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Multiple Realization and Robustness

In Marta Bertolaso, Silvia Caianiello & Emanuele Serrelli (eds.), Biological Robustness. Emerging Perspectives from within the Life Sciences. Cham: Springer. pp. 75-94 (2018)

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  1. Robustness and Modularity.Trey Boone - forthcoming - British Journal for the Philosophy of Science.
    Functional robustness refers to a system’s ability to maintain a function in the face of perturbations to the causal structures that support performance of that function. Modularity, a crucial element of standard methods of causal inference and difference-making accounts of causation, refers to the independent manipulability of causal relationships within a system. Functional robustness appears to be at odds with modularity. If a function is maintained despite manipulation of some causal structure that supports that function, then the relationship between that (...)
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  • Evolving Concepts of Functional Localization.Joseph B. McCaffrey - 2023 - Philosophy Compass 18 (5):e12914.
    Functional localization is a central aim of cognitive neuroscience. But the nature and extent of functional localization in the human brain have been subjects of fierce theoretical debate since the 19th Century. In this essay, I first examine how concepts of functional localization have changed over time. I then analyze contemporary challenges to functional localization drawing from research on neural reuse, neural degeneracy, and the context-dependence of neural functions. I explore the consequences of these challenges for topics in philosophy of (...)
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  • VII—Novel Explanation in the Special Sciences: Lessons from Physics.Eleanor Knox - 2017 - Proceedings of the Aristotelian Society 117 (2):123-140.
    This paper aims to understand how recent discussion of novel and robust behaviour in physics might be applied in biology and other special sciences. In particular, it looks at the prospects for extending an account of novel explanation to biological examples. Despite the differences in the disciplines, the prospects look good, at least when we look at a biological example in which a certain kind of reduction is possible.
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  • Emergence in Complex Physiological Processes: The Case of Vitamin B12 Functions in Erythropoiesis.Francesca Bellazzi & Marta Bertolaso - 2024 - Systems 12.
    In this paper, we will explore the relation between molecular structure and functions displayed by biochemical molecules in complex physiological processes by using tools from the philosophy of science and the philosophy of scientific practice. We will argue that biochemical functions are weakly emergent from molecular structure by using an account of weak. In order to explore this thesis, we will consider the role of vitamin B12 in contributing to the process of erythropoiesis. The structure of the paper is the (...)
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  • Biochemical Kinds and the Unity of Science.Francesca Bellazzi - 2023 - Dissertation, University of Bristol
    The present thesis explores some metaphysical issues concerning biochemical kinds and the relations between chemical and biological properties and phenomena. The main result of this thesis is that there is something sui generis about biochemical kinds. This result is motivated by two theoretical steps. The first is characterising biochemical functions as weakly emergent from the chemical structure [Chapter 3, Chapter 6]. The second is via an account for which biochemical kinds are natural categories [Chapter 4, Chapter 7]. The thesis comprises (...)
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  • The emergence of the postgenomic gene.Francesca Bellazzi - 2022 - European Journal for Philosophy of Science 12 (1):1-21.
    The identity and the existence of genes has been challenged by postgenomic discoveries. Specifically, the consideration of molecular and cellular phenomena in which genes are embedded has proved relevant for their understanding. In response to these challenges, I will argue that the complexity of genetic phenomena supports the weak emergence of genes from the DNA. In Section 2, I will expose what genes are taken to be in the postgenomic world. In Section 3, I will present the relevant account of (...)
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