The characterization of second-order type isomorphisms is a purely syntactical problem that we propose to study under the enlightenment of game semantics. We study this question in the case of second-order λμ-calculus, which can be seen as an extension of system F to classical logic, and for which we define a categorical framework: control hyperdoctrines.Our game model of λμ-calculus is based on polymorphic arenas which evolve during the play. We show that type isomorphisms coincide with the “equality” on arenas associated (...) with types. Finally we deduce the equational characterization of type isomorphisms from this equality. We also recover from the same model Roberto Di Cosmo’s characterization of type isomorphisms for system F.This approach leads to a geometrical comprehension on the question of second-order type isomorphisms, which can be easily extended to some other polymorphic calculi including additional programming features. (shrink)