In an earlier article on this journal I argued that the problem of empirical underdetermination can for the largest part be solved by theoretical virtues, and for the remaining part it can be tolerated. Here I confront two further challenges to scientific realism based on underdetermination. First, there are four classes of theories which may seem to be underdetermined even by theoretical virtues. Concerning them I argue that (i) theories produced by trivial permutations and (ii) “equivalent descriptions” are compatible with (...) the truth of standard theories; instead (iii) “as if” versions of standard theories are much worse from the point of view of theoretical virtues; finally (iv) mathematically intertranslatable theories either may become empirically decidable in the future, or can be discriminated by theoretical virtues, or realists may simply plead ignorance about their claims. Secondly, I consider Stanford’s underdetermination with respect unconceived alternatives, arguing that it essentially relies on the pessimistic meta-induction from the falsity of all past theories. Therefore, it can be resisted by (a) considering the radical advancement of present with respect to past science, and (b) arguing with selective realism that past successful theories, even if false, always included some true components. (shrink)