In this special issue, our objective is to clarify what biosemioticians may mean insofar as they claim that living systems are capable of making choices or that biosemiotic interpretations are partially indeterminate. A number of different senses of the term “chance” are discussed as we move toward a consensus. We find that biosemiosic chance may arise out of conditions involving quantum indeterminacy, randomness, deterministic chaos, or unpredictability, but biosemiosic chance is mainly due to the fact that living entities invest their (...) environments with different meanings and values, which are not inherent in the material aspects. Accordingly, interpretive responses are in part self-determined. A self-determined interpretation may be thought of as a process in which localized biases constrain the probabilities of the outcomes of the interactions between an agent and its environment. The agent’s internal formal constraints that are defined by similarity and proximity are relative and, as such, vague, and thus interpretation may be somewhat underdetermined and involve an element of chance. (shrink)