This paper connects veritistic teleological epistemology, VTE, with the epistemological dimension of the scientific realism debate. VTE sees our epistemic activities as a tradeoff between believing truths and avoiding error. I argue that van Fraassen’s epistemology is not suited to give a justification for a crucial presupposition of his Bad Lot objection to inference to the best explanation (IBE), the presupposition that believing that p is linked to p being more likely to be true. This makes him vulnerable to a (...) counterargument, tailored after Musgrave’s defense of IBE, which would result in a stalemate between them about presuppositions of rationality. I will, however, show that switching to VTE can justify van Fraassen’s presupposition. This leads to a dismissal of common IBE arguments for realism as presented by Boyd and Musgrave, but I also argue that a more cautious version of realism can be rescued from the Bad Lot objection. Finally, I raise some worries about epistemic risk-attitude consistency for constructive empiricists and develop an alternative anti-realist position.1. (shrink)