The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of a (...) chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. (shrink)

Evidence shows that the COVID-19 pandemic has increased stress and despair levels. During the outbreak, everyone’s health and safety are given high importance. The only practical option at this time is for schools and institutions all around the world to switch to online classes. Students, parents, professors, and teachers in the Philippines are aware of the long-term difficulties of online learning, notably their effects on college student’s mental health. This hasn't, however, been adequately documented. The challenges and consequences of online (...) learning on the mental health of students taking up the Hospitality Management program at Romblon State University were investigated in this study. It would add to the body of knowledge regarding mental health, especially for Filipino students. The descriptive quantitative research was employed in the study, and purposive sampling was used to choose the respondents. A researcher-modified instrument with a Perceived Stress Scale (PSS-10) was translated into a Google form and it was used as the standard tool to collect data. The online survey was carried out and data analysis was done using frequency and percentage distribution as well as weighted mean. According to the results, the respondent’s 3-5 hours weekly online activity demonstrates their lack of involvement. Home distractions, a lack of engaging online teaching techniques, procrastination, increased workload, depression, and anxiety are a few of the difficulties encountered. The effect on the HM students is a perceived stress scale interpreted as stressed sometimes. (shrink)

Ito ay pag-aaral sa ibat-ibang form ng nawn preys sa isla ng Biri, Northern Samar. Ang balidasyon, muling pagsusuri, at pag-aanalisa sa mga datos ay ginawa mismo ng mananaliksik bilang taal na mananalita ng Biri-Waray. Inilimita lamang ang pagsusuring ito sa mga fityur at istraktyur ng nawn at mga konstityuwent na bumubuo sa nawn preys sa Biri-Waray. Ang analisis sa pag-aaral na ito ay ibinatay lamang mula sa nakalap na datos mula sa siyam na informant na nagmula sa walong (8) (...) barangay (Poblacion, Sto. Nino, Progress, Pio Del Pilar, Causwagan, MacArthur, San Pedro, at San Antonio) ng munisipalidad ng Biri. Batay sa ginawang pagsusuri, ang NP sa Biri-Waray ay isang preys na maaaring: (1) binubuo ng marker, pronawn, kwantifayer at adjektiv na kumakatawan bilang hed ng nawn, at (2) binubuo ng nawn bilang hed at sinusundan ng mga konstityuwent na nagsisilbing modefayer. May mga form ang NP sa Biri-Waray na binubuo ng mga marker at nawn na kung saan ang marker ang nagpapakilala sa gamit at relasyon sa iba pang mga konstityuwent sa loob ng sentens. May kaibahan ang mga form ng NP ng Biri-Waray sa wikang Tagalog at iba pang mga Bisayan na mga dayalekto kapag binubuo ang NP ng posesiv pronawn + nawn (possessed) dahil hindi nagyayari ang pagkakabit ng ligatyur bilang pang-ugnay. May mga NP rin sa Biri-Waray na nabubuo sa pamamagitan ng relatibisasyon. Sa pamamagitan nito, nangyayari ang pagkatanggal sa nawn na minomodify ng predikeyt na hindi nawn at relativizer na at ang predikeyt na hindi nawn ang sumusunod sa nominativ marker an ‘ang’. Ang pag aaral na ito ay nakitang kahalagahan ng pagsusuri na magagabayan higit lalo na ang mga hindi taal na mananalita ng Biri-Waray sa pag-unawa sa gramatikal na istukrtura ng naturang wika. (shrink)

Identification of factors that predict recurrent antisocial behavior is integral to the social sciences, criminal justice procedures, and the effective treatment of high-risk individuals. Here we show that error-related brain activity elicited during performance of an in- hibitory task prospectively predicted subsequent rearrest among adult offenders within 4 y of release (N =96). The odds that an offender with relatively low anterior cingulate activity would be rearrested were approximately double that of an offender with high activity in this region, holding (...) constant other observed risk factors. These results suggest a potential neurocognitive biomarker for persistent antisocial behavior. (shrink)

In order to achieve the World Health Organization’s Millennium Development Goal of reducing maternal mortality by three quarters by 2015, a strong global commitment is needed to address this issue in low-income nations where the risk to women is greatest. A comprehensive international effort must include provision of obstetric and general medical care as well as community-based interventions, with an emphasis on the latter in nations where the majority of women deliver babies at home without a trained attendant. Methods: This (...) systematic analysis evaluates interventions published in Medline and CINAHL whose outcome measure is maternal mortality. Analysis includes components of the intervention, nation and maternal death rates. Results: Nine studies documented the effectiveness of various clinical and community-based interventions, including specific drug regimens and procedures, in reducing the risk of maternal death. Six studies reported interventions that did not significantly alter maternal mortality outcomes, and the intervention in one study demonstrated increased risk of maternal death. Conclusion: The dearth of evidence highlights the need for increased focus on translational research that bridges the gap between medical advances and community-based interventions that are feasible in low-income nations. This cannot be accomplished without a stronger commitment to reducing maternal mortality by global health practitioners and researchers. (shrink)

This study investigated the effect of urbanization pull indices on the viability of small businesses in the Calabar Metropolis. The investigation was guided by two objectives, two research questions, and two null hypotheses. The study covered 3001 small scale business operators, comprising 2,800 Operators of Manufacturing Industry (OMIs) and 201 Operators of Service Industry (OSIs). A total of 352 participants was the sample of the study. The Taro Yamane formula was used to generate the sample. The Urbanization Pull Indices and (...) the Small-Scale Business (SSB) Sustainability Questionnaire was used to collect data. This instrument was trial-tested on 30 respondents from within and outside the study area. Cronbach Alpha statistics were used to determine internal consistency, yielding reliability coefficients of 0.83 and 0.79 for the instrument. Mean statistics were used to answer the research questions, while independent t-test was used to test the null hypotheses at .05 level of significance. The findings indicate that the mean ratings for the effect of infrastructure and government policies on SSB sustainability in the Calabar metropolitan area did not differ significantly across OMIs and OSIs. Based on these findings, the study recommends that the state government make it easier for small businesses to run sustainably. (shrink)

Ang pag-aaral na ito ay naglalahad ng isang komprehensibong istruktura ng gramatika na nakatuon sa katangian ng Nawn Preys (NP). Ito ang kauna-unahang pag-aaral na nakapokus sa katangian ng NP ng isang varayti ng wikang Waray na wala pang anumang naisagawang pag-aaral. Ang balidasyon, muling pagsusuri, at pag-aanalisa sa mga datos ay ginawa mismo ng mananaliksik bilang taal na mananalita ng Biri-Waray at sa gabay ng tagapayo. Ang mga kinapanayam ay mga nasa edad 47- 67 at mga taal na mananalita (...) ng Biri-Waray. Sila ang siyam (9) na piniling kapanayamin sapagkat bukod sa sila ay taal na mananalita ng Biri-Waray, nakapagtapos din sila ng pag-aaral at may ganap na pag-unawa sa gramatika. Ang listahan ng mga pangungusap na may kabuuang 384 ay nakasulat sa wikang Tagalog na isinasalin nang mga informant nang pasalita. Mula sa pag-aaral, sinuri ang mga katangian ng Nawn sa Biri-Waray, mga konstityuwent na bumubuo sa iba’t ibang anyo ng NP sa Biri-Waray, at iba’t ibang gamit ng NP sa istrukturang gramatikal sa Biri-Waray. Ang implikasyon sa mga teyorya sa pagkakapare-pareho ng mga wika sa istrukturang gramatikal ay nakabatay pa rin sa katangian ng isang wika. Isa na rito ang proseso paglilipat ng posisyon sa sabjek sa unahang bahagi ng gramatikal istraktyur na hindi nangyayari sa Biri-Waray sa mga nan-verbal na pangungusap kapag ang predikeyt at sabjek ay parehong may nominal marker an ‘ang’. Dulot ito ng walang direktang katumbas o zero (ø) ‘ay’ order marker ng wikang Tagalog ang Biri-Waray. Isa ito sa nakitang kahalagahan ng pagsusuri na magagabayan higit lalo na ang mga hindi taal na mananalita ng Biri-Waray sa pag-unawa sa gramatikal na istukrtura ng naturang wika. (shrink)

Ang pag-aaral na ito ay naglalahad ng isang komprehensibong istruktura ng gramatika na nakatuon sa katangian ng Nawn Preys (NP). Ito ang kauna-unahang pag-aaral na nakapokus sa katangian ng NP ng isang varayti ng wikang Waray na wala pang anumang naisagawang pag-aaral. Ang balidasyon, muling pagsusuri, at pag-aanalisa sa mga datos ay ginawa mismo ng mananaliksik bilang taal na mananalita ng Biri-Waray at sa gabay ng tagapayo. Ang mga kinapanayam ay mga nasa edad 47- 67 at mga taal na mananalita (...) ng Biri-Waray. Sila ang siyam (9) na piniling kapanayamin sapagkat bukod sa sila ay taal na mananalita ng Biri-Waray, nakapagtapos din sila ng pag-aaral at may ganap na pag-unawa sa gramatika. Ang listahan ng mga pangungusap na may kabuuang 384 ay nakasulat sa wikang Tagalog na isinasalin nang mga informant nang pasalita. Mula sa pag-aaral, sinuri ang mga katangian ng Nawn sa Biri-Waray, mga konstityuwent na bumubuo sa iba’t ibang anyo ng NP sa Biri-Waray, at iba’t ibang gamit ng NP sa istrukturang gramatikal sa Biri-Waray. Ang implikasyon sa mga teyorya sa pagkakapare-pareho ng mga wika sa istrukturang gramatikal ay nakabatay pa rin sa katangian ng isang wika. Isa na rito ang proseso paglilipat ng posisyon sa sabjek sa unahang bahagi ng gramatikal istraktyur na hindi nangyayari sa Biri-Waray sa mga nan-verbal na pangungusap kapag ang predikeyt at sabjek ay parehong may nominal marker an ‘ang’. Dulot ito ng walang direktang katumbas o zero (ø) ‘ay’ order marker ng wikang Tagalog ang Biri-Waray. Isa ito sa nakitang kahalagahan ng pagsusuri na magagabayan higit lalo na ang mga hindi taal na mananalita ng Biri-Waray sa pag-unawa sa gramatikal na istukrtura ng naturang wika. (shrink)

This essay considers how scholarly approaches to the development of molecular biology have too often narrowed the historical aperture to genes, overlooking the ways in which other objects and processes contributed to the molecularization of life. From structural and dynamic studies of biomolecules to cellular membranes and organelles to metabolism and nutrition, new work by historians, philosophers, and STS scholars of the life sciences has revitalized older issues, such as the relationship of life to matter, or of physicochemical inquiries to (...) biology. This scholarship points to a novel molecular vista that opens up a pluralist view of molecularizations in the twentieth century and considers their relevance to current science. (shrink)