a novel basis for addressing objections against evolutionary functions raised by Robert Cummins. (shrink)

This wide ranging discourse covers many disciplines of science and the human condition in an attempt to fully understand the manifestation of time. Time's Paradigm is, at its inception, a philosophical debate between the theories of 'Presentism' and 'The Block Model', beginning with a pronounced psychological analysis of 'free will' in an environment where the past and the future already exist. It lays the foundation for the argument that time is a cyclical, contained progression, rather than a meandering voyage into (...) infinity, bringing into question the validity of a commensurate 'Big Bang'. Following, the proposal widens to encompass physics. It tackles clock rates and time dilation, acausality and the nuisance of a universal clock, and demonstrates that conscious consideration creates the present moment - time's flow - separating the solid state past and future whose reality is devoid of space. Arguments relating to Quantum Physics theory, including the Uncertainty Principle and a Superposition of States, lend credibility to key areas involving cognitive awareness. It is posited that defined points in time and space prohibit progress in linear models for progression. Thus motile paradoxes can be resolved with the absence of infinities; temporal perception, it is concluded, being the result of uncertainty. Time's Paradigm takes the bold step of asking us to consider a tangible dimension of time, representing an intimate extension of our three, known spatial dimensions. Chaos theory is briefly introduced leading to the configuration of a fractal fourth dimension of time whose assumption demands only one direction of flow. Further, it asks whether our universe is expanding or contracting. It considers the simple physics of bodies contracting in a fourth dimension of time (UC), and how that marries comfortably with standard scientific models such as Special Relativity. The rate at which matter is contracting in the universe is illustrated in a reduction factor of 1.618... coinciding with Fibonacci's Ratio and countering Time Dilation. Lastly the more complex aspects of relativistic velocities are tackled together with the conundrum of Zero Velocity and The Speed of Light being attributes of the same event in Cyclical Space-Time, and ultimately, the prospect of superluminal velocities by interaction with parallel time-zones in a multi-layered block universe. (shrink)

This article discusses Harvey Siegel’s general justification of the epistemological theory of argumentation in his seminal essay “Arguing with Arguments." On the one hand, the achievements of this essay are honoured—in particular, a thorough differentiation of the different meanings of ‘argument’ and ‘argumentation,’ the semantic justification of the fundamentality of arguments as sequences of propositions, and the detailed critiques of alternative theories of argumentation. On the other hand, suggestions for strengthening the theory are added to Siegel's expositions, which make different (...) perspectives within the epistemological theory of argumentation recognisable. (shrink)

Early work on the frequency theory of probability made extensive use of the notion of randomness, conceived of as a property possessed by disorderly collections of outcomes. Growing out of this work, a rich mathematical literature on algorithmic randomness and Kolmogorov complexity developed through the twentieth century, but largely lost contact with the philosophical literature on physical probability. The present chapter begins with a clarification of the notions of randomness and probability, conceiving of the former as a property of a (...) sequence of outcomes, and the latter as a property of the process generating those outcomes. A discussion follows of the nature and limits of the relationship between the two notions, with largely negative verdicts on the prospects for any reduction of one to the other, although the existence of an apparently random sequence of outcomes is good evidence for the involvement of a genuinely chancy process. (shrink)

I explain in what sense the structure of space and time is probably vague or indefinite, a notion I define. This leads to the mathematical representation of location in space and time by a vague interval. From this, a principle of complementary inaccuracy between spatial location and velocity is derived, and its relation to the Uncertainty Principle discussed. In addition, even if the laws of nature are deterministic, the behaviour of systems will be random to some degree. These and other (...) considerations draw classical physics closer to Quantum Mechanics. An arrow of entropy is also derived, given an arrow of time. Lastly, chaos is given an additional, objective meaning. (shrink)

Hájek (Erkenntnis 70(2):211–235, 2009) argues that probabilities cannot be the limits of relative frequencies in counterfactual infinite sequences. I argue for a different understanding of these limits, drawing on Norton’s (Philos Sci 79(2):207–232, 2012) distinction between approximations (inexact descriptions of a target) and idealizations (separate models that bear analogies to the target). Then, I adapt Hájek’s arguments to this new context. These arguments provide excellent reasons not to use hypothetical frequencies as idealizations, but no reason not to use them as (...) approximations. (shrink)

William Rowe has argued that if there is an infinite sequence of improving worlds then an essentially perfectly good being must actualize some world in the sequence and must not actualize any world in the sequence. Since that is impossible, there exist no perfectly good beings. I show that Rowe's argument assumes that the concept of a maximally great being is incoherent. Since we are given no reason to believe that the concept of a maximally great being (...) is incoherent we have no reason to believe Rowe's Argument from Improvability is sound. (shrink)

Modern life sciences research is increasingly relying on artificial intelligence (AI) approaches to model biological systems, primarily centered around the use of machine learning (ML) models. Although ML is undeniably useful for identifying patterns in large, complex data sets, its widespread application in biological sciences represents a significant deviation from traditional methods of scientific inquiry. As such, the interplay between these models and scientific understanding in biology is a topic with important implications for the future of scientific research, yet it (...) is a subject that has received little attention. Here, we draw from an epistemological toolkit to contextualize recent applications of ML in biological sciences under modern philosophical theories of understanding, identifying general principles that can guide the design and application of ML systems to model biological phenomena and advance scientific knowledge. We propose that conceptions of scientific understanding as information compression, qualitative intelligibility, and dependency relation modelling provide a useful framework for interpreting ML-mediated understanding of biological systems. Through a detailed analysis of two key application areas of ML in modern biological research – protein structure prediction and single cell RNA-sequencing – we explore how these features have thus far enabled ML systems to advance scientific understanding of their target phenomena, how they may guide the development of future ML models, and the key obstacles that remain in preventing ML from achieving its potential as a tool for biological discovery. Consideration of the epistemological features of ML applications in biology will improve the prospects of these methods to solve important problems and advance scientific understanding of living systems. (shrink)

(The Kindle book can be ordered for $3.21 from Amazon) -/- Thinking is a fundamental activity of our species – those that give names to other creatures and call themselves humans. Textbooks tell us that there is about 1.2 kg of matter called the brain inside the human body. It sounds small but actually is proportionally the biggest among all animals on Earth. -/- I became more aware of thinking at around 5th grade upon hearing about an ancient paradox. It (...) can be summarized as follows. -/- ¤ -/- Once upon a time, there was a stupid king. In his kingdom lived a sage who was highly respected for his intelligence. The King did not appreciate this fact. Maybe the Sage made fun of the King’s intellect, but I am not so sure. Anyway, one day, the King summoned the Sage, intending to kill him. -/- The King said, “Wise man, I heard you earn a living by thinking and arguing. Now I give you two options to die.” -/- The Sage said, “Please tell me the choices, Your Majesty.” -/- The King continued, “You live by your tongue, so I will let you say one sentence before you die. If what you say is true, you will die by hanging. If what you say is false, you will die by beheading.” -/- Little did the King know that this was a stupid order. After a short while, the Sage confidently spoke his “last words”, which actually were what saved his life: -/- “Your Majesty, I am about to be beheaded!” -/- ¤ -/- As a “wild animal” going out into life from a young age, my brain spent a lot of time and energy looking for food. Now that I have become older, my body no longer needs so much sustenance. However, my mind craves a different type of nourishment: food for thought. -/- Food for thought can directly lead to food (on the table). My main job as a scientist exemplifies what I have just stated. Maybe we were wrong. Maybe it has been “thought for food” all along, like in such a sequence as TFFTTTFTFFTTFFFT... -/- In the hyper-chaotic infosphere today, we are surrounded by the noises of information, not only as wavy shores or waterfalls but also mega-tsunamis, through Twitter, Facebook, Tiktok, Instagram, Youtube, etc. More than ever, tranquility and calmness are necessary. Like what you have seen in wilderness video clips, predators such as lions, bears, and alligators act lightning-fast when catching prey. But when food is served, the natural world returns to its peaceful, soothing silence. -/- This short book is in its own tidy infosphere, where each little story is also brief and self-contained. Despite this small appearance, I hope the content inside carries the value of tranquility and life observation. The book is petite, but pretty sure not malnourished. A not-too-small detail is that the way the content was shaped and distilled reflects some innovations of mine and my research team: the mindsponge theory, a new theory of serendipity, the bayesvl R package, the BMF analytics, as well as other experiences from working in the field of science. After all, scientific works were my main source of food (before this book sells well – if it does). -/- Welcome to the priceless sober moments – with a chicken-burger price tag! -/- I hope this book will bring readers some moments of calmness, peaceful smiles, and maybe a couple of good laughs too. -/- ~~~ -/- *This update: December 12, 2023 (Third edition, with additions). (shrink)

Renaissance philosopher, mathematician, and theologian Nicholas of Cusa (1401-1464) said that there is no proportion between the finite mind and the infinite. He is fond of saying reason cannot fully comprehend the infinite. That our best hope for attaining a vision and understanding of infinite things is by mathematics and by the use of contemplating symbols, which help us grasp "the absolute infinite". By the late 19th century, there is a decisive intervention in mathematics and its philosophy: the philosophical mathematician (...) Georg Cantor (1845-1918) says that between the realm of the finite and the absolute infinite, there is an intermediate realm partaking in properties in a certain sense of both the finite and the infinite: the transfinite realm. Like the finite, the transfinite realm is a realm of mathematical objects, numbers, and knowledge. Like the absolute infinite, the transfinite is a form of infinity insofar as transfinite sets and numbers transcend any finite number. Echoing Cusanus and neo-Platonism, Cantor says that the transfinite sequence of all ordinals is a symbol of the absolutely infinite, that is, God. This paper considers how the doctrine of symbolism and the philosophers' different commitments to the laws of logic, especially the Law of Non-Contradiction (LNC), enables these thinkers to articulate a transcendental apophatic approach to divinity. (shrink)

Investigation into the sequence structure of the genetic code by means of an informatic approach is a real success story. The features of human language are also the object of investigation within the realm of formal language theories. They focus on the common rules of a universal grammar that lies behind all languages and determine generation of syntactic structures. This universal grammar is a depiction of material reality, i.e., the hidden logical order of things and its relations determined by (...) natural laws. Therefore mathematics is viewed not only as an appropriate tool to investigate human language and genetic code structures through computer sciencebased formal language theory but is itself a depiction of material reality. This confusion between language as a scientific tool to describe observations/experiences within cognitive constructed models and formal language as a direct depiction of material reality occurs not only in current approaches but was the central focus of the philosophy of science debate in the twentieth century, with rather unexpected results. This article recalls these results and their implications for more recent mathematical approaches that also attempt to explain the evolution of human language. (shrink)

The paper traces the sequence of events which brought Popperian philosophy (including Lakatos) to its position on the issues of excess content, novelty and scientific progress. The general approach is to analyze Popper's and Lakatos's positions on these issues as an appropriate response to a particular philosophical problem situation in which they found themselves. The paper closes with a discussion of how these issues relate to economics and economic methodology.

I attempt to respond to the many questions and objections raised by the commentaries. The responses are grouped by themes, rather than focusing on the essays in sequence. So there are sections on worries about my analytical history, concerns about my meta-ethical perspective, doubts about my normative stance and complaints about my perpetration of a ‘naturalistic fallacy’.

Vagueness does not necessarily come in with vague predicates, nor need it be expressed by them , but undoubtedly 'vague predicates' are traditionally in the focus of main stream discussions of vagueness. In her current modal logic presentation and discussion of the Sorites paradox Susanne Bobzien[1] lists among the properties of a Sorites series a rather weak modal tolerance principle governing the 'grey zone' containing the borderline cases of the Sorites series, which later proves crucial for her solution of the (...) Sorites paradox by use of epistemic interpreted modal operators in 1st order modal logic. We suggest (for different research interest) instead a non-modal description of the switch in the grey zone (respecting tolerance), by resort to similarity sequences, thus getting tangent to two other areas of research in the field. Let's say -any way- the Sorites paradox vanishes, the Sorites series does not. (shrink)

In this paper I focus on a recently discussed phenomenon illustrated by sentences containing predicates of taste: the phenomenon of " perspectival plurality " , whereby sentences containing two or more predicates of taste have readings according to which each predicate pertains to a different perspective. This phenomenon has been shown to be problematic for (at least certain versions of) relativism. My main aim is to further the discussion by showing that the phenomenon extends to other perspectival expressions than predicates (...) of taste and by proposing a general solution to the problem raised by it on behalf of the relativist. The core claim of the solution (" multiple indexing ") is that utterances of sentences containing perspectival expressions should be evaluated with respect to (possibly infinite) sequences of perspective parameters. (shrink)

Naive observers viewed a sequence of colored Mondrian patterns, simulated on a color monitor. Each pattern was presented twice in succession, first under one daylight illuminant with a correlated color temperature of either 16,000 or 4,000 K and then under the other, to test for color constancy. The observers compared the central square of the pattern across illuminants, either rating it for sameness of material appearance or sameness of hue and saturation or judging an objective property—that is, whether its (...) change of color originated from a change in material or only from a change in illumination. Average color constancy indices were high for material appearance ratings and binary judgments of origin and low for hue–saturation ratings. Individuals’ performance varied, but judgments of material and of hue and saturation remained demarcated. Observers seem able to separate phenomenal percepts from their ontological projections of mental appearance onto physical phenomena; thus, even when a chromatic change alters perceived hue and saturation, observers can reliably infer the cause, the constancy of the underlying surface spectral reflectance. (shrink)

Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the editing and (...) design metaphors suggest. Such metaphors are therefore highly problematic phrases in the context of new gene technologies, for two reasons. On one hand, to design a child of choice by modifying the genome would require modifying any gene of choice, which is more than can be done with current gene technologies, such as CRISPR/Cas. On the other hand, a modification of genes would need to be enough to create any characteristic of choice in the future child. The latter presupposes the assumption of genetic determinism. Moreover, the CRISPR/Cas technology can not only be used in a potentially therapeutic manner at the germline level. In addition, there is the (more likely) scenario of a future clinical therapeutic use of these new gene technologies for modifying the DNA sequence of other cells of the body (somatic genome editing). There is also the option of modifying the epigenome, that is, the spatial configuration of DNA (epigenome editing) (see table 1). Like genetics and genome editing, epigenetics has been at the center of recent popular scientific and ethical discourse as well as scientific debates. The concept of epigenetics has given rise to very different notions of inheritability and responsibility for health, which, however, are oftentimes based on scientifically controversial basic assumptions. That there continues to be covert genetic determinism in the form of epigenetic determinism (see table 2) in debates about epigenetics has been pointed out in ethical analyses of epigenetics. Neither genetic determinism nor epigenetic determinism has been confirmed scientifically. It is therefore important to recognize the concepts that are discussed (and sometimes harshly criticized) in debates about genome editing and epigenetics—for example, concepts about the causal role of DNA for our own life course. This importance is based on the fact that if we understand such controversial concepts, we will be able to remain critical when evaluating scientific knowledge and ethical arguments about genome editing and epigenetics. This chapter, therefore, explains some of these concepts. For an ethical analysis of epigenetics as well as of genome editing, it is necessary to understand and critically reflect upon the underlying concepts of genetic determinism and other, related -isms. The following section offers a detailed introduction to these -isms (section 2; see also table 2). Section 3 provides an ethical analysis of genome editing and epigenetics based on the explanations in section 2. Section 3 focuses on inheritability and responsibility, justice, safety, the problem of consent, and the effects of genome editing and epigenetics on embryos and future generations. This section does not discuss in detail further points that can be found in ethical debates about epigenetics as well as in ethical debates about genome editing. These points include (among others): • fear that the findings of epigenetics and that the methods of genome editing are misused—this also with respect to eugenics and enhancement; • naturalness—an issue we mention in passing a few times in the following analysis; • a possible connection between the genome/epigenome and the concept of human dignity, and the derived danger of instrumentalization and infringement of autonomy when intervening in the genome or epigenome. Since current discourse about ethical issues associated with genome editing focuses mainly on germline interventions, which are, for instance, interventions into a human embryo’s genome, we mainly focus on germline interventions when comparing the debates on genome editing and on epigenetics in section 3. (shrink)

Pietro Gori dedicates Nietzsche’s Pragmatism “To the wanderers and Good Europeans,” and Anglophone wanderers into Sarah de Sanctis’s translation will indeed find good European Nietzsche scholarship. The table of contents is a helpful map of the book, with five chapters consisting of twenty-eight sections on a sequence of philosophical and interpretive topics. Perspectival thought, addressed in the subtitle, is the explicit topic of the third chapter. Pragmatism, mentioned in the title, is the explicit topic of the fifth and final (...) chapter. While both topics also are discussed in many other places, the overall focus is on Nietzsche’s views of epistemology and truth.The first chapter discusses Nietzsche’s views of... (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users. (shrink)

Throughout this research, imposing the training of an Artificial Neural Network (ANN) to play tic-tac-toe bored game, by training the ANN to play the tic-tac-toe logic using the set of mathematical combination of the sequences that could be played by the system and using both the Gradient Descent Algorithm explicitly and the Elimination theory rules implicitly. And so on the system should be able to produce imunate amalgamations to solve every state within the game course to make better of results (...) of winnings or getting draw. (shrink)

The potential to collect brain data more directly, with higher resolution, and in greater amounts has heightened worries about mental and brain privacy. In order to manage the risks to individuals posed by these privacy challenges, some have suggested codifying new privacy rights, including a right to “mental privacy.” In this paper, we consider these arguments and conclude that while neurotechnologies do raise significant privacy concerns, such concerns are—at least for now—no different from those raised by other well-understood data collection (...) technologies, such as gene sequencing tools and online surveillance. To better understand the privacy stakes of brain data, we suggest the use of a conceptual framework from information ethics, Helen Nissenbaum’s “contextual integrity” theory. To illustrate the importance of context, we examine neurotechnologies and the information flows they produce in three familiar contexts—healthcare and medical research, criminal justice, and consumer marketing. We argue that by emphasizing what is distinct about brain privacy issues, rather than what they share with other data privacy concerns, risks weakening broader efforts to enact more robust privacy law and policy. (shrink)

In “Bayesianism, Infinite Decisions, and Binding”, Arntzenius et al. (Mind 113:251–283, 2004 ) present cases in which agents who cannot bind themselves are driven by standard decision theory to choose sequences of actions with disastrous consequences. They defend standard decision theory by arguing that if a decision rule leads agents to disaster only when they cannot bind themselves, this should not be taken to be a mark against the decision rule. I show that this claim has surprising implications for a (...) number of other debates in decision theory. I then assess the plausibility of this claim, and suggest that it should be rejected. (shrink)