This paper responds to an invitation to historians of political thought to enter the debate on new materialism. It combines Simondon’s philosophy of individuation with some aspects of post-humanist and new materialist thought, without abandoning a more classically ‘historical’ characterization of materialism. Two keywords drawn from Barad and Simondon respectively – ‘ontoepistemology’ and ‘axiontology’ – represent the red thread of a narrative that connects the early modern invention of civil science (emblematically represented here by the ‘conceptual couple’ Descartes-Hobbes) to Wiener’s (...) cybernetic theory of society. The political stakes common to these forms of mechanical materialism were attacked ontologically, epistemologically and politically by Simondon. His approach, I will argue, opens the path for a genuine materialist critique of the political anthropology implicit in modern political thought, and shifts political thinking from politics conceived as a problem to be solved to politics as an arena of strategic experimentation. (shrink)