In this paper, we study the power and limitations of computing effectively generic sequences using effectively random oracles. Previously, it was known that every 2-random sequence computes a 1-generic sequence and every 2-random sequence forms a minimal pair in the Turing degrees with every 2-generic sequence. We strengthen these results by showing that every Demuth random sequence computes a 1-generic sequence and that every Demuth random sequence forms a minimal pair with every pb-generic sequence. Moreover, we prove that for every (...) comeager${\cal G} \subseteq {2^\omega }$, there is some weakly 2-random sequenceXthat computes some$Y \in {\cal G}$, a result that allows us to provide a fairly complete classification as to how various notions of effective randomness interact in the Turing degrees with various notions of effective genericity. (shrink)