Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be intentionally exploited to extend analgesic therapeutic effects. Is it possible to extend the effects of drug treatments by interspersing placebos? We reviewed a database of placebo studies, searching for studies that indicate that placebos given after repeated administration of active treatments acquire medication-like (...) effects. We found a total of 22studies in both animals and humans hinting of evidence that placebos may work as a sort of dose extender of active painkillers. Wherever effective in relieving clinical pain, such placebo use would offer several advantages. First, extending the effects of a painkiller through the use of placebos may reduce total drug intake and side effects. Second, dose-extending placebos may decrease patient dependence. Third, using placebos along with active medication, for part of the course of treatment, should limit dose escalation and lower costs. Importantly, provided that nondisclosure is pre-authorized in the informed consent process and that robust evidence indicates therapeutic benefit comparable to that of standard full-dose therapeutic regimens, introducing dose-extending placebos into the clinical arsenal should be considered. This novel prospect of placebo use has the potential to change our general thinking about painkiller treatments, the typical regimens of painkiller applications, and the ways in which treatments are evaluated. (shrink)

Philosophy of science studies science and the production of scientific knowledge. Usually, philosophical investigations of this field focus mainly on metaphysical, epistemological, and methodological aspects of science. Despite being divided into the general philosophy of science and philosophy of special sciences, philosophy of science, in a general way, is still distant from scientific practice per se. In order to fill this gap, a third subfield has emerged, philosophy of science in practice. This article provides a brief introduction to the philosophy (...) of science in practice and to the Society for Philosophy of Science in Practice. It discusses its goals, methods, its social and empirical engagement. It is expected that this article will shed light on the diversity and possibility of investigations for a philosophy of science beyond meta-analysis, in other words, that is empirically engaged and socially informed. - A filosofia da ciência estuda a ciência, o modus operandi da ciência e o conhecimento científico. Convencionalmente, as investigações filosóficas desse campo se debruçam principalmente sobre aspectos metafísicos, epistemológicos e metodológicos da produção de conhecimento nas ciências. Muito embora seja tradicionalmente subdividida em filosofia geral das ciências e filosofia das ciências especiais, a filosofia da ciência de uma forma geral ainda se mantém distante das práticas científicas propriamente ditas. Para suprir tal demanda surge uma terceira subdivisão, ainda embrionária, a filosofia da ciência em prática. Este artigo apresenta uma breve introdução à filosofia da ciência em prática e à Sociedade de Filosofia da Ciência em Prática, discute seus objetivos e estratégias metodológicas, bem como seu engajamento social e empírico. Espero que, com esse artigo, seja possível trazer uma breve noção sobre a diversidade de investigações e as possibilidades de uma filosofia da ciência que pode ir para além do escopo meta-analítico, que pode ser empiricamente engajada e socialmente informada. (shrink)

This article addresses the contributions of the literature on the new mechanistic philosophy of science for the scientific practice of model building in ecology. This is reflected in a one-to-one interdisciplinary collaboration between an ecologist and a philosopher of science during science-in-the-making. We argue that the identification, reconstruction and understanding of mechanisms is context-sensitive, and for this case study mechanistic modeling did not present a normative role but a heuristic one. We expect our study to provides useful epistemic tools for (...) the improvement of empirically-riven work in the debates about mechanistic explanation of ecological phenomena. (shrink)

Philosophy of Science in Practice (PoSiP) has the “practice of science” as its object of research. Notwithstanding, it does not possess yet any general or specific methodology in order to achieve its goal. Instead of sticking to one protocol, PoSiP takes advantage of a set of approaches from different fields. This thesis takes as a starting point a collaborative and interdisciplinary research between two Ph.D. students from distinct areas: ecology and philosophy. This collaboration showed how a scientist could benefit from (...) philosophy of science (in this case study the philosophical approach of. mechanistic explanation) to construct a model of his explanandum, by means of heuristics approach (heuristics as an instrument but also a methodological approach) and, also allowed philosophy of science take a closer look into the scientific practice to investigate how explanations are constructed and how scientific understanding is achieved (in this thesis, with a dialogue with the contextual theory of scientific understanding). As a result, it is asserted that (i) mechanistic explanation possess limitations but may work as epistemic instruments that mediate between theories, data, scientists, and models; (ii) explanation construction and scientific understanding deeply relies on intuition; (iii) scientific understanding is an instant, a moment, a temporary achievement, and its process may happen in degrees; (iv) philosophy of science, by means of heuristics process, may enhance scientists’ epistemic virtues, improving his academic skills, by means of self-evaluation. This research shows that interdisciplinarity and collaborative work can act, through heuristics, as a toolbox for PoSiP to achieve its goal of understanding how science is made. Despite its success, an analysis of this collaborative practice leads to some fundamental issues. First, philosophy of science in practice is a philosophy of past practice, in that the majority of examples used by mainstream PoSiP come from the final products of science. Second, is it philosophy of [science in practice] or philosophy of science [in practice]? How to practice philosophy of scientific practice and, how to practice interdisciplinarity in the philosophy of scientific practices simultaneously to its scientific activity? This research exposes the epistemic role heuristics and interdisciplinarity possess as methodological toolboxes for philosophy of science in practice. It is defended that other ways of constructing sciences would be through different dynamics such as collaborative networks and interdisciplinarity research contributing to the vision of Trading Zones from Peter Galison, in which bridges between specialized disciplines are created in order to exchange knowledge and information. (shrink)

The Roman years of Tommaso Campanella were made possible by the protection and patronage of the pope Urbano VIII Barberini. Campanella composed from 1627 to 1631 three series of lengthy Commentaria on the Poemata, the book of Barberini’s Latin poems. What are the Commentaria? This complex, full-length bunch of manuscripts is often dismissed as pure flattery or as another strange, slightly delirious fruit of the exalted mind of the prophet-monk. We think instead that the Commentaria were seen by Campanella as (...) a new start for his philosophical system, furthermore shedding on it a new light: the light of a system, and the reassuring clarity of a pedagogy. Moreover, with the “Collegio Barberino” project, strongly tied to the Commentaria, Campanella tries to lay the foundations of a new educational system fitted for the new Rome and the cultural needs of the 17th-century élite. (shrink)

The term ‘scientism’ has not attracted consensus about its meaning or about its scope of application. In this paper, we consider Mizrahi’s suggestion to distinguish ‘Strong’ and ‘Weak’ scientism, and the consequences this distinction may have for philosophical methodology. While we side with Mizrahi that his definitions help advance the debate, by avoiding verbal dispute and focussing on questions of method, we also have concerns about his proposal as it defends a hierarchy of knowledge production. Mizrahi’s position is that Weak (...) Scientism should be adopted, stating that “of all the knowledge we have, scientific knowledge is the best knowledge”. This version of scientism, however, has consequences for philosophical methodology. In particular, if one conceives of philosophy as an a priori discipline and holds Weak Scientism, the introduction of empirical methods in philosophy may threaten its very essence or soul. In this chapter, we will defend the move to adopt empirical methods in philosophy and argue that, rather than threatening its essence or soul, these methods put philosophy in a better position to contribute to knowledge production, an endeavor shared with the sciences, and in a very interdisciplinary spirit. Our point of disagreement with Mizrahi is that we should avoid any hierarchy of knowledge, and instead focus on what each perspective -- scientific, philosophical, historical, or other -- can contribute to understanding phenomena. (shrink)

Known as the Darwin of the twenty-first century, the German biologist Ernst Walter Mayr (1904-2005) studied a great variety of subjects such as Ornithology, Genetics, Evolution, Classification, History, and Philosophy of Biology. This scientist was a giant of the previous century and an icon of Evolutionary Biology. He became famous for his Biological Species Concept and his conclusion that allopatry is the main cause for the origin of species. He provided a decisive contribution to the New Systematics and was the (...) pioneer of the punctuated equilibrium idea. Mayr was one of the main architects of the evolutionary synthesis as also of the Neo-Darwinian wave. Evaluated together, all of his works reveal several elements of his ambition – to organize a philosophical conception inherent for Biology. An assiduous defender of autonomous Biology, Mayr asserted that four sets of factors in Biology differ from those in the Exact Sciences: (I) refutation of essentialism, mechanism, vitalism, and teleology; (II) some physical principles cannot be applied to Biology; (III) absence of general laws in Biology; and (IV) basic principles of biology and their specific character cannot be applied to the inanimate world. The present study took as an axis a minor or even invisible theme from the Ernst Mayr literature and aims to analyze critically the theoretical and epistemological basis that subsidizes – or not– the affirmation that Biology is an autonomous Science. - O biólogo alemão Ernst Walter Mayr (1904-2005), conhecido como o Darwin do século XXI, trabalhou com uma grande variedade de temas: Ornitologia, Genética, Evolução, Classificação, História e Filosofia da Biologia. Esse cientista foi um dos gigantes do século XX e um ícone para a Biologia Evolutiva. Ficou famoso com o seu Conceito Biológico de Espécie e sua conclusão de que a alopatria era a principal causa da origem das espécies. Forneceu uma contribuição decisiva à Nova Sistemática, foi precursor da ideia de equilíbrio pontuado e um dos principais arquitetos da síntese evolutiva, bem como do movimento Neodarwinista. Quando avaliados em conjunto, seus trabalhos revelam os diversos elementos de sua ambição – organizar um corpo de concepções filosóficas próprias da Biologia. Defensor assíduo de uma Biologia autônoma, Mayr afirmou que há quatro conjuntos de fatores que diferenciam a Biologia do conjunto das Ciências Exatas: (I) refutação do essencialismo, do mecanicismo, do vitalismo e da teleologia; (II) convicção de que certos princípios da Física não podem ser aplicados à Biologia; (III) ausência de leis naturais universais em Biologia; e (IV) percepção do caráter único de certos princípios básicos da Biologia não aplicáveis ao mundo inanimado. O presente artigo tomou por eixo um tema aparentemente menor ou mesmo invisível na obra de Ernst Mayr e pretende realizar uma análise crítica acerca de suas bases teóricas e epistemológicas que subsidiaram – ou não – a afirmação da Biologia como uma Ciência autônoma. (shrink)

Book Review: De Regt, H. W. Understanding Scientific Understanding. New York: Oxford University Press, 2017.

A Série Investigação Filosófica, uma iniciativa do Núcleo de Ensino e Pesquisa em Filosofia do Departamento de Filosofia da UFPel e do Grupo de Pesquisa Investigação Filosófica do Departamento de Filosofia da UNIFAP, sob o selo editorial do NEPFil online e da Editora da Universidade Federal de Pelotas, com auxílio financeiro da John Templeton Foundation, tem por objetivo precípuo a publicação da tradução para a língua portuguesa de textos selecionados a partir de diversas plataformas internacionalmente reconhecidas, tal como a Stanford (...) Encyclopedia of Philosophy, por exemplo. O objetivo geral da série é disponibilizar materiais bibliográficos relevantes tanto para a utilização enquanto material didático quanto para a própria investigação filosófica. (shrink)

One of Fabio Rossi’s most important works analyses the themes of evil and suffering in 20th-century French philosophy. Among others, Rossi presents Louis Lavelle’s contribution on such themes and his reading of the mutual influences between philosophical reflection, emotional experience and religious transcendence. The article aims to make use of some of the conceptual tools made available by Rossi and Lavelle in order to understand François Mauriac’s treatment of evil and suffering in some of his novels, namely Le Mystère Frontenac, (...) Noeud de vipères and Le Mal. The role of family bonds, social rules, the body and its weaknesses, and nature are among the themes around which Mauriac centers his reflection about suffering and its inevitable presence in human life. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

Transdisciplinary research knits together knowledge from diverse epistemic communities in addressing social-environmental challenges, such as biodiversity loss, climate crises, food insecurity, and public health. This paper reflects on the roles of philosophy of science in transdisciplinary research while focusing on Indigenous and other subaltern forms of knowledge. We offer a critical assessment of demarcationist approaches in philosophy of science and outline a constructive alternative of transdisciplinary philosophy of science. While a demarcationist focus obscures the complex relations between epistemic communities, transdisciplinary (...) philosophy of science provides resources for meeting epistemic and political challenges of collaborative knowledge production. (shrink)

Transdisciplinary research challenges the divide between Indigenous and academic knowledge by bringing together epistemic resources of heterogeneous stakeholders. The aim of this article is to explore causal explanations in a traditional fishing community in Brazil that provide resources for transdisciplinary collaboration, without neglecting differences between Indigenous and academic experts. Semi-structured interviews were carried out in a fishing village in the North shore of Bahia and our findings show that community members often rely on causal explanations for local ecological phenomena with (...) different degrees of complexity. While these results demonstrate the ecological expertise of local community members, we also argue that recognition of local expertise needs to reflect on differences between epistemic communities by developing a culturally sensitive model of transdisciplinary knowledge negotiation. (shrink)

As COVID-19 emerged as a phenomenon of the total environment, and despite the intertwined and complex relationships that make humanity an organic part of the Bio- and Geospheres, the majority of our responses to it have been corrective in character, with few or no consideration for unintended consequences which bring about further vulnerability to unanticipated global events. Tackling COVID-19 entails a systemic and precautionary approach to human-nature relations, which we frame as regaining diversity in the Geo-, Bio-, and Anthropospheres. Its (...) implementation requires nothing short of an overhaul in the way we interact with and build knowledge from natural and social environments. Hence, we discuss the urgency of shifting from current to precautionary approaches to COVID-19 and look, through the lens of diversity, at the anticipated benefits in four systems crucially affecting and affected by the pandemic: health, land, knowledge and innovation. Our reflections offer a glimpse of the sort of changes needed, from pursuing planetary health and creating more harmonious forms of land use to providing a multi-level platform for other ways of knowing/understanding and turning innovation into a source of global public goods. These exemplary initiatives introduce and solidify systemic thinking in policymaking and move priorities from reaction-based strategies to precautionary frameworks. (shrink)

In February 1994, Stephen Mobley was convicted of the murder of John Collins. Mobley's lawyers attempted to introduce genetic evidence in an attempt to have Mobley's sentence reduced from death to life imprisonment. I examine the prospects for appeal to genetic determinism as a criminal defense. Guided by existing standards for insanity defenses, I argue that a genetic defense might be allowable in exceptional cases but will not be generally available as some have worried.

Review of David Ludwig, Inkeri Koskinen, Zinhle Mncube, Luana Poliseli, and Luis Reyes-Galindo, eds. Global Epistemologies and Philosophies of Science. Routledge, 2021, pp.i-xviii+319.