Philosophical work on explanation has focused on the following two topics: theories of explanation, intended to enumerate necessary and sufficient conditions for explanation, and inference to the best explanation as the strongest form of justification for ontological or metaphysical claims. I critically examine the most important philosophical work in both of these areas and defend my own conclusions about the connections between explanation and ontology. I argue that all of our inferences about the nature of the world, in ontology or (...) metaphysics, presuppose criteria for acceptable explanation. I first examine the metaphysics of Plato, Aristotle, and Leibniz, arguing that their metaphysical reasoning was guided by assumptions about the nature of explanation. I also survey some recent work in ontology and find inference to the best explanation offered as the strongest available method of defending existence claims. To conclude this discussion, I offer an original argument for the thesis that all reasoning about existence claims, being nondeductive, presupposes some criteria for acceptable explanations, or a theory of explanation. Carl Hempel and Wesley Salmon have been two of the most influential philosophers offering theories of explanation, and I examine their work with the intention of discovering ontological or metaphysical assumptions shaping their theories of explanation. I argue that Hempel's theory rests on deterministic assumptions, and I argue the Salmon's theory of causality, which he admits supports his theory of explanation, is subject to empiricist criticisms. Theories of explanation typically rest on assumptions about the nature of the world, I argue, and I explain why this is so with an original theory of explanation connecting it to the psychological phenomenon of understanding. We rely on understanding in the identification of explanations, and understanding requires establishing a metaphysical context for an explanandum-event. I end by indicating the possibility of generating vicious justificatory circles through the reciprocal relationship of support between explanation and ontology, and I argue that vicious circles can be avoided only by grounding all ontological reasoning in a fundamental explanatory task of giving order to experience through a system of categories. (shrink)