Previous research in Explainable Artificial Intelligence (XAI) suggests that a main aim of explainability approaches is to satisfy specific interests, goals, expectations, needs, and demands regarding artificial systems (we call these “stakeholders' desiderata”) in a variety of contexts. However, the literature on XAI is vast, spreads out across multiple largely disconnected disciplines, and it often remains unclear how explainability approaches are supposed to achieve the goal of satisfying stakeholders' desiderata. This paper discusses the main classes of stakeholders calling for explainability (...) of artificial systems and reviews their desiderata. We provide a model that explicitly spells out the main concepts and relations necessary to consider and investigate when evaluating, adjusting, choosing, and developing explainability approaches that aim to satisfy stakeholders' desiderata. This model can serve researchers from the variety of different disciplines involved in XAI as a common ground. It emphasizes where there is interdisciplinary potential in the evaluation and the development of explainability approaches. (shrink)

In this paper, we propose a regularity theory of causation. The theory aims to be reductive and to align with our pre‐theoretic understanding of the causal relation. We show that our theory can account for a wide range of causal scenarios, including isomorphic scenarios, omissions, and scenarios which suggest that causation is not transitive.

We define a formal semantics of conditionals based on _normatively ideal worlds_. Such worlds are described informally by Armgardt (Gabbay D, Magnani L, Park W, Pietarinen A-V (eds) Natural arguments: a tribute to john woods, College Publications, London, pp 699–708, 2018) to address well-known problems of the counterfactual approach to causation. Drawing on Armgardt’s proposal, we use iterated conditionals in order to analyse causal relations in scenarios of multi-agent interaction. This results in a refined counterfactual approach to causal responsibility in (...) legal contexts, which solves overdetermination problems in an intuitively accessible manner. (shrink)

The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally, experts assumed that this issue could be sufficiently addressed by insisting simply on the application of shared clinical terminologies or clinical information models. However, the use of the term ‘ontology’ has been steadily increasing more recently. We discuss criteria for distinguishing clinical ontologies from clinical terminologies and information models. Then, we briefly present the role clinical ontologies play in two multicentric research projects. Finally, (...) we discuss the interactions between these different kinds of knowledge representation artifacts and the stakeholders involved in developing interoperational real-world clinical applications. We provide ontology engineering examples from two EU-funded projects. (shrink)

Conscious existence is the product of a neural brain mechanism, which is largely identical with Immanuel Kant's Oneness Function, a service performed by 200 million neurons in the prefrontal lobe, & makes possible our interior cosmos, the record of our interconnected, or general, experience. Essential for us humans is the well-being of our interior cosmos, or Saint Teresa of Avila's interior castle, in all interactions with each other \& the greater environment. Any disorders of our cosmos are liable to make (...) us fall ill, setting our existence on a path of psychosomatic etiology of a large class of mysterious undiagnosed diseases. (shrink)

Recent advances in neuroscience lead to a wider realm for philosophy to include the science of the Darwinian-evolved computational brain, our inner world producing organ, a non-recursive super- Turing machine combining 100B synapsing-neuron DNA-computers based on the genetic code. The whole system is a logos machine offering a world map for global context, essential for our intentional grasp of opportunities. We start from the observable contrast between the chaotic universe vs. our orderly inner world, the noumenal cosmos. So far, philosophy (...) has been rehearsing our thoughts, our human-internal world, a grand painting of the outer world, how we comprehend subjectively our experience, worked up by the logos machine, but now we seek a wider horizon, how humans understand the world thanks to Darwinian evolution to adapt in response to the metaphysical gap, the chasm between the human animal and its environment, shaping the organism so it can deal with its variable world. This new horizon embraces global context coded in neural structures that support the noumenal cosmos, our inner mental world, for us as denizens of the outer environment. Kant’s inner and outer senses are fundamental ingredients of scientific philosophy. Several sections devoted to Heidegger, his lizard debunked, but his version of the metaphysical gap & his doctrine of the logos praised. Rorty and others of the behaviorist school discussed also. (shrink)

We will explicate Cantor’s principle of set existence using the Gödelian intensional notion of absolute provability and John Burgess’ plural logical concept of set formation. From this Cantorian Comprehension principle we will derive a conditional result about the question whether there are any absolutely unprovable mathematical truths. Finally, we will discuss the philosophical significance of the conditional result.

The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally, experts assumed that this issue could be sufficiently addressed by insisting simply on the application of shared clinical terminologies or clinical information models. However, the use of the term ‘ontology’ has been steadily increasing more recently. We discuss criteria for distinguishing clinical ontologies from clinical terminologies and information models. Then, we briefly present the role clinical ontologies play in two multicentric research projects. Finally, (...) we discuss the interactions between these different kinds of knowledge representation artifacts and the stakeholders involved in developing interoperational real-world clinical applications. We provide ontology engineering examples from two EU-funded projects. (shrink)

The aim of this paper is to scrutinize active externalism and its repercussions for externalism about mental content. I start from the claim that active externalism is a version of content externalism that follows from the extended cognition thesis as a thesis about cognitive vehicles. Various features of active content externalism are explored by comparison with the known forms of passive externalism – in particular with respect to the multiple realizability of the relevant external content-determining components and with respect to (...) mental causation. A crucial result is that social externalism is already a version of active externalism. I conclude with a first sketch of a general account of meaning inspired by extended cognition: a use theory supplemented by a functional-role account. (shrink)

In this essay, our goal is to discover science in Martin Heidegger's Introduction to Metaphysics, lecture notes for his 1935 summer semester course, because, after all, his subject is metaphysica generalis, or ontology, and this could be construed as a theory of the human brain. Here, by means of verbatim quotes from his text, we attempt to show that indeed these lectures can be viewed as suggestion for an objective scientific theory of human perception, the human capacity for deciphering phenomena, (...) ie. hermeneutics in its broadest sense. His added notes from the 1953 edition, all of which are comments, not corrections, imply that he never abandoned these thoughts on metaphysics, despite all of his utterances about a need to overcome it, and their popular interpretations to that effect. In his presentation, he further develops the colorful and intuitive style, an hermeneutic language, that he had created in his earlier work Being and Time. Of human existence he speaks in such expressions as being-there -- ``Dasein" -- and being-in-the-world, the latter term no longer explicit in the 1935 lectures. The lectures can be read as a pre-scientific analysis of how man, being-there, perceives his environment, artfully managing to deal with the manifold challenges posed by the phenomenal structures of the universe. Man attentively recognizes and deciphers their pre-linguistic contents and, while trying to make sense of it all, puts into words his awareness. There are numerous passages in Heidegger's work where he in fairly concrete terms provides us with hints for a perceptive science that, as it turns out and is demonstrated below in this essay, can be explained in terms of recent advances in neuroscience. It would be implausible, even unthinkable, unimaginable, for there not to be found essential agreement between on one hand his philosophical insights gained by hermeneutics of Dasein, into how our brain functions to let us know what's happening & on the other hand, scientific discoveries obtained through anatomy, EEG, fMRI, TMS, electrode implants, etc, of brain structures & functions employed in perception of the momentary scene. A nexus between science and philosophy is provided in Heidegger's definitive treatment of the Logos, here interpreted as a structural version of Platonic forms (Burchard, 2014). This allows for neurolinguistic brain functions to serve as meta-context for Heidegger's being-in-the-world. The logical functions of Dasein's anatomical brain are performed by the logos machine, formerly the human soul, using top-down processing based on a global context, the noumenal cosmos which humans maintain internally. Heidegger's 1942/43 winter semester lectures Parmenides extend in unbroken fashion his 1935 work, proving that he never abandoned, as is widely claimed, his metaphysical avenue of thought. (shrink)

Georg Cantor's absolute infinity, the paradoxical Burali-Forti class Ω of all ordinals, is a monstrous non-entity for which being called a "class" is an undeserved dignity. This must be the ultimate vexation for mathematical philosophers who hold on to some residual sense of realism in set theory. By careful use of Ω, we can rescue Georg Cantor's 1899 "proof" sketch of the Well-Ordering Theorem––being generous, considering his declining health. We take the contrapositive of Cantor's suggestion and add Zermelo's choice function. (...) This results in a concise and uncomplicated proof of the Well-Ordering Theorem. (shrink)

Dieser Band versammelt Beiträge zu den drei klassischen Disziplinen der Philosophie – dem Wahren, dem Guten, dem Schönen. Ihre Autoren zeichnet aus, dass sie aus dem akademischen Umfeld Michael Sukales zu seiner Zeit am Institut für Philosophie an der Carl-von-Ossietzky-Universität Oldenburg stammen. Ihm ist dieses Buch zum Abschied von seiner aktiven Lehrtätigkeit in Oldenburg gewidmet. Die thematische Vielfalt der enthaltenen Texte spiegelt die Bandbreite seines philosophischen Schaffens wider.

This is a proposal for rethinking the main lines of Plato’s philosophy, including some of the conceptual tools he uses for building and maintaining it. Drawing on a new interpretive paradigm for Plato’s overall vision, the central focus is on the so-called Forms. Regarding the guiding paradigm, we propose replacing the dualism of a world of Forms separated from a world of particulars, with the monistic model of a hierarchically structured universe comprising interdependent levels of reality. Regarding the tools of (...) the trade, we distinguish between three constructs that have come, one and all, and largely indiscriminately, to be regarded as Forms: Ideal Forms, Conceptual Forms, and Relational Forms. This recalibration of what we know of Plato’s outlook, tools, and methods, together with a realignment of these with his general aims, will also help restore the philosopher’s emphasis on that which is good, a perspective often blurred in the structure of two worlds. (shrink)

Gegenstand dieses Beitrags ist eine Auseinandersetzung mit der Wissenschaftlichkeit der Medizin. Den Leitfaden der Analyse bildet dabei ein jüngerer Ansatz in der analytischen Wissenschaftstheorie, wonach Systematizität als zentrales Kriterium von Wissenschaft anzusehen ist (Hoyningen-Huene 2013). Ich werde im Detail zeigen, dass die Medizin dieses mehrdimensionale Kriterium insgesamt erfüllt, dass aus der Wissenschaftlichkeit der Medizin aber gleichwohl normative Konsequenzen folgen, die beispielsweise zur Abgrenzung von der Homöopathie und einer kritischen Bewertung des biopsychosozialen Modells führen. Zudem resultieren der Anwendungscharakter der Medizin und (...) die zentrale Bedeutung des Arzt-Patienten-Verhältnisses nicht in einer Schwächung des Anspruchs der Medizin als Wissenschaft. (shrink)

Recent developments under the keywords dynamicism, embodiment and situated cognition suggest the view that cognitive systems are not confined to the neural sys‐tem but leak into the world beyond the traditional system boundaries. This is the thesis of extended cognition. Such an extension of the cognitive vehicles leads to a new kind of content externalism, known as active externalism. The essay pursues three objectives: firstly, to distinguish the theses of extended cognitive and active externalism. Secondly, to delineate active externalism from (...) its various passive-externalist precursors in the form of physical, historical and social externalism and to scrutinize its special position, which amounts to a comprehensive discussion and analysis of all variants of mental externalism. And thirdly, to show that social externalism as opposed to physical and historical externalism allows for a gradual transition from passive to active mental externalism. (shrink)

Multiple Realizability (MR) must still be regarded as one of the principal arguments against type reductionist accounts of higher-order properties and their special laws. Against this I argue that there is no unique MR but rather a multitude of MR categories. In a slogan: MR is itself “multi-realized”. If this is true then we cannot expect one unique reductionist strategy against MR as an anti-reductionist argument. The main task is rather to develop a taxonomy of the wide variety of MR (...) cases and to sketch possible reductionist answers for each class of cases. The paper outlines some first steps in this direction. (shrink)

Structural Realism (SR) is typically rated as a moderate realist doctrine about the ultimate entities of nature described by fundamental physics. Whether it must be extended to the higher-level special sciences is not so clear. In this short paper I argue that there is no need to ‘structuralize’ the special sciences. By mounting concrete examples I show that structural descriptions and structural laws certainly play a role in the special sciences, but that they don’t play any exclusive role nor that (...) they give us any reason to believe that all that there is on the various levels is structure. I fortify my points by arguing that structures are global entities (in order for SR not to collapse into a bundle ontology) and that the assumption of higher-level structures as genuinely global or holistic entities is even more arcane. (shrink)

In der modernen Physik spielen Symmetrien eine herausragende Rolle zur Identifikation und Klassifizierung der fundamentalen Theorien und Entitäten. Symmetrien dienen der Darstellung invarianter Strukturen, das geeignete mathematische Werkzeug hierfür ist die Gruppentheorie. Eine Struktur lässt sich als eine Menge von Relationen verstehen, die einer Menge von Objekten aufgeprägt sind. Strukturell charakterisierte Objekte sind daher wesentlich über ihre relationalen Eigenschaften charakterisiert. Sieht man die theoretischen Entitäten wissenschaftlicher Theorien vornehmlich in dieser strukturellen Weise an, vertritt man eine moderate Variante eines wissenschaftlichen Realismus, (...) die als Strukturenrealismus bekannt ist. Im Umfeld dieser drei Konzepte – Symmetrien, Strukturen, Realismus – bewegt sich der folgende Aufsatz. (shrink)

The paper presents and discusses the “which-is-which content of handedness,” the meaning of left as left and right as right, as a possible candidate for the idea of a genuine embodied cognitive content. After showing that the Ozma barrier, the non-transferability of the meaning of left and right, provides a kind of proof of the non-descriptive, indexical nature of the which-is-which content of handedness, arguments are presented which suggest that the classical representationalist account of cognition faces a perplexing problem of (...) underdetermination of reference of left and right in the which-is-which sense. By way of contrast, no such problems occur in a framework were embodied contents are not mediated by some extra body model which carries the representational power, but are instead directly represented. (shrink)

Im ersten Abschnitt illustrierte ich die These der erweiterten Kognition und diskutiere einige mögliche Missverständnisse. Im zweiten Abschnitt werde ich vier Domänen kognitiver Erweiterung auseinanderhalten, nämlich eine Erweiterung in die körperliche, physikalische, 'informatorische' und soziale Umgebung betreffend. Um die These der erweiterten Kognition vor dem Einwand der kognitiven Inflation zu schützen, muss man für jeden dieser Bereiche (und gegebenenfalls noch spezieller) spezifische Bedingungen und Mechanismen der kognitiven Kopplung an die externen Komponenten angeben. Im dritten Abschnitt unterscheide ich die These der (...) erweiterten Kognition, von der sich im ersten Abschnitt bereits zeigen wird, dass sie eine These kognitiver Vehikel ist, von einer externalistischen Gehaltsthese. Letztere bezeichne ich im Anklang an Clark und Chalmers als aktiven Externalismus und illustriere dessen Unterschiede und Besonderheiten gegenüber den bekannten 'passiven' Formen des semantischen oder mentalen Externalismus in der Philosophie des Geistes, die sich mit den Namen Putnam, Millikan und Burge verbinden. Im vierten Abschnitt verfolge ich die spezifische Idee, die Mechanismen geteilter Intentionalität als Kopplungsmechanismen kognitiver Erweiterung in die soziale Umgebung, speziell soziale Interaktionspartner, anzusehen. Dazu mache ich in einigem Detail von Bratmans bekannter Plan-Konzeption geteilter Intentionalität Gebrauch. Anhand der Ergebnisse dieser Analyse wird sich im fünften und letzten Abschnitt zeigen, in welchem Sinne es sich dabei im Keim bereits um einen sozialen Externalismus handelt. Der soziale Externalismus, so der Clou, stellt bereits eine verkappte Variante eines aktiven Externalismus dar. (shrink)

The essay brings a summation of human efforts seeking to understand our existence. Plato and Kant & cognitive science complete reduction of philosophy to a neural mechanism, evolved along elementary Darwinian principles. Plato in his famous Cave Allegory explains that between reality and our experience of it there exists a great chasm, a metaphysical gap, fully confirmed through particle-wave duality of quantum physics. Kant found that we have two kinds of perception, two senses: By the spatial outer sense we perceive (...) phenomena, objects in space. Our temporal inner sense lets us perceive our inner state, noumena . Kant's two senses are fully confirmed through bilateral brain duality of cognitive science. The bilateral brain serves inner, temporal sense, logic & noumena in the left hemisphere. The right brain half is for the outer, spatial sense, geometry & phenomena. We form a whole system, a bilateral interior cosmos, a kind of world model, expressing what may lie beyond the metaphysical gap. In the right brain we build a phenomenal cosmos, to resemble the outer environment. In the brain's left hemisphere a noumenal cosmos, a model of our private world including Saint Teresa of Avila's castillo interior. The cosmos is regularly updated with novel sense data integrated into our memory banks. This was recognized early by Helmholtz (1860s). Our lives, health & well-being depend on us keeping our interior cosmos in good order. This used to be seen as saving one's precious soul from perdition. While we endeavour to keep our phenomenal cosmos neat & orderly by protecting the environment from harm, our noumenal cosmos to be livable requires us to engage in ethical conduct. This bilateral cosmos is responsible for our common sense judgment power, that we depend on for being able to lead a good & benign life. The 200 million neurons of BA10 in the prefrontal lobe have global access to the interior cosmos, & apply massive feedback to identify environmental conditions rapidly. The global access also gives conscious presence of the individual to itself, all that is present in the interior cosmos, for total freedom of action. In the left brain private ego, we are guarded by faith in divine mercy, & guided to choose the best course of action, able to survive under the most adverse conditions. For this, we receive directions from the Holy Ghost in Saint Teresa's castillo interior. (shrink)

The paper deals with Weizsäcker’s position within the philosophy of mind. It turns out that Weizsäcker’s ontology is based on an unorthodox conception both in the philosophy of physics and in the philosophy of mind. His quantum information theoretic reductionism is based on a subtle combination of atomism and holism, his philosophy of mind connected to this is a neutral monism, which proposes a bold intertwining of mind, matter, and space.

Der Aufsatz lotet den zeitgenössischen Reduktionismus aus. Im ersten Teil wird in zentrale Stationen der wissenschaftstheoretischen Debatte um Theorien-Reduktion eingeleitet, wobei das Schaffner-Hooker-Modell und die Bedeutung von Näherungsbegriffen hervorgehoben werden. Der zweite Teil behandelt die multiple Realisierbarkeit als eines der nach wie vor zentralen anti-reduktionistischen Argumente. Die Analyse soll zeigen, dass es sich hierbei nicht um ein einheitliches Phänomen handelt, sondern dass sehr verschiedene Kategorien von Multirealisierbarkeit zu unterscheiden sind. In einem vereinfachten Slogan: multiple Realisierbarkeit ist ihrerseits multirealisiert. Der Aufsatz (...) entwickelt eine rohe Taxonomie von Typen multipler Realisierbarkeit und möglicher reduktionistischer Strategien, wobei genuine Fälle von Multirealisierbarkeit auf geteilte Eigenschaften zurückgeführt werden. Im letzten Teil wird die besondere Rolle von Näherungen im Zusammenhang mit der explanatorischen Spannung zwischen ontischem Reduktionismus und epistemischen Anti-Reduktionismus verdeutlicht. (shrink)

From the earliest times, American ethics, the rules for the moral \& intellectual life of the West, used to be founded upon the two principles of self-reliance and good neighborliness. Here we consider the underlying functions of neural brain circuits, organic structures that have evolved adaptively by Darwinian rules subject to selection pressure. In the left brain resides our self-reliant private Ego, making plans, launching initiatives. Your public Ego dwells in the right brain, looking around, meeting with your friendly neighbor. (...) A main component is our bilateral interior cosmos, providing us with all the detailed information about our environment as well as the universe at large. (shrink)

Origin of the Yellowstone hotspot & Columbia River Basalts has remained uncertain until now. Here, we present evidence of meteorite impact origin. The hotspot is shallow, only 200 km deep, invalidating a theory of mantle plume origin. The hotspot track runs from the Yellowstone National Park in NW Wyoming to the volcanic Modoc Plateau in NE California. We present evidence of apparent remnants of an impact crater existing in the Modoc, a large multi-ring structure at least 160 km diameter. Much (...) of the complex crater has become obliterated by later Cascadia and Sierra orogenies. The crater has a tall 4,100 foot central uplift cone, locally known as Chalk Mountain, consisting of diatomaceous earth, presumably the rebound cone of a meteorite impact. This falsifies a theoretical prohibition of cosmic impact volcanism. Based on recent insights into explosive volcanism a plausible mechanism is proposed for how meteorite impacts can lead to resurgent calderas of the Yellowstone type, & of apparent LIP origin from thin crust ET impacts, invalidating theoretical constructs of mantle plumes. We mention chaotic terrains, including plutons, arising antipodal to impacts. (shrink)

Guided by key insights of the four great philosophers mentioned in the title, here, in review of and expanding on our earlier work (Burchard, 2005, 2011), we present an exposition of the role played by language, & in the broader sense, λογοζ, the Logos, in how the CNS, the brain, is running the human being. Evolution by neural Darwinism has been forcing the linguistic nature of mind, enabling it to overcome & exploit the cognitive gap between an animal and its (...) world by recognizing environmental structures. Our work was greatly influenced by Heidegger’s lecture notes on metaphysics (Heidegger, 1935). We found agreement with recent progress in neuroscience, but also mathematical foundations of language theory, equating Logos with the mathematical concept of structure. The mystery of perception across the gap is analyzed as radiation and molecules impinging on sensory neurons that carry linguistic information about gross environmental structures, and only remotely about the physical reality of elementary particles. The most important logical brain function is Ego or Self, guiding the workings of the brain as a logos machine. Ego or Self operates from neurons in frontopolar cortex with global receptive fields. The logos machine can function only by availing itself of global context, its internally stored noumenal cosmos NK, and the categorical-conceptual apparatus CCA, updated continually through the neural default mode network (Raichle, 2005). In the Transcendental Deduction, Immanuel Kant discovered that Ego or Self is responsible for conscious control in perception relying on concepts & categories for a fitting percept to be incorporated intoNK. The entire CNS runs as a “movie-in-the-brain” (Parvizi & Damasio, 2001), at peak speed processing simultaneously in a series of cortical centers a stack of up to twelve frames in gamma rhythm of 25 ms intervals. We equate global context, or NK, with our human world, Heidegger’s Dasein being-in-the-world, and are able to demonstrate that the great philosopher in EM parallels neuro-science concerning the human mind. (shrink)

In this article I argue that including relaxed epistemic values in the justification of democracy through a pragmatist and non-monist approach is compatible with the democratic values of self-rule and pluralism (which are often seen as incompatible with "political truth"). First, I contend that pragmatist epistemology offers a more suitable approach to politics instead of the correspondence theory of finding "the one truth". Secondly, I argue that instead of choosing between monist (purely epistemic or procedural) accounts of justification of democracy (...) we should see epistemic values as part of a hybrid interpretation. Thirdly, I argue that epistemic values in democracy should be interpreted in a non-demanding way. Fourth and corresponding to previous points, I claim weak political cognitivism is phenomenologically most plausible for the democratic participant. I then continue to show that both the values of autonomy and pluralism, which are often considered antithetical to truth-claims, can be accommodated and even enhanced by epistemic values in the justification of democracy. (shrink)

Propomos uma tipologia dos artefatos de representação para as áreas de saúde e ciências biológicas, e a associação dessa tipologia com diferentes tipos de ontologia formal e lógica, chegando a conclusões quanto aos pontos fortes e limitações da ontologia de diferentes tipos de recursos lógicos, enquanto mantemos o foco na lógica descritiva. Consideramos quatro tipos de representação de área: (i) representação léxico-semântica, (ii) representação de tipos de entidades, (iii) representação de conhecimento prévio, e (iv) representação de indivíduos. Defendemos uma clara (...) distinção entre os quatro tipos de representação, de forma a oferecer uma base mais racional para o uso das ontologias e artefatos relacionados no avanço da integração de dados e interoperabilidade de sistemas de raciocínio associados. Destacamos que apenas uma pequena porção de fatos cientificamente relevantes em áreas como a biomedicina pode ser adequadamente representada por ontologias formais, quando estas últimas são concebidas como representações de tipos de entidades. Particularmente, a tentativa de codificar conhecimento padrão ou probabilístico pela utilização de ontologias assim concebidas é fadada à produção de modelos não intencionais e errôneos. (shrink)

How could ectogestative technology disrupt gender roles, parenting practices, and concepts such as ‘birth’, ‘body’, or ‘parent’? In this chapter, we situate this emerging technology in the context of the history of reproductive technologies and analyse the potential social and conceptual disruptions to which it could contribute. An ectogestative device, better known as ‘artificial womb’, enables the extra-uterine gestation of a human being, or mammal more generally. It is currently developed with the main goal of improving the survival chances of (...) extremely premature neonates. We argue that the intended use of the technology in neonatal intensive care units, as an alternative to current incubators (’partial-ectogestation’), challenges concepts such as ‘birth’, ‘fetus’, and ‘neonate’, and has several ethico-legal implications. We moreover address a more futuristic scenario where the entire embryological and fetal development could happen within an artificial womb (’full-ectogestation’). Such a scenario reveals the disruption of gender roles, parenting practices, and concepts such as ‘mother’, ‘father’, and ‘parent’. Both full- and partial-ectogestation would have implications for engineering and design, law-making, ethics, and philosophical anthropology. (shrink)

Studie se zabývá tím, jak se v českých zemích obráželo bouřlivé období vývoje biologického myšlení od přelomu 19. a 20. století do první světové války, kdy vedle sebe existovaly velmi různé názory na evoluci. Mnohovrstevnatost teoretickou přitom doplňuje i kulturní a vědecká mnohovrstevnatost českých zemí, kde se jednak mísí vlivy německé a české biologie na svých autonomních institucích, a jednak lze spatřovat rozdíly i mezi lokálními centry Prahou a Brnem se svými badatelskými tradicemi a nezávislými vazbami na další centra ve (...) Vídni a evropských univerzitách. Centrem zájmu jsou teoreticky uvažující biologové, kteří buď sami dlouhodobě profilovali české biologické myšlení, anebo na něj měli díky zdejšímu působení přímý vliv. V letech ca 1900–1915 došlo k prvnímu otevřenému a diskutovanému vrcholu v české recepci evolucionismu a před jednoznačnými pozicemi a „velkými teoriemi“ má navrch spíše prostředkování diferencované zahraniční diskuse, podněty vlastní experimentální práce a opatrné očekávání od nového studia variability a dědičnosti. (shrink)

In this paper we present applications of the ACGT Master Ontology (MO) which is a new terminology resource for a transnational network providing data exchange in oncology, emphasizing the integration of both clinical and molecular data. The development of a new ontology was necessary due to problems with existing biomedical ontologies in oncology. The ACGT MO is a test case for the application of best practices in ontology development. This paper provides an overview of the application of the ontology within (...) the ACGT project thus far. (shrink)

This volume contains new and original papers on Martin Heidegger’s complex relation to Friedrich Nietzsche’s philosophy. The authors not only critically discuss the many aspects of Heidegger’s reading of Nietzsche, they also interpret Heidegger’s thought from a Nietzschean perspective. Here is presented for the first time an overview of not only Heidegger’s and Nietzsche’s philosophy but also an overview of what is alive – and dead – in their thinking. Many authors through a reading of Heidegger and Nietzsche deal with (...) current issues such as technology, ecology, and politics. This volume is of interest for everyone interested in Heidegger’s and Nietzsche’s thought. Contributors include: Babette Babich, Charles Bambach, Robert Bernasconi, Virgilio Cesarone, Stuart Elden, Michael Eldred, Markus Enders, Charles Feitosa, Véronique Fóti, Luanne T. Frank, Jeffery Kinlaw, Theodore Kisiel, William D. Melaney, Eric Sean Nelson, Abraham Olivier, Friederike Rese, Karlheinz Ruhstorfer, Harald Seubert, Robert Sinnerbrink, Robert Switzer, Jorge Uscatescu Barrón, Nancy A. Weston, Dale Wilkerson, Angel Xolocotzi, Jens Zimmermann. (shrink)

Recreational Drugs European Network (ReDNet) project aims to use the Psychonaut Web Mapping Project database (Psychonaut Web Mapping Group, 2009) containing novel psychoactive compounds usually not mentioned in the scientific literature and thus unknown to clinicians as a unique source of information. The database will be used to develop an integrated ICT prevention approach targeted at vulnerable individuals and focused on novel synthetic and herbal compounds and combinations. Particular care will be taken in keeping the health professionals working directly with (...) young people showing problematic behaviors regularly updated in terms of novel compounds and combinations as well. A user-friendly project website will be developed aimed primarily at delivering the information/prevention approaches, but will also be a way of communicating with project partners and relevant stakeholders (e.g. thematic forum facilities, instant messages, blogs, video chat, wikiblog, newsletters distributed via mailing list). The website will support various ICT prevention tools, including an SMS alert service. Different areas and sections will be aimed specifically at the different target groups. -/- . (shrink)

Symposium review of Richard Healey, Gauging What’s Real: The Conceptual Foundations of Contemporary Gauge Theories. Oxford: Oxford University Press, 2007. Pp. 297. $99.00 HB.

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

The neo-Kantian Hermann Cohen is famously anti-empiricist in that he denies that sensations can make a definable contribution to knowledge. However, in the second edition of Kant’s Theory of Experience (1885), Cohen considers a proposition that contrasts with both his other work and that of his followers: a Kantian who studies scientific claims to truth—and the grounds on which they are made—cannot limit himself to studying mathematics and logical principles, but needs to also investigate underlying presuppositions about the empirical element (...) of science. Due to his subjectivist approach, Cohen argues, Kant not only failed to explain how scientific observation and experiments are possible, but also misconceived the role of the ideas, particularly the idea of a system of nature. (shrink)

Grete Hermann’s essay “Die naturphilosophischen Grundlagen der Quantenmechanik” has received much deserved scholarly attention in recent years. In this paper, I follow the lead of Elise Crull who sees in Hermann’s work the general outlines of a neo-Kantian interpretation of quantum theory. In full support of this view, I focus on Hermann’s central claim that limited spatio-temporal, and even analogically causal, representations of events exist within an overall relational structure of entangled quantum mechanical states that defy any unified spatio-temporal description. (...) In my view, Hermann also advances an important transcendental argument that perspectival spatio-temporal representations of nature have their foundations in general relational networks that are not spatio-temporal. The key point is that the adoption of a perspectival system within the general network induces the representation but only for that context. These ideas are consistent with a perspectival subject–object principle in Kant and also with Weyl’s work on Lie groups and their representations. (shrink)

In Bertrand Russell's 1903 Principles of Mathematics, he offers an apparently devastating criticism of the neo-Kantian Hermann Cohen's Principle of the Infinitesimal Method and its History (PIM). Russell's criticism is motivated by his concern that Cohen's account of the foundations of calculus saddles mathematics with the paradoxes of the infinitesimal and continuum, and thus threatens the very idea of mathematical truth. This paper defends Cohen against that objection of Russell's, and argues that properly understood, Cohen's views of limits and infinitesimals (...) do not entail the paradoxes of the infinitesimal and continuum. Essential to that defense is an interpretation, developed in the paper, of Cohen's positions in the PIM as deeply rationalist. The interest in developing this interpretation is not just that it reveals how Cohen's views in the PIM avoid the paradoxes of the infinitesimal and continuum. It also reveals some of what is at stake, both historically and philosophically, in Russell's criticism of Cohen. (shrink)

Nineteenth-century scientist Hermann von Helmholtz’s peculiar wavering between empiricism and transcendentalism in his philosophy of science in general, and in his theory of perception in particular, is a much debated and well-documented topic in the history and philosophy of science. This contribution aims at providing a fresh angle on this classical issue, by considering Helmholtz’s account of differential consciousness against the background of a centuries-old philosophical debate between the empiricist tradition and the tradition of transcendental idealism. By placing Helmholtz’s psychology (...) against the background of a historical narrative stretching from Hume to Fichte, one can gain insight into the possible merits of his empirico-transcendentalism with regard to the problem of differentiation. More particularly, it is argued that Helmholtz’s psychology tilted towards transcendentalism when met with the classical theoretical problems of strict empiricism in dealing with the foundation of consciousness, most notably circularity and infinite regress. Without claiming that Helmholtz’s theorizing presented a self-conscious attempt to overcome the latter issues, his well-known wavering between perspectives in general, and his appropriation of the a priori in particular, might have served him well in avoiding the deadlocks of empiricism. As noted at the end, however, Helmholtz’s account produced complex philosophical problems of its own. (shrink)

European Journal of Philosophy, Volume 30, Issue 1, Page 148-168, March 2022.

In my dissertation, I present Hermann Cohen's foundation for the history and philosophy of science. My investigation begins with Cohen's formulation of a neo-Kantian epistemology. I analyze Cohen's early work, especially his contributions to 19th century debates about the theory of knowledge. I conclude by examining Cohen's mature theory of science in two works, The Principle of the Infinitesimal Method and its History of 1883, and Cohen's extensive 1914 Introduction to Friedrich Lange's History of Materialism. In the former, Cohen gives (...) an historical and philosophical analysis of the foundations of the infinitesimal method in mathematics. In the latter, Cohen presents a detailed account of Heinrich Hertz's Principles of Mechanics of 1894. Hertz considers a series of possible foundations for mechanics, in the interest of finding a secure conceptual basis for mechanical theories. Cohen argues that Hertz's analysis can be completed, and his goal achieved, by means of a philosophical examination of the role of mathematical principles and fundamental concepts in scientific theories. (shrink)

(2005). Hermann Cohen and the Renewal of Kantian philosophy2. Angelaki: Vol. 10, continental philosophy and the sciences the german traditionissue editor: damian veal, pp. 95-108.

The Prussian Protestant Daniel Hermann is an important Neo-Latin poet. He lived from probably 1543 until 1601. Hermann studied at Königsberg, Straßburg, Basel and Wittenberg. Afterwards he served as a secretary at the Imperial Court at Vienna, later as a secretary of the city of Danzig and permanent ambassador of Danzig at the Royal Polish court during the wars against Russia. After the war he married and settled down in Riga and became the secretary of the Polish governor Cardinal Radziwil (...) and later of the general Georg Fahrensbach. Besides lots of poems on academical, political and private occasions he wrote letters in poetic form as well as theological, philosophical and political poems. This paper provides an overview over Hermann ’s life and his poetry, especially the poems written and published in Riga, and a short summary of the research on this poet. (shrink)