Stigmata, wounds resembling those of Christ, have been reported since the 13th century. The wounds typically appear in association with visions following prolonged fasting. This paper argues that self-starvation holds the key to understanding this unique event. Stigmata may result from self-mutilation occurring during dissociation, phenomena precipitated in part by dietary constriction. Psychophysiological mechanisms produced by natural selection adjust the salience of risk in light of current resource abundance. As a result, artificial dietary constriction results in indifference to harm. A (...) variety of data links dramatic dietary constriction, reduced serotonergic functioning, altered states of consciousness, and self-injurious behavior. Catholic representations of Christ's crucifixion provide a cultural context that both motivates and lends meaning to the experiences of individuals whose predispositions and life histories increase the likelihood of dietary constriction, dissociation, and self-mutilation. Examining this case raises interesting questions about both the evolutionary and the cultural grounds for defining individual psychopathology. (shrink)