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  1. Rethinking Innovation Accounting in Pharmaceutical Regulation: A Case Study in the Deconstruction of Therapeutic Advance and Therapeutic Breakthrough. [REVIEW]John Abraham & Courtney Davis - 2011 - Science, Technology, and Human Values 36 (6):791-815.
    The controversy over the prescription drug, alosetron, is examined in order to investigate what is permitted to count as ‘therapeutic advance’ and ‘therapeutic breakthrough’ within pharmaceutical innovation and regulation. It is argued that those official accounting categories can mask very modest efficacy of some drugs by reference to the official techno-scientific evidence, thus leading to questionable acceptance of risks to public health. This is explained by: the drug availability options set by the commercial interests of manufacturers; the FDA management's need (...)
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  • Heteroglossic Representations of Scientific Uncertainty: A Sociolinguistic Analysis of Expert Witness Testimony to the Bristol Inquiry. [REVIEW]Beth Kewell - 2011 - Science, Technology, and Human Values 36 (6):816-841.
    The Bristol Inquiry is arguably one of the most important cases of judicial medical investigation held in the United Kingdom, which continues to raise important insights into the social construction of medical and scientific risks. As a way of marking the inquiry’s tenth anniversary year, this article returns to an important conversation held between noted pediatric cardiothoracic and cardiovascular specialists, on days 49 and 50 of the inquiry’s proceedings. Their conversance principally describes a pathway of scientific advancement across four decades. (...)
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  • The Construction of Lay Expertise: AIDS Activism and the Forging of Credibility in the Reform of Clinical Trials.Steven Epstein - 1995 - Science, Technology and Human Values 20 (4):408-437.
    In an unusual instance of lay participation in biomedical research, U.S. AIDS treatment activists have constituted themselves as credible participants in the process of knowledge construction, thereby bringing about changes in the epistemic practices of biomedical research. This article examines the mechanisms or tactics by which these lay activists have constructed their credibility in the eyes of AIDS researchers and government officials. It considers the inwlications of such interventions for the conduct of medical research; examines some of the ironies, tensions, (...)
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  • The Law-Set: The Legal-Scientific Production of Medical Propriety.Gary Edmond - 2001 - Science, Technology, and Human Values 26 (2):191-226.
    This article examines some of the interactions between law, science, and society taking place during a trial. By focusing on a restricted set of scientific and nonscientific actors engaged in negotiating the meaning, relevance, and reliability of scientific evidence, the article illustrates how the categories—law, science, and society—are inextricably interrelated in the legal negotiations and outcome. The introduction of scientific evidence into adversarial legal settings produces strategies, opinions, and claims that are not shaped solely by scientists, lawyers, or legal processes. (...)
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