This article addresses how it is possible to view Damien Hirst as a brand name. It argues that the brand name is not the mark of an originary relation between producer and product but of a set of highly mediated relations between products. In a discussion of the spot paintings, the process of mediation is seen to contribute to the open-endedness of the relations between products or works established in Hirst’s practice. This open-endedness contributes to the distinctiveness of the Hirst (...) brand name as ‘life as it is lived’ or living-ness. This characterization of the distinctiveness of the Hirst brand name draws attention to the ways in which his practice may be seen as a commentary on contemporary science, in particular the bio-sciences. It is further argued that Hirst does not merely represent himself as a scientist, but as a pharmacist, thus drawing attention to the role of branding in shifts in the processes of creativity, invention and discovery across the arts and sciences. (shrink)

This paper builds on previous work that investigated anticancer drugs as ‘informed materials’, i.e., substances that undergo an informational enrichment that situates them in a dense relational web of qualifications and measurements generated by clinical experiments and clinical trials. The paper analyzes the recent transformation of anticancer drugs from ‘informed’ to ‘informing material’. Briefly put: in the post-genomic era, anti-cancer drugs have become instruments for the production of new biological, pathological, and therapeutic insights into the underlying etiology and evolution of (...) cancer. Genomic platforms characterize individual patients’ tumors based on their mutational landscapes. As part of this new approach, drugs targeting specific mutations transcend informational enrichment to become tools for informing their targets, while also problematizing the very notion of a ‘target’. In other words, they have become tools for the exploration of cancer pathways and mechanisms. While several studies in the philosophy and history of biomedicine have called attention to the heuristic relevance and experimental use of drugs, few have investigated concrete instances of this role of drugs in clinical research. (shrink)

The regulation of chemicals is undergoing drastic changes with the use of computational models to predict environmental toxicity. This particular issue has not attracted much attention, despite its major impacts on the regulation of chemicals. This raises the problem of causality at the crossroads between data and regulatory sciences, particularly in the case models known as quantitative structure–activity relationship models. This paper shows that models establish correlations and not scientific facts, and it engages anew the way regulators deal with uncertainties. (...) It does so by exploring the tension and problems raised by the possibility of causal explanation afforded by quantitative structure–activity relationship models. It argues that the specificity of predictive modelling promotes rethinking of the regulation of chemicals. (shrink)

The origin and the development of scientific disciplines has been a topic of reflection for several decades. The few extensive case studies support the thesis that scientific disciplines are not monolithic structures but can be characterized by distinct social, organizational and scientific–technical practices. Nonetheless, most disciplinary histories of genetics confine themselves largely to an uncontested account of the content of the discipline or occasionally institutional factors. Little attention is paid to the large number of researchers who, by their joint efforts, (...) ultimately shaped the discipline. We contribute to this aspect of disciplinary historiography by discussing the role of women researchers at the Institute for Heredity Research, founded in 1914 in Berlin under the directorship of Erwin Baur, and the sister of the John Innes Institute at Cambridge. This paper investigates how and why Baur built a highly successful research programme that relied on the efforts of his female staff, whose careers, notably Elisabeth Schiemann's, are also assessedin toto. These women undertook the necessary ‘technoscience’ and in some cases innovative work and helped increase the prestige of the institute and its director. Together they played a pivotal role in the establishment of genetics in Germany. Without them the discipline would have developed much more slowly and along a divergent path. (shrink)

This paper explores the distinctive features of the critical agenda associated with the ‘Social Life of Methods’. I argue that although this perspective can be associated with the increasing interest, often associated with scholars in Science and Technology Studies, to reflect on how methods can become objects of inquiry, it also needs to be rooted in the current crisis of positivist methods. I identify the challenge for positivism in terms of the decreasing ability of its procedures to effectively organize increasingly (...) ‘lively’ sources of standardized data, which can now be assembled using aesthetic registers. In developing this argument, I dispute the idea that this development is due to historical shifts linked to the way that methodological devices are playing an increasingly significant role in contemporary social life, which might be argued by writers such as Thrift or Castells. I also argue that by opening up issues of method to the aesthetic, we also recast the relationship between theory and method, pointing to the exhaustion of a certain kind of cultural theory within the social sciences. I contextualize these issues by considering how methods are implicated in the intellectual differentiation between scientific and humanities expertise. Rather than conceiving the ‘Social Life of Methods’ in terms of the rise of instrumentalist modes of governance, it is preferable to place it within the dialectic of transparency and the relationship between the implicit and explicit. These issues are addressed through introducing the papers in the special issue. (shrink)

The aim of the article is to intervene in debates about the digital and, in particular, framings that imagine the digital in terms of epochal shifts or as redefining life. Instead, drawing on recent developments in digital methods, we explore the lively, productive and performative qualities of the digital by attending to the specificities of digital devices and how they interact, and sometimes compete, with older devices and their capacity to mobilize and materialize social and other relations. In doing so, (...) our aim is to explore the implications of digital devices and data for reassembling social science methods or what we call the social science apparatuses that assemble digital devices and data to ‘know’ the social and other relations. Building on recent work at CRESC on the social life of methods, we recommend a genealogical approach that is alive to the ways in which digital devices are simultaneously shaped by social worlds, and can in turn become agents that shape those worlds. This calls for attending to the specificities of digital devices themselves, how they are varied and composed of diverse socio-technical arrangements, and are enrolled in the creation of new knowledge spaces, institutions and actors. Rather than exploring what large-scale changes can be revealed and understood through the digital, we argue for explorations of how digital devices themselves are materially implicated in the production and performance of contemporary sociality. To that end we offer the following nine propositions about the implications of digital data and devices and argue that these demand rethinking the theoretical assumptions of social science methods: transactional actors; heterogeneity; visualization; continuous time; whole populations; granularity; expertise; mobile and mobilizing; and non-coherence. (shrink)

This article is based on a performance piece, Thought Conductor # 2, by the artist Bruce Gilchrist. In a live-art context, the signals generated by an individual hooked up to an EEG are converted into passages of musical notation and played by a string quartet. What is happening here, or rather what kind of happening is taking place, is the focus of this article. The article explores the relations between the author, the score, and the sound in Thought Conductor # (...) 2 as well in John Cage’s 4’33”, the landmark work that inspired the Thought Conductor pieces, and which has been described as one of the first happenings in America. These key elements offer clues to the different kinds of ‘presences’ that the performances embody, and the different notions of ‘life’ to which they refer. The sound of TC2 is the sound of an event. (shrink)

This article provides an overview of the analysis of technological zones. A technological zone can be understood as a space within which differences between technical practices, procedures and forms have been reduced, or common standards have been established. Such technological zones take broadly one of three forms: (1) metrological zones associated with the development of common forms of measurement; (2) infrastructural zones associated with the creation of common connection standards; and (3) zones of qualification which come into being when objects (...) and practices are assessed according to common standards and criteria. The article argues that technological zones can have more or less clear borders, but such borders increasingly do not correspond to the borders of nation-states. Through a discussion of the global oil industry, some of the ways in which the formation of technological zones has become critical to contemporary economic and political life are examined. (shrink)

This article explores what might happen to the concept of performativity within arguments that are understood as ‘topological’. It argues that we might ‘decline’ performativity, which is to say, elaborate the concerns that are expressed in the concept, but inclining it more boldly towards the complexities of a world whose elements are always in process of constitution, of reiterative enfolding. Taking a cue from Isabelle Stengers’ recent work in which she posits the notion of ecologies of practice, on the one (...) hand, and Whitehead’s concept of concern, on the other, the paper argues that emergent entities have differential requirements – not least according to the disciplines to which they appeal – and subtend different modes of implied obligation. An adherence to these requirements needs to be accompanied by persuasive presentation that obliges a community to affirm any entity. On many levels of abstraction, ecologies need to show concern for an entity to facilitate its emergence and to sustain its mode of being. In an expanded vision, then, human and non-human entities at all levels enter into multifarious relational modes of becoming, but these become of sustained consequence only through persuasion of communities, sometimes organized into disciplines. The survival of entities requires forms of differentiation, division and of value. The paper relates these arguments to forms of sociological enquiry that give glimpses of how sociology might respond. It ends with a hesitation around the radical anti-anthropomorphism of the stance developed, and argues that this does not entirely eclipse the importance of political hope. (shrink)

This paper advances two arguments about environmental problems. First, it interrogates the strength and limitations of empiricist accounts of problems and issues offered by actor-network theory. Drawing on the work of C.S. Peirce, it considers how emerging environmental problems often lead to abductive inferences about the existence of hidden causes that may or may not have caused the problem to emerge. The analysis of environmental problems should be empiricist in so far as it is sceptical of the claims of those (...) who know in advance what the problem is, but it should also be alert to processes and things that are not readily traceable or perceived. Secondly, the paper’s contention is that environmental problems almost invariably involve an encounter between unlike or disparate materials or processes. In such circumstances, the challenge is to develop a form of inquiry that is alert to both the specificity of such encounters and to the specificity of the political situations in which they come to matter. (shrink)