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  1. A Tale of Two Chimeras: Applying the Six Principles to Human Brain Organoid Xenotransplantation.Andrew J. Barnhart & Kris Dierickx - 2023 - Cambridge Quarterly of Healthcare Ethics 32 (4):555-571.
    Cerebral organoid models in-of-themselves are considered as an alternative to research animal models. But their developmental and biological limitations currently inhibit the probability that organoids can fully replace animal models. Furthermore, these organoid limitations have, somewhat ironically, brought researchers back to the animal model via xenotransplantation, thus creating hybrids and chimeras. In addition to attempting to study and overcome cerebral organoid limitations, transplanting cerebral organoids into animal models brings an opportunity to observe behavioral changes in the animal itself. Traditional animal (...)
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  • Moving beyond the moral status of organoid‐entities.Andrew J. Barnhart & Kris Dierickx - 2023 - Bioethics 37 (2):103-110.
    Ethical deliberations are unfolding for potentially controversial organoid‐entities such as brain organoids and embryoids. Much of the ethical deliberation centers on the questionable moral status of such organoid‐entities. However, while such work is important and appropriate, ethical deliberations may become too exclusively rooted in moral status and potentially overshadow other relevant moral dilemmas. The ethical discussion on organoid models can benefit from insights brought forth by both Judith Jarvis Thomson and Don Marquis in how they attempted to advance the abortion (...)
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  • Cardiac organoids do not warrant additional moral scrutiny.Jannieke N. Simons, Rieke van der Graaf & Johannes J. M. van Delden - 2024 - BMC Medical Ethics 25 (1):1-5.
    Certain organoid subtypes are particularly sensitive. We explore whether moral intuitions about the heartbeat warrant unique moral consideration for newly advanced contracting cardiac organoids. Despite the heartbeat’s moral significance in organ procurement and abortion discussions, we argue that this significance should not translate into moral implications for cardiac organoids.
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