The need to better balance the promotion of scientific and technological innovation with risk management for consumer protection has inspired several recent reforms attempting to make regulations more flexible and adaptive. The pharmaceutical sector has a long, established regulatory tradition, as well as a long history of controversies around how to balance incentives for needed therapeutic innovations and protecting patient safety. The emergence of disruptive biotechnologies has provided the occasion for regulatory innovation in this sector. This article investigates the regulation (...) of advanced biotherapeutics in the European Union and shows that it presents several defining features of an adaptive regulation regime, notably institutionalized processes of planned adaptation that allow regulators to gather, generate, and mobilize new scientific and risk evidence about innovative products. However, our in-depth case analysis highlights that more attention needs to be paid to the consequences of the introduction of adaptive regulations, especially for critical stakeholders involved in this new regulatory ecosystem, the capacity and resource requirements placed on them to adapt, and the new tradeoffs they face. In addition, our analysis highlights a deficit in how we currently evaluate the performance and public value proposition of adaptive regulations vis-à-vis their stated goals and objectives. (shrink)

Concerns about emerging and re-emerging infectious diseases have given a new lease of life to quarantinist measures: a series of time-honoured techniques for controlling the spread of infectious diseases through breaking the chain of human contagion. Since such measures typically infringe individual rights or privacy their use is subject to legal regulations and gives rise to ethical and political worries and suspicions. Yet in some circumstances they can be very effective. After considering some case studies that show how epidemics are (...) unique, fluid and affected by a multitude of contingent factors, it is argued that the legal and ethical guidelines may not always be the best approach to discipline the use of quarantinist measures. An alternative model based on ex-post political accountability for reasonableness is proposed. This model restores the centrality of political decision and expert judgement in situations characterized by high risk, uncertainty and contingency. It is argued that such alternative model affords quicker and more flexible responses to serious outbreaks of infections, while providing adequate protection against abuses. (shrink)

The paper discusses the possibility that the benefits of pharmacogenomics will not be distributed equally and will create orphan populations. I argue that since these inequalities are not substantially different from those produced by ‘traditional’ drugs and are not generated with the intention to discriminate, their production needs not be unethical. Still, the final result is going against deep-seated moral feelings and intuitions, as well as broadly accepted principles of just distribution of health outcomes and healthcare. I thus propose two (...) provisos that would prevent the most offensive outcomes and moderate the scope of the produced inequalities. The first proviso rejects pharmacogenomics innovations that worsen existing group inequalities and aggravate the disadvantage of communities with a history of discrimination. The second proviso requires that there is a strategy in place to even out as much as possible the distribution of benefits in the future and that a system of compensations is in place for pharmacogenomic orphans. Given that only one moral problem generated by pharmacogenomics has been tackled, the list of provisos might be expanded when other issues are considered. (shrink)

This collection addresses two different audiences: 1) historians and philosophers of the life sciences reflecting on collaborations across disciplines, especially as regards defining and addressing Grand Challenges; 2) researchers and other stakeholders involved in cross-disciplinary collaborations aimed at tackling Grand Challenges in the life and medical sciences. The essays collected here offer ideas and resources both for the study and for the practice of goal-driven cross-disciplinary research in the life and medical sciences. We organise this introduction in three sections. The (...) first section provides some background and context. The second motivates our take on this topic and then outlines the central ideas of each paper. The third section highlights the specificity and significance of this approach by considering: a) how this collection departs from existing literature on inter- and trans-disciplinarity, b) what is characteristic about this approach, and c) what role this suggests for the history and philosophy of the life sciences in addressing Grand Challenges. (shrink)

The paper points out three serious problems in Ruud ter Meulen’s view of solidarity and of its role in healthcare ethics. First, it is not clear whether and to what extent ter Meulen expects normative concepts to be rooted in existing social practices: his criticism of liberal theories of justice seems to imply a different view on this issue than his implicit assumption that normative concepts are independent from social and historical trends. Second, it is not clear at which level (...) his notion of solidarity is meant to be applied: does it provide principles for individuals or for institutions? Nor is it clear at what level of generality it should work: is it meant for healthcare institutions or for states, for citizens or for healthcare practitioners? Third, it is not at all clear how the communitarian and the universalist aspirations in his conception of solidarity can be reconciled. In light of such difficulties it is argued that within philosophical discourse solidarity can be a useful notion only if it can be clearly distinguished from existing and commonly used ethical concepts. Three examples of such narrow and specific uses of solidarity are presented. Finally, a sceptical view of confining the work of applied philosophers to articulating normative concepts is put forward and an alternative view of blending empirical and philosophical analysis is proposed. This vision of field philosophy requires serious attention and careful understanding of the circumstances and constraints within which normative recommendations operate. It is suggested that such a modest and empirically grounded understanding of normative work is a better way of honouring the belief that philosophy is rooted in social institutions and in complex webs of relations. (shrink)

The idea of personalised medicine (PM) has gathered momentum recently, attracting funding and generating hopes as well as scepticism. As PM gives rise to differing interpretations, there have been several attempts to clarify the concept. In an influential paper published in this journal, Schleidgen and colleagues have proposed a precise and narrow definition of PM on the basis of a systematic literature review. Given that their conclusion is at odds with those of other recent attempts to understand PM, we consider (...) whether their systematic review gives them an edge over competing interpretations. We have found some methodological weaknesses and questionable assumptions in Schleidgen and colleagues’ attempt to provide a more specific definition of PM. Our perplexities concern the lack of criteria for assessing the epistemic strength of the definitions that they consider, as well as the logical principles used to extract a more precise definition, the narrowness of the pool from which they have drawn their empirical data, and finally their overlooking the fact that definitions depend on the context of use. We are also worried that their ethical assumption that only patients’ interests are legitimate is too simplistic and drives all other stakeholders’ interests—including those that are justifiable—underground, thus compromising any hope of a transparent and fair negotiation among a plurality of actors and interests. As an alternative to the shortcomings of attempting a semantic disciplining of the concept we propose a pragmatic approach. Rather than considering PM to be a scientific concept in need of precise demarcation, we look at it as an open and negotiable concept used in a variety of contexts including at the level of orienting research goals and policy objectives. We believe that since PM is still more an ideal than an achieved reality, a plurality of visions is to be expected and we need to pay attention to the people, reasons and interests behind these alternative conceptions. In other words, the logic and politics of PM cannot be disentangled and disagreements need to be tackled addressing the normative and strategic conflicts behind them. (shrink)

The background paper provides an introduction to the concept of pandemics and to the ethical and political issues related with pandemic preparedness.

The paper discusses some of the implications of regulatory innovation in the area of advanced biological therapies and personalised medicine. Benefits, risks and trade-offs are highlighted.

The paper uses two historical examples, public health (1840-1880) and town planning (1945-1975) in Britain, to analyse the challenges faced by goal-driven research, an increasingly important trend in science policy, as exemplified by the prominence of calls for addressing Grand Challenges. Two key points are argued. (1) Given that the aim of research addressing social or global problems is to contribute to improving things, this research should include all the steps necessary to bring science and technology to fruition. This need (...) is captured by the idea of practical integration, which brings this type of research under the umbrella of collective practical reason rather than under the aegis of science. Achieving practical integration is difficult for many reasons: the complexity of social needs, the plurality of values at stake, the limitation of our knowledge, the elusive nature of the skills needed to deal with uncertainty, incomplete information and asymmetries of power. Nevertheless, drawing from the lessons of the case studies, it is argued that (2) practical integration needs a proper balance between values, institutions and knowledge: i.e. a combination of mutual support and mutual limitation. Pursuing such a balance provides a flexible strategy for approximating practical integration. (shrink)

In this article we raise a problem, and we offer two practical contributions to its solution. The problem is that academic communities interested in digital publishing do not have adequate tools to help them in choosing a publishing model that suits their needs. We believe that excessive focus on Open Access (OA) has obscured some important issues; moreover exclusive emphasis on increasing openness has contributed to an agenda and to policies that show clear practical shortcomings. We believe that academic communities (...) have different needs and priorities; therefore there cannot be a ranking of publishing models that fits all and is based on only one criterion or value. We thus believe that two things are needed. First, communities need help in working out what they want from their digital publications. Their needs and desiderata should be made explicit and their relative importance estimated. This exercise leads to the formulation and ordering of their objectives. Second, available publishing models should be assessed on the basis of these objectives, so as to choose one that satisfies them well. Accordingly we have developed a framework that assists communities in going through these two steps. The framework can be used informally, as a guide to the collection and systematic organization of the information needed to make an informed choice of publishing model. In order to do so it maps the values that should be weighed and the technical features that embed them. Building on our framework, we also offer a method to produce ordinal and cardinal scores of publishing models. When these techniques are applied the framework becomes a formal decision–making tool. Finally, the framework stresses that, while the OA movement tackles important issues in digital publishing, it cannot incorporate the whole range of values and interests that are at the core of academic publishing. Therefore the framework suggests a broader agenda that is relevant in making better policy decisions around academic publishing and OA. (shrink)

In order to illustrate the difference between sensation and perception, Reid imagines a blind man that by ‘some strange distemper’ has lost all his notions of external objects, but has retained the power of sensation and reasoning. Reid argues that since sensations do not resemble external objects, the blind man could not possibly infer from them any notion of primary qualities. Condillac proposed a similar thought experiment in the Treatise on Sensations. I argue that Condillac can reach a conclusion opposite (...) to that of Reid only by assuming that some particular collections of sensations do indeed resemble the qualities of external objects. Reid had considered a similar case in a manuscript, but he again notices that such complex collections sensations do not resemble the qualities of external objects. (shrink)

While Hume had a favorable opinion of the new commercial society, Reid envisioned a utopian system that would eliminate private property and substitute the profit incentive with a system of state-conferred honors. Reid’s predilection for a centralized command economy cannot be explained by his alleged discovery of market failures, and has to be considered in the context of his moral psychology. Hume tried to explain how the desire for gain that motivates the merchant leads to industry and frugality. These, in (...) their turn, benefit all society. Reid still saw the desire for money as a degenerate form of the desire for power. The contrast between Hume and Reid, however, has not to be taken too far. On some particular matters of economic policy, such as paper credit, Hume and Reid eventually came to similar views. (shrink)

In a recent article on Reid’s theory of single and double vision, James Van Cleve considers an argument against direct realism presented by Hume. Hume argues for the mind-dependent nature of the objects of our perception from the phenomenon of double vision. Reid does not address this particular argument, but Van Cleve considers possible answers Reid might have given to Hume. He finds fault with all these answers. Against Van Cleve, I argue that both appearances in double vision could be (...) considered visible figures of the object, and show how this solution might preserve Reid’s direct realism. However, this solution is not compatible with the single appearance of an object predicted by Reid’s theory of single and double vision. This consequence will appear evident once we consider the critique of Reid’s theory of single and double vision formulated by William Charles Wells (1757-1817). Wells argues that Reid’s theory is either incomplete or incompatible with other claims made by Reid. It is incomplete since it fails to specify the unique direction in which we the object in single vision; if it not incomplete and is compatible with the law of monocular direction given by Reid, then it is incompatible with Reid’s claim that we do not perceive immediately distance by sight. (shrink)

Gender studies has generated numerous questions around “neutral” forms, such as the concept of “Self”. The aim of this analysis is to highlight how “neutral” forms are central to the reiteration of the binary model and the dominance of “man2”. Historically, man is the archetype, placing his supremacy as part of the natural order of things. Inserted into this model, many thinkers have considered the male as the transcendental gender, so, elevating the masculine as universal, a-sexed and decorporealised. In this (...) way, man has convinced himself that he’s not conditioned by his masculinity and can speak for all humanity, becoming the logosthrough which he declines the rest. Man, therefore, has made himself “neutral” – both in the conceptual sense and in the grammatical structure (particularly of binary languages such as Italian) – by taking control of language. Through it, he orders and constitutes the world, developing dichotomies and signifying anatomical bodies. In this research, it is intended to work on language and the relationship between “neutral” and power, emphasizing how that relationship is central to the reproduction of the patriarchal model. Through a critical philosophical reflection, which sees a logical-linguistic and historical-processual methodological structure, the discourse of the I-neutral will be crossed, pointing out how that “neutral” is in truth male. The concluding goal will be to, through “fluid” visions, build the basis for a language that is truly neutral and ready to embrace multiplicity, without relations of domination; a language really inclusive and not a reiterator of the patriarchal model. (shrink)

With the introduction/start of Horizon Europe, the European Commission made gender equality plans a basic requirement for participation in its research framework programme. Not all institutions have adopted the GEP – some have done so only partially – however, the document represents an attempt to pursue gender equality in different areas. The GEP at the academic level may represent an attempt to apply the vulnerability paradigm to contexts. In accordance with the purpose of the GEP, the analysis of language becomes (...) central, especially in its performative and reiterative key of discriminatory patterns. Reflecting on communication opens the possibility of counteracting stereotypes and creating equal environments through, for example, the creation of specific vademecums. Therefore, using the theoretical lenses of vulnerability and language, a reflection on the opportunities offered by the adoption of GEP is made. (shrink)

Climate change is an existential risk reinforced by ordinary actions in afuent societies—often silently present in comfortable and enjoyable habits. This silence is sometimes broken, presenting itself as a nagging reminder of how our habits fuel a catastrophe. As a case in point, global warming has created a state of urgency among wine makers in Spain, as the alcohol level has risen to a point where it jeopardises wine quality and thereby Spanish viticulture. Eforts are currently being made to solve (...) this problem technologically by developing (non-GMO) strains of yeast that produce less alcohol. If successful, this could help save Spanish viticulture. This kind of technological solution is routinely criticised for ofering simplistic “techno-fx” solutions to solve complex societal problems. However, it is not clear what features are criticised by the notion of techno-fx and hence how to avoid this criticism. In our interpretation, the techno-fx notion is not exclusively used as a dismissive term. The notion points to a general virtue of engineering: to create technological solutions that work silently in the background. This asset of technological solutions might sometimes be problematic and sometimes not. Hence, it needs to be analysed case-by-case by paying attention to the moral relevance of the hidden implications of the technology and of the unrefective actions and habits that they facilitate. Such moral analysis will in turn inform strategies for foregrounding this technology to counteract silencing. We discuss what this means in the case of modifying yeast as a viticultural climate resilience strategy. (shrink)

Pietro Piovani is a philosopher who is still, unjustly, little known. Here we set out to investigate the absence of foundation as a crossroads in contemporary philosophy and to evaluate the new contribution of Piovani’s reflection. In our study, we analysed mainly the works of the past twenty years and especially Principi di una filosofia della morale (1972) and Oggettivazione etica e assenzialismo(1980). The basic option in Piovani’s thinking is that, given the finite nature of the individual, as the willing (...) who was not self-willed, man no longer needs any foundation. In fact, the contemporary individual is more unfounded than ever, having to constantly base himself on and interact with a reality that is ever changing. Piovani reaches the height of his critical foundation by stating that, forced to stabilise his own instability, man must base his existence on an absence. Here, Piovani, through the "non self-willed willing", eradicates the assumptions of modern thought, and captures the beginning of existence in the experience of limitation and finiteness. Man, who is based on de-ontology, on de-esse, is a sign of a dissatisfaction that asks to be satisfied, of an inadequacy. This study highlights how Piovani’s thinking, having abandoned the perspectives of Western ontology, proposes a new reflection on the positivity of the inadequate where absence is heralded as the greatest energy force of life. Philosophy, therefore, has a future only as negative philosophy. -/- -/- . (shrink)

Feminist considerations have induced a rethinking of many aspects of our contemporary world, such as the concept of gender and power relations. This has led to a re-examination of the entire previous tradition of thought, finding in phallogocentrism the paradigm of reference. This term indicates, starting with Derrida's considerations, the Western tendency to have centred not only the logos, but also the phallus, weaving an intricate relationship between masculinity and language. It's precisely this bond that makes man the archetype on (...) which society is founded, placing his supremacy in the natural order, defining power relations and nailing pre-established categories. A being-nailed in the Lévinasian sense, thus an adherence between the agreement of voices and being, which produces 'category-beings' in which pre-delineated social identity is concealed in a condition of 'nature', such as the 'being-male'. It's precisely this naturalness, discursively produced, that has made man universal. Consequently, man has convinced himself that he can speak for all humanity, becoming the logos through which he declines the rest. Declinations that have produced rigid and hierarchical categories that precede and define each person, prescribing 'consonant' ways, rhetorically assumed as 'human nature'. The "nature" of being man or woman does not, in fact, concern monolithic essentialisms, but rather movements of intertwined meanings in a process that Derrida defines as différance. A process, therefore, in becoming, which has over time produced unequal power relations, justifying them as "natural", and which daily reiterates a hegemonic and sexist social model. The aim of this analysis, hence, will be to bring phallogocentric masculinity and consequent hegemonic structures into the field of philosophical reflection, with the purpose of redirecting praxis towards performative processes of characterisation the person, rather than a pre-delineated categorisation. Thus, to release being from socio-cultural categories, which historical-performative praxis nails to each body. (shrink)

Gender studies has produced various analyses around issues such as social “roles,”coexistence and power relations; seeing language as a central aspect, especially since the development of performativity theory produced by philosopher Judith Butler. In this paper, so, I would like to focus on the existing relationship between language and gender relations, particularly in the workplace; pointing out how some possibilities and structures are dense with unequal and sexist modalities. The analysis will consist of a first theoretical section, in which the (...) specific relationship between the gendered “male”subject and language will be emphasized, and a second in which these considerations will be portrayed in the corporate context. The purpose is to show how specific aspects of masculinity have generated specific power relations, delineating, and defining stereotypes and categorizing views. Attributes that have then flowed into the different social dynamics of our society, establishing different job roles and possibilities. To give more profundity, I adopted a methodology that fuses the logical-linguistic theoretical perspective, to the analysis of empirical data collected through interviews, questionnaires, and training meetings at two partner companies. (shrink)

Feminist reflections have led to a rethinking of many aspects of our contemporary world, such as the concept of masculinity and its power relations. In Western civilisation, in fact, man is the archetype, thus making his supremacy part of the natural order of things. This very naturalness, discursively produced and performed, is what has made man invisible and universal, hence without the need to think-and think oneself-in terms of gender. As a result, man has convinced himself that he is not (...) influenced by his own masculinity and can speak for all mankind, becoming the logos through which he declines the rest, prescribing 'consonant' ways of being a man or a woman. Historically, then, different power relations have developed, generating violent forms of communication that, on a daily basis, reiterate a hegemonic and sexist social model. This has led to the production of certain stereotypical attributes that have subsequently flowed into different social dynamics, establishing different roles and work possibilities that have welded structural problems: such as, for example, the 'glass ceiling'. The aim of this analysis, therefore, will be to reason about the concept of masculinity and the consequent hegemonic-linguistic structures, wondering how such reflections can be translated back into the corporate sphere. This is with the aim of producing anti-discriminatory and equal systems that improve workers' conditions, as well as their general outlook on gender issues. The methodology adopted will see the use of philosophical-pragmatic theoretical reflection, in particular around the theory of linguistic performativity, fused with empirical data collection in the corporate sphere as a result of questionnaires, contextual analyses and training courses carried out at an Italian corporation. (shrink)

The analysis of the moral doctrines contained in the Moralis philosophia of Roger Bacon reveals the central place reserved to the vice of anger. Bacon considers it a very serious sin, which goes against the human nature and makes many devastating effects on individuals and their social relations. Bacon’s moral doctrines are based on a source that has been recently rediscovered, Seneca’s De ira. Bacon is one of the first authors to quote extensively that work. Bacon’s enthusiasm for the Latin (...) philosopher is the result of his conviction of the superiority of pagan philosophers over the Christians, especially in the field of ethics. The knowledge of the ancients, which is necessary for the life of individuals and for the proper function of institutions, is a duty for Christian thinkers. (shrink)

The thought of Pietro Piovani (Naples 1922 1980) ranges from moral philosophy, the history of philosophy and the philosophy of law, but in the anti-ontology of his most original core. In Principles of moral philosophy Piovani said that given the finite nature of the individual, the existing "no longer needs no foundation (...) because it is based." In particular, the contemporary individual is more than ever unfounded, having to constantly rely so. In this regard Piovani speaks of assenzialismo: being a (...) be "limited" man bases its existence on an absence, that does not constitute something negative, but, on the contrary, represents that "most" of Nietzsche's memory is unique about the individual. -/- . (shrink)

Heraclitus is the first philosopher, and one of the few ones, who is aware of original contradiction. His thought still presents some ambiguities mostly due to the still intuitive discovery of the relation between language, contradiction and logos. Heraclitus saw the contradiction. He does not care about how the fact of communication is possible, as it indeed is, but rather he endeavours to put into question its problematic essence. -/- .

Gender studies have generated numerous questions regarding the potential of language and the power relations it produces, especially after the philosopher Judith Butler's reinterpretation of Austinian performativity theory. She in fact reinterpreted this theory not only in linguistic terms, but also in relation to the normative power that nails biological fates to anatomical bodies, pinning them into roles and permissions defined by dominant praxis. With the theory of gender performativity, the connection between language, identity and power becomes even clearer and (...) more incisive, seeing hate speech as playing a central role in both the maintenance of praxis and the disciplining of people in accordance with such praxis. Starting from a reflection on the universalization of man through the appropriation of language-logos, the aim of this paper will therefore be to highlight the intricate link between hate speech and hegemonic masculinity. It will then emphasize how the denigrating and punitive functionality of hate speech is central to the reiteration of the subordinating binarism on which patriarchal hegemony is founded. In this way, it will be possible to think of strategies, such as re-signification, that not only disarm the violent potential of hate speech, but also contribute to rewriting the underlying social praxis, producing anti-discriminatory and equalitarian models. (shrink)

An analysis on the topic of lightness according to a philosophical perspective, which, on the trace of Parmenides, questions what is positive: the lightness or heaviness? The main point is that of Nietzsche and Calvin, but references ranging from Ovid to Kundera to the world of science. That of light, literary, scientific, philosophy, appears to be the preferred way forward in the eternal man's attempt to bring order to chaos. -/- .

Aristóteles comparte con Platón la concepción de la forma como causa del ser y del conocimiento de las cosas. Sin embargo, un análisis de sus críticas a las Ideas muestra que encuentra en la separación de las Ideas y las cosas sensibles la aporía fundamental de la teoría platónica. Con el propósito de circunscribir el significado de “separación” aplicable a las Ideas, concentraremos nuestro estudio en dos objeciones: 1) el argumento que conduce al tercer hombre y 2) la inutilidad de (...) las Ideas como causas. En el primer caso, creemos que la separación entraña homonimia, por lo que la solución aristotélica implicará la comunidad de naturaleza entre el individuo y su esencia. En el segundo, la separación implica trascendencia o falta de contacto entre generante y generado, por lo que la solución aristotélica apuntará a concebir la forma de las entidades naturales como un principio inmanente, inseparable de la materia y del movimiento, pero a la vez eterno a través de su reproducción en otros individuos de la misma especie. Creemos que en ambas soluciones opera un principio de sinonimia, que constituye su propia contribución al problema de la separación. (shrink)

We analyse the computational complexity of three problems in judgment aggregation: (1) computing a collective judgment from a profile of individual judgments (the winner determination problem); (2) deciding whether a given agent can influence the outcome of a judgment aggregation procedure in her favour by reporting insincere judgments (the strategic manipulation problem); and (3) deciding whether a given judgment aggregation scenario is guaranteed to result in a logically consistent outcome, independently from what the judgments supplied by the individuals are (the (...) problem of the safety of the agenda). We provide results both for specific aggregation procedures (the quota rules, the premisebased procedure, and a distance-based procedure) and for classes of aggregation procedures characterised in terms of fundamental axioms. (shrink)

Frente a quienes sostienen una incompatibilidad entre historia de la filosofía y filosofía, en cuanto plantean una disyuntiva entre una práctica descriptiva y una argumentativa, en este trabajo nos proponemos mostrar, examinando la labor histórico-filosófica de Aris- tóteles, que esa disyuntiva no es excluyente. Para ello, en primer lugar, examinaremos algunos pasajes de su obra en los que ofrece indicaciones metodológicas que permiten comprender la doble función que cumplen las exposiciones críticas de los filósofos precedentes en la constitución misma de (...) su filosofía. En segundo lugar, ilustraremos el tipo de argumentación aristotélica a través del análisis de las críticas que dirige a las Ideas platónicas como causas. Contra Platón, Aristóteles establece que, para dar cuenta de la ingenerabilidad e incorruptibilidad de las formas, no es necesario caracterizarlas como entidades separadas de la materia y del movimiento. Basta asegurar la eternidad de la forma a través de su reproducción en otros individuos de la misma especie. Tal análisis nos permite concluir, finalmente, que filosofía o historia de la filosofía constitu- yen una falsa disyuntiva en Aristóteles, por lo que el examen dialéctico de las doctrinas precedentes es un método adecuado de indagación filosófica. (shrink)

La exposición y crítica de las doctrinas antiguas tiene un lugar importante en los escritos de Aristóteles. Sin embargo, ciertas dudas se han vuelto corrientes acerca de la confiabilidad de sus descripciones. Más aún, se ha sostenido que Aristóteles deforma la comprensión histórica a través de la introducción de conceptos y términos propios. En este libro se aborda el problema a través de un análisis de las críticas que Aristóteles dirige a la teoría platónica de las Ideas, que permite explicar (...) la constitución y desarrollo de importantes conceptos aristotélicos a partir de la confrontación dialéctica con las doctrinas de su maestro. En efecto, las dificultades genuinas que Aristóteles descubre en el platonismo constituyen el motor para gestar nuevos conceptos, que no son ajenos, sino que surgen como implicaciones del examen crítico. Así, la imposición de términos propios no debe interpretarse como distorsión, sino como el modo que Aristóteles adopta para exhibir su particular solución a los problemas que los filósofos anteriores dejaron sin solución. (shrink)

Many collective decision making problems have a combinatorial structure: the agents involved must decide on multiple issues and their preferences over one issue may depend on the choices adopted for some of the others. Voting is an attractive method for making collective decisions, but conducting a multi-issue election is challenging. On the one hand, requiring agents to vote by expressing their preferences over all combinations of issues is computationally infeasible; on the other, decomposing the problem into several elections on smaller (...) sets of issues can lead to paradoxical outcomes. Any pragmatic method for running a multi-issue election will have to balance these two concerns. We identify and analyse the problem of generating an agenda for a given election, specifying which issues to vote on together in local elections and in which order to schedule those local elections. (shrink)

Ethical concerns in e-social science are often raised with respect to privacy, confidentiality, anonymity and the ethical and legal requirements that govern research. In this article, the authors focus on ethical aspects of e-research that are not directly related to ethical regulatory framework or requirements. These frameworks are often couched in terms of benefits or harms that can be incurred by participants in the research. The authors shift the focus to the sources of value in terms of which benefits or (...) harms are understood in real social situations. A central claim of this paper is that the technologies that are used for research are not value neutral, but serve to reinforce some values at the expense of others. The authors discuss databases, modelling and simulation, network analysis as examples of technologies which affect the articulation of values. A view of e-social science as a techno-scientific constellation of researchers, technologies and society, in which values are always already embedded, is put forward as a basis for a view of ethics as reflexive and active engagement, conducted with awareness. Methodological pluralism and proactive openness are also proposed as responses to this view of the ethical dimensions of e-social science. (shrink)

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...) identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies. (shrink)

An important part of the Unified Medical Language System (UMLS) is its Semantic Network, consisting of 134 Semantic Types connected to each other by edges formed by one or more of 54 distinct Relation Types. This Network is however for many purposes overcomplex, and various groups have thus made attempts at simplification. Here we take this work further by simplifying the relations which involve the three Semantic Types – Diagnostic Procedure, Laboratory Procedure and Therapeutic or Preventive Procedure. We define operators (...) which can be used to generate terms instantiating types from this selected set when applied to terms designating certain other Semantic Types, including almost all the terms specifying clinical tasks. Usage of such operators thus provides a useful and economical way of specifying clinical tasks. The operators allow us to define a mapping between those types within the UMLS which do not represent clinical tasks and those which do. This mapping then provides a basis for an ontology of clinical tasks that can be used in the formulation of computer-interpretable clinical guideline models. (shrink)

La práctica de Actividad Física y Deportiva en los procesos de reinserción promueve escenarios formativos integrales para la construcción de relaciones saludables dentro del entramado social, presentándose como una herramienta efectiva para el trabajo con jóvenes en situación de riesgo por contexto de pandillas. Esta investigación tuvo como objetivo analizar la práctica del rugby como alternativa dentro de los procesos de reinserción social de jóvenes ex-integrantes de pandillas junto al Colectivo Calle, Paz y Respeto de la ciudad de Ibarra-Ecuador. La (...) investigación empleó un enfoque cualitativo basado en el estudio de caso y análisis etnográfico, utilizando entrevistas semiestructuradas para recopilar datos. El análisis, codificación y categorización de la información se realizó mediante el software MAXQDA, enfocándose en tres categorías: Actividad Física y Deportiva, Reinserción Social e Identidad. Los resultados revelan correlaciones significativas, como la relación entre reinserción social y oportunidades de superación; uso adecuado del tiempo libre y salud mental; y, la decisión de cambiar y oportunidades de superación. Se concluye que el rugby se presenta como un medio eficaz para la reinserción social de jóvenes en situación de riesgo, gracias a su potencial para mitigar conflictos, regular conductas violentas e inculcar hábitos positivos como la disciplina, respeto y compromiso. (shrink)

Outcomes research in healthcare has been a topic much addressed in recent years. Efforts in this direction have been supplemented by work in the areas of guidelines for clinical practice and computer-interpretable workflow and careflow models.In what follows we present the outlines of a framework for understanding the relations between organizations, guidelines, individual patients and patient-related functions. The derived framework provides a means to extract the knowledge contained in the guideline text at different granularities, in ways that can help us (...) to assign tasks within the healthcare organization and to assess clinical performance in realizing the guideline. It does this in a way that preserves the flexibility of the organization in the adoption of the guidelines. (shrink)

Review of Emanuele Banfi, Nicola Grandi - Le lingue extraeuropee: Americhe, Australia e lingue di contatto.

Tra il 1950 e il 1976, malgrado le prove e i contrattempi, Patočka ha ripreso spesso la sua meditazione sul mondo nel quale viviamo e dal quale la scienza ci allontana nello momento stesso in cui ne scopre l’oggettività. I dieci saggi qui raccolti permettono di seguire l’itinerario di pensiero che ha portato il filosofo ceco a porre la questione di una fenomenologia trans-soggettiva e a ripensare, in questa prospettiva, il concetto aristotelico di movimento. Lungo il percorso appare evidente che (...) dal 1910 Husserl liberava il significato fondamentale del “problema” di un mondo naturale; tuttavia, soltanto una fenomenologia che porta a compimento ciò che la Kehre heideggeriana inaugura, ha qualche possibilità di reperire le giustificazioni di un quotidiano in cui mito, lavoro e scienza trovano senso in queste grandi manifestazioni della libertà con l’altro che sono il sacrificio e la cosiddetta vita normale. (shrink)

Nel presente scritto, l’attività di insegnamento filosofico viene sottoposta ad interrogativi riguardanti gli elementi che la caratterizzano, ovvero ciò che viene insegnato, chi insegna e a chi si insegna. Nasce così una riflessione teoretica su tre concetti basilari, ovvero la filosofia, il soggetto e l’altro. Attraverso le suggestioni di grandi pensatori, in primis l’Heidegger di Essere e Tempo, ma anche Platone, Aristotele, Cartesio, Deleuze e Levinas, vengono proposte possibili definizioni dei concetti suddetti. La filosofia viene così considerata in senso (...) statico, come sentiero diretto al sapere, e dinamico, come prassi sempre rinnovantesi. Per quanto riguarda il “chi”, una volta stabilito che, per natura o necessità ontica, ogni uomo tende al sapere, viene definito il soggetto in grado di insegnare la filosofia ad altri. Questi può essere sia il semplice studioso di filosofia, che il filosofo vero e proprio. La differenza tra i due si configura come segue: il primo si occupa solo della conoscenza di sentieri già tracciati, il secondo ne traccia anche di nuovi. Il destinatario dell’insegnamento filosofico si configura, invece, come alterità a cui la soggettività docente deve relazionarsi. Si giunge pure qui ad una definizione duplice, ovvero dell’allievo come semplice conoscente, la cui componente attiva è limitata alla ricezione dei contenuti, e dell’allievo come praticante, che sperimenta vari metodi e si mette in gioco nella teoresi. Vengono infine delineate possibili configurazioni in base a queste tre coppie di concetti, configurazioni che, a propria volta, diventano molteplici nelle realtà singolari. (shrink)

Il design industriale è sempre più importante come mezzo per differenziare i prodotti e aumentarne il valore. Allo stesso tempo, la velocità con cui un prodotto viene offerto nel mercato dipende dalla capacità di integrare il design nel processo di produzione. Tuttavia, molte PMI - in particolare le nuove aziende basate sulla tecnologia - mancano di competenze specialistiche nella gestione del design e spesso non prestano sufficiente attenzione a questo aspetto. L'industria automobilistica e le grandi aziende come Philips e (...) Braun gestiscono e misurano l'impatto del design come strumento innovativo. Negli ultimi anni, le aziende industriali che sono in prima linea nella produzione di determinati prodotti stanno iniziando a sperimentare una forte concorrenza che non è egualmente protetta. Subiscono gli impatti dell'esperienza offerta da quasi gli stessi prodotti a prezzi inferiori, grazie a un minore investimento in ricerca e sviluppo, che riduce la struttura dei costi. (shrink)

Nel primo paragrafo sarà esaminato l’impianto normativo che regola le pubbliche amministrazioni, riformato dalle l. n. 142 e n. 241 del 1990, dal D.Lgs. 29/1993, dalle “leggi Bassanini” e dalla legge-quadro 150/2000, sia riguardo al diritto di accesso nei confronti dell’attività dell’amministrazione, sia in merito al radicamento di criteri di efficacia, efficienza ed economicità delle policies sia agli strumenti con cui gli Enti locali e cittadini possono comunicare. Gli anni ‘90 segnano l’inizio di un processo volto alla riorganizzazione delle PA (...) a partire dalla centralità della comunicazione istituzionale ma anche della concezione del “diritto all’informazione” nelle tre accezioni di diritto “di informare, “di informarsi” e “essere informati”. La Levi ha ben sottolineato “la rapidità inusuale nella storia nazionale” di tale riforma e la centralità assunta in essa dalle dimensioni dell’informazione, della comunicazione e della partecipazione: "In sintesi, si può ritenere legittimo concludere che le riforme del decennio 1990-2000 abbiano segnato il passaggio dal segreto alla trasparenza e dall’unilateralità alla partecipazione. Le politiche di modernizzazione in tema di comunicazione pubblica e di maggiore trasparenza dell’attività dell’amministrazione si sono mosse verso una più marcata tutela dei diritti dei cittadini e verso l’accentuazione del risultato dell’azione amministrativa" (2004, p. 16). Grandi ha ribadito che tale evoluzione costituisce nella cultura politica dello stato di diritto una «sorta di pre-condizione dell’emergere dei nuovi diritti di cittadinanza, intesi quale partecipazione consapevole e informata al processo decisionale pubblico» (Grandi 20022, 13). Nel secondo paragrafo verranno descritte gli ambiti di applicazione, le finalità, gli obiettivi e le strutture della comunicazione istituzionale disciplinate dalla legge n. 150/2000 e dai conseguenti regolamenti attuativi: il Portavoce, l’Ufficio stampa, l’Ufficio per le relazioni al pubblico. Come vedremo, si tratta di una normativa che rappresenta un punto di arrivo e un punto di partenza, in quanto, da un lato, se chiude il decennio delle riforme amministrative, d’altro lato, problematizza compiutamente per la prima volta il rapporto di comunicazione tra PA e cittadini e pone in evidenza tutte le difficoltà nell’implementare le norme nella realtà. Agli elementi critici della comunicazione istituzionale sono riservate le considerazioni conclusive: dal reclutamento e formazione del personale, al coordinamento delle strutture, dal persistere di mentalità burocratiche e autoreferenziale alla carenza di risorse. Il problema delle dotazioni organiche e finanziarie, in particolare, è molto sentito dalle amministrazioni di dimensioni più piccole, le quali spesso ricorrono alla “esternalizzazione” di attività degli uffici di comunicazione, non solo per la produzione editoriale, le campagne pubblicitarie e i servizi di gestione degli eventi, ma anche per il sito internet e i compiti di informazione più tradizionali. In tale situazione, la comunicazione istituzionale, pur dichiarata come strategica, rischia di rimanere un momento residuale dell’azione pubblica sia in termini di processo sia in termini di contenuto, slegata dagli obiettivi dell’organizzazione. (shrink)

Che cosa distingue, concettualmente, l’esattore delle tasse che esiga da un uomo, a pena di sanzioni, una determinata somma di denaro, dal bandito che gli intimi, sotto la minaccia di un’arma, di consegnargli la medesima somma? È sul soddisfacimento del requisito della giustizia che si fonda, come sostenne Agostino, l’eterogeneità tra uno Stato e un’accolita di furfanti? «Se non è rispettata la giustizia, che cosa sono gli Stati, se non delle grandi bande di ladri? Perché le bande di briganti (...) che cosa sono, se non dei piccoli Stati?». Il volume ripercorre le risposte più autorevoli fornite nel XX secolo, entro un orizzonte postmetafisico, alla domanda agostiniana: prima dell’avvento del regime nazista, la tesi che un’associazione a delinquere sia indistinguibile da uno Stato è stata sostenuta da Benedetto Croce, Santi Romano e Hans Kelsen; dopo l’esperienza del nazismo e delle sue atrocità, perpetrate in nome dello Stato e della legge, le questioni relative alla natura del diritto e alla relazione tra morale e diritto hanno assunto – come ha osservato Robert Alexy – «l’urgenza di un problema scottante», e la domanda filosofica sulla validità della legge ingiusta è apparsa ineludibile non solo ai maggiori filosofi del diritto (Herbert L.H. Hart, Alf Ross, Ronald Dworkin e lo stesso Alexy), ma alle stesse corti tedesche. (shrink)

Una riflessione, a 400 anni dalla morte di Giovan Battista Della Porta Napoletano, uno dei grandi geni del Rinascimento.

Le discussioni sulle tecnologie digitali e Internet e sulle loro applicazioni nel campo della politica sono l’inevitabile portato di un mutamento di più ampia rilevanza che coinvolge ogni aspetto economico, sociale e culturale della contemporaneità. È in corso una “rivoluzione tecnologica” di cui ancora non siamo pienamente consapevoli, che scombina assetti ritenuti stabili e sposta l’orizzonte del possibile. Il ceto politico in parte la condiziona e in parte la subisce. Nell’uno e nell’altro caso, possiamo rilevare che non è in grado (...) di capirla. Alle ICT (Information and Communication Technologies) si guarda con la speranza di sincronizzare finalmente l’operato del sistema politico-amministrativo alla rapidità e complessità dei nuovi tempi; e di avvicinare i governati ai governanti visto che la distanza tra le parti è sempre più marcata. Un sano scetticismo verso la capacità dell’apparato istituzionale di ri-generarsi spinge a credere che sarà un’opportunità sprecata se lasciata alla sola iniziativa dei politici: è necessario che la società civile si faccia carico del futuro, del suo futuro. La proposta non è così irrealistica; le comunità del XXI secolo potranno sfidare un divenire sempre più incerto solamente promuovendo la libertà e la responsabilità dei loro membri e creando le condizioni per sprigionare un’“intelligenza collettiva” attualmente dispersa e disconosciuta. Su questo piano si situa l’apporto teorico-analitico di Pierre Lévy, a cui va il merito di aver posto le domande giuste alla scienza e alla politica e di aver stimolato un movimento generale delle idee coerente con i grandi cambiamenti culturali e sociali odierni. (shrink)

Nella sua straordinaria opera scientifica, Franco Selleri si è sempre opposto alla rinuncia alla comprensione della struttura della realtà e della natura degli oggetti fisici, che egli considera come l’elemento caratterizzante delle principali teorie della fisica del Novecento e che è stata stigmatizzata da Karl Popper come tesi della “fine della strada in fisica”. Sin dalla fine degli anni ’60, egli ha sviluppato quella riflessione critica nei confronti delle teorie fondamentali della fisica moderna, in particolar modo della teoria delle particelle (...) elementari e della meccanica quantistica, e in un secondo tempo delle teorie relativistiche, che contraddistingue il suo programma di ricerca. Nel corso della sua intensa e infaticabile attività scientifica, Selleri è entrato in proficuo contatto con molti grandi fisici e filosofi della scienza, instaurando un intenso dialogo critico con Louis de Broglie, John Bell e Karl Popper. Le sue originali e non convenzionali ricerche lo hanno portato a risultati significativi non solo nell’ambito dei fondamenti della fisica, ma anche della storia e della filosofia della fisica. Per questo abbiamo voluto dedicare un numero speciale di Isonomia al nostro impareggiabile amico e collega, sia per la sua passione instancabile e la sua profonda conoscenza dei fondamenti formali, concettuali e filosofici delle teorie della fisica contemporanea, sia e forse ancor più come maestro di una prospettiva perennemente critica che egli ha sempre seguito e proposto con particolare rigore ed estrema determinazione. (shrink)

Jürgen Habermas ha dedicato più di trent’anni dei suoi studi alle scienze sociali al fine di definire, attraverso la ricostruzione delle tradizioni di pensiero in esse presenti, un quadro teorico di riferimento che orienti i programmi della ricerca storico-sociale. Al pari dei grandi classici del pensiero sociologico, egli ha cercato di affrontare i “problemi della società nel suo insieme” esplicitando gli assunti, i metodi e gli obiettivi della teoria sociale come presupposto indispensabile per un’indagine che ampli i confini disciplinari (...) della sociologia, da un lato, alla riflessione filosofica, dall’altro alla ricerca storiografica. Nel lungo itinerario della sua formazione scientifica questo programma rappresenta il filo conduttore nell’analisi dei “sistemi culturali”, dei “sistemi sociali”, dei “sistemi della personalità” e, soprattutto, nella “teoria dell’evoluzione sociale”, dalla ricostruzione delle condizioni necessarie alla genesi antropologica delle forme socio-culturali di vita – l’“ominizzazione” – sino all’esame della logica e della dinamica di sviluppo delle “formazioni sociali” che egli suddivide in primitive, tradizionali, moderne e contemporanee. Nella Postfazione all’edizione italiana di Profili politico-filosofici (2000), una raccolta che contiene scritti di quarantacinque anni di studi (1953-1998), Leonardo Ceppa sottolinea i due aspetti essenziali dell’opera di Habermas: “la coerenza teorica” e il “carattere assimilatorio”. Habermas non è un pensatore “rivoluzionario” ma un “riformista” che, ricorrendo a un’immagine ingegneristica, all’isolamento del “pensiero che scava fossati” preferisce “costruire ponti” tra i campi del sapere. Questa ricerca si segnala per il tentativo di recepire criticamente le acquisizioni specialistiche delle scienze sociali e della filosofia finalizzando questa tensione apprenditiva alla costruzione di un quadro generale. Nato dai nostri colloqui seminariali, di cui mantiene la forma dialogica dei “turni di parola”, il presente volume focalizza lo sguardo sulle società contemporanee – ripercorrendone la struttura, le sfide presenti e gli scenari futuri – e sulla funzione sociale della sociologia. Ne scaturisce un’indagine di fenomeni fondamentali per comprendere le trasformazioni della modernità: la modernizzazione, il capitalismo organizzato, lo stato sociale, la democrazia politica, la diversità culturale, l’opinione pubblica nell’epoca dei media, la globalizzazione, la crisi ecologica, le disuguaglianze mondiali, i conflitti nazionalistici, il terrorismo islamico, la secolarizzazione, l’ingegneria genetica, l’integrazione europea e la politica mondiale. Nel riordinare i temi sociologici da lui proposti abbiamo cercato di sistemare l’analisi delle società contemporanee a un livello che non si accomodi sul piano dei commenti troppo facili che gli intellettuali, i politici e la gente comune amano fare sull’attualità e che, mantenendo una visione d’insieme sull’opera, chiarisca il testo e i suoi punti ciechi. Il volume si propone come uno strumento di lavoro che accompagni a una lettura critica. Sullo sfondo rimane la domanda se Habermas riesca davvero a conseguire, nei suoi itinerari attraverso la “storia delle idee”, la coerenza logica e la profondità d’indagine necessarie a “sistematizzare” le ricerche delle scienze sociali. Alcune perplessità avvalorate dal confronto con i testi e con la letteratura critica ci hanno suggerito di riservare ai problemi metodologici uno studio specifico che chiarisca il concetto di “scienza ricostruttiva” e ne illustri le applicazioni nell’ambito delle teorie della riproduzione culturale, della socializzazione e dell’evoluzione delle formazioni sociali – uno studio le cui linee sono solo anticipate nell’Introduzione. Il programma di ricerca e la sua recezione critica, relativamente agli assunti della teoria dell’evoluzione sociale. Riprendendo una felice espressione di Karl Popper, ci auguriamo di aver raggiunto la chiarezza argomentativa e la semplicità linguistica dovuta al lettore, confidando nella “cooperazione amichevole-ostile di molti scienziati”. (shrink)

La meccanica quantistica è una delle più grandi conquiste intellettuali del xx secolo. Le sue leggiregolano il mondo atomico e subatomico e si riverberano su una miriade di fenomeni del mondomacroscopico, dalla formazione dei cristalli alla superconduttività, dalle proprietà dei fluidi a bassatemperatura agli spettri di emissione di una candela che brucia o di una supernova che esplode, daimeccanismi di combustione della fornace solare ai principi di base delle nanotecnologie. Non c’èquasi nulla nel mondo che ci circonda su cui (...) non soffi l’alito delle leggi quantistiche. Tuttavia, per come è usualmente presentata nei libri di testo, la meccanica quantistica è sostanzialmenteun’insieme di regole per calcolare le distribuzioni di probabilità dei risultati di qualunqueesperimento (nel dominio di validità della meccanica quantistica). In quanto tale, non ci forniscedirettamente una descrizione della realtà. Una descrizione della realtà, cioè un’ ontologia , dovrebbedirci che cosa c’è nel mondo e come si comporta, quali sono i processi che si realizzano a livellomicroscopico e, di conseguenza, fornirci una spiegazione del formalismo quantistico. (shrink)