Results for 'non-coding RNA'

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  1. The Development of Non-Coding RNA Ontology.Jingshan Huang, Karen Eilbeck, Barry Smith, Judith Blake, Deijing Dou, Weili Huang, Darren Natale, Alan Ruttenberg, Jun Huan, Michael Zimmermann, Guoqian Jiang, Yu Lin, Bin Wu, Harrison Strachan, Nisansa de Silva & Mohan Vamsi Kasukurthi - 2016 - International Journal of Data Mining and Bioinformatics 15 (3):214--232.
    Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic (...)
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  2. A Domain Ontology for the Non-Coding RNA Field.Jingshan Huang, Karen Eilbeck, Judith A. Blake, Dejing Dou, Darren A. Natale, Alan Ruttenberg, Barry Smith, Michael T. Zimmermann, Guoqian Jiang & Yu Lin - 2015 - In IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2015). pp. 621-624.
    Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.
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  3.  67
    The Non-Coding RNA Ontology : A Comprehensive Resource for the Unification of Non-Coding RNA Biology.Huang Jingshan, Eilbeck Karen, Barry Smith, A. Blake Judith, Dou Dejing, Huang Weili, A. Natale Darren, Ruttenberg Alan, Huan Jun & T. Zimmermann Michael - 2016 - Journal of Biomedical Semantics 7 (1).
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary (...)
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  4. Two Genetic Codes: Repetitive Syntax for Active Non-Coding RNAs; Non-Repetitive Syntax for the DNA Archives.Witzany Guenther - 2017 - Communicative and Integrative Biology 10 (2):e1297352-1 - e1297352-12.
    Current knowledge of the RNA world indicates 2 different genetic codes being present throughout the living world. In contrast to non-coding RNAs that are built of repetitive nucleotide syntax, the sequences that serve as templates for proteins share—as main characteristics—a non-repetitive syntax. Whereas non-coding RNAs build groups that serve as regulatory tools in nearly all genetic processes, the coding sections represent the evolutionarily successful function of the genetic information storage medium. This indicates that the differences in their syntax (...)
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  5. A Semantic Approach for Knowledge Capture of microRNA-Target Gene Interactions.Jingshan Huang, Fernando Gutierrez, Dejing Dou, Judith A. Blake, Karen Eilbeck, Darren A. Natale, Barry Smith, Yu Lin, Xiaowei Wang & Zixing Liu - 2015 - In IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2015),. pp. 975-982.
    Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In (...)
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  6. Identification of Possible Differences in Coding and Non Coding Fragments of DNA Sequences by Using the Method of the Recurrence Quantification Analysis.Sergio Conte, Alessandro Giuliani & Elio Conte - 2012 - Journal of Research and Review in Applied Science 13 (2):1-28.
    Starting with the results of Li et al. in 1992 there is valuable interest in finding long range correlations in DNA sequences since it raises questions about the role of introns and intron-containing genes. In the present paper we studied two sequences that are the human T-cell receptor alpha/delta locus, Gen-Bank name HUMTCRADCV, a noncoding chromosomal fragment of M = 97630 bases (composed of less than 10% of coding regions), and the Escherichia Coli K12, Gen-Bank name ECO110K, a genomic fragment (...)
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  7. Crucial Steps to Life: From Chemical Reactions to Code Using Agents.Witzany Guenther - 2016 - Biosystems 140:49-57.
    The concepts of the origin of the genetic code and the definitions of life changed dramatically after the RNA world hypothesis. Main narratives in molecular biology and genetics such as the “central dogma,” “one gene one protein” and “non-coding DNA is junk” were falsified meanwhile. RNA moved from the transition intermediate molecule into centre stage. Additionally the abundance of empirical data concerning nonrandom genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not (...)
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  8.  26
    DNA Habitats and Their RNA Inhabitants.Guenther Witzany (ed.) - 2015
    Most molecular biological concepts derive from physical chemical assumptions about the genetic code that are basically more than 40 years old. Additionally, systems biology, another quantitative approach, investigates the sum of interrelations to obtain a more holistic picture of nucleotide sequence order. Recent empirical data on genetic code compositions and rearrangements by mobile genetic elements and non-coding RNAs, together with results of virus research and their role in evolution, does not really fit into these concepts and compel a re-examination. (...)
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  9.  64
    OmniSearch: A Semantic Search System Based on the Ontology for MIcroRNA Target for microRNA-Target Gene Interaction Data.Huang Jingshan, Gutierrez Fernando, J. Strachan Harrison, Dou Dejing, Huang Weili, A. Blake Judith, Barry Smith, Eilbeck Karen, A. Natale Darren & Lin Yu - 2016 - Journal of Biomedical Semantics 7 (1):1.
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary (...)
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  10. Rethinking Quasispecies Theory: From Fittest Type to Cooperative Consortia.Luis Villarreal & Guenther Witzany - 2013 - World Journal of Biological Chemistry 4:79-90.
    Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops are the basic players. We thus redefine quasispecies as RNA quasispecies consortia (...)
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  11. Non‐Classical Knowledge.Ethan Jerzak - 2019 - Philosophy and Phenomenological Research 98 (1):190-220.
    The Knower paradox purports to place surprising a priori limitations on what we can know. According to orthodoxy, it shows that we need to abandon one of three plausible and widely-held ideas: that knowledge is factive, that we can know that knowledge is factive, and that we can use logical/mathematical reasoning to extend our knowledge via very weak single-premise closure principles. I argue that classical logic, not any of these epistemic principles, is the culprit. I develop a consistent theory validating (...)
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  12. Function of Aggregated Reticulocyte Ribosomes in Protein Synthesis.Alfred Gierer - 1963 - J. Mol. Biol 6:148-157.
    Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due (...)
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  13. Ontological Pluralism About Non-Being.Sara Bernstein - forthcoming - In Sara Bernstein & Tyron Goldschmidt (eds.), Non-being: New Essays on Nonexistence.
    I develop ontological pluralism about non-being, the view that there are multiple ways, kinds, or modes of non-being. I suggest that the view is both more plausible and defensible and than it first seems, and that it has many useful applications across a wide variety of metaphysical and explanatory problems. After drawing out the relationship between pluralism about being and pluralism about non-being, I discuss quantificational strategies for the pluralist about non-being. I examine historical precedent for the view. Finally, I (...)
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  14. On the Possibility of Constructive Neutral Evolution.Arlin Stoltzfus - 1999 - Journal of Molecular Evolution 49 (2):169-181.
    The neutral theory often is presented as a theory of "noise" or silent changes at an isolated "molecular level", relevant to marking the steady pace of divergence, but not to the origin of biological structure, function, or complexity. Nevertheless, precisely these issues can be addressed in neutral models, such as those elaborated here in regard to scrambled ciliate genes, gRNA-mediated RNA editing, the transition from self-splicing to spliceosomal splicing, and the retention of duplicate genes. All of these are instances of (...)
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  15. Equilibrium Explanation as Structural Non-Mechanistic Explanation: The Case Long-Term Bacterial Persistence in Human Hosts.Javier Suárez & Roger Deulofeu - 2019 - Teorema: International Journal of Philosophy 3 (38):95-120.
    Philippe Huneman has recently questioned the widespread application of mechanistic models of scientific explanation based on the existence of structural explanations, i.e. explanations that account for the phenomenon to be explained in virtue of the mathematical properties of the system where the phenomenon obtains, rather than in terms of the mechanisms that causally produce the phenomenon. Structural explanations are very diverse, including cases like explanations in terms of bowtie structures, in terms of the topological properties of the system, or in (...)
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  16. Genetic, Epigenetic and Exogenetic Information in Development and Evolution.Paul Edmund Griffiths - 2017 - Interface Focus 7 (5).
    The idea that development is the expression of information accumulated during evolution and that heredity is the transmission of this information is surprisingly hard to cash out in strict, scientific terms. This paper seeks to do so using the sense of information introduced by Francis Crick in his sequence hypothesis and central dogma of molecular biology. It focuses on Crick's idea of precise determination. This is analysed using an information-theoretic measure of causal specificity. This allows us to reconstruct some of (...)
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  17. Predictive Coding and Representationalism.Paweł Gładziejewski - 2016 - Synthese 193 (2).
    According to the predictive coding theory of cognition , brains are predictive machines that use perception and action to minimize prediction error, i.e. the discrepancy between bottom–up, externally-generated sensory signals and top–down, internally-generated sensory predictions. Many consider PCT to have an explanatory scope that is unparalleled in contemporary cognitive science and see in it a framework that could potentially provide us with a unified account of cognition. It is also commonly assumed that PCT is a representational theory of sorts, in (...)
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  18. Is Attention a Non-Propositional Attitude?Sebastian Watzl - forthcoming - In Alex Grzankowski & Michelle Montague (eds.), Non-Propositional Intentionality. Oxford University Press.
    I argue first that attention is a (maybe the) paradigmatic case of an object-directed, non-propositional intentional mental episode. In addition attention cannot be reduced to any other (propositional or non-propositional) mental episodes. Yet, second, attention is not a non-propositional mental attitude. It might appear puzzling how one could hold both of these claims. I show how to combine them, and how that combination shows how propositionality and non-propositionality can co-exist in a mental life. The crucial move is one away from (...)
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  19.  90
    Non-Normal Modalities in Variants of Linear Logic.D. Porello & N. Troquard - 2015 - Journal of Applied Non-Classical Logics 25 (3):229-255.
    This article presents modal versions of resource-conscious logics. We concentrate on extensions of variants of linear logic with one minimal non-normal modality. In earlier work, where we investigated agency in multi-agent systems, we have shown that the results scale up to logics with multiple non-minimal modalities. Here, we start with the language of propositional intuitionistic linear logic without the additive disjunction, to which we add a modality. We provide an interpretation of this language on a class of Kripke resource models (...)
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  20.  69
    Judgement Aggregation in Non-Classical Logics.Daniele Porello - 2017 - Journal of Applied Non-Classical Logics 27 (1-2):106-139.
    This work contributes to the theory of judgement aggregation by discussing a number of significant non-classical logics. After adapting the standard framework of judgement aggregation to cope with non-classical logics, we discuss in particular results for the case of Intuitionistic Logic, the Lambek calculus, Linear Logic and Relevant Logics. The motivation for studying judgement aggregation in non-classical logics is that they offer a number of modelling choices to represent agents’ reasoning in aggregation problems. By studying judgement aggregation in logics that (...)
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  21. Ethical Non-Naturalism and the Metaphysics of Supervenience.Tristram McPherson - 2012 - In Oxford Studies in Metaethics Vol 7. pp. 205.
    It is widely accepted that the ethical supervenes on the natural, where this is roughly the claim that it is impossible for two circumstances to be identical in all natural respects, but different in their ethical respects. This chapter refines and defends the traditional thought that this fact poses a significant challenge to ethical non-naturalism, a view on which ethical properties are fundamentally different in kind from natural properties. The challenge can be encapsulated in three core claims which the chapter (...)
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  22. We Need Non-Factive Metaphysical Explanation.Michael Bertrand - forthcoming - Erkenntnis:1-21.
    Suppose that A explains B. Do A and B need to be true? Provided that we have metaphysical explanation in mind, orthodoxy answers “yes:” metaphysical explanation is factive. This article introduces and defends a non-factive notion of metaphysical explanation. I argue that we need a non-factive notion of explanation in order to make sense of explanationist arguments where we motivate a view by claiming that it offers better explanations than its competitors. After presenting and rejecting some initially plausible rivals, I (...)
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  23. Kant on Perception: Naive Realism, Non-Conceptualism, and the B-Deduction.Anil Gomes - 2014 - Philosophical Quarterly 64 (254):1-19.
    According to non-conceptualist interpretations, Kant held that the application of concepts is not necessary for perceptual experience. Some have motivated non-conceptualism by noting the affinities between Kant's account of perception and contemporary relational theories of perception. In this paper I argue (i) that non-conceptualism cannot provide an account of the Transcendental Deduction and thus ought to be rejected; and (ii) that this has no bearing on the issue of whether Kant endorsed a relational account of perceptual experience.
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  24. Aquinas, Finnis and Non-Naturalism.Craig Paterson - 2006 - In Craig Paterson & Matthew Pugh (eds.), Analytical Thomism: Traditions in Dialogue. Ashgate.
    In this chapter I seek to examine the credibility of Finnis’s basic stance on Aquinas that while many neo-Thomists are meta-ethically naturalistic in their understanding of natural law theory (for example, Heinrich Rommen, Henry Veatch, Ralph McInerny, Russell Hittinger, Benedict Ashley and Anthony Lisska), Aquinas’s own meta-ethical framework avoids the “pitfall” of naturalism. On examination, the short of it is that I find Finnis’s account (while adroit) wanting in the interpretation stakes vis-à-vis other accounts of Aquinas’s meta-ethical foundationalism. I think (...)
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  25. The Supervenience Challenge to Non-Naturalism.Pekka Väyrynen - 2017 - In Tristram McPherson & David Plunkett (eds.), The Routledge Handbook of Metaethics. Routledge. pp. 170-84.
    This paper is a survey of the supervenience challenge to non-naturalist moral realism. I formulate a version of the challenge, consider the most promising non-naturalist replies to it, and suggest that no fully effective reply has yet been given.
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  26. Moral Attitudes for Non-Cognitivists: Solving the Specification Problem.Gunnar Björnsson & Tristram McPherson - 2014 - Mind 123 (489):1-38.
    Moral non-cognitivists hope to explain the nature of moral agreement and disagreement as agreement and disagreement in non-cognitive attitudes. In doing so, they take on the task of identifying the relevant attitudes, distinguishing the non-cognitive attitudes corresponding to judgements of moral wrongness, for example, from attitudes involved in aesthetic disapproval or the sports fan’s disapproval of her team’s performance. We begin this paper by showing that there is a simple recipe for generating apparent counterexamples to any informative specification of the (...)
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  27.  59
    Non-Deterministic Algebraization of Logics by Swap Structures.Marcelo E. Coniglio, Aldo Figallo-Orellano & Ana Claudia Golzio - forthcoming - Logic Journal of the IGPL.
    Multialgebras (or hyperalgebras or non-deterministic algebras) have been much studied in mathematics and in computer science. In 2016 Carnielli and Coniglio introduced a class of multialgebras called swap structures, as a semantic framework for dealing with several Logics of Formal Inconsistency (or LFIs) that cannot be semantically characterized by a single finite matrix. In particular, these LFIs are not algebraizable by the standard tools of abstract algebraic logic. In this paper, the first steps towards a theory of non-deterministic algebraization of (...)
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  28. The Law of Non-Contradiction as a Metaphysical Principle.Tuomas Tahko - 2009 - Australasian Journal of Logic 7:32-47.
    The goals of this paper are two-fold: I wish to clarify the Aristotelian conception of the law of non-contradiction as a metaphysical rather than a semantic or logical principle, and to defend the truth of the principle in this sense. First I will explain what it in fact means that the law of non-contradiction is a metaphysical principle. The core idea is that the law of non-contradiction is a general principle derived from how things are in the world. For example, (...)
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  29.  28
    David Boonin on the Non-Identity Argument: Rejecting the Second Premise.Molly Gardner - 2019 - Law, Ethics and Philosophy 7:29-47.
    According to various “harm-based” approaches to the non-identity problem, an action that brings a particular child into existence can also harm that child, even if his or her life is worth living. In the third chapter of The Non-Identity Problem and the Ethics of Future People, David Boonin surveys a variety of harm-based approaches and argues that none of them are successful. In this paper I argue that his objections to these various approaches do not impugn a harm-based approach that (...)
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  30. Whose Problem Is Non-Identity?Paul Hurley & Rivka Weinberg - 2014 - Journal of Moral Philosophy 12 (6):699-730.
    Teleological theories of reason and value, upon which all reasons are fundamentally reasons to realize states of affairs that are in some respect best, cannot account for the intuition that victims in non-identity cases have been wronged. Many philosophers, however, reject such theories in favor of alternatives that recognize fundamentally non-teleological reasons, second-personal reasons that reflect a moral significance each person has that is not grounded in the teleologist’s appeal to outcomes. Such deontological accounts appear to be better positioned to (...)
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  31. Noise, Uncertainty, and Interest: Predictive Coding and Cognitive Penetration.Jona Vance & Dustin Stokes - 2017 - Consciousness and Cognition 47:86-98.
    This paper concerns how extant theorists of predictive coding conceptualize and explain possible instances of cognitive penetration. §I offers brief clarification of the predictive coding framework and relevant mechanisms, and a brief characterization of cognitive penetration and some challenges that come with defining it. §II develops more precise ways that the predictive coding framework can explain, and of course thereby allow for, genuine top-down causal effects on perceptual experience, of the kind discussed in the context of cognitive penetration. §III develops (...)
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  32. The Kantian (Non)‐Conceptualism Debate.Colin McLear - 2014 - Philosophy Compass 9 (11):769-790.
    One of the central debates in contemporary Kant scholarship concerns whether Kant endorses a “conceptualist” account of the nature of sensory experience. Understanding the debate is crucial for getting a full grasp of Kant's theory of mind, cognition, perception, and epistemology. This paper situates the debate in the context of Kant's broader theory of cognition and surveys some of the major arguments for conceptualist and non-conceptualist interpretations of his critical philosophy.
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  33.  66
    The Case for Valuing Non-Health and Indirect Benefits.Govind Persad & Jessica du Toit - 2020 - In Ole F. Norheim, Ezekiel J. Emanuel & Joseph Millum (eds.), Global Health Priority-Setting: Beyond Cost-Effectiveness. New York, NY, USA: pp. 207-222.
    Health policy is only one part of social policy. Although spending administered by the health sector constitutes a sizeable fraction of total state spending in most countries, other sectors such as education and transportation also represent major portions of national budgets. Additionally, though health is one important aspect of economic and social activity, people pursue many other goals in their social and economic lives. Similarly, direct benefits—those that are immediate results of health policy choices—are only a small portion of the (...)
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  34. No Harm Done? An Experimental Approach to the Non-Identity Problem.Matthew Kopec & Justin P. Bruner - manuscript
    A driving force behind much of the literature on the non-identity problem is the widely shared intuition that actions or policies that change who comes into existence don't, as a result, lose their morally problematic features. We hypothesize that this intuition isn’t entirely shared by the general public, which might have widespread implications concerning how to best motivate public support for large-scale, identity-affecting policies like those involved in climate change mitigation. To test our hypothesis, we ran a behavioural economic experiment, (...)
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  35. Goblet Words and Moral Knack: Non-Cognitive Moral Realism in the Zhuangzi?Christopher Kirby - 2019 - In Colin Marshall (ed.), Comparative Metaethics: Neglected Perspectives on the Foundations of Morality. New York: Routledge. pp. 159-178.
    This chapter focuses on Daoist praxeology and language in order to build something of a moral realist position (the contours of which may differ from most western versions insofar as it need not commit to moral cognitivism) that hinges on the seemingly paradoxical notions of ineffable moral truths and non-transferable moral skill.
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  36. Non-Domination and Political Liberal Citizenship Education.Blain Neufeld - 2019 - In Colin Macleod & Christine Tappolet (eds.), Philosophical Perspectives on Moral and Civic Education. London, UK: Routledge. pp. 135-155.
    According to Philip Pettit, we should understand republican liberty, freedom as ‘non-domination,’ as a ‘supreme political value.’ It is its commitment to freedom as non-domination, Pettit claims, that distinguishes republicanism from various forms of liberal egalitarianism, including the political liberalism of John Rawls. I explain that Rawlsian political liberalism is committed to a form of non-domination, namely, a ‘political’ conception, which is: (a) limited in its scope to the ‘basic structure of society,’ and (b) ‘freestanding’ in nature (that is, compatible (...)
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  37. Non-Naturalistic Moral Explanation.Samuel Baron, Mark Colyvan, Kristie Miller & Michael Rubin - forthcoming - Synthese.
    This paper focuses on a particular kind of non-naturalism: moral non-naturalism. Our primary aim is to argue that the moral non-naturalist places herself in an invidious position if she simply accepts that the non-natural moral facts that she posits are not explanatory. This has, hitherto, been the route that moral non-naturalists have taken. They have attempted to make their position more palatable by pointing out that there is reason to be suspicious of the explanatory criterion of ontological commitment. That is (...)
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  38.  19
    Punishing Non-Citizens.Bill Wringe - forthcoming - Journal of Applied Philosophy.
    In this paper, I discuss a distinctively non-paradigmatic instance of punishment: the punishment of non-citizens. I shall argue that the punishment of non-citizens presents considerable difficulties for one currently popular account of criminal punishment: Antony Duff’s communicative expressive theory of punishment. Duff presents his theory explicitly as an account of the punishment of citizens - and as I shall argue, this is not merely an incidental feature of his account. However, it is plausible that a general account of the criminal (...)
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  39. Del hombre-máquina a la máquina-hombre: materialismo, mecanicismo y transhumanismo.Martín López Corredoira - 2019 - Naturaleza y Libertad. Revista de Estudios Interdisciplinares 12:179-190.
    El materialismo de la Edad Moderna nos describe al hombre como una máquina, comparable a un complejo artilugio mecánico. Cabe entonces imaginar que una máquina no-biológica pueda constituir un ser pensante como lo son los seres humanos, e incluso cabría pensar en la posibilidad de codificación de una mente humana real para su posterior trasvase a un sustrato artificial. Considero que estas últimas posiciones son más propias de la cultura friki o de amantes de la ciencia ficción que de una (...)
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  40. That is Life: Communicating RNA Networks From Viruses and Cells in Continuous Interaction.Guenther Witzany - 2019 - Annals of the New York Academy of Sciences:1-16.
    All the conserved detailed results of evolution stored in DNA must be read, transcribed, and translated via an RNAmediated process. This is required for the development and growth of each individual cell. Thus, all known living organisms fundamentally depend on these RNA-mediated processes. In most cases, they are interconnected with other RNAs and their associated protein complexes and function in a strictly coordinated hierarchy of temporal and spatial steps (i.e., an RNA network). Clearly, all cellular life as we know it (...)
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  41. Non‐Observational Knowledge of Action.John Schwenkler - 2012 - Philosophy Compass 7 (10):731-740.
    Intuitively, the knowledge of one’s own intentional actions is different from the knowledge of actions of other sorts, including those of other people and unintentional actions of one's own. But how are we to understand this phenomenon? Does it pertain to all actions, under every description under which they are known? If so, then how is this possible? If not, then how should we think about cases that are exceptions to this principle? This paper is a critical survey of recent (...)
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  42.  17
    Non-Positivism and Encountering a Weakened Necessity of the Separation Between Law and Morality – Reflections on the Debate Between Robert Alexy and Joseph Raz.Wei Feng - 2019 - Archiv Für Rechts- Und Sozialphilosophie, Beiheft 158:305-334.
    Nearly thirty years ago, Robert Alexy in his book The Concept and Validity of Law as well as in other early articles raised non-positivistic arguments in the Continental European tradition against legal positivism in general, which was assumed to be held by, among others, John Austin, Hans Kelsen and H.L.A. Hart. The core thesis of legal positivism that was being discussed among contemporary German jurists, just as with their Anglo- American counterparts, is the claim that there is no necessary connection (...)
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  43. Non-Existent Objects and Epistemological Ontology.William J. Rapaport - 1985 - Grazer Philosophische Studien 25 (1):61-95.
    This essay examines the role of non-existent objects in "epistemological ontology" — the study of the entities that make thinking possible. An earlier revision of Meinong's Theory of Objects is reviewed, Meinong's notions of Quasisein and Außersein are discussed, and a theory of Meinongian objects as "combinatorially possible" entities is presented.
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  44. Non-Realist Cognitivism, Truth and Objectivity.Jussi Suikkanen - 2017 - Acta Analytica 32 (2):193-212.
    In On What Matters, Derek Parfit defends a new metaethical theory, which he calls non-realist cognitivism. It claims that normative judgments are beliefs; that some normative beliefs are true; that the normative concepts that are a part of the propositions that are the contents of normative beliefs are irreducible, unanalysable and of their own unique kind; and that neither the natural features of the reality nor any additional normative features of the reality make the relevant normative beliefs true. The aim (...)
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  45. A Harm Based Solution to the Non-Identity Problem.Molly Gardner - 2015 - Ergo: An Open Access Journal of Philosophy 2:427-444.
    Many of us agree that we ought not to wrong future people, but there remains disagreement about which of our actions can wrong them. Can we wrong individuals whose lives are worth living by taking actions that result in their very existence? The problem of justifying an answer to this question has come to be known as the non-identity problem.[1] While the literature contains an array of strategies for solving the problem,[2] in this paper I will take what I call (...)
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  46.  64
    Non-Descriptive Relativism: Adding Options to the Expressivist Marketplace.Matthew Bedke - 2018 - Oxford Studies in Metaethics 13:48-70.
    This chapter identifies a novel family of metaethical theories that are non-descriptive and that aim to explain the action-guiding qualities of normative thought and language. The general strategy is to consider different relations language might bear to a given content, where we locate descriptivity (or lack of it) in these relations, rather than locating it in a theory that begins with the expression of states of mind, or locating it in a special kind of content that is not way-things-might-be content. (...)
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  47. Non-Classical Metatheory for Non-Classical Logics.Andrew Bacon - 2013 - Journal of Philosophical Logic 42 (2):335-355.
    A number of authors have objected to the application of non-classical logic to problems in philosophy on the basis that these non-classical logics are usually characterised by a classical metatheory. In many cases the problem amounts to more than just a discrepancy; the very phenomena responsible for non-classicality occur in the field of semantics as much as they do elsewhere. The phenomena of higher order vagueness and the revenge liar are just two such examples. The aim of this paper is (...)
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  48. Geoengineering and Non-Ideal Theory.David R. Morrow & Toby Svoboda - 2016 - Public Affairs Quarterly 30 (1):85-104.
    The strongest arguments for the permissibility of geoengineering (also known as climate engineering) rely implicitly on non-ideal theory—roughly, the theory of justice as applied to situations of partial compliance with principles of ideal justice. In an ideally just world, such arguments acknowledge, humanity should not deploy geoengineering; but in our imperfect world, society may need to complement mitigation and adaptation with geoengineering to reduce injustices associated with anthropogenic climate change. We interpret research proponents’ arguments as an application of a particular (...)
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  49.  55
    Laruelle Qua Stiegler: On Non-Marxism and the Transindividual.Ekin Erkan - 2019 - Identities: Journal for Politics, Gender and Culture 16 (1-2).
    Alexander R. Galloway and Jason R. LaRiviére’s article “Compression in Philosophy” seeks to pose François Laruelle’s engagement with metaphysics against Bernard Stiegler’s epistemological rendering of idealism. Identifying Laruelle as the theorist of genericity, through which mankind and the world are identified through an index of “opacity,” the authors argue that Laruelle does away with all deleterious philosophical “data.” Laruelle’s generic immanence is posed against Stiegler’s process of retention and discretization, as Galloway and LaRiviére argue that Stiegler’s philosophy seeks to reveal (...)
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  50. Nietzsche and Non-Cognitivism.Nadeem J. Z. Hussain - 2012 - In Simon Robertson & Christopher Janaway (eds.), Nietzsche, Naturalism & Normativity. Oxford University Press.
    Though Nietzsche traditionally often used to be interpreted as a nihilist, a range of possible metaethical interpretations, including varieties of realism, subjectivism and fictionalism, have emerged in the secondary literature. Recently the possibility that Nietzsche is a non-cognitivist has been broached. If one sees Hume as a central non-cognitivist figure, as recent non-cognitivists such as Simon Blackburn have, then the similarities between Nietzsche and Hume can make this reading seem plausible. This paper assesses the general plausibility of interpreting Nietzsche as (...)
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