Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

Recent research on the metaethical beliefs of ordinary people appears to show that they are metaethical pluralists that adopt different metaethical standards for different moral judgments. Yet the methods used to evaluate folk metaethical belief rely on the assumption that participants interpret what they are asked in metaethical terms. We argue that most participants do not interpret questions designed to elicit metaethical beliefs in metaethical terms, or at least not in the way researchers intend. As a result, existing methods are (...) not reliable measures of metaethical belief. We end by discussing the implications of our account for the philosophical and practical implications of research on the psychology of metaethics. (shrink)

Traditionally, the investigation of truth has been anchored in a priori reasoning. Cognitive science deviates from this tradition by adding empirical data on how people understand and use concepts. Building on psychophysics and machine learning methods, we introduce conceptual scaling, an approach to map people's understanding of abstract concepts. This approach, allows computing participant-specific conceptual maps from obtained ordinal comparison data, thereby quantifying perceived similarities among abstract concepts. Using this approach, we investigated individual's alignment with philosophical theories on truth and (...) the predictive capacity of conceptual maps. The obtained results indicated that, while people's understanding of truth is multifaceted and encapsulates notions of coherence and authenticity, alignment is best for the correspondence theory of truth. Furthermore, conceptual maps allowed predicting individual outcomes with an accuracy of roughly 70%. This research demonstrates that conceptual scaling offers accurate descriptions of individual's understanding of abstract concepts, behavioral predictions, and quantification of alignment with theoretical perspectives. (shrink)

In the latter half of the twentieth century, philosophers of science have argued (implicitly and explicitly) that epistemically rational individuals might compose epistemically irrational groups and that, conversely, epistemically rational groups might be composed of epistemically irrational individuals. We call the conjunction of these two claims the Independence Thesis, as they together imply that methodological prescriptions for scientific communities and those for individual scientists might be logically independent of one another. We develop a formal model of scientific inquiry, define four (...) criteria for individual and group epistemic rationality, and then prove that the four definitions diverge, in the sense that individuals will be judged rational when groups are not and vice versa. We conclude by explaining implications of the inconsistency thesis for (i) descriptive history and sociology of science and (ii) normative prescriptions for scientific communities. (shrink)

We propose a formal framework for interpretable machine learning. Combining elements from statistical learning, causal interventionism, and decision theory, we design an idealised explanation game in which players collaborate to find the best explanation for a given algorithmic prediction. Through an iterative procedure of questions and answers, the players establish a three-dimensional Pareto frontier that describes the optimal trade-offs between explanatory accuracy, simplicity, and relevance. Multiple rounds are played at different levels of abstraction, allowing the players to explore overlapping causal (...) patterns of variable granularity and scope. We characterise the conditions under which such a game is almost surely guaranteed to converge on a optimal explanation surface in polynomial time, and highlight obstacles that will tend to prevent the players from advancing beyond certain explanatory thresholds. The game serves a descriptive and a normative function, establishing a conceptual space in which to analyse and compare existing proposals, as well as design new and improved solutions. (shrink)

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

To the extent that dualism is even taken to be a serious option in contemporary discussions of personal identity and the philosophy of mind, it is almost exclusively either Cartesian dualism or property dualism that is considered. The more traditional dualism defended by Aristotelians and Thomists, what I call hylemorphic dualism, has only received scattered attention. In this essay I set out the main lines of the hylemorphic dualist position, with particular reference to personal identity. First I argue that overemphasis (...) of the problem of consciousness has had an unhealthy effect on recent debate, claiming instead that we should emphasize the concept of form. Then I bring in the concept of identity by means of the notion of substantial form. I continue by analyzing the relation between form and matter, defending the traditional theses of prime matter and of the unicity of substantial form. I then argue for the immateriality of the substantial form of the human person, viz. the soul, from an account of the human intellect. From this follows the soul's essential independence of matter. Finally, although the soul is the immaterial bearer of personal identity, that identity is still the identity of an essentially embodied being. I explain how these ideas are to be reconciled. Footnotesa I am grateful to Stephen Braude, John Cottingham, John Haldane, David Jehle, Joel Katzav, Eduardo Ortiz, and Fred Sommers for helpful comments and discussion of a draft of this essay. I would also like to thank Ellen Paul, whose suggestions have helped greatly to improve the essay's style and content. (shrink)

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

Corruptionism is the view that following physical death, the human being ceases to exist but their soul persists in the afterlife. Survivalism holds that both the human being and their soul persist in the afterlife, as distinct entities, with the soul constituting the human. Each position has its defenders, most of whom appeal both to metaphysical considerations and to the authority of St Thomas Aquinas. Corruptionists claim that survivalism violates a basic principle of any plausible mereology, while survivalists tend to (...) reject the principle, though without as much detail as one would like. In this paper I examine both the key exegetical issues and the mereological question, arguing that Aquinas cannot be shown to have supported the principle in question, and that the principle should be rejected on independent grounds. If correct, some key planks in support of survivalism are established, with others to await further examination. (shrink)

This study explores experiences of ex-incels—men who have withdrawn from incel communities—through eleven qualitative interviews analysed using R.W. Connell’s hegemonic masculinity (HM) framework. Findings reveal some ex-incels adopt flexible masculinities, while others struggle with prescriptive norms perpetuated by the anti-feminist ‘manosphere’. Findings spotlight identity reconstructions, where men both reject and remain influenced by rigid archetypes, performing hybrid masculinities. This study deepens understanding of incel ideology, its impact on identity, and interplay between inceldom and masculinities via contributing to hybrid masculinities theorising. (...) Insights presents applications for gender theory and inform further research on HM’s influence within unique cultural contexts. (shrink)

This is a brief introduction to the origin and development of Protestant ethical works in the tradition of Aristotle’s Nicomachean Ethics.

There is a tension between the reasonable desire not to be judgmental of other people’s behaviour or character, and the moral necessity of making negative judgments in some cases. I sketch a way in which we might accommodate both, via an evaluation of the good of reputation and the ethics of judgment of other people’s character and behaviour. I argue that a good reputation is a highly valuable good for its bearer, akin to a property right, and not to be (...) damaged without serious reason deriving from the demands of justice and the common welfare. Rash judgment wrongfully damages reputation and is sometimes a seriously immoral act. Rashness is not merely about lack of evidence, but involves lack of charity and is to be avoided even in some cases where the evidence of bad character or action is epistemically sufficient for judgment. I argue that the desirability of a good name for its holder, whether the reputation is deserved or not, means that in all but a relatively narrow range of cases it is always wrong to think badly of someone, even if they are bad. (shrink)

The computational genomics community has come increasingly to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). We here address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations in the hope that this will lead to better representations of biological reality through (...) both the annotation process and ontology development, and in more informed use of the GO resources by experimental scientists. (shrink)

Many scholars have argued that the Protestant Reformation generally departed from virtue ethics, and this claim is often accepted by Protestant ethicists. This essay argues against such discontinuity by demonstrating John Calvin’s reception of ethical concepts from Augustine and Aristotle. Calvin drew on Augustine’s concept of eudaimonia and many aspects of Aristotle’s Nicomachean Ethics , including concepts of choice, habit, virtue as a mean, and the specific virtues of justice and prudence. Calvin also evaluated the problem of pagan virtue in (...) light of traditional Augustinian texts discussed in the medieval period. He interpreted the Decalogue as teaching virtue, including the cardinal virtues of justice and temperance. Calvin was not the harbinger of an entirely new ethical paradigm, but rather a participant in the mainstream of Christian thinkers who maintained a dual interest in Aristotelian and Augustinian eudaimonist virtue ethics. (shrink)

Behavioral genetic (BG) research has yielded many important discoveries about the origins of human behavior, but offers little insight into how we might improve outcomes. We posit that this gap in our knowledge base stems in part from the epidemiologic nature of BG research questions. Namely, BG studies focus on understanding etiology as it currently exists, rather than etiology in environments that could exist but do not as of yet (e.g., etiology following an intervention). Put another way, they focus exclusively (...) on the etiology of “what is” rather than “what could be”. The current paper discusses various aspects of this field-wide methodological reality, and offers a way to overcome it by demonstrating how behavioral geneticists can incorporate an experimental approach into their work. We outline an ongoing study that embeds a randomized intervention within a twin design, connecting “what is” and “what could be” for the first time. We then lay out a more general framework for a new field—experimental BGs—which has the potential to advance both scientific inquiry and related philosophical discussions. (shrink)

Richard Baxter, one of the most famous Puritans of the seventeenth century, is generally known as a writer of practical and devotional literature. But he also excelled in knowledge of medieval and early modern scholastic theology, and was conversant with a wide variety of seventeenth-century philosophies. Baxter was among the early English polemicists to write against the mechanical philosophy of René Descartes and Pierre Gassendi in the years immediately following the establishment of the Royal Society. At the same time, he (...) was friends with Robert Boyle and Matthew Hale, corresponded with Joseph Glanvill, and engaged in philosophical controversy with Henry More. In this book, David Sytsma presents a chronological and thematic account of Baxter's relation to the people and concepts involved in the rise of mechanical philosophy in late-seventeenth-century England. -/- Drawing on largely unexamined works, including Baxter's Methodus Theologiae Christianae (1681) and manuscript treatises and correspondence, Sytsma discusses Baxter's response to mechanical philosophers on the nature of substance, laws of motion, the soul, and ethics. Analysis of these topics is framed by a consideration of the growth of Christian Epicureanism in England, Baxter's overall approach to reason and philosophy, and his attempt to understand creation as an analogical reflection of God's power, wisdom, and goodness, understood as vestigia Trinitatis. Baxter's views on reason, analogical knowledge of God, and vestigia Trinitatis draw on medieval precedents and directly inform a largely hostile, though partially accommodating, response to mechanical philosophy. (shrink)

Shepherd argues that we can know that there exists a universe external to the mind because that universe is the only possible cause of our sensations. As a part of that argument, Shepherd eliminates the possibility that sensations might be caused by other sensations on the grounds that sensations are merely momentary existences and so not capable of standing in causal relations with each other. And yet she claims that sensations do stand in causal relations to other objects, both as (...) the effects of the combination of the external world, our organs of sense, and our minds, and as the partial causes of other sensations. These claims together generate a puzzle. If sensations are too fleeting to stand in causal relations with each other, how are they nonetheless capable of standing in causal relations to other objects? I suggest that because sensations exist only for a moment, to stand in synchronous causal relations with other sensations would require that the two sensations exist at precisely the same moment. But since cause and effect are identical during the moment in which they are combined, any two sensations that exist for only the moment of their combination are identical. Nothing can be its own cause, so sensations cannot be the sole cause of other sensations. Sensations can be the partial cause or effect of other objects, though, so long as those objects endure for more than a single moment. For example, external objects, organs of sense, and the mind, all exist both before and after the moments in which they combine to form a sensation. So, while their combination is identical to that sensation in that moment, all of these other objects exist outside of that moment, and that combination as well. (shrink)

Sacrificial dilemmas such as the trolley problem play an important role in experimental philosophy (x-phi). But it is increasingly argued that, since we are not likely to encounter runaway trolleys in our daily life, the usefulness of such thought experiments for understanding moral judgments in more ecologically valid contexts may be limited. However, similar sacrificial dilemmas are experienced in real life by animal research decision makers. As part of their job, they must make decisions about the suffering, and often the (...) death, of many non-human animals. For this reason, a context-specific investigation of so-called “3R dilemmas” (i.e., dilemmas where there is a conflict between the principles of replacement, reduction, and refinement of the use of animals in research) is essential to improve the situation of both non-human animals and human stakeholders. An approach well suited for such investigation is experimental philosophical bioethics (“bioxphi”), which draws on methods similar to x-phi to probe more realistic, practical scenarios with an eye to informing normative debates and ethical policy. In this article, we argue for a need to investigate 3R dilemmas among professional decision-makers using the tools of bioxphi. In a first step, we define 3R dilemmas and discuss previous investigations of professionals’ attitudes in such cases. In a second step, we show how bioxphi is a promising method to investigate the whys and hows of professional decision-making in 3R dilemmas. In a last step, we provide a bioxphi template for 3R dilemmas, give recommendations on its use, explore the normative relevance of data collected by such means, and discuss important limitations. (shrink)

This essay examines the development of Reformed treatments of the affections in the period of early orthodoxy (ca. 1565-1640). I argue that discussion of the affections during this period grew within the broad framework of the Aristotelian psychology and certain polemical concerns initially established by early Reformed theologians. With the advent of Protestant universities and academies, Reformed ethicists and theologians treated the affections in greater detail, with a majority drawing on a generally Thomistic approach to the nature and division of (...) the affections, although not without a dissenting Scotistic minority. (shrink)

Shepherd’s argument against Hume’s thesis that an object can begin its existence uncaused has received short shrift in the secondary literature. I argue that the key to understanding that argument’s success is understanding its dialectical context. Shepherd sees the dialectical situation as follows. Hume presents an argument against Locke and Clarke the conclusion of which is that an object can come into existence uncaused. An essential premise of that argument is Hume’s theory of mental representation. Hume’s theory of mental representation, (...) however, is itself implausible and unsupported. Therefore, one need not accept this premise or this conclusion. Thus, Shepherd proceeds to her discussion of the relation of cause and effect free to help herself to the thesis that every beginning of existence must have a cause. Additionally, she elsewhere pays down the debt she incurs in that argument by presenting her own alternative theory of mental representation, which is both plausible in its own right, and can account for the error that she takes Hume to make. (shrink)

This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

This critical edition is the first ever publication of Hale's Of the Law of Nature, which previously existed only in manuscript form. After discussing and defining the law in general, Hale examines the natural law in particular, its discovery and divine origin, and how it relates to both biblical and human laws. Hale's treatise, which was likely written as part of his personal meditations, and was circulated among English lawyers after his death, reveals not only the close relationship between law (...) and theology in his thought, but also the importance of natural law to early modern legal thought. (shrink)

Dispositional essentialists argue that physical properties have their causal roles essentially. This is typically taken to mean that physical properties are identical to dispositions. I argue that this is untenable, and that we must instead say that properties bestow dispositions. I explore what it is for a property to have such a role essentially. Dispositional essentialists argue for their view by citing certain epistemological and metaphysical implications, and I appeal to these implications to place desiderata on the concept of essence (...) involved. I argue that the traditional modal theory of essence meets these desiderata, but that the resulting theory wrongly implies that certain dispositions essential to mass are essential to charge, thereby offering a new argument against modal theories of essence. I argue that dispositional essentialism requires a primitive notion of essence, and develop a primitivist theory based on Kit Fine's views. I show that the primitivist theory has all the virtues of the modal alternative, and none of the vices. I develop a novel way of thinking about the relationship between properties, laws and dispositions, and argue that it has distinct advantages over standard dispositional essentialist formulations. (shrink)

According to Richard Gelwick, one of the fundamental implications of Polanyi’s epistemology is that all intellectual disciplines are inherently heuristic. This article draws out the implications of a heuristic vision of theology latent in Polanyi’s thought by placing contemporary theologian David Brown’s dynamic understanding of tradition, imagination, and revelation in the context of a Polanyian-inspired vision of reality. Consequently, such a theology will follow the example of science, reimagining its task as one of discovery rather than mere reflection on (...) a timeless body of divine revelation. The ongoing development of a theological tradition thus involves the attempt to bring one’s understanding of the question of God to bear on the whole of the human experience. The pursuit of theology as a heuristic endeavor is a bold attempt to construct an integrated vision of nothing less than the entirety of all that is, without absolutizing one’s vision, and without giving up on the question of truth. (shrink)

This is a study of J.G. Fichte’s philosophy of mathematics and theory of geometry. It investigates both the external, formal & internal, cognitive parallels between the axioms, intuitions and constructions of geometry and the scientific methodology of the Fichtean system of philosophy. In contrast to 'ordinary' Euclidean geometry, in his Erlanger Logik of 1805 Fichte posits a model of an 'ursprüngliche' or original geometry. – That is to say, a synthetic and constructivistic conception of geometry grounded in ideal archetypal elements (...) that are grasped through geometrical or intelligible intuition. -/- Accordingly, this study classifies Fichte’s philosophy of mathematics as a whole as a species of mathematical Platonism or neo-Platonism, and concludes that the Wissenschaftslehre itself may be read as an attempt at a new philosophical mathesis, or a “mathesis of the mind.” -/- . (shrink)

Hylomorphists hold that substances are, in some sense, composites of matter and form. The form of a substance is typically taken to play a fundamental role in determining the unity or identity of the whole. Staunch hylomorphists think that this role is of a kind that precludes the ontological reduction of form to the physical and thus take their position to be inconsistent with physicalism. Forms, according to staunch hylomorphism, play a fundamental role in grounding their bearers’ proper parts and (...) that, it seems, rules out the physical grounding of form itself. I shall develop a physicalist version of hylomorphism that treats form as geometric structure and which, I shall argue, entails many of the central theses endorsed by staunch hylomorphists. Based on Shoemaker’s notion of conditional powers, I shall argue that the geometric structures of complex wholes are the conditions on at least some of the conditional powers of their bearers’ proper parts, transforming those powers into powers simpliciter. Thus, forms play a fundamental role in the dynamical evolution of the physical world, but without bestowing causal powers themselves and hence without violating the causal closure of the physical domain. If a substance’s proper parts are taken to be individuated by their powers simpliciter, then they derive their identities from their places in the substantial whole, which thus determines the identities of its proper parts without changing their intrinsic natures. (shrink)

Plato's Phaedo is a literary gem that develops many of his most famous ideas. David Ebrey's careful reinterpretation argues that the many debates about the dialogue cannot be resolved so long as we consider its passages in relative isolation from one another, separated from their intellectual background. His book shows how Plato responds to his literary, religious, scientific, and philosophical context, and argues that we can only understand the dialogue's central ideas and arguments in light of its overall structure. (...) This approach yields new interpretations of the dialogue's key ideas, including the nature and existence of 'Platonic' forms, the existence of the soul after death, the method of hypothesis, and the contemplative ethical ideal. Moreover, this comprehensive approach shows how the characters play an integral role in the Phaedo's development and how its literary structure complements Socrates' views while making its own distinctive contribution to the dialogue's drama and ideas. (shrink)

The notion of maximal greatness is arguably part of the very concept of God: something greater than God is not even possible. But how should we understand this notion? The aim of this paper is to provide a Śaivist answer to this question by analyzing the form of theism advocated in the Pratyabhijñā tradition. First, I extract a model of divine greatness, the Hierarchical Model, from Nagasawa’s work "Maximal God". According to the Hierarchical Model, God is that than which nothing (...) could be greater by virtue of being better suited than all other beings in relation to certain great-making properties (§1). I then offer an analysis of the form of theism advocated in the Pratyabhijñā tradition by discussing passages from the works of Somānanda, the founder of the Pratyabhijñā school, and of Utpaladeva, the most prominent of Somānanda’s disciples. I argue that the Pratyabhijñā theist cannot account for divine greatness in terms of the Hierarchical Model. My argument is that the Hierarchical Model requires a comparison between God and other beings that cannot be made with the Pratyabhijñā God (§2). Finally, I develop an original alternative model, the Unlimited Nature Model, that accounts for God’s maximal greatness in a way that suits Pratyabhijñā’s theism. According to the Unlimited Nature Model, the nature of all ordinary beings is metaphysically limited as a result of realizing only a small portion of the potential of what could be, and God is maximally great because only he has a completely unlimited nature (§3). (shrink)

Are the special sciences autonomous from physics? Those who say they are need to explain how dependent special science properties could feature in irreducible causal explanations, but that’s no easy task. The demands of a broadly physicalist worldview require that such properties are not only dependent on the physical, but also physically realized. Realized properties are derivative, so it’s natural to suppose that they have derivative causal powers. Correspondingly, philosophical orthodoxy has it that if we want special science properties to (...) bestow genuinely new causal powers, we must reject physical realization and embrace a form of emergentism, in which such properties arise from the physical by mysterious brute determination. In this paper, I argue that contrary to this orthodoxy, there are physically realized properties that bestow new causal powers in relation to their realizers. The key to my proposal is to reject causal-functional accounts of realization and embrace a broader account that allows for the realization of shapes and patterns. Unlike functional properties, such properties are defined by qualitative, non-causal specifications, so realizing them does not consist in bestowing causal powers. This, I argue, allows for causal novelty of the strongest kind. I argue that the molecular geometry of H2O—a qualitative, multiply realizable property—plays an irreducible role in explaining its dipole moment, and thereby bestows novel powers. On my proposal, special science properties can have the kind of causal novelty traditionally associated with strong emergence, without any of the mystery. (shrink)

Edited proceedings of an interdisciplinary symposium on consciousness held at the University of Cambridge in January 1978. Includes a foreword by Freeman Dyson. Chapter authors: G. Vesey, R.L. Gregory, H.C. Longuet-Higgins, N.K. Humphrey, H.B. Barlow, D.M. MacKay, B.D. Josephson, M. Roth, V.S. Ramachandran, S. Padfield, and (editorial summary only) E. Noakes. A scanned pdf is available from this web site (philpapers.org), while alternative versions more suitable for copying text are available from https://www.repository.cam.ac.uk/handle/1810/245189. -/- Page numbering convention for the pdf version (...) viewed in a pdf viewer is as follows: 'go to page n' accesses the pair of scanned pages 2n and 2n+1. Applicable licence: CC Attribution-NonCommercial-ShareAlike 2.0. (shrink)

This paper offers an original interpretation of the Daodejing 道德經 as containing a distinctive account of creation. In my reading, the Daodejing envisions the creation of the cosmos by Dao (1) as a movement from the absence of phenomenal forms to phenomenal forms and (2) as a movement from nothingness to existence. I interpret creation as a unique metaphysical operation that explains how (1) and (2) are possible. The paper is organized into two sections. First, I introduce the distinctions between (...) the lack and presence of phenomenal forms (§1.1) and between nothingness and existence (§1.2), using them to map the distinction between Dao and the created world. Then, I propose my account of the Daodejing’s metaphysics of creation (§2.1) and elaborate on its connection with the previously drawn distinctions while answering a potential objection (§2.2). I conclude with some considerations about the connections between the Daodejing’s view of creation and its soteriology. (shrink)

Fichte-Studien 49 (2021), edited by David W. Wood, published by Brill/Rodopi, 471pp. -/- Presenting new critical perspectives on J.G. Fichte’s Wissenschaftslehre, this volume of articles in English by an international group of scholars addresses the topic of first principles in Fichte’s writings. Especially discussed are the central text of his Jena period, the 1794/95 Grundlage der gesammten Wissenschaftslehre, as well as later versions like the Wissenschaftslehre nova methodo (1796-99) and the presentations of 1804 and 1805. Also included are new (...) studies on the first principles of the particular sub-disciplines of Fichte’s system, such as the doctrines of aesthetics, nature, right, ethics, and history. The volume also contains a number of miscellaneous essays on Fichte research, as well as several book reviews. (shrink)

• Aggregates of previously isolated cells of Hydra are capable, under suitable solvant conditions, of regeneration forming complete animals. In a first stage, ecto- and endodermal cells sort out, producing the bilayered hollow structure characteristic of Hydra tissue; thereafter, heads are formed (even if the original cell preparation contained no head cells), eventually leading to the separation of normal animals with head, body column and foot. Hydra appears to be the highest type of organism that allows for regeneration of the (...) entire structure from random cell aggregates. The system is particularly useful for studying cell interactions, tissue polarity, pattern formation, and cell differentiation. (shrink)

I argue that Meno’s Paradox targets the type of knowledge that Socrates has been looking for earlier in the dialogue: knowledge grounded in explanatory definitions. Socrates places strict requirements on definitions and thinks we need these definitions to acquire knowledge. Meno’s challenge uses Socrates’ constraints to argue that we can neither propose definitions nor recognize them. To understand Socrates’ response to the challenge, we need to view Meno’s challenge and Socrates’ response as part of a larger disagreement about the value (...) of inquiry. (shrink)

A spirited reading of Derrida’s view of ethics as transcendental and performative.

Lady Mary Shepherd holds that the relation of cause and effect consists of the combination of two objects to create a third object. She also holds that this account implies that causes are synchronous with their effects. There is a single instant in which the objects that are causes combine to create the object which is their effect. Hume argues that cause and effect cannot be synchronous because if they were then the entire chain of successive causes and effects would (...) all collapse into a single moment, and succession would not be possible. I argue that Shepherd has a ready, although implicit response, to Hume’s argument. Since causation is combination on Shepherd’s view, she is free to hold that there are times in between those instants in which combinations occur, during which times other, non-combinatory changes occur, which changes account for succession. (shrink)

In the recent literature, it has been shown that the wave function in the de Broglie–Bohm theory can be regarded as a new kind of field, i.e., a "multi-field", in three-dimensional space. In this paper, I argue that the natural framework for the multi-field is the original second-order Bohm’s theory. In this context, it is possible: i) to construe the multi-field as a real-valued scalar field; ii) to explain the physical interaction between the multi-field and the Bohmian particles; and iii) (...) to clarify the status of the energy-momentum conservation and the dynamics of the theory. (shrink)

According to dispositionalism about modality, a proposition <p> is possible just in case something has, or some things have, a power or disposition for its truth; and <p> is necessary just in case nothing has a power for its falsity. But are there enough powers to go around? In Yates (2015) I argued that in the case of mathematical truths such as <2+2=4>, nothing has the power to bring about their falsity or their truth, which means they come out both (...) necessary and not possible. Combining this with axiom (T), it is easy to derive a contradiction. I suggested that dispositionalists ought to retreat a little and say that <p> is possible just in case either p, or there is a power to bring it about that p, grounding the possibility of mathematical propositions in their truth rather than in powers. Vetter’s (2015) has the resources to provide a response to my argument, and in her (2018) she explicitly addresses it by arguing for a plenitude of powers, based on the idea that dispositions come in degrees, with necessary properties a limiting case of dispositionality. On this view there is a power for <2+2=4>, without there being a power to bring about its truth. In this paper I argue that Vetter’s case for plenitude does not work. However, I suggest, if we are prepared to accept metaphysical causation, a case can be made that there is indeed a power for <2+2=4>. (shrink)

Musical works change. Bruckner revised his Eighth Symphony. Ella Fitzgerald and many other artists have made it acceptable to sing the jazz standard “All the Things You Are” without its original verse. If we accept that musical works genuinely change in these ways, a puzzle arises: why can’t I change Bruckner’s Eighth Symphony? More generally, why are some individuals in a privileged position when it comes to changing musical works and other artifacts, such as novels, films, and games? I give (...) a view of musical works that helps to answer these questions. Musical works, on this view, are created abstract objects with no parts. The paradigmatic changes that musical works undergo are socially determined normative changes in how they should be performed. Due to contingent social practices, Bruckner, but not I, can change how his symphony should be performed. Were social practices radically different, I would be able to change his symphony. This view extends to abstract artifacts beyond music, including novels, films, words, games, and corporations. (shrink)

If the reliability of a source of testimony is open to question, it seems epistemically illegitimate to verify the source’s reliability by appealing to that source’s own testimony. Is this because it is illegitimate to trust a questionable source’s testimony on any matter whatsoever? Or is there a distinctive problem with appealing to the source’s testimony on the matter of that source’s own reliability? After distinguishing between two kinds of epistemically illegitimate circularity—bootstrapping and self-verification—I argue for a qualified version of (...) the claim that there is nothing especially illegitimate about using a questionable source to evaluate its own reliability. Instead, it is illegitimate to appeal to a questionable source’s testimony on any matter whatsoever, with the matter of the source’s own reliability serving only as a special case. (shrink)

Sydney Shoemaker has been arguing for more than a decade for an account of the mind–body problem in which the notion of realization takes centre stage. His aim is to provide a notion of realization that is consistent with the multiple realizability of mental properties or events, and which explains: how the physical grounds the mental; and why the causal work of mental events is not screened off by that of physical events. Shoemaker's proposal consists of individuating properties in terms (...) of causal powers, and defining realization as a relation of inclusion between sets of causal powers. Thus, as the causal powers that define a mental property are a subset of the causal powers that characterize a physical property, it can be said that physical properties realize mental properties. In this paper we examine the physicalist credentials of Shoemaker's mind–body theory in relation to three important issues: the direction of the relation of dependence that the theory is committed to; the possibility of mental properties existing without being anchored by physical properties; and the compatibility of the theory with the causal closure of the physical world. We argue that Shoemaker's theory is problematic in all three respects. After that we consider whether the theory should count as a mind–body theory at all, given that it seems to be committed to a distorted view of mental properties. (shrink)

Derek Parfit, in On What Matters, argues that all subjective accounts of normative reasons for action are false. This chapter focuses on his “Agony Argument.” The first premise of the Agony Argument is that we necessarily have current reasons to avoid our own future agony. Its second premise is that subjective accounts cannot vindicate this fact. So, the argument concludes, subjective accounts must be rejected. This chapter accepts the first premise of this argument and that it is valid. The main (...) thesis of this chapter is that subjectivists can account for our reasons to get pleasure and avoid agony. The chapter concludes that the Agony Argument does not justify the rejection of subjective accounts. The chapter also examines Parfit's understanding of the distinction between objective and subjective theories. The chapter claims Parfit offers a surprisingly narrow understanding of subjectivism such that even if his critique were successful, this would be bad news for fewer theories than we might have thought. Finally, the chapter replies to some possible worries about the arguments of this chapter. (shrink)

For Kant, any authentic moral demands are wholly distinct from the demands of prudence. This has led critics to complain that Kantian moral demands are incompatible with our human nature as happiness-seekers. Kant’s defenders have pointed out, correctly, that Kant can and does assert that it is permissible, at least in principle, to pursue our own happiness. But this response does not eliminate the worry that a life organized around the pursuit of virtue might turn out to be one from (...) which we cannot expect any of this (permissible) happiness. To address this worry, Kant would need to establish that there is a kind of harmony between virtue and our own happiness that can give us confidence that aiming at morality does not require us to abandon our hope for happiness in this life. This paper aims to show that Kant—building on insights from Rousseau that Kant identifies with Cynicism—does offer an account of such a harmony between virtue and worldly happiness. (shrink)

Formally-inclined epistemologists often theorize about ideally rational agents--agents who exemplify rational ideals, such as probabilistic coherence, that human beings could never fully realize. This approach can be defended against the well-know worry that abstracting from human cognitive imperfections deprives the approach of interest. But a different worry arises when we ask what an ideal agent should believe about her own cognitive perfection (even an agent who is in fact cognitively perfect might, it would seem, be uncertain of this fact). Consideration (...) of this question reveals an interesting feature of the structure of our epistemic ideals: for agents with limited information, our epistemic ideals turn out to conflict with one another. (shrink)

Paul Feyerabend argued that theories can be faced with experimental anomalies whose refuting character can only be recognized by developing alternatives to the theory. The alternate theory must explain the experimental results without contrivance and it must also be supported by independent evidence. I show that the situation described by Feyerabend arises again and again in experiments or observations that test the postulates in the standard cosmological model relating to dark matter. The alternate theory is Milgrom’s modified dynamics. I discuss (...) three examples: the failure to detect dark-matter particles in laboratory experiments; the lack of evidence for dark-matter sub-haloes and the dwarf galaxies that are postulated to inhabit them; and the failure to confirm the predicted orbital decay of Milky Way satellite galaxies and other systems due to dynamical friction against the dark matter. In each case, Feyerabend’s criterion directs us to interpret the experimental or observational results as an indirect refutation of the standard cosmological model in favor of Milgrom’s theory. (shrink)

Failure to recognize the "realistic" motivations for Putnam's commitment to internal realism has led to a widely shared misunderstanding of Putnam's arguments against metaphysical realism. Realist critics of these arguments frequently offer rebuttals that fail to confront his arguments. Simply put, Putnam's arguments --the brains in a vat argument as well as the model-theoretic argument -- are "reductios" that are intended to show that "metaphysical realism itself is not sufficiently realistic". If that claim can be substantiated then Putnam can go (...) on to argue that his own view is, by comparison, more realistic than metaphysical realism. (shrink)