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Mohammad Reaza Shakibaie
Kerman University of Medical Sciences
  1.  20
    Prevalence of Β-Lactamase Genes, Class 1 Integrons, Major Virulence Factors and Clonal Relationships of Multidrug-Resistant Pseudomonas Aeruginosa Isolated From Hospitalized Patients in Southeast of Iran.Hossein Sharifi Mansouri, Gholamreza Pouladfar, Mohammad Reza Shakibaie, Bahman Pourabbas, Jalal Mardaneh, Shahla & Hosein Sharifi - 2019 - Iranian Journal Basic Medical Sciences 22 (7):806-812.
    Objective(s): Pseudomonas aeruginosa is one of the most important nosocomial pathogens causing a high rate of mortality among hospitalized patients. Herein, we report the prevalence of antibiotic resistance genes, class 1 integrons, major virulence genes and clonal relationship among multidrug- resistant (MDR) P. aeruginosa, isolated from four referral hospitals in the southeast of Iran. Materials and Methods: In this study, 208 isolates of P. aeruginosa were collected from four referral hospitals in southeast of Iran. Disk diffusion method was used to (...)
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  2. Evaluation Synergistic Effect of TiO2, ZnO Nanoparticles and Amphiphilic Peptides (Mastoparan-B, Indolicidin) Against Drug-Resistant Pseudomonas Aeruginosa, Klebsiella Pneumoniae and Acinetobacter Baumannii.Shalaleh Masoumi & Mohammad Reza Shakibaie - 2018 - Archives of Pediatric Infectious Diseases 6 (3):1-8.
    Backgound: The aims of this study were to evaluate the antimicrobial properties and synergistic effects of nano-titanium dioxide (TiO2), nano- zinc oxide (ZnO) and two synthetic peptides (mastoparan-B, indolicidin) against drug-resistant strains of Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. -/- Methods: From March to August 2015, a total of 30 (10 each) isolates of the above bacteria were recovered from patients in the ICU of two referral hospitals in Kerman, Iran. The sizes and purities of nano-TiO2, nano-ZnO were determined (...)
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  3.  29
    Bacterial Biofilm and its Clinical Implications. [REVIEW]Mohammad Reza Shakibaie - 2018 - Annals of Microbiology and Research 2:45-50.
    Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable conditions such as presence of antibiotics, host defense or oxidative stresses. Biofilms are often considered hot spot for horizontal gene transfer among same or different bacterial species. Furthermore, bacteria with increased hydrophobicity facilitate biofilm formation by reducing repulsion between the extracellular matrix and the bacterium. There (...)
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  4.  22
    Analysis of Amino Acid Substitution Mutations of gyrA and parC Genes in Clonal Lineage of Klebsiella Pneumoniae Conferring High-Level Quinolone Resistance.Mohammad Reza Shakibaie - 2014 - Journal of Medical Microbiology and Infectious Diseases 2 (3):109-117.
    Background: Emergence Klebsiella pneumoniae resistant to quinolone antibiotics due to mutations in gyrA and parC genes created problem for treatment of patients in different hospitals in Iran. The objective of this study was to determine the amino acid substitutions of GyrA and ParC proteins in certain clonal lineages of the K. pneumoniae conferring high level quinolone resistance. Methods: One hundred and eleven isolates of K. pneumoniae were recovered from clinical specimens in a teaching hospital in Kerman, Iran. The antibiotic susceptibility (...)
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  5.  59
    Molecular Analysis and Expression of Bap Gene in Biofilm-Forming Multi-Drug-Resistant Acinetobacter Baumannii.Omid Azizi, Mohammad Reza Shakibaie & Fereshteh Shahcherghi - 2016 - Reports of Biochemistry and Molecular Biology 5 (1):1-8.
    Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm among multi-drug-resistant A. baumannii (MDRAB). Sixty-five MDRAB isolates from clinical samples were collected. Molecular typing was carried out by random amplified polymorphism DNA polymerase chain reaction (RAPD-PCR). Biofilm (...)
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