News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global. Of special interest was the fact that the mitochondrial replacement procedure happened in Mexico. One of the scientists behind this world first was quoted as having said that he and his team went to Mexico to carry out the procedure because, in Mexico, there are no rules. In (...) this paper, we explore Mexico's rule of law in relation to mitochondrial replacement techniques and show that, in fact, certain instances of MRTs are prohibited at the federal level and others are prohibited at the state level. According to our interpretation of the law, the scientists behind this first successful MRT procedure broke federal regulations regarding assisted fertilization research. (shrink)

In 2015 the United Kingdom (UK) became the first nation to legalize egg and zygotic nuclear transfer procedures using mitochondrial replacement techniques (MRTs) to prevent the maternal transmission of serious mitochondrial DNA diseases to offspring. These techniques are a form of human germline genetic modification and can happen intentionally if female embryos are selected during the MRT clinical process, either through sperm selection or preimplantation genetic diagnosis (PGD). In the same year, an MRT was performed by a (...) United States (U.S.)-based physician team. This experiment involved a cross-border effort: the MRT procedure per se was carried out in the US, and the embryo transfer in Mexico. The authors examine the ethics of MRTs from the standpoint of genetic relatedness and gender implications, in places that lack adequate laws and regulation regarding assisted reproduction. Then, we briefly examine whether MRTs can be justified as a reproductive option in the US and Mexico, after reassessing their legalization in the UK. We contend that morally inadequate and ineffective regulations regarding egg donation, PGD, and germline genetic modifications jeopardize the ethical acceptability of the implementation of MRTs, suggesting that MRTs are currently difficult to justify in the US and Mexico. In addition to relevant regulation, the initiation and appropriate use of MRTs in a country require a child-centered follow-up policy and more evidence for its safety. (shrink)

Abstract Background The first live birth following the use of a new reproductive technique, maternal spindle transfer (MST), which is a mitochondrial replacement technique (MRT), was accomplished by dividing the execution of the MST procedure between two countries, the USA and Mexico. This was done in order to avoid US legal restrictions on this technique. -/- Sources of data Academic articles, news articles, documents obtained through freedom of information requests, laws, regulations and national reports. -/- Areas of agreement (...) MRTs are new reproductive techniques that present novel ethical and legal challenges, since genetic material from three people is employed to create a child. -/- Areas of controversy Could the first MST procedure that culminated in a live birth negatively impact reproductive medicine in Mexico? -/- Growing points The USA and Mexico need specific and clear legislation on MRTs, in order for such techniques not to be governed by prior existing legislation on assisted reproduction that is inadequate for dealing with the new challenges that these techniques present. -/- Areas timely for developing research There is a pressing need for work to be done on the international governance of new reproductive techniques. (shrink)

Mitochondrial replacement therapy requires oocytes of women whose mitochondrial DNA will be transmitted to resultant children. These techniques are scientifically, ethically and socially controversial; it is likely that some women who donate their oocytes for general in vitro fertilisation usage would nevertheless oppose their genetic material being used in MRT. The possibility of oocytes being used in MRT is therefore relevant to oocyte donation and should be included in the consent process when applicable. In present circumstances, specific (...) consent should be obtained. However, once MRT becomes more routine, such consent could be incorporated into the general consent process for oocyte donation. The reported lack of proper consent for MRT from the oocyte donor in the first baby born via the technique is an ethical failing and should be corrected in any future practice of MRT. (shrink)

Mitochondrial DNA (mtDNA) diseases are a group of neuromuscular diseases that often cause suffering and premature death. New mitochondrial replacement techniques (MRTs) may offer women with mtDNA diseases the opportunity to have healthy offspring to whom they are genetically related. MRTs will likely be ready to license for clinical use in the near future and a discussion of the ethics of the clinical introduction ofMRTs is needed. This paper begins by evaluating three concerns about the safety of (...) MRTs for clinical use on humans: (1) Is it ethical to use MRTs if safe alternatives exist? (2) Would persons with three genetic contributors be at risk of suffering? and (3) Can society trust that MRTs will be made available for humans only once adequate safety testing has taken place, and that MRTs will only be licensed for clinical use in a way that minimises risks? It is then argued that the ethics debate about MRTs should be reoriented towards recommendingways to reduce the possible risks of MRT use on humans. Two recommendations are made: (1) licensed clinical access to MRTs should only be granted to prospective parents if they intend to tell their children about their MRT conception by adulthood; and (2) sex selection should be used in conjunction with the clinical use ofMRTs, in order to reduce transgenerational health risks. (shrink)

Some Comments on de Melo-Martin and Harris.

A new reprogenetic technology, mitochondrial replacement, is making its appearance and, unsurprisingly given its promise to wash off our earthly stains --or at least the scourges of sexual reproduction--, John Harris finds only reasons to celebrate this new scientific feat.1 In fact, he finds mitochondrial replacement techniques (MRTs) so “unreservedly welcome” that he believes those who reject them suffer from “a large degree of desperation and not a little callousness.”2 Believing myself to be neither desperate nor (...) callous, but finding myself also no closer at all – not even after reading his article—to following Harris in welcoming these technologies wholeheartedly, it seems appropriate to respond. (shrink)

It has recently been argued that reproductive genetic manipulation technologies like mitochondrial replacement and germline CRISPR modifications cannot be said to save anyone’s life because, counterfactually, no one would suffer more or die sooner absent the intervention. The present article argues that, on the contrary, reproductive genetic manipulations may be life-saving (and, from this, have therapeutic value) under an appropriate population health perspective. As such, popular reports of reproductive genetic manipulations potentially saving lives or preventing disease are not (...) necessarily mistaken, though such terminology still requires further empirical validation. (shrink)

With the recent report of a live birth after use of Mitochondrial replacement therapy, sometimes called ‘Three-parent IVF’, the clinical application of the technique is fast becoming a reality. While the United Kingdom allows the procedure under regulatory scrutiny, it remains effectively outlawed in many other countries. We argue that such prohibitions may violate individuals’ procreative rights, grounded in individuals’ interest in genetic affinity. The interest in genetic affinity was recently endorsed by Singapore’s highest court, reflecting an emphasis (...) on the importance of biological ties found across the globe. We apply that reasoning to make the case for a right to ‘Three-parent IVF’. (shrink)

In a recent publication Tom Douglas and Katrien Devolder have proposed a new account of genetic parenthood, building on the work of Heidi Mertes. Douglas and Devolder’s account aims to solve, among other things, the question of who are the genetic parents of an individual created through somatic cell nuclear transfer (i.e. cloning): (a) the nuclear DNA provider or (b) the progenitors of the nuclear DNA provider. Such a question cannot be answered by simply appealing to the folk account of (...) genetic parenthood, according to which the genetic parents of an individual are those individuals who produced the egg and sperm, respectively, which fused to create the embryo. It cannot be so as in cloning there is no fertilization as such. In this article I critically examine Douglas and Devolder’s new account of genetic parenthood and demonstrate that it is vulnerable to counterexamples that exploit the lack of a condition specifying that genetic parents should cause a child’s coming into existence. (shrink)

In this article, I consider whether there are values intrinsic to development theory and practice that are dubious in light of a characteristically African ethic. In particular, I focus on what a certain philosophical interpretation of the sub-Saharan value of communion entails for appraising development, drawing two major conclusions. One is that a majority of the criticisms that have been made of development by those sympathetic to African values are weak; I argue that, given the value of communion, development should (...) not be rejected because it is essentially, say, overly materialistic and scientistic, or insufficiently spiritual and local. The second conclusion, however, is that three criticisms of development are strong from the perspective of Afro-communalism and are particularly powerful when set in that context. I argue that development theory and practice are characteristically anthropocentric, individualist and technocratic, and that a reading of the sub-Saharan value of communion provides a unitary foundation for rejecting these features and for grounding an alternative, more relational approach to social progress and to what justice demands from the West in relation to Africa. (shrink)

Of the dozens of purported solutions to the liar paradox published in the past fifty years, the vast majority are "traditional" in the sense that they reject one of the premises or inference rules that are used to derive the paradoxical conclusion. Over the years, however, several philosophers have developed an alternative to the traditional approaches; according to them, our very competence with the concept of truth leads us to accept that the reasoning used to derive the paradox is sound. (...) That is, our conceptual competence leads us into inconsistency. I call this alternative the inconsistency approach to the liar. Although this approach has many positive features, I argue that several of the well-developed versions of it that have appeared recently are unacceptable. In particular, they do not recognize that if truth is an inconsistent concept, then we should replace it with new concepts that do the work of truth without giving rise to paradoxes. I outline an inconsistency approach to the liar paradox that satisfies this condition. (shrink)

What’s the basis for considering an egg donor a genetic parent but not a mitochondrial donor? I will argue that a closer look at the biological facts will not give us an answer to this question because the process by which one becomes a genetic parent, i.e., the process of reproduction, is not a concept that can be settled by looking. It is, rather, a concept in need of philosophical attention. The details of my argument will rest on recent (...) developments in biological technology, but the persuasiveness of my argument will turn on the history of another biological concept, death. Given some important similarities between the two concepts, the way in which ‘death’ evolved in the recent past can provide guidance on how we should think about ‘reproduction.’. (shrink)

Most people agree that inflicting unnecessary suffering upon animals is wrong. Many fewer people, including among ethicists, agree that painlessly killing animals is necessarily wrong. The most commonly cited reason is that death (without pain, fear, distress) is not bad for them in a way that matters morally, or not as significantly as it does for persons, who are self-conscious, make long-term plans and have preferences about their own future. Animals, at least those that are not persons, lack a morally (...) significant interest in continuing to live. At the same time, some argue that existence itself can be good, insofar as one’s life is worth living. For animals, a good life can offset a quick, if early, death. So, it seems to follow that breeding happy animals that will be (prematurely) killed can be a good thing overall. Insofar as slaughter and sale makes it economically sustainable to raise new ones, who would otherwise not exist, raising and killing animals for food who will have lives worth living is good overall. It benefits them as well as consumers, and makes the world better by adding to the sum of happiness. The process of raising and killing animals with positive welfare produces a sequence of replacement that maintains or increases overall welfare, all else being equal (assuming in particular no overall negative impact on the welfare of other parties). Call this the Replaceability Argument (RA) and the ensuing controversy the Replaceability Problem (RP). This is a problem at the crossroads of the ethics of killing, agricultural ethics, procreation ethics, and population ethics. (shrink)

Florence Ashley has argued that requiring patients with gender dysphoria to undergo an assessment and referral from a mental health professional before undergoing hormone replacement therapy is unethical and may represent an unconscious hostility towards transgender people. We respond, first, by showing that Ashley has conflated the self-reporting of symptoms with self-diagnosis, and that this is not consistent with the standard model of informed consent to medical treatment. Second, we note that the model of informed consent involved in cosmetic (...) surgery resembles the model Ashley defends, and that psychological assessment and referral is recognised as an important aspect of such a model. Third, we suggest that the increased prevalence of psychiatric morbidity in the transgender population arguably supports the requirement of assessment and referral from a mental health professional prior to undergoing HRT. (shrink)

In this paper I defend anti-realism about race and a new theory of racialization. I argue that there are no races, only racialized groups. Many social constructionists about race have adopted racial formation theory to explain how ‘races’ are formed. However, anti-realists about race cannot adopt racial formation theory, because it assumes the reality of race. I introduce interactive constructionism about racialized groups as a theory of racialization for anti-realists about race. Interactive constructionism moves the discussion away from the dichotomous (...) (social vs. biological) metaphysics that has marred this debate, and posits that racialized groups are the joint products of a broad range of non-racial factors, which interact. (shrink)

In a recent letter, Dillion et. al (2023) make various suggestions regarding the idea of artificially intelligent systems, such as large language models, replacing human subjects in empirical moral psychology. We argue that human subjects are in various ways indispensable.

The article is an extended critical discussion of Kevin Scharp’s Replacing Truth. Scharp’s case for the claim that the concept of truth is inconsistent is criticized, and so is his case for the claim that the concept of truth must be replaced because of its inconsistency.

Previous studies have shown that zinc deficiency leads to apoptosis of neuronal precursor cells in vivo and in vitro. In addition to the role of p53 as a nuclear transcription factor in zinc deficient cultured human neuronal precursors (NT-2), we have now identified the translocation of phosphorylated p53 to the mitochondria and p53-dependent increases in the pro-apoptotic mitochondrial protein BAX leading to a loss of mitochondrial membrane potential as demonstrated by a 25% decrease in JC-1 red:green fluorescence ratio. (...) Disruption of mitochondrial membrane integrity was accompanied by efflux of the apoptosis inducing factor (AIF) from the mitochondria and translocation to the nucleus with a significant increase in reactive oxygen species (ROS) after 24 h of zinc deficiency. Measurement of caspase cleavage, mRNA, and treatment with caspase inhibitors revealed the involvement of caspases 2, 3, 6, and 7 in zinc deficiency-mediated apoptosis. Down-stream targets of caspase activation, including the nuclear structure protein lamin and polyADP ribose polymerase (PARP), which participates in DNA repair, were also cleaved. Transfection with a dominant-negative p53 construct and use of the p53 inhibitor, pifithrin- ␮, established that these alterations were largely dependent on p53. Together these data identify a cascade of events involving mitochondrial p53 as well as p53-dependent caspase-mediated mechanisms leading to apoptosis during zinc deficiency. (shrink)

Animal replaceability is supposed to be a feature of some consequentialist theories, like Utilitarianism. Roughly, an animal is replaceable if it is permissible to kill it because the disvalue thereby caused will be compensated by the value of a new animal’s life. This is specially troubling since the conditions for such compensation seem easily attainable by improved forms of raising and killing animals. Thus, grounding a strong moral status of animals in such theories is somewhat compromised. As is, consequently, their (...) position as an alternative to rights-based theories in animal ethics. Recognising this, some utilitarians tried to disassociate utilitarianism and replaceability. I will here add my voice to this project. However, instead of seeing the culprit in the usual suspects (hedonism, maximisation or the total view), I advance a new proposal. After identifying that the compensating value for a disvaluable action has to be its consequence, I present a restriction on consequences: consequences of sequences of actions cannot be consequences of the isolated actions in the sequences. Given this, the main argument is simple: killing an animal is permissible only if the the value of the new animal’s life is a consequence of the killing; but this value is a consequence of a sequence of actions which involves the killing plus some additional actions; therefore, since, via the restriction, such value is not a consequence of the killing, it is irrelevant to its normative status. I then present two further motivations for the restriction: firstly, it prevents the value of conditional actions from trivially influencing the value of the actions on which they are conditional; secondly, it is useful – even if not a complete solution – to reply other objections to consequentialism: the accordion effect of action and the cluelessness problem. I finally consider a couple of objections. (shrink)

Robert Kraut has proposed an analogy between valuing a loved one as irreplaceable and the sort of “rigid” attachment that (according to Saul Kripke’s account) occurs with the reference of proper names. We wanted to see if individuals with Kripkean intuitions were indeed more likely to value loved ones (and other persons and things) as irreplaceable. In this empirical study, 162 participants completed an online questionnaire asking them to consider how appropriate it would be to feel the same way about (...) a perfect replica of a loved one, as well as other questions about replaceability. Participants who previously had endorsed Kripkean reference (n = 96) rated loved ones as less replaceable on two different measures than participants who had previously endorsed Descriptivist reference (n = 66, t(160)> 2.27, p <.02, eta2> .03). Additional results suggest that this difference extends to other targets as well and is at least partially dependent on sentimental attachment. (shrink)

If it is within our power to provide a significantly better world for future generations at a comparatively small cost to ourselves, we have a strong moral reason to do so. One way of providing a significantly better world may involve replacing our species with something better. It is plausible that in the not‐too‐distant future, we will be able to create artificially intelligent creatures with whatever physical and psychological traits we choose. Granted this assumption, it is argued that we should (...) engineer our extinction so that our planet's resources can be devoted to making artificial creatures with better lives. (shrink)

This paper considers ethical concerns with regard to replacing human relations with humanoid robots. Many have written about the impact that certain types of relations with robots may have on us, and why we should be concerned about robots replacing human relations. There has, however, been no consideration of this issue from an African philosophical perspective. Ubuntu philosophy provides a novel perspective on how relations with robots may impact our own moral character and moral development. This paper first discusses what (...) humanoid robots are, why and how humans tend to anthropomorphise them, and what the literature says about robots crowding out human relations. It then explains the ideal of becoming “fully human”, which pertains to being particularly moral in character. In ubuntu philosophy, we are not only biologically human, but must strive to become better, more moral versions of ourselves, to become fully human. We can become fully human by having other regarding traits or characteristics within the context of interdependent, or humane, relationships (such as by exhibiting human equality, reciprocity, or solidarity). This concept of becoming fully human is important in ubuntu philosophy. Having explained that idea, the main argument of the paper is then put forward: that treating humanoid robots as if they are human is morally concerning if they crowd out human relations, because such relations prevent us from becoming fully human. This is because we cannot experience human equality, solidarity, and reciprocity with robots, which can be seen to characterise interdependent, or humane, relations with human beings. (shrink)

I propose that meat replacement is to meat, as drag is to gender. Meat replacement has the potential to shake concepts of meat, like drag does for gender. Meat replacements not only mimic meat but disclose how meat itself is performed in carnivorous culture -and show that it may be performed otherwise. My approach is inspired by the show RuPaul’s Drag Race. The argument builds on an imitation of Judith Butler’s work on gender performativity, performed by replacing ‘drag/ (...) gender/ sex/ heterosexism’ terms and relations in Butler’s text with ‘meat replacement/ meat/ species/ carnism’ ones. (shrink)

Lovers typically entertain two sorts of thoughts about their beloveds. On the one hand, they think that some qualities of their beloveds provide reasons for loving them. Romeo would say that he loves Juliet in virtue of the way she is. On the other hand, they regard their beloveds as irreplaceable. Romeo would never be willing to exchange Juliet with another maiden. Yet it may be asked how these two sorts of thoughts can coherently coexist. If some qualities of Juliet (...) justify Romeo’s love for her, shouldn’t another maiden with the same qualities be equally lovable for him? This paper draws some distinctions that we take to be crucial to the understanding of reasons for love. Its aim is to show that, even though the claim that beloveds as irreplaceable is plausible to some extent, there is at least one interesting sense in which lovers are replaceable. (shrink)

One of the most expected properties of a logical system is that it can be algebraizable, in the sense that an algebraic counterpart of the deductive machinery could be found. Since the inception of da Costa's paraconsistent calculi, an algebraic equivalent for such systems have been searched. It is known that these systems are non self-extensional (i.e., they do not satisfy the replacement property). More than this, they are not algebraizable in the sense of Blok-Pigozzi. The same negative results (...) hold for several systems of the hierarchy of paraconsistent logics known as Logics of Formal Inconsistency (LFIs). Because of this, these logics are uniquely characterized by semantics of non-deterministic kind. This paper offers a solution for two open problems in the domain of paraconsistency, in particular connected to algebraization of LFIs, by obtaining several LFIs weaker than C1, each of one is algebraizable in the standard Lindenbaum-Tarski's sense by a suitable variety of Boolean algebras extended with operators. This means that such LFIs satisfy the replacement property. The weakest LFI satisfying replacement presented here is called RmbC, which is obtained from the basic LFI called mbC. Some axiomatic extensions of RmbC are also studied, and in addition a neighborhood semantics is defined for such systems. It is shown that RmbC can be defined within the minimal bimodal non-normal logic E+E defined by the fusion of the non-normal modal logic E with itself. Finally, the framework is extended to first-order languages. RQmbC, the quantified extension of RmbC, is shown to be sound and complete w.r.t. BALFI semantics. (shrink)

In Replacing Truth, Scharp takes the concept of truth to be fundamentally incoherent. As such, Scharp reckons it to be unsuited for systematic philosophical theorising and in need of replacement – at least for regions of thought and talk which permit liar sentences and their ilk to be formulated. This replacement methodology is radical because it not only recommends that the concept of truth be replaced, but that the word ‘true’ be replaced too. Only Tarski has attempted anything (...) like it before. I dub such a view Conceptual Marxism. In assessing this view, my goals are fourfold: to summarise the many components of Scharp’s theory of truth; to highlight what I take to be some of the excess baggage carried by the view; to assess whether, and to what extent, the extreme methodology on offer is at all called for; finally, to briefly propose a less radical replacement strategy for resolving the liar paradox. (shrink)

Review of Adam Kotsko (2020), Agamben’s Philosophical Trajectory. Edinburgh: Edinburgh University Press, pp. 241.

In his recent article "Advent of Google means we must rethink our approach to education", Sugata Mitra argues that our education system needs to change. He suggests that the existence of modern technologies such as Google make the skills of the past obsolete. For Mitra, the only reason we continue to teach skills such as longhand multiplication is because we have some sort of romantic attachment to the past. In this short article I respond to his central claim that we (...) should replace the Intellectual Traditionalist form of education with a new system. I argue that Mitra description of the Intellectual Traditionalist system is a strawman. Further, I argue that it would be a mistake to replace Intellectual Traditionalism with a constructivist pedagogy. (shrink)

ABSTRACTAndrew Bacon, Matti Eklund, and Patrick Greenough have individually proposed objections to the project in my book, Replacing Truth. Briefly, the book outlines a conceptual engineering project – our defective concept of truth is replaced for certain purposes with a team of concepts that can do some of the jobs we thought truth could do. Here, I respond to their objections and develop the views expressed in Replacing Truth in various ways.

Philosophers of science have offered different accounts of what it means for one scientific theory to reduce to another. I propose a more or less friendly amendment to Kenneth Schaffner’s “General Reduction-Replacement” model of scientific unification. Schaffner interprets scientific unification broadly in terms of a continuum from theory reduction to theory replacement. As such, his account leaves no place on its continuum for type irreducible and irreplaceable theories. The same is true for other accounts that incorporate Schaffner's continuum, (...) for example, those developed by Paul Churchland, Clifford Hooker, and John Bickle. Yet I believe a more general account of scientific unification should include type irreducible and irreplaceable theories in an account of their partial reduction, specifically, when there is a reduction of their tokens. Thus I propose a “Reduction-Reception-Replacement” model wherein type irreducible and irreplaceable theories are accepted or received for the purpose of unifying domains of particulars. I also suggest a link between this kind of token reduction and mechanistic explanation. (shrink)

We will examine how the diversity of historical sources affects the portrayal of the Balkan Slavs by following two writings that notably differ. First is De Аdministrando Imperio, written in the X century. Our second source is the Chronicle of the Priest of Duklja about which very little is known. The two sources have a strong influence on our understanding of the earliest history of the Slavs that dwell in the Western Balkans. Hence, on our understanding of the modern nations, (...) i.e. Croats and Serbs. These sources are so different when regarding their historicity, time of composition etc. But in terms of myths, we see the same patterns: coming of pagan peoples in Roman Dalmatia, story of their origin, how they were baptised, who were their rulers, what kind of dynasties they had, when did it happen and many more. Following this general ethnogenetic and mythological framework, we will try to conclude the relationship between myth and the identity of a European populace. To achieve this goal, we used qualitative and quantitative content analysis and provided their narrative networks of the mentioned texts. These networks illustrate patterns of connections between different ethnogenetic elements in the writings that serve to form groups identities of interest. (shrink)

According to the Self-Location Thesis, certain types of visual experiences have self-locating and so first-person, spatial contents. Such self-locating contents are typically specified in relational egocentric terms. So understood, visual experiences provide support for the claim that there is a kind of self-consciousness found in experiential states. This paper critically examines the Self-Location Thesis with respect to dynamic-reflexive visual experiences, which involve the movement of an object toward the location of the perceiving subject. The main aim of this paper is (...) to offer an alternative interpretation of these cases which resists attributing them self-locating content, arguing for a replacement of the de se component with a non-conceptual equivalent of the indexical ‘here’. In its final section, the paper also considers an extension of the h-replacement account to cases of visual kinesthesis. (shrink)

Until recently, the problem of traumatic brain injury in sports and the problem of performance enhancement via hormone replacement have not been seen as related issues. However, recent evidence suggests that these two problems may actually interact in complex and previously underappreciated ways. A body of recent research has shown that traumatic brain injuries, at all ranges of severity, have a negative effect upon pituitary function, which results in diminished levels of several endogenous hormones, such as growth hormone and (...) gonadotropin. This is a cause for concern for many popular sports that have high rates of concussion, a mild form of TBI. Emerging research suggests that hormone replacement therapy is an effective treatment for TBI-related hormone deficiency. However, many athletic organizations ban or severely limit the use of hormone replacing substances because many athletes seek to use them solely for the purposes of performance enhancement. Nevertheless, in the light of the research linking traumatic brain injury to hypopituitarism, this paper argues that athletic organizations’ policies and attitudes towards hormone replacement therapy should change. We defend two claims. First, because of the connection between TBI and pituitary function, it is likely many more athletes than previously acknowledged suffer from hormone deficiency and thus could benefit from hormone replacement therapy. Second, athletes’ hormone levels should be tested more rigorously and frequently with an emphasis on monitoring TBI and TBI-related issues, rather than simply monitoring policy violations. (shrink)

Florence Ashley has responded to our response to ‘Gatekeeping hormone replacement therapy for transgender patients is dehumanising.’ Ashley criticises some of our objections to their view that patients seeking hormone replacement therapy (HRT) for gender dysphoria should not have to undergo a prior psychological assessment. Here we clarify our objections, most importantly that concerning the parity between cosmetic surgery and the sort of intervention Ashley has in mind. Firstly, we show Ashley’s criticism of our comparison is insubstantial. We (...) then examine their comments regarding the analogy between abortion and HRT, and the language of informed consent. We also scrutinize the data upon which Ashley relies to defend the claim that informed consent without assessment always yields positive outcomes, finding this conclusion to be overstated. Finally, even if Ashley’s arguments were vindicated, the claim that the gatekeeping of HRT is motivated by hostility towards transgender people remains unsupported. (shrink)

Hegel often says that his "logic" is meant to replace metaphysics. Since Hegel's Science of Logic is so different from a standard logic, most commentators have not treated the portion of that work devoted to logical forms as relevant to this claim. This paper argues that Hegel's discussion of logical forms of judgment and syllogism is meant to be the foundation of his reformation of metaphysics. Implicit in Hegel's discussion of the logical forms is the view that the metaphysical concepts (...) discussed in Books I and II of the Science of Logic supervene on the role of subject and predicate terms in the logical forms discussed in Book III. Hegel thus has an explanation for the nature and significance of metaphysical concepts that resembles Kant's "metaphysical deduction," according to which the categories can be derived from the table of judgments. Though Hegel's metaphysics is often supposed to be influenced by Kant, prevailing interpretations do not show how Hegel's fine-grained treatment of logical forms is relevant to his critical view of metaphysics. The present interpretation provides a model for Hegel's explanation of metaphysical concepts, as well as a new picture of the structure of his Science of Logic that emphasizes the priority of its Doctrine of the Concept. (shrink)

Elections are not the solution to political crisis, they’re the problem. In lively dialogue form, The Democracy Manifesto explains why elections are anti-democratic and should be replaced with government in which decision-makers are randomly selected from the population at large.

Quantum leaps happen in texts, too. This reading of the role of the quantum leap in Karen Barad's agential realism is necessary, because arguing that the diffractive reading strategy proposed by Barad's ethico-onto-epistemology mirrors the physical phenomenon of diffraction would indeed be representationalist. Reviewing how Barad—in her own oeuvre—has transformed diffraction into an innovative reading methodology that could not only potentially challenge the epistemological underpinnings of the canonization process that is at work in feminist theory, but could also radically change (...) the canonization practice of feminist oeuvres itself, our article embarks on a detailed examination of the ways in which the oeuvres of Simone de Beauvoir and Luce Irigaray have been mistakenly categorized and canonized in a hierarchical and Oedipalized manner. This conflict-based narrative has not only paralyzed the oeuvres of Irigaray and Beauvoir, but also has had a negative impact on the canonization of sexual difference philosophy as a whole in feminist theory. By (re)reading the oeuvres diffractively, this article brings the feminist philosophies of Beauvoir and Irigaray together by invalidating the idea that the feminist canonization process always has to run along the lines of discontinuity, Oedipalization and dialectization. (shrink)

It has been claimed that we need singular self-knowledge to function properly as rational agents. I argue that this is not strictly true: agents in certain relations could dispense with singular self-knowledge and instead rely on plural self-knowledge. In defending the possibility of this kind of ‘selfless agent’, I thereby defend the possibility of a certain kind of ‘seamless’ collective agency; agency in a group of agents who have no singular self-knowledge, who do not know which member of the group (...) they are. I discuss four specific functions for which singular self-knowledge has been thought indispensable: distinguishing intentional from unintentional actions, connecting non-indexical knowledge with action, reflecting on our own reasoning, and identifying which ultimate practical reasons we have. I argue in each case that by establishing certain relations between agents – relations I label ‘motor vulnerability’, ‘cognitive vulnerability’, ‘evidential unity’ and ‘moral unity’ – we would allow those agents to do everything a rational agent needs to do while relying only on plural, rather than singular, self-knowledge. Finally, I consider the objection that any agents who met the conditions I lay out for selfless agency would thereby cease to qualify as distinct agents, merging into a single agent without agential parts. Against this objection, I argue that we should recognise the possibility of simultaneous agency in whole and parts, and not regard either as disqualifying the other. (shrink)

What to say in response to a campaign for economics based on more realistic assumptions? The usual defence of assumptions that appear unrealistic, given a certain common way of thinking about people, is what does it matter as long as there is predictive accuracy? I outline a different defence: that rarer results are obtained by departing from realistic assumptions.

This paper targets a series of potential issues for the discussion of, and modal resolution to, the alethic paradoxes advanced by Scharp (2013). I proffer four novel extensions of the theory, and detail five issues that the theory faces.

Guidelines on embryo storage prioritise 'respect for the embryo' above the wishes of the women whose labour and tissue have gone into creating the embryo in the first place, effectively making women and the female body disappear. In this article I draw a parallel between this phenomenon relating to embryo storage and other instances of a similar phenomenon that I have called 'the lady vanishes', particularly in stem cell and 'mitochondrial transfer' research. I suggest that a modified property regime (...) could protect women's interests in embryo storage, making a parallel with the Yearworth case, in which it was recognised that men had limited but actionable interests in their stored sperm.. (shrink)

In the third edition of ‘Practical Ethics’ (2011), Peter Singer reexamines the so-called “replaceability argument,” according to which merely sentient beings, as opposed to persons (self-conscious and with a robust sense of time), are replaceable—it is in principle permissible to kill them provided that they live pleasant lives that they would not have had otherwise and that they be replaced by equally happy beings. On this view, existence is a benefit and death is not a harm. Singer’s challenge is to (...) avoid (i) the replaceability of persons while preserving the replaceability of merely sentient beings, (ii) the implication that parents are morally required to procreate if they can have happy children, and (iii) to do avoid these implications without having the proposed solution (the “debit view” of preferences) imply negative utilitarianism, or the conclusion that a nonsentient universe is better than any sentient universe. I review Singer’s changing views since 1975 and I argue that his attempt to avoid the replaceability of persons fails: either both non-persons and persons are replaceable or neither are. Singer can only avoid this conclusion by appealing to controversial metaethical claims (attitude-independent moral objectivism) and/or giving up on essential features of utilitarianism. (shrink)

Problems for 'precise replacements' as a way out of sorites paradoxes.

In this paper, we offer a brief, critical survey of contemporary work on truth. We begin by reflecting on the distinction between substantivist and deflationary truth theories. We then turn to three new kinds of truth theory—Kevin Scharp's replacement theory, John MacFarlane's relativism, and the alethic pluralism pioneered by Michael Lynch and Crispin Wright. We argue that despite their considerable differences, these theories exhibit a common "pluralizing tendency" with respect to truth. In the final section, we look at the (...) underinvestigated interface between metaphysical and formal truth theories, pointing to several promising questions that arise here. (shrink)

ABSTRACT Sometimes it seems that an existing bearer of value should be preserved even though it could be destroyed and replaced with something of equal or greater value. How can this conservative intuition be explained and justified? This paper distinguishes three answers, which I call existential, attitudinal, and object-affecting conservatism. I raise some problems for existential and attitudinal conservatism, and suggest how they can be solved by object-affecting conservatism.

I examine the two-level utilitarian case for humane animal agriculture (by R. M. Hare and Gary Varner) and argue that it fails on its own terms. The case states that, at the ‘intuitive level’ of moral thinking, we can justify raising and killing animals for food, regarding them as replaceable, while treating them with respect. I show that two-level utilitarianism supports, instead, alternatives to animal agriculture. First, the case for humane animal agriculture does not follow from a commitment to two-level (...) utilitarianism combined with a commitment to respecting animal lives. Secondly, the two-level utilitarian case falls prey to a compartmentalization problem and cannot uphold both respect and replaceability. What I call ‘humane lives’ are not appropriately valued by the lights of two-level utilitarianism itself. (shrink)

Without a proper restriction on mappings, virtually any system could be seen as implementing any computation. That would not allow characterization of systems in terms of implemented computations and is not compatible with a computationalist philosophy of mind. Information-based criteria for independence of substates within structured states are proposed as a solution. Objections to the use of requirements for transitions in counterfactual states are addressed, in part using the partial-brain argument as a general counterargument to neural replacement arguments.