Results for 'Gene-Drive'

961 found
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  1. Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologies.Jonathan Pugh - 2016 - Journal of Medical Ethics 42 (9):578-581.
    Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in ‘gene-drive’ technology have raised the prospect of eradicating certain species of mosquito via genetic modification. This technology has attracted a great deal of media attention, and the idea of using gene-drive technology to eradicate mosquitoes has been met with criticism in the public domain. In this paper, I shall dispel two moral (...)
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  2. When Extinction Is Warranted: Invasive Species, Suppression-Drives and the Worst-Case Scenario.Ann C. Thresher - 2022 - Ethics, Policy and Environment 25 (2):132-152.
    Most current techniques to deal with invasive species are ineffective or have highly damaging side effects. To this end suppression-drives based on clustered regularly inter-spaced short palindromic repeats (CRISPR/Cas9) have been touted as a potential silver bullet for the problem, allowing for a highly focused, humane and cost-effective means of removing a target species from an environment. Suppression-drives come with serious risks, however, such that the precautionary principle seems to warrant us not deploying this technology. The focus of this paper (...)
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  3. Genes, Affect, and Reason: Why Autonomous Robot Intelligence Will Be Nothing Like Human Intelligence.Henry Moss - 2016 - Techné: Research in Philosophy and Technology 20 (1):1-15.
    Abstract: Many believe that, in addition to cognitive capacities, autonomous robots need something similar to affect. As in humans, affect, including specific emotions, would filter robot experience based on a set of goals, values, and interests. This narrows behavioral options and avoids combinatorial explosion or regress problems that challenge purely cognitive assessments in a continuously changing experiential field. Adding human-like affect to robots is not straightforward, however. Affect in organisms is an aspect of evolved biological systems, from the taxes of (...)
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  4. Ecological Models for Gene Therapy. II. Niche Construction, Nongenetic Inheritance, and Ecosystem Perturbations.Arnaud Pocheville, Maël Montévil & Régis Ferrière - 2014 - Biological Theory 9 (4):414-422.
    In this paper, we apply the perspective of intra-organismal ecology by investigating a family of ecological models suitable to describe a gene therapy to a particular metabolic disorder, the adenosine deaminase deficiency (ADA-SCID). The gene therapy is modeled as the prospective ecological invasion of an organ (here, bone marrow) by genetically modified stem cells, which then operate niche construction in the cellular environment by releasing an enzyme they synthesize. We show that depending on the chosen order (a choice (...)
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  5. Genomic Stress Responses Drive Lymphocyte Evolvability: An Ancient and Ubiquitous Mechanism.Bartlomiej Swiatczak - 2020 - Bioessays 42 (10):2000032.
    Somatic diversification of antigen receptor genes depends on the activity of enzymes whose homologs participate in a mutagenic DNA repair in unicellular species. Indeed, by engaging error-prone polymerases, gap filling molecules and altered mismatch repair pathways, lymphocytes utilize conserved components of genomic stress response systems, which can already be found in bacteria and archaea. These ancient systems of mutagenesis and repair act to increase phenotypic diversity of microbial cell populations and operate to enhance their ability to produce fit variants during (...)
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  6. CRISPR as a Driving Force: The Model T of Biotechnology.Carlos Mariscal & Angel Petropanagos - 2016 - Monash Bioethics Review 34 (2):1-16.
    The CRISPR system for gene editing can break, repair, and replace targeted sections of DNA. Although CRISPR gene editing has important therapeutic potential, it raises several ethical concerns. Some bioethicists worry CRISPR is a prelude to a dystopian future, while others maintain it should not be feared because it is analogous to past biotechnologies. In the scientific literature, CRISPR is often discussed as a revolutionary technology. In this paper we unpack the framing of CRISPR as a revolutionary technology (...)
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  7. A Revolutionary New Metaphysics, Based on Consciousness, and a Call to All Philosophers.Lorna Green - manuscript
    June 2022 A Revolutionary New Metaphysics, Based on Consciousness, and a Call to All Philosophers We are in a unique moment of our history unlike any previous moment ever. Virtually all human economies are based on the destruction of the Earth, and we are now at a place in our history where we can foresee if we continue on as we are, our own extinction. As I write, the planet is in deep trouble, heat, fires, great storms, and record flooding, (...)
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  8. Review of Are We Hardwired by Clark and Grunstein (2000).Michael Starks - 2017 - Philosophy, Human Nature and the Collapse of Civilization Michael Starks 3rd Ed. (2017).
    This is an excellent review of gene/environment interactions on behavior and, in spite of being a bit dated, is an easy and worthwhile read. They start with twin studies which show the overwhelming impact of genetics on behavior. They note the increasingly well known studies of Judith Harris which extend and summarize the facts that shared home environment has almost no effect on behavior and that adopted children grow up to be as different from their stepbrothers and sisters as (...)
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  9. Ellebogenwerk en stress. De evolutie staat nooit stil.Pouwel Slurink - 2000 - Filosofie Magazine 9 (08):40-45.
    Evolution never stops. Stress is often a manifestation of competition which seems to drive human gene-culture coevolution. A popular, Dutch account on evolution in everyday life. People often claim that we are thoroughly cultural beings, but culture is based on a series of talents which are a product of directional and stabilizing selection. Culture also presupposes certain psychological characteristics. People adopt and change culture to fit their biopsychological needs.
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  10. Symmetry-breaking dynamics in development.Noah Moss Brender - 2017 - Phenomenology and the Cognitive Sciences 16 (4):585-596.
    Recognition of the plasticity of development — from gene expression to neuroplasticity — is increasingly undermining the traditional distinction between structure and function, or anatomy and behavior. At the same time, dynamic systems theory — a set of tools and concepts drawn from the physical sciences — has emerged as a way of describing what Maurice Merleau-Ponty calls the “dynamic anatomy” of the living organism. This article surveys and synthesizes dynamic systems models of development from biology, neuroscience, and psychology (...)
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  11. Precis of A Better Ape.Victor Kumar & Richmond Campbell - 2023 - Biology and Philosophy 38 (4):1-9.
    A Better Ape covers the evolution of morality from the birth of our ape family through the evolution of human species and all the way up to the development of modern societies. In this summary, we highlight several main elements of this account: the co-evolution of morality with intelligence and complex sociality; the role of social institutions and religious morality in the cultural evolution of behaviorally modern humans in prehistory; the increasing complexity of the moral mind through biological evolution in (...)
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  12. Brains Emerging: On Modularity and Self-organisation of Neural Development In Vivo and In Vitro.Paul Gottlob Layer - 2019 - In Lars H. Wegner & Ulrich Lüttge (eds.), Emergence and Modularity in Life Sciences. Springer Verlag. pp. 145-169.
    Molecular developmental biology has expanded our conceptions of gene actions, underpinning that embryonic development is not only governed by a set of specific genes, but as much by space–time conditions of its developing modules. Typically, formation of cellular spheres, their transformation into planar epithelia, followed by tube formations and laminations are modular steps leading to the development of nervous tissues. Thereby, actions of organising centres, morphogenetic movements, inductive events between epithelia, tissue polarity reversal, widening of epithelia, and all these (...)
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  13. The Interstellar Stakes Against God.Julian Friedland - 2015 - The Humanist 1:6-8.
    Pope Francis takes the Big Bang as supplying empirical evidence for God’s existence, going so far as to credit God’s will as the force behind natural selection. So if natural selection is the emanation of divine will, then so too is what Richard Dawkins calls the “selfish gene” underlying it. The trouble is that the natural forces of self-interest may win out over the better angels of our nature, spelling disaster for the human species—and the planet sustaining it. For (...)
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  14. Crucial steps to life: From chemical reactions to code using agents.Witzany Guenther - 2016 - Biosystems 140:49-57.
    The concepts of the origin of the genetic code and the definitions of life changed dramatically after the RNA world hypothesis. Main narratives in molecular biology and genetics such as the “central dogma,” “one gene one protein” and “non-coding DNA is junk” were falsified meanwhile. RNA moved from the transition intermediate molecule into centre stage. Additionally the abundance of empirical data concerning nonrandom genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not (...)
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  15. The logic of metabolism and its fuzzy consequences.A. Danchin - 2014 - Environmental Microbiology 16 (1):19-28.
    Intermediary metabolism molecules are orchestrated into logical pathways stemming from history (L-amino acids, D-sugars) and dynamic constraints (hydrolysis of pyrophosphate or amide groups is the driving force of anabolism). Beside essential metabolites, numerous variants derive from programmed or accidental changes. Broken down, variants enter standard pathways, producing further variants. Macromolecule modification alters enzyme reactions specificity. Metabolism conform thermodynamic laws, precluding strict accuracy. Hence, for each regular pathway, a wealth of variants inputs and produces metabolites that are similar to but not (...)
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  16. Darwinism and Meaning.Lonnie W. Aarssen - 2010 - Biological Theory 5 (4):296-311.
    Darwinism presents a paradox. It discredits the notion that one’s life has any intrinsic meaning, yet it predicts that we are designed by Darwinian natural selection to generally insist that it must—and so necessarily designed to misunderstand and doubt Darwinism. The implications of this paradox are explored here, including the question of where then does the Darwinist find meaning in life? The main source, it is proposed, is from cognitive domains for meaning inherited from sentient ancestors—domains that reveal our evolved (...)
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  17. Puberdade e Estacionalidade Reprodutiva dos Animais.Emanuel Isaque Cordeiro da Silva - manuscript
    OBJETIVO -/- O estudante de Zootecnia e de Veterinária, quando se depara com a produção animal, um dos pilares importantes é a reprodução, uma vez que é a perpetuação da espécie, seja para gerar filhas de uma vaca campeã em produção leiteira e de um touro com rusticidade e com aptidão produtiva de corte, ou mesmo para reposição de um plantel, o mesmo deve estar consciente de que esse ramo é de extrema responsabilidade, já que estará intimamente lidando com a (...)
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  18.  63
    (2 other versions)Review of Sex, Ecology, Spirituality by Ken Wilber 2nd ed. 851p (2001).Michael Starks - 2016 - In Suicidal Utopian Delusions in the 21st Century: Philosophy, Human Nature and the Collapse of Civilization-- Articles and Reviews 2006-2017 2nd Edition Feb 2018. Las Vegas, USA: Reality Press. pp. 509-519.
    It is both amazing and fitting that this huge, jargon-laden (this book really needs a glossary!), heavily academic work has become a best seller in the world of the educated. One has to be dedicated to learn the jargon and then plow through 551 pages of text and 238 pages of notes. Meanwhile, we are told time and again that this is just an outline of what is to come! -/- Though he severely criticizes the excesses of the three movements, (...)
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  19. Comic Cure for Delusional Democracy: Plato's Republic.Gene Fendt - 2014 - Lanham, MD: Lexington Books.
    In this book, author Gene Fendt shows how Plato's Republic provides a liturgical purification for the political and psychic delusions of democratic readers, even as Socrates provides the same for his interlocutors at the festival of Bendis. Each of the several characters is analyzed in accord with Book Eight's 6 geometrically possible kinds of character showing how their answers and failures in the dialogue exhibit the particular kind of movement and blindness predictable for the type.
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  20. Ion.Gene Fendt - 1997 - International Studies in Philosophy 29 (4):23-50.
    This reading of Plato's Ion shows that the philosophic action mimed and engendered by the dialogue thoroughly reverses its (and Plato's) often supposed philosophical point, revealing that poetry is just as defensible as philosophy, and only in the same way. It is by Plato's indirections we find true directions out: the war between philosophy and poetry is a hoax on Plato's part, and a mistake on the part of his literalist readers. The dilemma around which the dialogue moves is false, (...)
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  21. Sublimity and Human Works: Kant on Tragedy and War.Gene Fendt - 1995 - Proceedings of the Eighth International Kant Congress 2:509-517.
    Kant admits that there are two kinds of human works that have something sublime about them, the work of the poet, e.g., tragedy, and the work of the politician, i.e., war. This paper will explore Kant's reasoning about the sublime element in these two human works.
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  22. Winch on Following a Rule: A Wittgensteinian Critique of Oakeshott.Gene Callahan - 2012 - Collingwood and British Idealism Studies 18 (2):167-175.
    Peter Winch famously critiqued Michael Oakeshott's view of human conduct. He argued that Oakeshott had missed the fact that truly human conduct is conduct that 'follows a rule.' This paper argues that, as is sometimes the case with Oakeshott, what seems, on the surface, to be a disagreement with another, somewhat compatible thinker about a matter of detail in some social theory in fact turns out to point to a deeper philosophical divide. In particular, I contend, Winch, as typical of (...)
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  23. Psychology, Character, and Performance in Hamlet.Gene Fendt - 2008 - In Psychology, Character, and Performance in Hamlet. San Francisco, CA, USA: pp. 217-230.
    As Shakespeare is closer in time and spirit to medieval psychology than to popular modern explanations of psyche, this article presents a fourfold analysis of ecstasy from Aquinas' Summa Theologiae to examine the characters of the play. I also suggest performance choices which make a variety of these ecstasies of soul more visible.
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  24. (1 other version)How to play the Platonic flute: Mimêsis and Truth in Republic X.Gene Fendt - 2018 - In How to play the Platonic flute: Mimêsis and Truth in Republic X. Sioux city, Iowa: pp. 37-48.
    The usual interpretation of Republic 10 takes it as Socrates’ multilevel philosophical demonstration of the untruth and dangerousness of mimesis and its required excision from a well ordered polity. Such readings miss the play of the Platonic mimesis which has within it precisely ordered antistrophes which turn its oft remarked strophes perfectly around. First, this argument, famously concluding to the unreliability of image-makers for producing knowledge begins with two images—the mirror (596e) and the painter. I will show both undercut the (...)
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  25. The Writ against Religious Drama: Frater Taciturnus v. Søren Kierkegaard.Gene Fendt - 1997 - In Niels Jørgen Cappelørn & Jon Stewart (eds.), Kierkegaard revisited: proceedings from the Conference "Kierkegaard and the Meaning of Meaning It", Copenhagen, May 5-9, 1996. New York: Walter de Gruyter. pp. 48-74.
    In a very literarily complicated setting, Frater Taciturnus sets a remark about Hamlet not being a Christian tragedy. After unpeeling that literary setting and noting that Taciturnus' remark aims more at Jacob Börne than at Shakespeare, the paper shows how Frater Taciturnus' remark calls into question the religious project of a certain danish author. For, Taciturnus' primary concern is to show that religious drama is not possible, or at least "ought not be." This general law applies to Hamlet as well, (...)
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  26. Pagan Politics, War, and the Construction of Nomoi.Gene Fendt - 1997 - In Plato's Political Philosophy, Vol. 2. pp. 58-71.
    The problem Plato sounds from the first lines of LAWS, his final dialogue, might be put in Jean-François Lyotard's term: it is the problem of the differend. Lyotard's position is briefly explained, shown to be applicable to the discussion in several ways (not the least of which is the three different gods appealed to as sources of the laws). We then see how Plato makes a chorus of the differend, resolving Lyotard's modern problem.
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  27. The Others In/Of Aristotle’s Poetics.Gene Fendt - 1997 - Journal of Philosophical Research 22:245-260.
    This paper aims at interpreting (primarily) the first six chapters of Aristotle’s Poetics in a way that dissolves many of the scholarly arguments conceming them. It shows that Aristotle frequently identifies the object of his inquiry by opposing it to what is other than it (in several different ways). As a result aporiai arise where there is only supposed to be illuminating exclusion of one sort or another. Two exemplary cases of this in chapters 1-6 are Aristotle’s account of mimesis (...)
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  28. The Idea of a Social Cycle.Gene Callahan & Andreas Hoffman - manuscript
    The paper aims to explore what it means for something to be a social cycle, for a theory to be a social cycle theory, and to offer a suggestion for a simple, yet, we believe, fundamentally grounded schema for categorizing them. We show that a broad range of cycle theories can be described within the concept of disruption and adjustments. Further, many important cycle theories are true endogenous social cycle theories in which the theory provides a reason why the cycle (...)
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  29. Ideal Types and the Historical Method.Gene Callahan - 2007 - Collingwood and British Idealism Studies 13 (1):53-68.
    A number of social theorists have contended that the essence of historical analysis is the employment of ideal types to comprehend past goings-on. But, while acknowledging that the study of history through ideal types can yield genuine insight, we may still ask if it represents the full emancipation of historical understanding from other modes of conceiving the past. This paper follows Michael Oakeshott's work on the philosophy of history in arguing that explaining the historical past by means of ideal types, (...)
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  30. Addiction: An Emergent Consequence of Elementary Choice Principles.Gene M. Heyman - 2013 - Inquiry: An Interdisciplinary Journal of Philosophy 56 (5):428 - 445.
    ABSTRACT Clinicians, researchers and the informed public have come to view addiction as a brain disease. However, in nature even extreme events often reflect normal processes, for instance the principles of plate tectonics explain earthquakes as well as the gradual changes in the face of the earth. In the same way, excessive drug use is predicted by general principles of choice. One of the implications of this result is that drugs do not turn addicts into compulsive drug users; they retain (...)
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  31. Intrinsicality without naturalness.D. Gene Witmer, William Butchard & Kelly Trogdon - 2005 - Philosophy and Phenomenological Research 70 (2):326–350.
    Defense of an account of intrinsic properties in terms of (what is now called) grounding rather than naturalness.
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  32. Full and partial grounding.Kelly Trogdon & D. Gene Witmer - 2021 - Journal of the American Philosophical Association 7 (2):252-271.
    Discussion of partial grounds that aren't parts of full grounds; definition of full grounding in terms of partial grounding.
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  33. The Gene as a Natural Kind.Francesca Bellazzi - 2023 - In José Manuel Viejo & Mariano Sanjuán (eds.), Life and Mind - New Directions in the Philosophy of Biology and Cognitive Sciences. Springer. pp. pp 259–278.
    What is a gene? Does it represent a natural kind, or is it just a tool for genomics? A clear answer to these questions has been challenged by postgenomic discoveries. In response, I will argue that the gene can be deemed a natural kind as it satisfies some requirements for genuine kindhood. Specifically, natural kinds are projectible categories in our best scientific theories, and they represent nodes in the causal network of the world (as in Khalidi. Natural Categories (...)
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  34. Genes and the Agents of Life: The Individual in the Fragile Sciences Biology.Robert A. Wilson - 2004 - New York, NY, USA: Cambridge University Press.
    Genes and the Agents of Life undertakes to rethink the place of the individual in the biological sciences, drawing parallels with the cognitive and social sciences. Genes, organisms, and species are all agents of life but how are each of these conceptualized within genetics, developmental biology, evolutionary biology, and systematics? The 2005 book includes highly accessible discussions of genetic encoding, species and natural kinds, and pluralism above the levels of selection, drawing on work from across the biological sciences. The book (...)
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  35. Gute Gene sind alles? Der genetisch codierte Mensch im Transhumanismus.Anna Puzio - 2024 - In Mariano Delgado & Klaus Vellguth (eds.), Der bessere Mensch. Religionswissenschaftliche, ethische und theologische Perspektiven. Ostfildern: Grünewald. pp. 165–192.
    Mit den Fortschritten in Generativer Künstlicher Intelligenz, Large Language Models, Brain-Computer Interfaces und genetischen Eingriffen gewinnt auch der Transhumanismus an Relevanz. Der Transhumanismus ist ein beliebtes Thema der Medien und wird in Tages- und Wochenzeitungen sowie im Fernsehen gerne aufgegriffen. Außerdem gibt es inzwischen viele Filme, die den Transhumanismus thematisieren, z. B. die Dokumentation „Endlich unendlich“ (2021, Regie: Stephan Bergmann). Der Transhumanismus wurde in Österreich auch Gegenstand einer Verschwörungserzählung, über die der Bayrische Rundfunk aufgeklärt hat. Auf den Wahlplakaten der „Partei (...)
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  36. Autonomous Driving and Public Reason: a Rawlsian Approach.Claudia Brändle & Michael W. Schmidt - 2021 - Philosophy and Technology 34 (4):1475-1499.
    In this paper, we argue that solutions to normative challenges associated with autonomous driving, such as real-world trolley cases or distributions of risk in mundane driving situations, face the problem of reasonable pluralism: Reasonable pluralism refers to the fact that there exists a plurality of reasonable yet incompatible comprehensive moral doctrines within liberal democracies. The corresponding problem is that a politically acceptable solution cannot refer to only one of these comprehensive doctrines. Yet a politically adequate solution to the normative challenges (...)
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  37. Gene Mobility and the Concept of Relatedness.Jonathan Birch - 2014 - Biology and Philosophy 29 (4):445-476.
    Cooperation is rife in the microbial world, yet our best current theories of the evolution of cooperation were developed with multicellular animals in mind. Hamilton’s theory of inclusive fitness is an important case in point: applying the theory in a microbial setting is far from straightforward, as social evolution in microbes has a number of distinctive features that the theory was never intended to capture. In this article, I focus on the conceptual challenges posed by the project of extending Hamilton’s (...)
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  38. Cohesion, Gene flow, and the Nature of Species.Matthew J. Barker & Robert A. Wilson - 2010 - Journal of Philosophy 107 (2):59-77.
    A far-reaching and influential view in evolutionary biology claims that species are cohesive units held together by gene flow. Biologists have recognized empirical problems facing this view; after sharpening the expression of the view, we present novel conceptual problems for it. At the heart of these problems is a distinction between two importantly different concepts of cohesion, what we call integrative and response cohesion. Acknowledging the distinction problematizes both the explanandum of species cohesion and the explanans of gene (...)
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  39. Drives as Inverted Forms: Nietzsche’s Correction of Socrates’s Philosophical Psychology (As pulsões como formas invertidas: a correção de Nietzsche à psicologia filosófica de Sócrates).Brian Lightbody - 2024 - Kalagatos 21 (2):1-28.
    A recent paper by Tom Stern suggests that Socrates’s philosophical psychology, which emphasizes rational reflection, is superior to Nietzsche’s drive model when explaining human behavior. I argue that Stern’s analysis is wrong on three fronts. First, the models share common, though inverted, features. Second, Stern fails to consider the role of Socrates’s daimon when evaluating Socrates’s philosophy of mind; third, Nietzsche’s model is more warranted. In sum, Nietzsche’s philosophical psychology is a correction of the Socratic.
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  40. Gene Editing and Journal Editing.Trevor Stammers - 2018 - The New Bioethics 24 (1):1-1.
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  41. Plasticity genes: what are they, and why should we care?Massimo Pigliucci - 1998 - In H. Greppin, R. Degli Agosti & C. Penel (eds.), The Co-Action Between Living Systems and the Planet. University of Geneva.
    A critical examination of the dispute about the existence and significance of "plasticity genes.".
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  42. Genes `for' phenotypes: A modern history view.Jonathan Michael Kaplan & Massimo Pigliucci - 2001 - Biology and Philosophy 16 (2):189--213.
    We attempt to improve the understanding of the notion of agene being `for a phenotypic trait or traits. Considering theimplicit functional ascription of one thing being `for another,we submit a more restrictive version of `gene for talk.Accordingly, genes are only to be thought of as being forphenotypic traits when good evidence is available that thepresence or prevalence of the gene in a population is the resultof natural selection on that particular trait, and that theassociation between that trait and (...)
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  43. Genes and organisms in the legacy of the modern synthesis.J. Arvid Ågren - 2023 - In T. E. Dickins & B. J. Dickins (eds.), Evolutionary Biology: Contemporary and Historical Reflections Upon Core Theory. Springer. pp. 555–568.
    The gene's-eye view of evolution is an influential but contentious perspective on biology. It emerged in the aftermath of the Modern Synthesis and both proponents and detractors have stressed the link between the two. In particular, both the Modern Synthesis and the gene's-eye view have been criticized for overemphasizing the role genes at the expense of organisms in evolutionary explanations. In this chapter, I discuss the connection between the Modern Synthesis and the gene’s-eye view and evaluate the (...)
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  44. Gene Editing, the Mystic Threat to Human Dignity.Vera Lúcia Raposo - 2019 - Journal of Bioethical Inquiry 16 (2):249-257.
    Many arguments have been made against gene editing. This paper addresses the commonly invoked argument that gene editing violates human dignity and is ultimately a subversion of human nature. There are several drawbacks to this argument. Above all, the concept of what human dignity means is unclear. It is not possible to condemn a practice that violates human dignity if we do not know exactly what is being violated. The argument’s entire reasoning is thus undermined. Analyses of the (...)
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  45. Ethics of Driving Automation. Artificial Agency and Human Values.Fabio Fossa - 2023 - Cham: Springer.
    This book offers a systematic and thorough philosophical analysis of the ways in which driving automation crosses path with ethical values. Upon introducing the different forms of driving automation and examining their relation to human autonomy, it provides readers with in-depth reflections on safety, privacy, moral judgment, control, responsibility, sustainability, and other ethical issues. Driving is undoubtedly a moral activity as a human act. Transferring it to artificial agents such as connected and automated vehicles necessarily raises many philosophical questions. When (...)
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  46.  44
    Virtue in Nietzsche's Drive Psychology.Mark Alfano - 2019 - In Tom Stern (ed.), The New Cambridge Companion to Nietzsche. New York: Cambridge University Press.
    Nietzsche promises to “translate man back into nature,” but it remains unclear what he meant by this and to what extent he succeeded at it. To help come to grips with Nietzsche’s conceptions of drive (Trieb), instinct (Instinkt) and virtue (Tugend and/or Keuschheit), I develop novel digital humanities methods to systematically track his use of these terms, constructing a near-comprehensive catalogue of what he takes these dispositions to be and how he thinks they are related. Nietzsche individuate drives and (...)
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  47. Public views on gene editing and its uses.Hub Zwart, George Gaskell & Imre Bard - 2017 - Nature Biotechnology 35 (11):121-123.
    Rapid advances in genome editing and its potential application in medicine and enhancement have been hotly debated by scientists and ethicists. Although it has been proposed that germline gene editing be discouraged for the time being1, the use of gene editing in somatic human cells in the clinical context remains controversial, particularly for interventions aimed at enhancement2. In a report on human genome editing, the US National Academies of Sciences, Engineering, and Medicine (NAS; Washington, DC) notes that “important (...)
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  48. Gene Ontology annotations: What they mean and where they come from.David P. Hill, Barry Smith, Monica S. McAndrews-Hill & Judith A. Blake - 2008 - BMC Bioinformatics 9 (5):1-9.
    The computational genomics community has come increasingly to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). We here address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations in the hope that this will lead to better representations of biological reality (...)
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  49. The ontology of the Gene Ontology.Barry Smith, Jennifer Williams & Steffen Schulze-Kremer - 2003 - In Smith Barry, Williams Jennifer & Schulze-Kremer Steffen (eds.), AMIA 2003 Symposium Proceedings. AMIA. pp. 609-613.
    The rapidly increasing wealth of genomic data has driven the development of tools to assist in the task of representing and processing information about genes, their products and their functions. One of the most important of these tools is the Gene Ontology (GO), which is being developed in tandem with work on a variety of bioinformatics databases. An examination of the structure of GO, however, reveals a number of problems, which we believe can be resolved by taking account of (...)
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  50.  77
    Germs, Genes, and Memes: Function and Fitness Dynamics on Information Networks.Patrick Grim, Daniel J. Singer, Christopher Reade & Stephen Fisher - 2015 - Philosophy of Science 82 (2):219-243.
    Understanding the dynamics of information is crucial to many areas of research, both inside and outside of philosophy. Using computer simulations of three kinds of information, germs, genes, and memes, we show that the mechanism of information transfer often swamps network structure in terms of its effects on both the dynamics and the fitness of the information. This insight has both obvious and subtle implications for a number of questions in philosophy, including questions about the nature of information, whether there (...)
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