This paper examines the research leading from the initial discovery of a disease in 1957 to its complete description twenty years later. The analysis reveals four stages in the discovery process and attempts to pinpoint the key characteristics of each of those stages. It is suggested that the early stages in the process have some of the characteristics depicted by T. H. Kuhn about the logic of discovery whereas the later stages exemplify the characteristics of the logic of discovery propounded (...) by Karl Popper. (shrink)