With the publication of this inaugural issue of the internationally peer-reviewed journal Biosemiotics, our still-developing young interdiscipline marks yet another milestone in its journey towards adulthood. For this occasion, the editors of Biosemiotics have asked me to provide for those readers who may be newcomers to our field a very brief overview of the history of biosemiotics, contextualizing it within and against the larger currents of philosophical and scientific thinking from which it has emerged. To explain the origins of this (...) most twenty-first century endeavour effectively, however, will require tracing—at least to the level of a thumbnail sketch—how the ‘sign’ concept appeared, was lost, and now must be painstakingly rediscovered and refined in science. To relate this long history, this article will appear in Biosemiotics in three instalments, examining, respectively: (1) The History of the Sign Concept in Pre-Modernist Science, (2) The History of the Sign Concept in Modernist Science, and (3) The Biosemiotic Attempt to Develop a More Useful Sign Concept for Contemporary Science. In this instalment, we begin our introductory ‘stroll through the woods of sciences and signs’ by following the development of the sign concept within the context of scientific inquiry, in necessarily broad outline, from the beginnings of such inquiry in sixth century BCE, through its long development in the Middle Ages, and up unto the onset of modernity. For only within this larger historical context can our contemporary attempt to develop a naturalistic understanding of sign relations be understood. (shrink)