Switch to: References

Add citations

You must login to add citations.
  1. Are explanatory trials ethical? Shifting the burden of justification in clinical trial design.Kirstin Borgerson - 2013 - Theoretical Medicine and Bioethics 34 (4):293-308.
    Most phase III clinical trials today are explanatory. Because explanatory, or efficacy, trials test hypotheses under “ideal” conditions, they are not well suited to providing guidance on decisions made in most clinical care contexts. Pragmatic trials, which test hypotheses under “usual” conditions, are often better suited to this task. Yet, pragmatic, or effectiveness, trials are infrequently carried out. This mismatch between the design of clinical trials and the needs of health care professionals is frustrating for everyone involved, and explains some (...)
    Download  
     
    Export citation  
     
    Bookmark   10 citations  
  • Reviewing the Unsubstantiated Claims for the Methodological Superiority of 'Placebo' over 'Active' Controlled Trials: Reply to Open Peer Commentaries.Jeremy Howick - 2009 - American Journal of Bioethics 9 (9):5-7.
    A resilient issue in research ethics is whether and when a placebo-controlled trial is justified if it deprives research subjects of a recognized treatment. The clinicians' moral duty to provide the best available care seems to require the use of ‘active’ controlled trials that use an established treatment as a control whenever such a therapy is available. In another regard, ACTs are supposedly methodologically inferior to PCTs. Hence, the moral duty of the clinical researcher to use the best methods will (...)
    Download  
     
    Export citation  
     
    Bookmark   2 citations