Definition of the problem “Dual use” refers to the applicability of a research result or methods for purposes that concern the internal or external security of a society. This includes research that can be used for military, intelligence, terrorist, or criminal purposes. Dual use has been an increasingly aggravating problem for many areas of the life sciences and medicine for over a decade. The main cause for this is that many of their results are capable of demonstrating how humans, but (...) also (domestic) animals and plants, can be manipulated and attacked, and which tools are particularly suitable for this purpose. Arguments The digitalization in the life sciences has two distinguishable impacts on the dual-use problem: an intensifying and an expanding one. By enabling faster and more comprehensive research and development processes, digitalization exacerbates the existing dual-use problem because it increases the pace at which the results of this research can be utilized for security-related purposes. Moreover, the digitalization of the life sciences expands the dual-use problem, as some of the digital tools developed and used in the life sciences can themselves have military or security-relevant applications. Conclusion Therefore, a broad-based governance including wide participation of stakeholders in the research process and broader information on dual use in good scientific practice education across institutions, career stages, and disciplines is necessary. (shrink)