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  1. Beyond the oncogene paradigm: Understanding complexity in cancerogenesis.M. Bizzarri, A. Cucina, F. Conti & F. D’Anselmi - 2008 - Acta Biotheoretica 56 (3):173-196.
    In the past decades, an enormous amount of precious information has been collected about molecular and genetic characteristics of cancer. This knowledge is mainly based on a reductionistic approach, meanwhile cancer is widely recognized to be a ‘system biology disease’. The behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. There is not solely a matter how to integrate all available knowledge in such a way that we can still deal with complexity, (...)
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  • Darwin´s two hundred years: is not time for a change?Armando Aranda-Anzaldo - 2009 - Ludus Vitalis 17 (32):87-99.
    Two hundred years after Darwin’s birth, the evolution of living systems is an accepted fact but there is scope for controversy on the mechanisms involved in such a process. Mainstream neo-Darwinism champions the role of natural selection (NS) as the fundamental cause of the evolutionary process as well as of random, contingent events at the genetic level as the main source of variation upon which NS performs its causal role. Thus, according to neo-Darwinism the course of biological evolution is quite (...)
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  • Back to the future: Aristotle and molecular biology.Armando Aranda Anzaldo - 2007 - Ludus Vitalis 15 (28):195-198.
    The Aristotelian axiom that function follows form was beautifully instantiated in molecular biology by the discovery of DNA’s structure that immediately suggested how DNA might work as depository and vehicle for genetic information. However, later on molecular biology became infatuated with the gene that became the center of the universe. This gene-centered viewpoint is an obstacle for the emerging field of evo-devo aiming at finding the causal connections between evolution and biological development. Here it is argued that molecular biology must (...)
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