When it comes to disagreements about religious, moral or political questions, many people consider a tolerant ‘live-and-let-live’ attitude to be the best reaction toward conflicting opinions. However, many epistemologists are rather skeptical about the epistemic acceptability of such a tolerant attitude. More specifically, the worry is that a tolerant reaction toward recognized disagreement is necessarily epistemically irrational. After setting out this worry in a little more detail, I will present and discuss three different arguments for the epistemic irrationality of a (...) tolerant attitude toward disagreement. I will argue that while all these arguments ultimately fail, they still reveal some substantial limitations to the epistemic adequacy of intellectual tolerance. (shrink)