In this paper, I seek to extract what I call an empiricist mode of existence through a combined reading of two under-researched vectors of Gilles Deleuze's thought: his ‘transcendental empiricism’ and his ‘affirmative naturalism’. This empiricist mode of existence co-positions Deleuze's empiricism and naturalism as pertaining to a stylistics of life which is ontologically experimentalist, epistemologically open, and immanently engaged in the world. That is, a processual praxis of demystification and organising encounters towards joy.