Much has been said about the need for improving the current definitions of scientific authorship, but an aspect that is often overlooked is how to formulate and communicate these definitions to ensure that they are comprehensible and useful for researchers, notably researchers active in international research consortia. In light of a rapid increase in international collaborations within natural sciences, this article uses authorship of this branch of sciences as an example and provides suggestions to improve the comprehensibility of the definitions (...) of authorship in natural sciences. It assesses whether the definition of authorship provided by the European Code of Conduct for Research Integrity can deal with current issues and problems of scientific authorship. Notably, problems that are experienced in project groups with researchers coming from multiple countries. Using theories developed by Jürgen Habermas and Robert Merton, a normative framework is developed to articulate ethical authorship in natural sciences. Accordingly, enriching the current definition of authorship with normative elements and using discipline-specific metaphors to communicate them are introduced as possible ways of improving the comprehensibility of the definition of authorship in international environments. Finally, this article provides a proposal to be considered in the future revisions of the European Code of Conduct for Research Integrity. (shrink)
The practice of assigning authorship for a scientific publication tends to raise two normative questions: 1) ‘who should be credited as an author?’; 2) ‘who should not be credited as an author but should still be acknowledged?’. With the publication of the revised version of The European Code of Conduct for Research Integrity (ECCRI), standard answers to these questions have been called into question. This article examines the ways in which the ECCRI approaches these two questions and compares these approaches (...) to standard definitions of ‘authorship’ and ‘acknowledgment’ in guidelines issued by the International Committee of Medical Journal Editors (ICMJE) and the World Association of Medical Editors (WAME). In light of two scenarios and the problems posed by these kinds of ‘real-world’ examples, we recommend specific revisions to the content of the ECCRI in order not only to provide a more detailed account of the tasks deserving of acknowledgment, but to improve the Code’s current definition of authorship. (shrink)
This essay briefly evaluates the ongoing controversy between LIU Qingping and GUO Qiyong (and their followers) about the “moral heart ”of Confucianism in order to draw acomparison with Islamic ethics for mutual illumination of the two traditions.
Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable conditions such as presence of antibiotics, host defense or oxidative stresses. Biofilms are often considered hot spot for horizontal gene transfer among same or different bacterial species. Furthermore, bacteria with increased hydrophobicity facilitate biofilm formation by reducing repulsion between the extracellular matrix and the bacterium. There (...) is a marked increase in the rate of persons nonresponsive to antibiotic therapy for infections of the Urinary Tract (UTIs), burns and upper respiratory tract due to biofilm formations. It is estimated that 90% of nosocomial infections are mediated by biofilm. The role of biofilm in infections has become so great that the treatment of such antibiotic resistance infections is proving difficult and costly to health care systems. The biofilm related infections varied from dental plaque, destruction of prosthetic valve to death of cystic fibrosis patients. This review aims to provide a summary of role of bacterial biofilm and its clinical implications for the patients. (shrink)
I try to show that Richard Rorty, although is not a moral philosopher like Kant, nerveless, has moral philosophy that must be taken seriously. Rorty was not engaged with moral philosophy in the systematic manner common among leading modern and contemporary moral philosophers. This paper has two parts: first part, in brief, is concerned with principles of his philosophy such as anti-essentialism, Darwinism, Freudism, and historicism. Second part which be long and detailed, considers many moral themes in Rorty's thought such (...) as critique of Kantian morality, solidarity, moral progress, cruelty and concept of other, etc. Subsequently, I will try to answer the research question of the article namely, has Rorty a moral philosophy? (shrink)
This paper clarifies the philosophical connection between Al-Ghazali and Descartes, with the goal to articulate similarities and differences in their famous journeys from doubt to certainty. As such, its primary focus is on the chain of their reasoning, starting from their conceptions of truth and doubt arguments, until their arrival at truth. Both philosophers agreed on the ambiguous character of ordinary everyday knowledge and decided to set forth in undermining its foundations. As such, most scholars tend to agree that the (...) doubt arguments used by Descartes and Al-Ghazali are similar, but identify their departures from doubt as radically different: while Descartes found his way out of doubt through the cogito and so reason, Al-Ghazali ended his philosophical journey as a Sufi in a sheer state of passivity, waiting for the truth to be revealed to him by God. This paper proves this is not the case. Under close textual scrutiny and through the use of basic Husserlian-phenomenological concepts, I show that Al-Ghazali's position was misunderstood, thus disclosing his true philosophic nature. (shrink)
در اين جستار بر آنيم اصول وجود شناختي و معرفت شناختي افلاطون در محاورات اوليه و علي الخصوص لاخس، خارميدس، اوثيفرون، اوتيدموس و هيپياس بزرگ را بر مبناي سه عنصر آنچه «دور سقراطي» مي ناميم يعني پرسش سقراطي، ادعاي سقراطي انكار دانش و النخوس مورد بررسي قرار دهيم. حاصل اين بررسي شش اصل وجود - معرفت شناختي است: شناخت الف، معرفتشناسي دوقطبي، وجودشناسي دوقطبي، معرفت گسسته، وجود گسسته و معرفت وجود. اگرچه اين اصول عمدتاً جديد نبوده و پيشتر مورد بحث (...) محققان قرار گرفتهاند، آنچه مورد نظر اين جستار است در نظر گرفتن آين اصول در كنار يكديگر و تاكيد بر هماهنگي و مطلق بودن آنهاست. تناسب و هماهنگي ميان اصول معرفت شناختي و اصول وجودشناختي و همساني آنها در برخي ويژگي ها همچون مطلق بودن و گسستگي علاوه بر آنكه نشان دهنده سازگاري نظري محاورات اوليه است، مي تواند تاييدي بر نتايج اين تحقيق باشد. (shrink)
در اين جستار برآنيم كه ترتيبي جديد از محاورات افلاطون ارائه نمائيم؛ ترتيبي كه بر مبناي توسعه وجودشناختي و معرفت شناختي افلاطون مبتني است و تفاوتهاي اساسي با كرونولوژي غالب امروزي محاورات دارد. در حاليكه در همه كرونولوژي هاي پذيرفته شده فعلي، پارمنيدس به عنوان نقد نظريه مثال در محاورات مياني و بنابراين متأخر از اين محاورات در نظر گرفته ميشود، كرونولوژي پيشنهادي ما پارمنيدس را پس از محاورات اوليه و پيش از محاورات مياني قرار ميدهد. بر اساس اين تغيير (...) نه تنها منون، فايدون، فايدروس و جمهوري پس از پارمنيدس قرار ميگيرند، بلكه ميان ثئايتتوس و سوفيست از يك طرف و فايدون و جمهوري از طرف ديگر، فاصله زيادي ايجاد ميشود به طوري كه منون و فايدون ميان جفت اول و سوفيست و تيمايوس ميان جفت دوم قرار ميگيرند. در اين جستار نشان خواهيم داد كه چگونه اين تغييرات ميتوانند به خوانشي سازگارتر از محاورات مياني و متأخر كمك كنند و در عين حال از بسياري مشكلات ناشي از كرونولوژيهاي ديگر بپرهيزند. (shrink)
در اين مقاله تلاش ميكنیم روايت ارسطو از پيشسقراطيان را بر اساس متون خود ارسطو و عمدتاً با استفاده از كتابهاي متافيزيك، فيزيك و كون و فساد مورد بررسي قرار دهیم و نشان دهيم چگونه ارسطو همه پيشسقراطيان را به يك نحو و بر مبناي چهارچوب فلسفه خودتفسير ميكند. او آرخه پيشسقراطي را به معناي عنصر يعني امري بسيط كه خود از چيز ديگري نيست و همه چيز از آن تركيب شده است، تفسير مي كند و حتي آن را به (...) عنوان جوهر و هر چيز ديگر را به عنوان عرض در نظرمي گيرد و تمايز آرخه و اشياء را بر مبناي اين تقابل در فلسفه خود مورد تفسير قرار ميدهد. ارسطو همچنين نگاه پیش سقراطیان به تغییر را بر مبناي تمايز خود ميان تغيير و كون و فساد تحليل ميكند. همه اين موارد نشانگر آن هستند که ارسطو پیش سقراطیان را ارسطوئی و بر مبنای اندیشه خود تفسیر کرده است. در اين صورت، با توجه به اينكه ارسطو از اولين و مهم ترين منابع انديشه هاي پيش سقراطيان است، در بررسي آنها همواره بايد نقش ارسطو را مد نظر قرار داد. (shrink)
That i) there is a somehow determined chronology of Plato’s dialogues among all the chronologies of the last century and ii) this theory is subject to many objections, are points this article intends to discuss. Almost all the main suggested chronologies of the last century agree that Parmenides and Theaetetus should be located after dialogues like Meno, Phaedo and Republic and before Sophist, Politicus, Timaeus, Laws and Philebus. The eight objections we brought against this arrangement claim that to place the (...) dialogues like Meno, Phaedo and Republic both immediately after the early ones and before Parmenides and Theaetetus is epistemologically and ontologically problematic. (shrink)
This paper aims to suggest a new arrangement of Plato’s dialogues based on a different theory of the ontological as well as epistemological development of his philosophy. In this new arrangement, which proposes essential changes in the currently agreed upon chronology of the dialogues, Parmenides must be considered as criticizing an elementary theory of Forms and not the theory of so-called middle dialogues. Dated all as later than Parmenides, the so-called middle and late dialoguesare regarded as two consecutive endeavors to (...) resolve the problems drawn out in there; an effort in the theory of knowledge through Theaetetus, Meno and Phaedo and another in ontology through the second part of Parmenides, Sophist and Republic. (shrink)
This paper aims to suggest a new approach to Plato’s theory of being in Republic V and Sophist based on the notion of difference and the being of a copy. To understand Plato’s ontology in these two dialogues we are going to suggest a theory we call Pollachos Esti; a name we took from Aristotle’s pollachos legetai both to remind the similarities of the two structures and to reach a consistent view of Plato’s ontology. Based on this theory, when Plato (...) says that something both is and is not, he is applying difference on being which is interpreted here as saying, borrowing Aristotle’s terminology, 'is is (esti) in different senses'. I hope this paper can show how Pollachos Esti can bring forth not only a new approach to Plato’s ontology in Sophist and Republic but also a different approach to being in general. (shrink)
Regarding the relation of Plato’s early and middle period dialogues, scholars have been divided to two opposing groups: unitarists and developmentalists. While developmentalists try to prove that there are some noticeable and even fundamental differences between Plato’s early and middle period dialogues, the unitarists assert that there is no essential difference in there. The main goal of this article is to suggest that some of Plato’s ontological as well as epistemological principles change, both radically and fundamentally, between the early and (...) middle period dialogues. Though this is a kind of strengthening the developmentalistic approach corresponding the relation of the early and middle period dialogues, based on the fact that what is to be proved here is a essential development in Plato’ ontology and his epistemology, by expanding the grounds of development to the ontological and epistemological principles, it hints to a more profound development. The fact that the bipolar and split knowledge and being of the early period dialogues give way to the tripartite and bound knowledge and benig of the middle period dialogues indicates the development of the notions of being and knowledge in Plato’s philosophy before the dialogues of the middle period. (shrink)
This essay intends to discuss what Plato was seeking as an explanation in Phaedo. In this dialogue, we observe Socrates criticizing both the natural scientists’ explanations and Anaxagoras’ theory of Mind because they could not explain all things, firstly, in a unitary and, secondary, in a real way. Thence, we are to call what Plato is seeking as his ideal explanation in Phaedo “One Real Explanation”. He talks at least about three kinds of explanation, two of which, the confused and (...) foolish way of explanation by Forms and the explanation by Forms appealing to essence, are just "second best" and lower degrees of explanation. His ideal explanation is an explanation that can explain all things by one thing and in a real way. Though he cannot show, at least in Phaedo, how this One Real Explanation can work, we can see Plato completing the theory by the Form of the Good in Republic. (shrink)
Investigating Plato’s ontological as well as epistemological status in each of his dialogues, this book is going to challenge the current theories of Plato’s development and suggest a new theory. Regarding the relation of Plato’s early and middle period dialogues, scholars have been divided to two opposing groups: unitarists and developmentalists. While developmentalists try to prove that there are some noticeable and even fundamental differences between Plato’s early and middle period dialogues, the unitarists assert that there is no essential difference (...) in there. The main goal of the first two chapters is to suggest that some of Plato’s ontological as well as epistemological principles change, both radically and fundamentally, between the early and middle period dialogues. Though this is a kind of strengthening the developmentalistic approach corresponding the relation of the early and middle period dialogues, based on the fact that what is to be proved here is a essential development in Plato’ ontology and his epistemology, by expanding the grounds of development to the ontological and epistemological principles, it hints to a more profound development. The fact that the bipolar and split knowledge and being of the early period dialogues give way to the tripartite and bound knowledge and benig of the middle period dialogues indicates the development of the notions of being and knowledge in Plato’s philosophy before the dialogues of the middle period. The first chapter entitled “Plato’s Onto-Epistemological Principles in the Early Dialogues” tries to draw out six principles out of Plato’s early dialogues specially Euthyphro, Laches, Charmides, Hippias Major and Euthydemus. We discuss that these principles present kind of a bipolar as well as split ontology and epistemology. The second chapter, “Revision of First Socrates’ Principles in the Middle Period Dialogues”, aims to argue that the onto-epistemological principles of the early dialogues are being radically changed in three dialogues of Meno, Phaedo and Republic in the middle period dialogues. Not only the bipolar ontology and epistemology of the early dialogues give place to a tripartite ontology and epistemology but also their split being and knowledge are inclined to be replaced by bound being and knowledge. Our next step in this book is to suggest a new approach to Plato’s theory of being in Republic V and Sophist based on the notion of difference and the being of a copy. To understand Plato’s ontology in these two dialogues we are going to suggest a theory we call Pollachos Esti; a name we took from Aristotle’s pollachos legetai both to remind the similarities of the two structures and to reach a consistent view of Plato’s ontology. Based on this theory, when Plato says that something both is and is not, he is applying difference on being which is interpreted here as saying, borrowing Aristotle’s terminology, 'is is (esti) in different senses'. I hope this paper can show how Pollachos Esti can bring forth not only a new approach to Plato’s ontology in Sophist and Republic but also a different approach to being in general. Thence, chapter three, “Pollachos Esti; Plato’s Ontology in Sophist and Republic”, intends to discuss that i) the theories of ‘being as difference’ and ‘being of a copy’, considered together in what we call the theory of pollachos esti, can well be compared to the structure of pollachos legetai in Aristotle when it is attached to the theories of pros hen and substance; and ii) the ontology of Republic V-VII is based on this theory and is, thus, almost the same as the ontology of Sophist. Investigating the most famous chronologies of the last 150 years from Campbell on, the fourth chapter, “The Standard Chronology of the Dialogues”, is to argue that all of them have a somewhat fix and dogmatic arrangement of Plato’s dialogues in which Meno, Phaedo and Republic are located after some early dialogues and before Theaetetus and Parmenides, on the one hand, and all the so-called late period dialogues after Theaetetus and Parmenides on the other hand. It is also reminded that all that the stylometric evidences can show is the lateness and homogeneity of the late period dialogues and, thence, nothing about the relation between dialogues like Theaetetus, Parmenides and Republic. The standard chronology is the subject of many criticisms some of which are discussed in our fifth chapter, “Objections against the Standard Chronology”, in three groups. While the first group of objections criticizes the place of the middle period dialogues immediately after the early ones, the second group attacks the place of late dialogues after the middle ones. The third group includes objections against the place of Parmenides in the standard chronology and tries to show that it cannot be considered after the middle period dialogues. The efforts of the first five chapters lead to a new theory of Plato’s ontological as well as epistemological development in an onto-epistemological chronology of his dialogues in our sixth chapter, “An Onto-Epistemological Chronology of Plato’s dialogues”. Instead of three periods, this chronology includes four waves of dialogues, Socratic wave, ontological wave, epistemological wave and political wave, in which all the so-called middle and late period dialogues are to be interpreted based on the problems presented in Parmenides I. The main changes we suggest in the standard chronology include firstly that Theaetetus and Parmenides I must be posited before Meno and Phaedo and, secondly, Republic must be posited after Sophist. Based on this arrangement, we can find Philosophos, Plato’s promised but unwritten dialogue, inside Republic. (shrink)
كانت وجود علم و اخلاق را پيش فرض ميگيرد و به بررسـي حـدود و ثغـور هـر يـك ميپردازد. در اين راه او از اصطلاحات «عقل» و «فاهمه» استفاده ميكند. در اين مقاله به تعريف اين دو مفهوم نزد كانت، از ديدگاهي كه وجـه تمـايز آنهـا را آشـكارتر كنـد، پرداخته ميشود؛ سپس جايگاه اين دو قوه در حيطـة علـم بررسـي و آنگـاه بـا بررسـي مواضع اخلاقي كانت نتيجه گرفته ميشود كه از ديدگاه وي كار ويـژة عقـل در حيطـه عمل و اخلاق (...) رخ مينمايد و عقل محض در ذات خود عملي است. (shrink)
In the article of Bueno titled “Davidson and Skepticism: How Not to Respond to the Skeptic,” he intends to demonstrate that although Davidson’s theory of Coherence holds many attractions, it does not entail a response to any kinds of skepticism including Global, Lottery, and Pyrrhonian. In this study, the goal is to criticize the work of Prof. Bueno in connection with two criticisms raised by him over Davidson’s anti-skeptical strategy. Further, by giving some reasons in favor of Davidson’s anti-skepticism argument, (...) it will be shown that neither the above stated criticisms nor the global skepticism response could undermine the validity of anti-skepticism argument. (shrink)
Turing does not provide an explanation for substituting the original question of his test – i.e., “Can machines think?” with “Can a machine pass the imitation game?” – resulting in an argumentative gap in his main thesis. In this article, I argue that a positive answer to the second question would mean attributing the ability of linguistic interactions to machines; while a positive answer to the original question would mean attributing the ability of thinking to machines. In such a situation, (...) defending the Turing Test requires establishing a relationship between thought and language. In this regard, Davidson's no-priority theory is presented as an approach for defending the test. (shrink)
Colistin is drug of choice for treatment of carbapenem resistant Acinetobacter baumannii infections, but increasing colistin resistance (Col-R) has been emerged across the globe. In this study, we collected 187 A. baumannii isolates from specimens of 240 patients admitted to intensive care units (ICUs) of two hospitals in Kerman, Iran during 2017-2018. Among the isolates, four isogenic extensive drug-resistant (XDR) strains with Minimum Inhibitory Concentration (MIC) ≥4 µg/mL against colistin were selected for further study. All the Col-R isolates harbored an (...) intrinsic blaOXA–51 and blaOXA-23 carbapenemase genes. They were resistant to all antibiotic classes except tigecycline and ampicillin-sulbactam. The Col-R isolates were belonged to clonal complex 2, a new ST type 1752 and had identical high-quality RAPD-PCR fingerprints. Phylogenetic tree analysis of PmrA/B suggested that, the Col-R A. baumannii were emerged by endogenous mutations rather than acquisition of preexisting clone. In addition, DNA sequencing of the Col-R genes, showed three different nonsynonymous substitutions in LpxA (N136→K), LpxC (P293→Q) and PmrB transmembrane motif (V21→F and S28→R) of the strains 1 and 3. Interestingly, these strains showed high level MIC against colistin (MIC 32µg/mL). Analysis of gene expression by relative quantitative real-time PCR (qRT-PCR) revealed 8- and 7.1-folds increases in the transcription levels of pmrB and pmrC genes in the strain 1 when cells grown in the presence of 16 µg/mL colistin (p≤0.01). In conclusion, the above results provide valuable insights into the mechanism of Col-R in A. baumannii and the expressions of relative genes. (shrink)
In this paper, an interpretation of "necessity", inspired by a Leibnizian idea and based on the method of dialogical logic, is introduced. The semantic rules corresponding to such an account of necessity are developed, and then some peculiarities, and some potential advantages, of the introduced dialogical explanation, in comparison with the customary explanation offered by the possible worlds semantics, are briefly discussed.
Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm among multi-drug-resistant A. baumannii (MDRAB). Sixty-five MDRAB isolates from clinical samples were collected. Molecular typing was carried out by random amplified polymorphism DNA polymerase chain reaction (RAPD-PCR). Biofilm (...) formation was assayed by the microtiter method. The sequence of bap was determined and deposited in the GenBank database (accession no. KR080550.1). Expression of bap in the presence of low iron was analyzed by relative quantitative real time PCR (rqRT-PCR). Nearly half of the isolates belonged to RAPD-types A and B remaining were either small clusters or singleton. The results of biofilm formation revealed that 23 (35.4%), 18 (27.7%), 13 (20%), and 11 (16.9%) of the isolates had strong, moderate, weak, and no biofilm activities, respectively. ompA and csuE genes were detected in all, while bap and blaPER-1 were detected in 43 (66%) and 42 (64%) of the isolates that showed strong and moderate biofilm activities (p ≤ 0.05), respectively. Analysis of bap expression by rqRT-PCR revealed five isolates with four-fold bap overexpression in the presence of low iron concentration (20 µM). The results suggest that bap overexpression may influence biofilm formation in presence of low iron concentration. (shrink)
This Paper attempts to Jude the axiology of Aristotle’s Philosophy based on Aristotelian Philosophy. For this Purpose, we will first Prove axiology as a kind of knowledge and then we will study the relation between axiology and two others knowledge domains, that is, ontology and epistemology. We will demonstrate that values like goodness and beauty, are same final cause and formal cause for explanation of values of every thing. At least, in the nature, goodness and beauty are the idea of (...) reality which is Present in every things. Although values Such as beauty and splendor, good and bad exist in relation with us. Indeed, Such values don’t have objective being nor ideal existence. Form epistemology Point of view, the values are known with their formal Cause ,that is, with their general form. In Aristotle’s axiology the concept of the end(Telos) is a fundamental concept which shows that the Aristotle’s Philosophy system is a coherent system. thus Aristotle maintains to ontological and epistemological aspects of the values. Also He has even considered hierarchy of value for creatures, knowledge and values itself. Thus , every thing lied in the hierarchy of valuation which has roots in the concept of the end. It also shows that Aristotle either in the position of philosopher or the position of valuation cannot be free from the valuation of ontology and epistemology. Whit such approach, the second section of the paper attempts to show that the end in Aristotle’s Ethic is Idea of perfect that the human attempts to reach happiness in accordance whit the most complete and the most excellent of the virtue and every one should take care of domination of reason over human behavior and whit continuous practice and one can accomplish the virtues whit no extreme this way, all ethic virtues will be obtained by trusting to one’s capability. (shrink)
One of the most important questions in epistemology is the nonphysical realities, like phenomenal consciousness. The main claim of physicalism is real explanations of events and properties are only physical explanations and representationalists are agree too. Thus these realities can explained by the rule of biases of physical and objective events.On the other hand , phenomenalists maintain that conscious experiences and aspect of subjectivity of phenomenal consciousness are not. In this article I attempt formulated the problem of phenomenal consciousness based (...) on the Perspectival Subjectivity and next proposed the solutions of theories of representation of mind then declare objections on the theories of representation of mind. There is a question as can be the theory of representation of mind the frame for causal explanation of the problems of phenomenal consciousness? (shrink)
Reflecting on Avicenna’s works indicates that by ‘Dhat’(ذات), when used in the context of universal essences, he means either the quiddity or the nature, and when used in the context of individual essence, especially God’s essence, he means the very existence. The second meaning, i.e. the nature, which is the result of his inquiry about the reality of things, is based on the first one, i.e. the quiddity. According to this second meaning, and througha kind of thought experiment and using (...) human mind’s capacity, Avicenna discusses different aspects of essence and their implications in various sciences. These conceptual analyses help us discover his idea of essentialism. The final conclusion is that Avicenna’s essentialism is consistent with his idea about existence and the definitions can refer to the essence of objects. (shrink)
Abstract In the light of the analysis of Avicenna’s definition of “nature” we can discover the main principles of his physics, which are: ‘The agency of the nature’, ‘the directness of this agency’, ‘the natural object’, and ‘the essential agency of the nature’. One of the main consequences of this analysis is that the nature could be considered as the direct cause of the motion, immobility and spatial balance of the material objects. Moreover, it shows that natural objects are essentially (...) capable of possess natural properties. Accordingly, Avicenna considers that the natural properties are the same as the essential properties, which material objects have them necessarily. (shrink)
Backgound: The aims of this study were to evaluate the antimicrobial properties and synergistic effects of nano-titanium dioxide (TiO2), nano- zinc oxide (ZnO) and two synthetic peptides (mastoparan-B, indolicidin) against drug-resistant strains of Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. -/- Methods: From March to August 2015, a total of 30 (10 each) isolates of the above bacteria were recovered from patients in the ICU of two referral hospitals in Kerman, Iran. The sizes and purities of nano-TiO2, nano-ZnO were determined (...) by scanning electron microscope (SEM) and X-ray diffraction (XRD). Similarly, mass spectroscopy and HPLC were used for checking the genunity of the peptides. Antibiotic sensitivity was determined by agar disk diffusion assay. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) activities of nanometals and synthetic peptides were assessed by CLSI broth microdilution test. Similarly, checkerboard and time-kill curve analysis were performed to determine the synergistic activities of these compounds. -/- Results: Mastoparan-B had potent toxicity to all isolates with an average MIC 4 ± 0.2 mg/L, while TiO2-NP had lowest antimicrobial activity with MIC range 1280 ≥ ± 0.2 mg/L (P. aeruginosa growth was not inhibited by TiO2 and ZnO NPs). The bactericidal activity against the isolates in descending order was mastoparan-B, indolicidin, nano ZnO, and nano TiO2, respectively. Further investigation on synergism using fractional inhibitory concentration index (FIC) revealed that, nano-TiO2 and nano-ZnO combination had an additive effect (FIC = 0.95 ± 0.1) on A. baumannii and K. pneumoniae strains, whereas, P. aeruginosa isolates were indifferent to this combination (FIC ≥ 2 ± 0.2). In contrast, mastoparan-B and indolicidin combination displayed broad synergistic effect (FIC = 0.5 ± 0.1) on all the isolates and caused rapid killing of the organisms within 4 h of incubation. -/- Conclusions: Our results showed that the combination of mastoparan-B and indolicidin peptides is a suitable candidate for substitution of the antibiotics for topical treatment of infections caused by drug- resistant bacteria. (shrink)
The Internet-of-Things (IoT) is gradually being established as the new computing paradigm, which is bound to change the ways of our everyday working and living. IoT emphasizes the interconnection of virtually all types of physical objects (e.g., cell phones, wearables, smart meters, sensors, coffee machines and more) towards enabling them to exchange data and services among themselves, while also interacting with humans as well. Few years following the introduction of the IoT concept, significant hype was generated as a result of (...) the proliferating number of IoT-enabled devices, which (according to many projections) are expected to amount to several billion in the next years. During recent years, this hype has been turning to reality, as a wave of IoT applications with significant social and economic has been emerging. Data analytics is the process of deriving knowledge from data, generating value like actionable insights from them. This article reviews work in the IoT and big data analytics from the perspective of their utility in creating efficient, effective and innovative applications and services for a wide spectrum of domains. We review the broad vision for the IoT as it is shaped in various communities, examine the application of data analytics across IoT domains, provide a categorization of analytic approaches and propose a layered taxonomy from IoT data to analytics. IoT data analysis is an integral element of any non- trivial IoT system. Nevertheless, IoT analytics are still in their infancy, as IoT data still remain largely unexploited. (shrink)
Comparative studies among cultures, particularly Western and Eastern ones, are vital and necessary. In this essay, we are presenting a comparison between Western and Islamic views. The focus of this study is on action-oriented educational research based on Charles Clark’s view as a more recent action-oriented view on educational research. The comparison between Clark’s view and the one we suggest that is inspired by the Islamic view of human action and shows that there are considerable commonalities between the two views (...) as both of them avoid the mechanistic orientation and take human action into account. There are also differences between the two views regarding the distinction between fact and value, as well as the relation between means and ends in research. (shrink)
The evaluation of universities from different perspectives is important for their scientific development. Analyzing the scientific papers of a university under the bibliometric approach is one main evaluative approach. The aim of this study was to conduct a bibliometric analysis and visualization of papers published by Hamadan University of Medical Science (HUMS), Iran, during 1992-2018. This study used bibliometric and visualization techniques. Scopus database was used for data collection. 3753 papers were retrieved by applying Affiliation Search in Scopus advanced search (...) section. Excel and VOSviewer software packages were used for data analysis and bibliometric indicator extraction. An increasing trend was seen in the numbers of HUMS's published papers and received citations. The highest rate of collaboration in national level was with Tehran University of Medical Sciences. Internationally, HUMS's researchers had the highest collaboration with the authors from the United States, the United Kingdom and Switzerland, respectively. All highly-cited papers were published in high level Q1 journals. Term clustering demonstrated four main clusters: epidemiological studies, laboratory studies, pharmacological studies, and microbiological studies. The results of this study can be beneficial to the policy-makers of this university. In addition, researchers and bibliometricians can use this study as a pattern for studying and visualizing the bibliometric indicators of other universities and research institutions. (shrink)
It seems necessary to introduce the basic concepts used in this article i.e. formalism, anti-formalism and moderate formalism. Formalists believe that the aesthetic appreciation of an art work generally involves an attentive awareness of its sensory or conceptual qualities and does not require knowledge about its non-perceptual properties. Anti-formalists on the hand hold that noon of the aesthetic properties in the work of art are formal. A number of philosophers have recently advocated a more moderate formalism. According to this view (...) although not all aesthetic properties are formal, many are, and some artworks possess only formal aesthetic qualities. The quarrel among these three rival views concerns what sort of knowledge, if any, is required for appropriate aesthetic appreciation of an art work. In what follows, we will give a brief exposition of these three view points. Subsequently we will give our preferred position with regard to these views. (shrink)
Introduction: The aim of the present study was to explore the relationship between sophisticated view of induction and science education. Method: This study is a critical review on the relation between philosophical approaches to science and science education. Thus, an analytic method is used in investigating the theories of science and their relationship to science education. Results: Analysing the arguments against induction, we argue that the sophisticated view of induction is not only resistant against the critiques but also inspiring for (...) science education. Conclusion: This paper concludes that the sophisticated view of induction provides the merits of both positivism and falsificationism in science and science education while avoiding their disadvantages. Accordingly, to avoid positivism, science education should reinforce students' imagination and theory development and to avoid falsificationism, it should embrace observation and induction. (shrink)
BĪRŪNĪ, ABŪ RAYḤĀN MOḤAMMAD b. Aḥmad (362/973- after 442/1050), scholar and polymath of the period of the late Samanids and early Ghaznavids and one of the two greatest intellectual figures of his time in the eastern lands of the Muslim world, the other being Ebn Sīnā.
Muslim Sufi ideology had been spread by the saints who came from various Islamic countries. The cultural and religious atmosphere of India was very favourable for Sufism which has a power to move the minds towards humanity and philanthropy. Quran teaches us that we must love God vehemently and the effect of which produces love for his creations. Sufis in their effort followed the commands of Almighty. They tried to come near all sorts of human beings and understood their agonies (...) and yearnings. They had the power to absorb the sadness of others in them and infuse a spirit of joy so that a congenial society may be formed. The spiritual orders in which people enter through someone who has the capability of evoking conscience. They not only make men by nature human but they try to inculcate a spirit among all which they obtained from the teachings of Islam. They had been closely following the religion which was then prevailing over the society. They adopted the good aspects of other religions and amalgamated such views with their own ideology such kind of noble scheme brought the mankind near to each other. This became the basis of integration and communal harmony. Shah Mohammad Kazim Qalander established a shrine at Kakori about two hundred years ago to spread the message of humanity and to find out the solution of the problems of human beings around. It has captured the hearts so much so that even today the place is famous as a Solace where people gather and find the balm for their wounds and cure of their diseases which had penetrated not only body but the souls as well. Shah Kazim Qalander lit a candle which spread light of learning and kindled the inner self of those who came to him in quest of real knowledge. Shah Kazim Qalander made his eldest son as his spiritual heir and thus he acquired the holy seat of his father. Shah Turab Ali Qalander eldest son of Shah Qazim Qalander excelled in all spheres of Sufi system. He diffused the knowledge that he attained from his spiritual guide and from his father for a long time from this holy place and became famous almost throughout the world. (shrink)
A cura di Ignazio Licata, Ammar J. Sakaji Jeffrey A. Barrett, Enrico Celeghini, Leonardo Chiatti, Maurizio Consoli, Davide Fiscaletti, Ervin Goldfain, Annick Lesne, Maria Paola Lombardo, Mohammad Mehrafarin, Ronald Mirman, Ulrich Mohrhoff, Renato Nobili, Farrin Payandeh, Eliano Pessa, L.I Petrova, Erasmo Recami, Giovanni Salesi, Francesco Maria Scarpa, Mohammad Vahid Takook, Giuseppe Vitiello This volume comes out from an informal discussion between friends and colleagues on the answer:what topic do you think as fundamental in theoretical physics nowadays? Obviously wereceived (...) different answers according to the disposition and the different research areas, and answersin superposition state too. And yet some attractors have emerged pointing out the keys forthe Physicists conception of Nature, all of them converging towards a group of stronglyinterconnectedproblems. Let's see them one by one:. The concept of particle identity in Quantum Mechanics (QM) and Quantum Field Theory (QFT);. The relationship between QM and QFT, in particular the non -local aspects in Field Theory andthe problem of non-perturbative solutions;. The local/global problem in the relationship between particle physics and cosmology;. The role of Renormalization group in describing the meso and macroscopic emergent behaviour;. The possible extension of Poincaré symmetry group and Quantum cosmology;. Higgs "mechanism" and the origin of mass. (shrink)
Many different meanings are attributed to the term Sufi. From the philosophical standpoint the sufi sect leans towards the mystic tradition, while taken etymologically the word implies anything which is extracted from wool. Sufi was the term applied to those individuals who went through life wearing a woolen gown, spending their life in mediation and prayer. Other scholars are of the opinion that the terms sufi is derived from the root “Suffa” which is applicable to the platform built by (...) class='Hi'>Mohammad in the mosque at Madina. Hence the term sufi applied to those benevolent and pure but homeless people who spent their time sitting on this platform and meditating upon this life and the hereafter. According to Gazzzali , the term sufi implies a man’s remaining at peace with the world, in mediation upon God. We can say that the Sufis are example of pure spiritual discipline which require a sense of dedication and humanity to get the ultimate goal of life i.e. self-realisation. (shrink)
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