This paper examines histories of postvaccinal breaks in immunity to rabies in domestic dogs between 1950 and the 1960s. It utilizes Veterinary and Native Commissioner's reports and newspapers in arguing that there is a gap in current southern African rabies historiography as it is yet to grapple with narratives about vaccine technologies. Current southern African rabies histories overly focus on white South African urban case studies. Focusing on the histories of postvaccinal breaks in immunity to rabies in Southern Rhodesia helps (...) to explain why rabies became an ineradicable canine disease in southern Africa during this period. The paper focuses on the political economy of the mass vaccination of dogs, the costs attached to the Veterinary Department's decision to ignore other canine diseases in African areas, and how this, combined with other policy measures such as dog taxation, in undermining rabies vaccination campaigns. Overall, it shows that African dog-owners resorted to a myriad of responses to coercive rabies regulations. This complexity ultimately resulted in canine rabies becoming a difficult disease to eradicate. (shrink)